Gene Gene information from NCBI Gene database.
Entrez ID 7058
Gene name Thrombospondin 2
Gene symbol THBS2
Synonyms (NCBI Gene)
EDSCLL3TSP2
Chromosome 6
Chromosome location 6q27
Summary The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor gr
miRNA miRNA information provided by mirtarbase database.
784
miRTarBase ID miRNA Experiments Reference
MIRT438198 hsa-miR-27b-3p Luciferase reporter assay 24177325
MIRT438198 hsa-miR-27b-3p Luciferase reporter assay 24177325
MIRT438198 hsa-miR-27b-3p Luciferase reporter assay 24177325
MIRT438198 hsa-miR-27b-3p Luciferase reporter assay 24177325
MIRT722595 hsa-miR-3922-5p HITS-CLIP 19536157
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
HOXB7 Repression 21183939
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19
GO ID Ontology Definition Evidence Reference
GO:0005201 Function Extracellular matrix structural constituent RCA 28327460, 28675934
GO:0005509 Function Calcium ion binding IEA
GO:0005515 Function Protein binding IPI 19818485
GO:0005576 Component Extracellular region HDA 27068509
GO:0005576 Component Extracellular region IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
188061 11786 ENSG00000186340
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P35442
Protein name Thrombospondin-2
Protein function Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.
PDB 1YO8 , 2RHP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00093 VWC 320 374 von Willebrand factor type C domain Family
PF00090 TSP_1 385 430 Thrombospondin type 1 domain Domain
PF00090 TSP_1 441 491 Thrombospondin type 1 domain Domain
PF00090 TSP_1 498 548 Thrombospondin type 1 domain Domain
PF07645 EGF_CA 590 646 Calcium-binding EGF domain Domain
PF12947 EGF_3 652 691 EGF domain Domain
PF02412 TSP_3 729 764 Thrombospondin type 3 repeat Repeat
PF02412 TSP_3 763 787 Thrombospondin type 3 repeat Repeat
PF02412 TSP_3 788 823 Thrombospondin type 3 repeat Repeat
PF02412 TSP_3 823 846 Thrombospondin type 3 repeat Repeat
PF02412 TSP_3 847 884 Thrombospondin type 3 repeat Repeat
PF02412 TSP_3 885 920 Thrombospondin type 3 repeat Repeat
PF02412 TSP_3 921 956 Thrombospondin type 3 repeat Repeat
PF05735 TSP_C 974 1171 Thrombospondin C-terminal region Family
Tissue specificity TISSUE SPECIFICITY: High expression in invertebral disk tissue. {ECO:0000269|PubMed:18455130}.
Sequence
MVWRLVLLALWVWPSTQAGHQDKDTTFDLFSISNINRKTIGAKQFRGPDPGVPAYRFVRF
DYIPPVNADDLSKITKIMRQKEGFFLTAQLKQDGKSRGTLLALEGPGLSQRQFEIVSNGP
ADTLDLTYWIDGTRHVVSLEDVGLADSQWKNVTVQVAGETYSLHVGCDLIDSFALDEPFY
EHLQAEKSRMYVAKGSARESHFRGLLQNVHLVFENSVEDILSKKGCQQGQGAEINAISEN
TETLRLGPHVTTEYVGPSSERRPEVCERSCEELGNMVQELSGLHVLVNQLSENLKRVSND
NQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTTCTCKKFKTICHQITCPPATC
ASPSFVEGECCPSC
LHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSI
QTRACSLSKC
DTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSG
RETKACQGAPC
PIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQER
QMCNKRSC
PVDGCLSNPCFPGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDI
CFSTSKVPRCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVC
EPENPCKDKTHNCH
KHAECIYLGHFSDPMYKCECQTGYAGDGLIC
GEDSDLDGWPNLNLVCATNATYHCIKDNC
PHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQADYDKDEVGDRCDNCP
YVHNPAQ
IDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPL
VHNPDQ
TDVDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNANQADHDRDGQGDACDPDD
DNDGVPDDRDNCRLVFNPDQ
EDLDGDGRGDICKDDFDNDNIPDIDDVCPENNAISETDFR
NFQMVPLDPKGTTQIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDR
DDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRN
ALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPI
YDQTYAGGRLGLFVFSQEMVYFSDLKYECRD
I
Sequence length 1172
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Phagosome
PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Cytoskeleton in muscle cells
Malaria
Human papillomavirus infection
  Signaling by PDGF
Defective B3GALTL causes Peters-plus syndrome (PpS)
O-glycosylation of TSR domain-containing proteins
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
18
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession Evidence Score
Ehlers-Danlos syndrome Pathogenic rs2483451503 RCV003985134
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Ehlers-Danlos syndrome, classic-like, 3 Pathogenic rs2483451503 RCV004577965
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ANORECTAL MALFORMATION GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BRAIN INFARCTION GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Cervical cancer Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma BEFREE 19578767, 9676856
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 27513329
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 12358136
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma LHGDN 12358136
★☆☆☆☆
Found in Text Mining only
Adenoma of large intestine Colorectal adenoma BEFREE 26482433
★☆☆☆☆
Found in Text Mining only
Adult Medulloblastoma Medulloblastoma BEFREE 31063715
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 26482433 Associate
★☆☆☆☆
Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA Syndromic microphthalmia BEFREE 28701476, 30569296, 30867830, 31676359
★☆☆☆☆
Found in Text Mining only
Aortic Aneurysm Abdominal Aortic aneurysm Pubtator 21593211, 32605321, 34669362 Associate
★☆☆☆☆
Found in Text Mining only
Aortic Valve Stenosis Aortic Valve Sclerosis BEFREE 22035575
★☆☆☆☆
Found in Text Mining only