TGM4 (transglutaminase 4)

Gene

• Entrez ID: 7047
• Gene name: Transglutaminase 4
• Gene symbol: TGM4
• Synonyms (NCBI Gene): TGP, hTGP
• Chromosome: 3
• Chromosome location: 3p21.31

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1421879	hsa-miR-21	CLIP-seq
MIRT1421880	hsa-miR-216b	CLIP-seq
MIRT1421881	hsa-miR-224	CLIP-seq
MIRT1421882	hsa-miR-320a	CLIP-seq
MIRT1421883	hsa-miR-320b	CLIP-seq
MIRT1421884	hsa-miR-320c	CLIP-seq
MIRT1421885	hsa-miR-320d	CLIP-seq
MIRT1421886	hsa-miR-326	CLIP-seq
MIRT1421887	hsa-miR-330-5p	CLIP-seq
MIRT1421888	hsa-miR-3616-3p	CLIP-seq
MIRT1421889	hsa-miR-4290	CLIP-seq
MIRT1421890	hsa-miR-4429	CLIP-seq
MIRT1421891	hsa-miR-4436b-3p	CLIP-seq
MIRT1421892	hsa-miR-4762-5p	CLIP-seq
MIRT1421893	hsa-miR-4775	CLIP-seq
MIRT1421894	hsa-miR-516b	CLIP-seq
MIRT1421895	hsa-miR-590-5p	CLIP-seq
MIRT1421880	hsa-miR-216b	CLIP-seq
MIRT2126550	hsa-miR-4270	CLIP-seq
MIRT2126551	hsa-miR-4441	CLIP-seq
MIRT1421892	hsa-miR-4762-5p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
SP1	Unknown	10580145
SP3	Unknown	10580145

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003810	Function	Protein-glutamine gamma-glutamyltransferase activity	IBA
GO:0003810	Function	Protein-glutamine gamma-glutamyltransferase activity	IEA
GO:0003810	Function	Protein-glutamine gamma-glutamyltransferase activity	NAS	7916568
GO:0005737	Component	Cytoplasm	IDA	20596668
GO:0005794	Component	Golgi apparatus	IDA	20569004
GO:0016740	Function	Transferase activity	IEA
GO:0016746	Function	Acyltransferase activity	IEA
GO:0031012	Component	Extracellular matrix	IBA
GO:0031012	Component	Extracellular matrix	IDA	20596668
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145

Other IDs

• MIM: 600585
• HGNC: 11780
• e!Ensembl: ENSG00000163810

Protein

• UniProt ID: P49221
• Protein name: Protein-glutamine gamma-glutamyltransferase 4 (EC 2.3.2.13) (Fibrinoligase) (Prostate transglutaminase) (Prostate-specific transglutaminase) (Transglutaminase P) (TG(P)) (TGP) (TGase P) (Transglutaminase-4) (TGase-4)
• Protein function: Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00868	Transglut_N	7 → 123	Transglutaminase family	Domain
  PF01841	Transglut_core	229 → 351	Transglutaminase-like superfamily	Family
  PF00927	Transglut_C	587 → 684	Transglutaminase family, C-terminal ig like domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Prostate.
• Sequence:

  MMDASKELQVLHIDFLNQDNAVSHHTWEFQTSSPVFRRGQVFHLRLVLNQPLQSYHQLKL
  EFSTGPNPSIAKHTLVVLDPRTPSDHYNWQATLQNESGKEVTVAVTSSPNAILGKYQLNV
  KTGNHILKSEENILYLLFNPWCKEDMVFMPDEDERKEYILNDTGCHYVGAARSIKCKPWN
  FGQFEKNVLDCCISLLTESSLKPTDRRDPVLVCRAMCAMMSFEKGQGVLIGNWTGDYEGG
  TAPYKWTGSAPILQQYYNTKQAVCFGQCWVFAGILTTVLRALGIPARSVTGFDSAHDTER
  NLTVDTYVNENGEKITSMTHDSVWNFHVWTDAWMKRPDLPKGYDGWQAVDATPQERSQGV
  FCCGPSPLTAIRKGDIFIVYDTRFVFSEVNGDRLIWLVKMVNGQEELHVISMETTSIGKN
  ISTKAVGQDRRRDITYEYKYPEGSSEERQVMDHAFLLLSSEREHRRPVKENFLHMSVQSD
  DVLLGNSVNFTVILKRKTAALQNVNILGSFELQLYTGKKMAKLCDLNKTSQIQGQVSEVT
  LTLDSKTYINSLAILDDEPVIRGFIIAEIVESKEIMASEVFTSFQYPEFSIELPNTGRIG
  QLLVCNCIFKNTLAIPLTDVKFSLESLGISSLQTSDHGTVQPGETIQSQIKCTPIKTGPK
  KFIVKLSSKQVKEINAQKIVLITK

• Sequence length: 684

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Essential tremor	Likely pathogenic	rs139860990	RCV001543420	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Benign Prostatic Hyperplasia	Benign Prostatic Hyperplasia	BEFREE	20177144, 29285211		★☆☆☆☆ Found in Text Mining only
Familial lichen amyloidosis	Lichen amyloidosis	BEFREE	29288003		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	17244021, 18983858, 19055846, 20177144, 21657838, 28179293, 29285211, 29288003, 31249104		★☆☆☆☆ Found in Text Mining only
Metastatic Prostate Carcinoma	Metastatic Prostate Carcinoma	BEFREE	10604718		★☆☆☆☆ Found in Text Mining only
Non-obstructive azoospermia	Non-obstructive azoospermia	BEFREE	22286264		★☆☆☆☆ Found in Text Mining only
Obstructive azoospermia	Obstructive azoospermia	BEFREE	22286264		★☆☆☆☆ Found in Text Mining only
Periodontitis	Periodontitis	BEFREE	22092925		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	17244021, 18983858, 19055846, 20177144, 21657838, 28179293, 29285211, 29288003, 31249104		★☆☆☆☆ Found in Text Mining only
Prostatic Hyperplasia	Prostatic hyperplasia	Pubtator	20177144	Associate	★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	20177144, 20596668, 21524313, 23974364, 27903962, 28179293, 36497036	Associate	★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	BEFREE	29285211		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	31249104	Stimulate	★☆☆☆☆ Found in Text Mining only