TFF2 (trefoil factor 2)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID 7032
Gene name Trefoil factor 2
Gene symbol TFF2
Synonyms (NCBI Gene)
SML1SP
Chromosome 21
Chromosome location 21q22.3
Summary Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are
miRNA miRNA information provided by mirtarbase database.
13
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Show/Hide all (13)
miRTarBase ID miRNA Experiments Reference
MIRT006110 hsa-miR-335-5p Luciferase reporter assayqRT-PCRWestern blot 21822301
MIRT006110 hsa-miR-335-5p Luciferase reporter assayqRT-PCRWestern blot 21822301
MIRT006110 hsa-miR-335-5p Luciferase reporter assayqRT-PCRWestern blot 21822301
MIRT006110 hsa-miR-335-5p Luciferase reporter assayqRT-PCRWestern blot 21822301
MIRT006110 hsa-miR-335-5p Luciferase reporter assayqRT-PCRWestern blot 21822301
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
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Transcription factor Regulation Reference
SP3 Repression 23000412
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
7
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 21982860, 32814053
GO:0005576 Component Extracellular region IEA
GO:0005615 Component Extracellular space IBA
GO:0030277 Process Maintenance of gastrointestinal epithelium IBA
GO:0031723 Function CXCR4 chemokine receptor binding IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
182590 11756 ENSG00000160181
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q03403
Protein name Trefoil factor 2 (Spasmolysin) (Spasmolytic polypeptide) (SP)
Protein function Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00088 Trefoil 31 → 72 Trefoil (P-type) domain Domain
PF00088 Trefoil 81 → 121 Trefoil (P-type) domain Domain
Tissue specificity TISSUE SPECIFICITY: Stomach.
Sequence
Sequence length 129
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (2)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
COLOR VISION DISORDER — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PANCREATIC CARCINOMA — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (69)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma BEFREE 11389052, 27523981, 30324235
★★★★★
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Rheumatoid arthritis Pubtator 31817054 Stimulate
★★★★★
★☆☆☆☆
Found in Text Mining only
Asthma Asthma BEFREE 22329990, 30447498
★★★★★
★☆☆☆☆
Found in Text Mining only
Barrett Esophagus Barrett esophagus BEFREE 18430189, 30831146
★★★★★
★☆☆☆☆
Found in Text Mining only
Barrett Esophagus Barrett esophagus Pubtator 24550372 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 14716296, 1735955, 1795101, 1829922, 28687783
★★★★★
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 28687783 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 11163773, 12717829, 16437709 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Lobular Lobular carcinoma Pubtator 21228366 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 22246423
★★★★★
★☆☆☆☆
Found in Text Mining only