NR2F1 (nuclear receptor subfamily 2 group F member 1)

Gene

• Entrez ID: 7025
• Gene name: Nuclear receptor subfamily 2 group F member 1
• Gene symbol: NR2F1
• Synonyms (NCBI Gene): BBOAS, BBSOAS, COUP-TFI, COUPTF1, EAR-3, EAR3, ERBAL3, SVP44, TCFCOUP1, TFCOUP1
• Chromosome: 5
• Chromosome location: 5q15
• Summary: The protein encoded by this gene is a nuclear hormone receptor and transcriptional regulator. The encoded protein acts as a homodimer and binds to 5`-AGGTCA-3` repeats. Defects in this gene are a cause of Bosch-Boonstra optic atrophy syndrome (BBOAS). [pr

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs530910180	C>A,T	Likely-pathogenic	Coding sequence variant, synonymous variant, stop gained
rs587777274	G>C	Pathogenic-likely-pathogenic	Genic upstream transcript variant, coding sequence variant, missense variant, upstream transcript variant
rs587777275	C>A,T	Pathogenic-likely-pathogenic	Missense variant, genic upstream transcript variant, upstream transcript variant, synonymous variant, coding sequence variant
rs587777276	T>C	Likely-pathogenic	Coding sequence variant, missense variant
rs587777277	G>A	Likely-pathogenic	Genic upstream transcript variant, coding sequence variant, missense variant, upstream transcript variant
rs778199728	A>G,T	Pathogenic	Missense variant, coding sequence variant, synonymous variant, upstream transcript variant, genic upstream transcript variant
rs863224903	T>C	Likely-pathogenic	Coding sequence variant, missense variant, upstream transcript variant, genic upstream transcript variant
rs886039714	G>A	Pathogenic	Coding sequence variant, missense variant, upstream transcript variant, genic upstream transcript variant
rs886041216	T>C	Pathogenic	Missense variant, initiator codon variant, genic upstream transcript variant
rs886041738	C>T	Pathogenic	Coding sequence variant, missense variant, upstream transcript variant, genic upstream transcript variant
rs1022192010	C>T	Pathogenic	Missense variant, genic upstream transcript variant, coding sequence variant, upstream transcript variant
rs1057519434	G>A	Pathogenic	Upstream transcript variant, missense variant, coding sequence variant, genic upstream transcript variant
rs1057522318	G>C	Likely-pathogenic	Upstream transcript variant, missense variant, coding sequence variant, genic upstream transcript variant
rs1064794459	TTC>-	Likely-pathogenic	Inframe deletion, coding sequence variant
rs1064796799	A>G	Pathogenic	Initiator codon variant, missense variant, genic upstream transcript variant
rs1064797311	C>A	Likely-pathogenic	Upstream transcript variant, coding sequence variant, genic upstream transcript variant, stop gained
rs1131691826	G>A	Likely-pathogenic	Upstream transcript variant, missense variant, coding sequence variant, genic upstream transcript variant
rs1287146448	C>G,T	Likely-pathogenic	Missense variant, coding sequence variant, genic upstream transcript variant, upstream transcript variant
rs1297603674	C>T	Likely-pathogenic	Stop gained, coding sequence variant
rs1554074673	A>C	Pathogenic	Coding sequence variant, missense variant, upstream transcript variant, genic upstream transcript variant
rs1554074682	G>T	Likely-pathogenic	Coding sequence variant, missense variant, upstream transcript variant, genic upstream transcript variant
rs1554074684	G>A,T	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant, upstream transcript variant, genic upstream transcript variant
rs1554074850	GC>CT	Likely-pathogenic	Coding sequence variant, stop gained
rs1554075105	T>C	Likely-pathogenic	Coding sequence variant, missense variant
rs1561523678	G>T	Likely-pathogenic	Coding sequence variant, missense variant, upstream transcript variant, genic upstream transcript variant
rs1561523796	T>G	Pathogenic	Coding sequence variant, stop gained, upstream transcript variant, genic upstream transcript variant
rs1580358347	CCGCGGCGGC>-	Likely-pathogenic	Frameshift variant, upstream transcript variant, coding sequence variant, genic upstream transcript variant
rs1580358650	AACT>-	Likely-pathogenic	Frameshift variant, upstream transcript variant, coding sequence variant, genic upstream transcript variant
rs1580358677	G>C	Likely-pathogenic	Upstream transcript variant, missense variant, coding sequence variant, genic upstream transcript variant
rs1580360308	AA>-	Pathogenic	Frameshift variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT047264	hsa-miR-181b-5p	CLASH	23622248
MIRT045568	hsa-miR-149-5p	CLASH	23622248

Transcription factors

Transcription factor	Regulation	Reference
CREB1	Repression	15955695
ESRRA	Repression	15955695
TWIST1	Activation	19051271
TWIST2	Activation	19051271

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	10644740
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	10644740
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	10644740
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IDA	10644740
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0003700	Function	DNA-binding transcription factor activity	TAS	2739739
GO:0004879	Function	Nuclear receptor activity	IBA
GO:0005515	Function	Protein binding	IPI	1517211, 11043578
GO:0005634	Component	Nucleus	IDA	10644740
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0007165	Process	Signal transduction	TAS	2739739
GO:0007399	Process	Nervous system development	IBA
GO:0007399	Process	Nervous system development	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0010977	Process	Negative regulation of neuron projection development	IEA
GO:0030154	Process	Cell differentiation	IBA
GO:0030522	Process	Intracellular receptor signaling pathway	IEA
GO:0043565	Function	Sequence-specific DNA binding	IDA	10644740
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0044323	Function	Retinoic acid-responsive element binding	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

Other IDs

• MIM: 132890
• HGNC: 7975
• e!Ensembl: ENSG00000175745

Protein

• UniProt ID: P10589
• Protein name: COUP transcription factor 1 (COUP-TF1) (COUP transcription factor I) (COUP-TF I) (Nuclear receptor subfamily 2 group F member 1) (V-erbA-related protein 3) (EAR-3)
• Protein function: Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGG
• PDB: 2EBL
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00105	zf-C4	84 → 153	Zinc finger, C4 type (two domains)	Domain
  PF00104	Hormone_recep	204 → 394	Ligand-binding domain of nuclear hormone receptor	Domain

• Sequence:

  MAMVVSSWRDPQDDVAGGNPGGPNPAAQAARGGGGGAGEQQQQAGSGAPHTPQTPGQPGA
  PATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTY
  TCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPLN
  GHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFF
  PDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIR
  IFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQY
  PNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSI
  QCS

• Sequence length: 423

Pathways

Reactome:

Nuclear Receptor transcription pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Autism spectrum disorder	Likely pathogenic	rs2480817986	RCV003127332	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Bosch-Boonstra-Schaaf optic atrophy syndrome	Pathogenic; Likely pathogenic	rs2149941586, rs1306612236, rs1342982789, rs2149946049, rs2149941592, rs2149941551, rs2149941524, rs1753260850, rs587777274, rs587777275, rs587777276, rs587777277, rs2149941611, rs2149946121, rs2149943098, rs2480817831, rs2480809148, rs2480802195, rs1561523716, rs2480802503, rs863224903, rs886041216, rs886041738, rs1753211000, rs2480818013, rs866011766, rs2480802260, rs1580358677, rs764011372, rs2480817819, rs1753210791, rs2480800376, rs1057519434, rs1554075105, rs1554074677, rs1554074684, rs1554074850, rs1287146448, rs1022192010, rs1580358347, rs1297603674, rs2480802519, rs1580360308, rs1753210329, rs1753206907, rs1753208096, rs1753213365, rs1753268855, rs1753211889	RCV001353109 RCV001353110 RCV001353111 RCV001353112 RCV001754557 RCV001775352 RCV001775376 RCV001775448 RCV000114387 RCV000114388 RCV000114389 RCV000114390 RCV001823039 RCV002249111 RCV002273331 RCV002287634 RCV002292714 RCV002471324 RCV002470479 RCV002795906 RCV000200428 RCV001353108 RCV005869202 RCV003314114 RCV003387581 RCV003482194 RCV003494604 RCV003883300 RCV003883305 RCV004560364 RCV004594768 RCV004594769 RCV000416416 RCV000505414 RCV001249826 RCV000677703 RCV000656396 RCV000677407 RCV000677401 RCV000824861 RCV000824821 RCV000985203 RCV001004747 RCV001027649 RCV001027693 RCV001192937 RCV001196876 RCV001198789 RCV001196236 RCV001253606 RCV001254042 RCV001270370	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Neurodevelopmental delay	Pathogenic; Likely pathogenic	rs2149943041, rs1554074682	RCV002274360 RCV002274359	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
NR2F1-related disorder	Likely pathogenic	rs2149941577	RCV003961562	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Seizure	Likely pathogenic	rs1064797311	RCV002275466	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
AUTISM SPECTRUM DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Epilepsy	Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPTIC ATROPHY	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CYSTS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Retinal dystrophy	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RETINITIS PIGMENTOSA 1	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenoma	Adenoma	BEFREE	9851803		★☆☆☆☆ Found in Text Mining only
Adrenal Cortical Adenoma	Adrenocortical adenoma	BEFREE	9851803		★☆☆☆☆ Found in Text Mining only
Anxiety	Anxiety Disorder	BEFREE	30653836		★☆☆☆☆ Found in Text Mining only
Anxiety Disorders	Anxiety Disorder	BEFREE	30653836		★☆☆☆☆ Found in Text Mining only
Atrophy	Atrophy	Pubtator	36702506	Associate	★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorder	Autism	Pubtator	31729143	Associate	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Autistic Disorder	Autism	Pubtator	30628890, 39972940	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	10772965, 17674191, 23785296, 24906407, 30322396		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	CTD_human_DG	11850205		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	19154418, 24906407	Stimulate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Breast Neoplasms	Breast neoplasm	Pubtator	30322396, 31146704, 35083026, 35471456, 37575267	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Carcinogenesis	Carcinogenesis	Pubtator	32784268	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	29602203, 38052560	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Intraductal Noninfiltrating	Intraductal noninfiltrating carcinoma	Pubtator	35471456	Inhibit	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	37455213	Associate	★☆☆☆☆ Found in Text Mining only
Central visual impairment	Central Visual Impairment	BEFREE	26350515		★☆☆☆☆ Found in Text Mining only
Central visual impairment	Central Visual Impairment	HPO_DG			★☆☆☆☆ Found in Text Mining only
Cerebellar Ataxia Deafness and Narcolepsy	Cerebellar ataxia, deafness, and narcolepsy	Pubtator	37584462	Associate	★☆☆☆☆ Found in Text Mining only
Cognition Disorders	Cognition disorder	Pubtator	40025604	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	26222778	Associate	★☆☆☆☆ Found in Text Mining only
Congenital Abnormalities	Congenital abnormalities	Pubtator	31729143	Associate	★☆☆☆☆ Found in Text Mining only
Congenital diaphragmatic hernia	Congenital diaphragmatic hernia	BEFREE	28527575		★☆☆☆☆ Found in Text Mining only
Congenital Heart Defects	Congenital heart defects	BEFREE	28527575		★☆☆☆☆ Found in Text Mining only
Corpus Luteum Cyst	Corpus Luteum Cyst	CTD_human_DG	21239663		★☆☆☆☆ Found in Text Mining only
Deafness	Deafness	Pubtator	19353646, 37584462	Associate	★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	30628890, 39972940	Associate	★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Development Disorder	BEFREE	31729143		★☆☆☆☆ Found in Text Mining only
Endometrial Carcinoma	Endometrial carcinoma	BEFREE	31801112		★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	37612452	Associate	★☆☆☆☆ Found in Text Mining only
Endometriosis	Endometriosis	Pubtator	20430378	Associate	★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	32329844	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	37968257	Associate	★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	BEFREE	28527575, 30653836		★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	HPO_DG			★☆☆☆☆ Found in Text Mining only
Hodgkin Disease	Hodgkin disease	Pubtator	12588891	Associate	★☆☆☆☆ Found in Text Mining only
Hypersensitivity Delayed	Hypersensitivity	Pubtator	40025604	Associate	★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	35283481	Stimulate	★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	BEFREE	24462372, 26138355, 29709504, 30653836		★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Intellectual developmental disorder	Pubtator	24462372, 31729143	Associate	★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	HPO_DG			★☆☆☆☆ Found in Text Mining only
Intervertebral Disc Degeneration	Intervertebral disc disease	Pubtator	35094651	Associate	★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	31801112		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	10772965, 17674191, 23785296, 24906407, 30322396		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	CTD_human_DG	11850205		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of endometrium	Endometrial Cancer	BEFREE	31801112		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	31357956		★☆☆☆☆ Found in Text Mining only
Mammary Carcinoma, Human	Marfan Syndrome	CTD_human_DG	11850205		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	CTD_human_DG	11850205		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	11973645, 24906407		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms, Human	Mammary Neoplasms	CTD_human_DG	11850205		★☆☆☆☆ Found in Text Mining only
Mental Retardation Autosomal Recessive 1	Intellectual developmental disorder	Pubtator	24462372	Associate	★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple sclerosis	Pubtator	30322396	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	15824151, 24906407, 31357956		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	33378023	Associate	★☆☆☆☆ Found in Text Mining only
Nystagmus	Nystagmus	HPO_DG			★☆☆☆☆ Found in Text Mining only
Optic Atrophy	Optic Atrophy	BEFREE	24462372, 26138355, 28527575, 31318166, 31729143		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Optic Atrophy	Optic atrophy	Pubtator	24462372, 31729143, 37584462	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Optic Atrophy	Optic Atrophy	HPO_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Optic atrophy, intellectual disability syndrome	Optic atrophy, intellectual disability syndrome	UNIPROT_DG	24462372		★☆☆☆☆ Found in Text Mining only
Optic atrophy, intellectual disability syndrome	Optic atrophy, intellectual disability syndrome	GENOMICS_ENGLAND_DG	24462372		★☆☆☆☆ Found in Text Mining only
Optic atrophy, intellectual disability syndrome	Optic atrophy, intellectual disability syndrome	ORPHANET_DG	24462372		★☆☆☆☆ Found in Text Mining only
Optic atrophy, intellectual disability syndrome	Optic atrophy, intellectual disability syndrome	BEFREE	26986877, 28527575, 29410510, 31600777, 31729143		★☆☆☆☆ Found in Text Mining only
Optic atrophy, intellectual disability syndrome	Optic atrophy, intellectual disability syndrome	CLINVAR_DG	26986877		★☆☆☆☆ Found in Text Mining only
Optic atrophy, intellectual disability syndrome	Optic atrophy, intellectual disability syndrome	CTD_human_DG			★☆☆☆☆ Found in Text Mining only
Optic atrophy-intellectual disability syndrome	Optic atrophy, intellectual disability syndrome	Orphanet			★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	31801112		★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	32945459	Associate	★☆☆☆☆ Found in Text Mining only
Ovarian Cysts	Ovarian Cysts	CTD_human_DG	21239663		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	35283481, 36457244	Associate	★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	23056316	Associate	★☆☆☆☆ Found in Text Mining only
Psychomotor Disorders	Psychiatric disorders	Pubtator	40025604	Associate	★☆☆☆☆ Found in Text Mining only
Refractory anemias	Anemia	BEFREE	11117523		★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	11117523		★☆☆☆☆ Found in Text Mining only
Seminoma	Seminoma	Pubtator	31965022	Associate	★☆☆☆☆ Found in Text Mining only
Spasms Infantile	Infantile spasms	Pubtator	28654857, 35830182	Associate	★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	31530388		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	35082283	Associate	★☆☆☆☆ Found in Text Mining only
Strabismus	Strabismus	HPO_DG			★☆☆☆☆ Found in Text Mining only
TARSAL-CARPAL COALITION SYNDROME	Tarsal-Carpal Coalition Syndrome	BEFREE	18387660		★☆☆☆☆ Found in Text Mining only
Thyroid carcinoma	Thyroid Carcinoma	BEFREE	31692033		★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Thyroid cancer	Pubtator	34408227	Associate	★☆☆☆☆ Found in Text Mining only
Transitional cell carcinoma of bladder	Bladder carcinoma	BEFREE	18387660		★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	37306188	Associate	★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	34414701, 35090432	Associate	★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	36087939	Inhibit	★☆☆☆☆ Found in Text Mining only
Vision Disorders	Visual disorder	Pubtator	24462372, 26350515, 31729143	Associate	★☆☆☆☆ Found in Text Mining only
West Syndrome	West Syndrome	BEFREE	25877686, 28654857		★☆☆☆☆ Found in Text Mining only