Gene Gene information from NCBI Gene database.
Entrez ID 694
Gene name BTG anti-proliferation factor 1
Gene symbol BTG1
Synonyms (NCBI Gene)
APRO2
Chromosome 12
Chromosome location 12q21.33
Summary This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein int
miRNA miRNA information provided by mirtarbase database.
543
miRTarBase ID miRNA Experiments Reference
MIRT028939 hsa-miR-26b-5p Microarray 19088304
MIRT041705 hsa-miR-484 CLASH 23622248
MIRT041705 hsa-miR-484 CLASH 23622248
MIRT053302 hsa-miR-372-3p Luciferase reporter assayqRT-PCRWestern blot 22020335
MIRT053303 hsa-miR-373-3p Luciferase reporter assayqRT-PCRWestern blot 22020335
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Transcription factor Regulation Reference
AR Repression 16281084
HLX Unknown 22897850
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
28
GO ID Ontology Definition Evidence Reference
GO:0003712 Function Transcription coregulator activity NAS 11420681
GO:0005515 Function Protein binding IPI 9712883, 9820826, 10617598, 11136725, 16189514, 20211142, 21900206, 27107012, 31515488, 32296183, 35512704
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IDA 9820826, 11420681
GO:0005634 Component Nucleus IMP 11420681
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
109580 1130 ENSG00000133639
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P62324
Protein name Protein BTG1 (B-cell translocation gene 1 protein)
Protein function Anti-proliferative protein.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07742 BTG 11 124 BTG family Family
Sequence
Sequence length 171
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  RNA degradation   FOXO-mediated transcription of cell cycle genes
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
7
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ARTHRITIS, JUVENILE CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
JUVENILE CHRONIC POLYARTHRITIS Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MONOARTICULAR JUVENILE RHEUMATOID ARTHRITIS Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute leukemia Leukemia BEFREE 24998463
★☆☆☆☆
Found in Text Mining only
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 20354172, 22072402, 22851563, 29552179, 31112375
★☆☆☆☆
Found in Text Mining only
Adult Acute Lymphocytic Leukemia Lymphocytic Leukemia BEFREE 22851563, 29552179, 31112375
★☆☆☆☆
Found in Text Mining only
Adult Diffuse Large B-Cell Lymphoma B-cell Lymphoma BEFREE 26657730
★☆☆☆☆
Found in Text Mining only
Adult Hepatocellular Carcinoma Liver carcinoma BEFREE 25173640
★☆☆☆☆
Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA Syndromic microphthalmia BEFREE 29076521
★☆☆☆☆
Found in Text Mining only
B-Cell Lymphomas B-Cell Lymphoma BEFREE 25173640
★☆☆☆☆
Found in Text Mining only
B-CELL MALIGNANCY, LOW-GRADE Lymphocytic Leukemia BEFREE 1373383
★☆☆☆☆
Found in Text Mining only
Benign Neoplasm Benign Neoplasm BEFREE 24084718
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 16818519, 23982470, 24272202, 24714932, 26503430, 28922388, 31570430
★☆☆☆☆
Found in Text Mining only