Gene Gene information from NCBI Gene database.
Entrez ID 6917
Gene name Transcription elongation factor A1
Gene symbol TCEA1
Synonyms (NCBI Gene)
GTF2SSIITCEATF2STFIIS
Chromosome 8
Chromosome location 8q11.23
miRNA miRNA information provided by mirtarbase database.
376
miRTarBase ID miRNA Experiments Reference
MIRT020490 hsa-miR-155-5p Proteomics 18668040
MIRT050483 hsa-miR-20a-5p CLASH 23622248
MIRT041184 hsa-miR-497-5p CLASH 23622248
MIRT698680 hsa-miR-4480 HITS-CLIP 23313552
MIRT698679 hsa-miR-889-3p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
20
GO ID Ontology Definition Evidence Reference
GO:0003676 Function Nucleic acid binding IEA
GO:0003677 Function DNA binding IEA
GO:0005515 Function Protein binding IPI 20178742, 20562857, 23748380, 28514442, 32296183, 33961781
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601425 11612 ENSG00000187735
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P23193
Protein name Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o)
Protein function Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in l
PDB 1TFI , 3NDQ , 5IY6 , 5IY7 , 5IY8 , 5IYA , 5IYB , 5IYC , 6O9L , 6ZUY , 6ZV4 , 7CNF , 7UNC , 7UND , 8A40 , 8UIS , 9EGX , 9EGY , 9EGZ , 9EH0 , 9EH2 , 9J0N
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08711 Med26 26 77 TFIIS helical bundle-like domain Domain
PF07500 TFIIS_M 138 248 Transcription factor S-II (TFIIS), central domain Domain
PF01096 TFIIS_C 261 299 Transcription factor S-II (TFIIS) Domain
Sequence
Sequence length 301
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Formation of RNA Pol II elongation complex
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
RNA Polymerase II Transcription Elongation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
INTRACRANIAL HEMORRHAGE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Lung cancer Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Breast Carcinoma Breast Carcinoma BEFREE 18474089
★☆☆☆☆
Found in Text Mining only
Clear-cell metastatic renal cell carcinoma Renal Carcinoma BEFREE 29178029
★☆☆☆☆
Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma Renal Carcinoma BEFREE 29178029
★☆☆☆☆
Found in Text Mining only
Cutaneous Mastocytosis Cutaneous mastocytosis BEFREE 31677940
★☆☆☆☆
Found in Text Mining only
Cystic Fibrosis Cystic Fibrosis BEFREE 30529075
★☆☆☆☆
Found in Text Mining only
Dementia Dementia BEFREE 30927918
★☆☆☆☆
Found in Text Mining only
Inflammatory Bowel Diseases Inflammatory Bowel Disease BEFREE 29272476
★☆☆☆☆
Found in Text Mining only
Liver carcinoma Liver carcinoma BEFREE 30416857
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of breast Breast Cancer BEFREE 18474089
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of pancreas Pancreatic cancer BEFREE 18474089
★☆☆☆☆
Found in Text Mining only