Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6886
Gene name	TAL bHLH transcription factor 1, erythroid differentiation factor
Gene symbol	TAL1
Synonyms (NCBI Gene)	SCLTCL5bHLHa17tal-1
Chromosome	1
Chromosome location	1p33

218

Show/Hide all (218)

miRTarBase ID	miRNA	Experiments	Reference
MIRT053370	hsa-miR-9-5p	MicroarrayqRT-PCR	23798388
MIRT054047	hsa-miR-223-3p	ChIP-seqMicroarrayWestern blot	23857984
MIRT054047	hsa-miR-223-3p	ChIP-seqMicroarrayWestern blot	23857984
MIRT054047	hsa-miR-223-3p	ChIP-seqMicroarrayWestern blot	23857984
MIRT665956	hsa-miR-3121-3p	HITS-CLIP	23313552
MIRT665955	hsa-miR-8485	HITS-CLIP	23313552
MIRT665954	hsa-miR-577	HITS-CLIP	23313552
MIRT665953	hsa-miR-4719	HITS-CLIP	23313552
MIRT698711	hsa-miR-340-3p	HITS-CLIP	23313552
MIRT698710	hsa-miR-6827-3p	HITS-CLIP	23313552
MIRT665952	hsa-miR-342-3p	HITS-CLIP	23313552
MIRT684336	hsa-miR-6895-3p	HITS-CLIP	23313552
MIRT665951	hsa-miR-377-3p	HITS-CLIP	23313552
MIRT665956	hsa-miR-3121-3p	HITS-CLIP	23313552
MIRT665955	hsa-miR-8485	HITS-CLIP	23313552
MIRT665954	hsa-miR-577	HITS-CLIP	23313552
MIRT665953	hsa-miR-4719	HITS-CLIP	23313552
MIRT665952	hsa-miR-342-3p	HITS-CLIP	23313552
MIRT684336	hsa-miR-6895-3p	HITS-CLIP	23313552
MIRT665951	hsa-miR-377-3p	HITS-CLIP	23313552
MIRT665956	hsa-miR-3121-3p	HITS-CLIP	23824327
MIRT665955	hsa-miR-8485	HITS-CLIP	23824327
MIRT665954	hsa-miR-577	HITS-CLIP	23824327
MIRT665953	hsa-miR-4719	HITS-CLIP	23824327
MIRT665952	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT665951	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT665956	hsa-miR-3121-3p	HITS-CLIP	23824327
MIRT665955	hsa-miR-8485	HITS-CLIP	23824327
MIRT665954	hsa-miR-577	HITS-CLIP	23824327
MIRT665953	hsa-miR-4719	HITS-CLIP	23824327
MIRT665952	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT665951	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT563546	hsa-miR-3922-5p	PAR-CLIP	20371350
MIRT516190	hsa-miR-1225-3p	PAR-CLIP	20371350
MIRT516189	hsa-miR-1233-3p	PAR-CLIP	20371350
MIRT516188	hsa-miR-561-5p	PAR-CLIP	20371350
MIRT516187	hsa-miR-6807-5p	PAR-CLIP	20371350
MIRT516186	hsa-miR-1273e	PAR-CLIP	20371350
MIRT516190	hsa-miR-1225-3p	PAR-CLIP	23446348
MIRT516189	hsa-miR-1233-3p	PAR-CLIP	23446348
MIRT516188	hsa-miR-561-5p	PAR-CLIP	23446348
MIRT516187	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT516186	hsa-miR-1273e	PAR-CLIP	23446348
MIRT498296	hsa-miR-320a	PAR-CLIP	22291592
MIRT498295	hsa-miR-320b	PAR-CLIP	22291592
MIRT498294	hsa-miR-320c	PAR-CLIP	22291592
MIRT498293	hsa-miR-320d	PAR-CLIP	22291592
MIRT498292	hsa-miR-4429	PAR-CLIP	22291592
MIRT498291	hsa-miR-4780	PAR-CLIP	22291592
MIRT665956	hsa-miR-3121-3p	HITS-CLIP	27418678
MIRT665956	hsa-miR-3121-3p	HITS-CLIP	27418678
MIRT665953	hsa-miR-4719	HITS-CLIP	27418678
MIRT665953	hsa-miR-4719	HITS-CLIP	27418678
MIRT665954	hsa-miR-577	HITS-CLIP	27418678
MIRT665954	hsa-miR-577	HITS-CLIP	27418678
MIRT665955	hsa-miR-8485	HITS-CLIP	27418678
MIRT665955	hsa-miR-8485	HITS-CLIP	27418678
MIRT665956	hsa-miR-3121-3p	HITS-CLIP	23313552
MIRT665955	hsa-miR-8485	HITS-CLIP	23313552
MIRT665954	hsa-miR-577	HITS-CLIP	23313552
MIRT665953	hsa-miR-4719	HITS-CLIP	23313552
MIRT698711	hsa-miR-340-3p	HITS-CLIP	23313552
MIRT698710	hsa-miR-6827-3p	HITS-CLIP	23313552
MIRT665952	hsa-miR-342-3p	HITS-CLIP	23313552
MIRT684336	hsa-miR-6895-3p	HITS-CLIP	23313552
MIRT665951	hsa-miR-377-3p	HITS-CLIP	23313552
MIRT665956	hsa-miR-3121-3p	HITS-CLIP	23313552
MIRT665955	hsa-miR-8485	HITS-CLIP	23313552
MIRT665954	hsa-miR-577	HITS-CLIP	23313552
MIRT665953	hsa-miR-4719	HITS-CLIP	23313552
MIRT665952	hsa-miR-342-3p	HITS-CLIP	23313552
MIRT684336	hsa-miR-6895-3p	HITS-CLIP	23313552
MIRT665951	hsa-miR-377-3p	HITS-CLIP	23313552
MIRT665956	hsa-miR-3121-3p	HITS-CLIP	23824327
MIRT665955	hsa-miR-8485	HITS-CLIP	23824327
MIRT665954	hsa-miR-577	HITS-CLIP	23824327
MIRT665953	hsa-miR-4719	HITS-CLIP	23824327
MIRT665952	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT665951	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT665956	hsa-miR-3121-3p	HITS-CLIP	23824327
MIRT665955	hsa-miR-8485	HITS-CLIP	23824327
MIRT665954	hsa-miR-577	HITS-CLIP	23824327
MIRT665953	hsa-miR-4719	HITS-CLIP	23824327
MIRT665952	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT665951	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT563546	hsa-miR-3922-5p	PAR-CLIP	20371350
MIRT516190	hsa-miR-1225-3p	PAR-CLIP	20371350
MIRT516189	hsa-miR-1233-3p	PAR-CLIP	20371350
MIRT516188	hsa-miR-561-5p	PAR-CLIP	20371350
MIRT516187	hsa-miR-6807-5p	PAR-CLIP	20371350
MIRT516186	hsa-miR-1273e	PAR-CLIP	20371350
MIRT516190	hsa-miR-1225-3p	PAR-CLIP	23446348
MIRT516189	hsa-miR-1233-3p	PAR-CLIP	23446348
MIRT516188	hsa-miR-561-5p	PAR-CLIP	23446348
MIRT516187	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT516186	hsa-miR-1273e	PAR-CLIP	23446348
MIRT498296	hsa-miR-320a	PAR-CLIP	22291592
MIRT498295	hsa-miR-320b	PAR-CLIP	22291592
MIRT498294	hsa-miR-320c	PAR-CLIP	22291592
MIRT498293	hsa-miR-320d	PAR-CLIP	22291592
MIRT498292	hsa-miR-4429	PAR-CLIP	22291592
MIRT498291	hsa-miR-4780	PAR-CLIP	22291592
MIRT1410164	hsa-miR-1233	CLIP-seq
MIRT1410165	hsa-miR-128	CLIP-seq
MIRT1410166	hsa-miR-1285	CLIP-seq
MIRT1410167	hsa-miR-1302	CLIP-seq
MIRT1410168	hsa-miR-1324	CLIP-seq
MIRT1410169	hsa-miR-193a-5p	CLIP-seq
MIRT1410170	hsa-miR-2964a-5p	CLIP-seq
MIRT1410171	hsa-miR-299-5p	CLIP-seq
MIRT1410172	hsa-miR-3122	CLIP-seq
MIRT1410173	hsa-miR-3126-5p	CLIP-seq
MIRT1410174	hsa-miR-3153	CLIP-seq
MIRT1410175	hsa-miR-3164	CLIP-seq
MIRT1410176	hsa-miR-3166	CLIP-seq
MIRT1410177	hsa-miR-3179	CLIP-seq
MIRT1410178	hsa-miR-3187-5p	CLIP-seq
MIRT1410179	hsa-miR-3199	CLIP-seq
MIRT1410180	hsa-miR-338-3p	CLIP-seq
MIRT1410181	hsa-miR-33a	CLIP-seq
MIRT1410182	hsa-miR-33b	CLIP-seq
MIRT1410183	hsa-miR-3613-3p	CLIP-seq
MIRT1410184	hsa-miR-3675-3p	CLIP-seq
MIRT1410185	hsa-miR-377	CLIP-seq
MIRT1410186	hsa-miR-3913-5p	CLIP-seq
MIRT1410187	hsa-miR-3926	CLIP-seq
MIRT1410188	hsa-miR-3941	CLIP-seq
MIRT1410189	hsa-miR-3942-3p	CLIP-seq
MIRT1410190	hsa-miR-4257	CLIP-seq
MIRT1410191	hsa-miR-4298	CLIP-seq
MIRT1410192	hsa-miR-4307	CLIP-seq
MIRT1410193	hsa-miR-4419a	CLIP-seq
MIRT1410194	hsa-miR-4432	CLIP-seq
MIRT1410195	hsa-miR-4468	CLIP-seq
MIRT1410196	hsa-miR-448	CLIP-seq
MIRT1410197	hsa-miR-4510	CLIP-seq
MIRT1410198	hsa-miR-451b	CLIP-seq
MIRT1410199	hsa-miR-4533	CLIP-seq
MIRT1410200	hsa-miR-466	CLIP-seq
MIRT1410201	hsa-miR-4662a-5p	CLIP-seq
MIRT1410202	hsa-miR-4672	CLIP-seq
MIRT1410203	hsa-miR-4676-5p	CLIP-seq
MIRT1410204	hsa-miR-4684-5p	CLIP-seq
MIRT1410205	hsa-miR-4691-3p	CLIP-seq
MIRT1410206	hsa-miR-4696	CLIP-seq
MIRT1410207	hsa-miR-4721	CLIP-seq
MIRT1410208	hsa-miR-4740-5p	CLIP-seq
MIRT1410209	hsa-miR-4747-5p	CLIP-seq
MIRT1410210	hsa-miR-4778-3p	CLIP-seq
MIRT1410211	hsa-miR-4799-5p	CLIP-seq
MIRT1410212	hsa-miR-575	CLIP-seq
MIRT1410213	hsa-miR-612	CLIP-seq
MIRT1410214	hsa-miR-622	CLIP-seq
MIRT1410215	hsa-miR-661	CLIP-seq
MIRT1410168	hsa-miR-1324	CLIP-seq
MIRT2122936	hsa-miR-1972	CLIP-seq
MIRT2122937	hsa-miR-2116	CLIP-seq
MIRT2122938	hsa-miR-3124-3p	CLIP-seq
MIRT2122939	hsa-miR-3127-3p	CLIP-seq
MIRT1410175	hsa-miR-3164	CLIP-seq
MIRT2122940	hsa-miR-3679-3p	CLIP-seq
MIRT1410187	hsa-miR-3926	CLIP-seq
MIRT1410193	hsa-miR-4419a	CLIP-seq
MIRT2122941	hsa-miR-4477b	CLIP-seq
MIRT1410197	hsa-miR-4510	CLIP-seq
MIRT2122942	hsa-miR-4519	CLIP-seq
MIRT1410201	hsa-miR-4662a-5p	CLIP-seq
MIRT1410203	hsa-miR-4676-5p	CLIP-seq
MIRT2122943	hsa-miR-4677-5p	CLIP-seq
MIRT1410207	hsa-miR-4721	CLIP-seq
MIRT2122944	hsa-miR-4724-3p	CLIP-seq
MIRT2122945	hsa-miR-508-5p	CLIP-seq
MIRT1410212	hsa-miR-575	CLIP-seq
MIRT2122946	hsa-miR-609	CLIP-seq
MIRT2122947	hsa-miR-939	CLIP-seq
MIRT2345266	hsa-miR-1224-3p	CLIP-seq
MIRT1410166	hsa-miR-1285	CLIP-seq
MIRT1410168	hsa-miR-1324	CLIP-seq
MIRT2345267	hsa-miR-146b-3p	CLIP-seq
MIRT1410169	hsa-miR-193a-5p	CLIP-seq
MIRT2122937	hsa-miR-2116	CLIP-seq
MIRT2345268	hsa-miR-3173-5p	CLIP-seq
MIRT1410178	hsa-miR-3187-5p	CLIP-seq
MIRT2345269	hsa-miR-3908	CLIP-seq
MIRT2345270	hsa-miR-3918	CLIP-seq
MIRT1410192	hsa-miR-4307	CLIP-seq
MIRT2345271	hsa-miR-4512	CLIP-seq
MIRT1410201	hsa-miR-4662a-5p	CLIP-seq
MIRT1410203	hsa-miR-4676-5p	CLIP-seq
MIRT2345272	hsa-miR-4685-5p	CLIP-seq
MIRT2345273	hsa-miR-4786-3p	CLIP-seq
MIRT1410212	hsa-miR-575	CLIP-seq
MIRT1410213	hsa-miR-612	CLIP-seq
MIRT1410215	hsa-miR-661	CLIP-seq
MIRT2345274	hsa-miR-874	CLIP-seq
MIRT2395513	hsa-miR-3120-5p	CLIP-seq
MIRT2345270	hsa-miR-3918	CLIP-seq
MIRT2395514	hsa-miR-4802-3p	CLIP-seq
MIRT2433772	hsa-miR-129-5p	CLIP-seq
MIRT2433773	hsa-miR-197	CLIP-seq
MIRT2433774	hsa-miR-4717-3p	CLIP-seq
MIRT2433775	hsa-miR-629	CLIP-seq
MIRT1410166	hsa-miR-1285	CLIP-seq
MIRT1410178	hsa-miR-3187-5p	CLIP-seq
MIRT1410194	hsa-miR-4432	CLIP-seq
MIRT1410198	hsa-miR-451b	CLIP-seq
MIRT1410206	hsa-miR-4696	CLIP-seq
MIRT1410213	hsa-miR-612	CLIP-seq
MIRT1410215	hsa-miR-661	CLIP-seq
MIRT1410166	hsa-miR-1285	CLIP-seq
MIRT2692621	hsa-miR-3184	CLIP-seq
MIRT1410178	hsa-miR-3187-5p	CLIP-seq
MIRT2692622	hsa-miR-423-5p	CLIP-seq
MIRT1410194	hsa-miR-4432	CLIP-seq
MIRT1410198	hsa-miR-451b	CLIP-seq
MIRT2122946	hsa-miR-609	CLIP-seq
MIRT1410213	hsa-miR-612	CLIP-seq
MIRT1410215	hsa-miR-661	CLIP-seq

Show/Hide all (1)

Transcription factor	Regulation	Reference
GATA1	Unknown	8058326

Show/Hide all (73)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000785	Component	Chromatin	IDA	20855495
GO:0000785	Component	Chromatin	ISA
GO:0000976	Function	Transcription cis-regulatory region binding	IEA
GO:0000976	Function	Transcription cis-regulatory region binding	ISS
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001525	Process	Angiogenesis	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	IDA	16763211
GO:0003682	Function	Chromatin binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IDA	19497860
GO:0005515	Function	Protein binding	IPI	7568177, 9824680, 19497860, 20028976, 21179004, 25394790, 33961781, 35140242
GO:0005634	Component	Nucleus	IDA	19497860
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005667	Component	Transcription regulator complex	IDA	15920471
GO:0005667	Component	Transcription regulator complex	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	ISS
GO:0006366	Process	Transcription by RNA polymerase II	IEA
GO:0007626	Process	Locomotory behavior	IEA
GO:0019899	Function	Enzyme binding	IPI	19497860
GO:0021527	Process	Spinal cord association neuron differentiation	IEA
GO:0021953	Process	Central nervous system neuron differentiation	IEA
GO:0030097	Process	Hemopoiesis	IEA
GO:0030097	Process	Hemopoiesis	ISS
GO:0030099	Process	Myeloid cell differentiation	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030218	Process	Erythrocyte differentiation	IEA
GO:0030218	Process	Erythrocyte differentiation	IEP	7678994
GO:0030218	Process	Erythrocyte differentiation	IMP	1396592
GO:0030219	Process	Megakaryocyte differentiation	IEA
GO:0030219	Process	Megakaryocyte differentiation	IEP	7678994
GO:0030220	Process	Platelet formation	IEA
GO:0030221	Process	Basophil differentiation	IEP	7678994
GO:0031334	Process	Positive regulation of protein-containing complex assembly	IDA	20855495
GO:0032991	Component	Protein-containing complex	IEA
GO:0035162	Process	Embryonic hemopoiesis	IEA
GO:0035162	Process	Embryonic hemopoiesis	ISS
GO:0035855	Process	Megakaryocyte development	IEA
GO:0042127	Process	Regulation of cell population proliferation	IEA
GO:0042826	Function	Histone deacetylase binding	IPI	19497860
GO:0043249	Process	Erythrocyte maturation	IEA
GO:0045165	Process	Cell fate commitment	IEA
GO:0045165	Process	Cell fate commitment	ISS
GO:0045637	Process	Regulation of myeloid cell differentiation	IEA
GO:0045648	Process	Positive regulation of erythrocyte differentiation	IDA	20028976
GO:0045648	Process	Positive regulation of erythrocyte differentiation	IEA
GO:0045648	Process	Positive regulation of erythrocyte differentiation	ISS
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	20028976
GO:0045931	Process	Positive regulation of mitotic cell cycle	IMP	20855495
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	20855495
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0046983	Function	Protein dimerization activity	IEA
GO:0048699	Process	Generation of neurons	IEA
GO:0051781	Process	Positive regulation of cell division	IMP	20855495
GO:0060018	Process	Astrocyte fate commitment	IEA
GO:0060216	Process	Definitive hemopoiesis	IEA
GO:0060217	Process	Hemangioblast cell differentiation	IEA
GO:0060218	Process	Hematopoietic stem cell differentiation	IEA
GO:0060375	Process	Regulation of mast cell differentiation	IEA
GO:0061629	Function	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	15920471
GO:0070888	Function	E-box binding	IDA	20855495
GO:0070888	Function	E-box binding	IEA
GO:1904672	Process	Regulation of somatic stem cell population maintenance	IEA
GO:1905269	Process	Positive regulation of chromatin organization	IMP	20855495

MIM	HGNC	e!Ensembl
187040	11556	ENSG00000162367

P17542

Protein name

T-cell acute lymphocytic leukemia protein 1 (TAL-1) (Class A basic helix-loop-helix protein 17) (bHLHa17) (Stem cell protein) (T-cell leukemia/lymphoma protein 5)

Protein function

Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).

PDB

2YPA , 2YPB

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00010	HLH	188 → 240	Helix-loop-helix DNA-binding domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Leukemic stem cell.

Sequence

MTERPPSEAARSDPQLEGRDAAEASMAPPHLVLLNGVAKETSRAAAAEPPVIELGARGGP
GGGPAGGGGAARDLKGRDAATAEARHRVPTTELCRPPGPAPAPAPASVTAELPGDGRMVQ
LSPPALAAPAAPGRALLYSLSQPLASLGSGFFGEPDAFPMFTTNNRVKRRPSPYEMEITD
GPHTKVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKLSKNEILRLAMKYINFLA
KLLNDQEEEGTQRAKTGKDPVVGAGGGGGGGGGGAPPDDLLQDVLSPNSSCGSSLDGAAS
PDSYTEEPAPKHTARSLHPAMLPAADGAGPR

Sequence length

331

Interactions

View interactions

	Reactome
			RUNX1 regulates transcription of genes involved in differentiation of HSCs

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LEUKEMIA, ACUTE LYMPHOBLASTIC	—	HPO	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPEN-ANGLE GLAUCOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TAL1-related disorder	Likely benign; Benign; Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (145)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute Erythroblastic Leukemia	Erythroblastic Leukemia	BEFREE	10688671, 1756722, 30185409, 7744799, 8437851		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute leukemia	Leukemia	BEFREE	10049045, 1886719, 8058726, 8255100		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	10049045, 11243385, 11839375, 12580964, 22226019, 22393458, 22563559, 24045615, 26264145, 30125757, 30938820, 7579412, 8350633		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute Undifferentiated Leukemia	Leukemia	BEFREE	11390401, 1311214, 14513050, 2467296, 2602361, 28179281, 31300405		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adult Acute Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	10049045, 11243385, 22226019, 24045615, 26264145, 30125757, 30938820, 7579412, 8350633		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adult T-Cell Lymphoma/Leukemia	T-Cell Lymphoma/Leukemia	BEFREE	1382561, 2209547, 2230650, 22982397, 23698277, 7672800, 8078932, 9211539, 9931488		★★★★★ ★☆☆☆☆ Found in Text Mining only
Agoraphobia	Agoraphobia	BEFREE	28167838, 30546323		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anhedonia	Anhedonia	BEFREE	31747876		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ankylosing spondylitis	Ankylosing Spondylitis	BEFREE	29303699		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anorexia Nervosa	Anorexia	BEFREE	28948079, 29455021, 29879886, 30062717		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anxiety	Anxiety Disorder	BEFREE	10483055, 10994648, 17210818, 1827639, 20064128, 27807927, 28328110, 28606893, 28707502, 28712415, 29045499, 29057552, 29246564, 29344846, 29434563 View all (14 more)		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anxiety Disorders	Anxiety Disorder	BEFREE	10483055, 10994648, 17210818, 1827639, 20064128, 27807927, 28328110, 28606893, 28707502, 28712415, 29045499, 29057552, 29246564, 29344846, 29434563 View all (14 more)		★★★★★ ★☆☆☆☆ Found in Text Mining only
Aplastic Anemia	Aplastic anemia	BEFREE	11328281		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis, Psoriatic	Psoriatic Arthritis	BEFREE	14693349		★★★★★ ★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	BEFREE	10607488		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ataxia Telangiectasia	Ataxia telangiectasia	Pubtator	12086890, 16621969, 2040693, 22581002, 25615415, 36632736, 7678994, 9695959	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Attention deficit hyperactivity disorder	Attention Deficit Hyperactivity Disorder	BEFREE	29362929, 29475216		★★★★★ ★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorders	Autism Spectrum Disorder	BEFREE	31275179		★★★★★ ★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	BEFREE	31275179		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bedwetting	Nocturnal enuresis	BEFREE	27665376		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	22895549		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	19442316, 20460541, 23992744		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bulimia Nervosa	Bulimia	BEFREE	28948079, 29455021, 29879886, 31695652		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	21179004, 9819382	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	17426052		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	31419443	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	22895549		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular Diseases	BEFREE	29303699		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	28265288, 30138228		★★★★★ ★☆☆☆☆ Found in Text Mining only
Childhood Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia	BEFREE	10049045, 11243385, 22226019, 24045615, 26264145, 30125757, 30938820, 7579412, 8350633		★★★★★ ★☆☆☆☆ Found in Text Mining only
Childhood Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia	CTD_human_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital chromosomal disease	Congenital Chromosomal Disease	BEFREE	1402676, 22563559, 7496160		★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital pectus excavatum	Congenital Pectus Excavatum	BEFREE	28626162		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dehydrated Hereditary Stomatocytosis Pseudohyperkalemia and Perinatal Edema	Hereditary xerocytosis	Pubtator	17389645	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Depression, Postpartum	Mental Depression	BEFREE	27418012		★★★★★ ★☆☆☆☆ Found in Text Mining only
Depressive disorder	Mental Depression	BEFREE	15842033, 17210818, 20064128, 20494447, 21531467, 21835094, 27807927, 28028732, 28328110, 28606893, 28707502, 29045499, 29092782, 29111383, 29179911 View all (19 more)		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	35046895	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	28659632		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diarrhea	Diarrhea	Pubtator	34217275	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Disruptive Behavior Disorder	Disruptive Behavior Disorder	BEFREE	28456023		★★★★★ ★☆☆☆☆ Found in Text Mining only
Disruptive, Impulse Control, and Conduct Disorders	Impulse control disorder	BEFREE	28558358		★★★★★ ★☆☆☆☆ Found in Text Mining only
Disseminated Intravascular Coagulation	Disseminated Intravascular Coagulation	BEFREE	24040098		★★★★★ ★☆☆☆☆ Found in Text Mining only
Disturbance in mood	Mood Disorder	BEFREE	31043102		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dysautonomia, Familial	Dysautonomia	BEFREE	29776354		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dysmorphism	Dysmorphism	BEFREE	28646788		★★★★★ ★☆☆☆☆ Found in Text Mining only
Eating Disorders	Eating Disorders	BEFREE	23775054, 28456023, 29179911, 29626825, 29846016, 29879886, 30977532, 31695652, 3346203		★★★★★ ★☆☆☆☆ Found in Text Mining only
Episodic Kinesigenic Dyskinesia 1	Episodic Kinesigenic Dyskinesia	BEFREE	28836553		★★★★★ ★☆☆☆☆ Found in Text Mining only
Erectile dysfunction	Erectile Dysfunction	BEFREE	29455021		★★★★★ ★☆☆☆☆ Found in Text Mining only
Gastritis, Atrophic	Gastritis	BEFREE	29353492		★★★★★ ★☆☆☆☆ Found in Text Mining only
Gastroesophageal reflux disease	Gastroesophageal Reflux Disease	BEFREE	29384872, 30345782		★★★★★ ★☆☆☆☆ Found in Text Mining only
Germ cell tumor	Tumor	BEFREE	26497383		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	30691465		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hemangioma	Hemangioma	BEFREE	23271126		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hematologic Neoplasms	Hematologic Neoplasms	BEFREE	30952670		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hematological Disease	Hematological Disease	BEFREE	9156576		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hemophilia A	Hemophilia	BEFREE	10360508		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hemophilia, NOS	Hemophilia	BEFREE	10360508		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary Motor and Sensory Neuropathies	Hereditary motor and sensory neuropathy	BEFREE	22329956		★★★★★ ★☆☆☆☆ Found in Text Mining only
Huntington Disease	Huntington Disease	BEFREE	17210818, 17481592, 24374998		★★★★★ ★☆☆☆☆ Found in Text Mining only
Idiopathic Pulmonary Fibrosis	Pulmonary Fibrosis	BEFREE	10607488		★★★★★ ★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	28553720		★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	BEFREE	30689871		★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	BEFREE	24428240		★★★★★ ★☆☆☆☆ Found in Text Mining only
L2 Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia	CTD_human_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Laryngeal Squamous Cell Carcinoma	Laryngeal Carcinoma	BEFREE	30548357		★★★★★ ★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	10498694, 12199779, 1375001, 16127683, 16166587, 17557895, 2040693, 20656931, 20855495, 24040098, 24904117, 26944678, 27550837, 28545085, 29556024 View all (5 more)		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	11964296, 12086890, 16621969, 17557895, 19406989, 2040693, 20656931, 26944678, 32086528, 34075404, 7605997, 7957052, 8159721, 8471769, 9111367, 9507011 View all (1 more)	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	LHGDN	12091340		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	12417757, 19442316, 34075404	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Promyelocytic Acute	Promyelocytic leukemia	Pubtator	9111367	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	7579412, 8035609, 9031072		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, T-Cell	T-cell leukemia	BEFREE	10625632, 11243382, 12681356, 1402666, 1964581, 2740341, 27443261		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, T-Cell	T-cell leukemia	LHGDN	16778171, 18495761		★★★★★ ★☆☆☆☆ Found in Text Mining only
liposarcoma	Liposarcoma	BEFREE	8058726		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	31419443		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Diseases, Interstitial	Lung Diseases	BEFREE	10607488		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	36902378	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoid leukemia	Lymphoid leukemia	BEFREE	22393458, 22563559, 8255100, 8547631		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	Pubtator	7833471	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	BEFREE	8321044, 9116269		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma, Follicular	Lymphoma	BEFREE	10233841		★★★★★ ★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	BEFREE	26717541		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	Malignant lymphoma, lymphocytic, intermediate differentiation	BEFREE	11781220		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	19442316, 20460541, 23992744		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	22895549		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	22895549		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	11243382, 1382561, 1387813, 22334400, 26356674, 29643827, 30813586, 7579411, 8058726, 8412312, 8640718, 8895560, 8912842, 9116269, 9171354		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mantle cell lymphoma	Mantle Cell Lymphoma	BEFREE	11781220		★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	1625484, 2740341, 28854983, 7496160		★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	2740341	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental Depression	Mental Depression	BEFREE	15842033, 17210818, 20064128, 20494447, 21531467, 21835094, 27807927, 28028732, 28328110, 28606893, 28707502, 29045499, 29092782, 29111383, 29179911 View all (19 more)		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental disorders	Mental Disorders	BEFREE	24428240, 29186861, 29246564, 30065872		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental Retardation	Mental retardation	BEFREE	24428240		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mild depression	Mental Depression	BEFREE	2934456		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mixed anxiety and depressive disorder	Mixed Anxiety And Depressive Disorder	BEFREE	10994648, 29100973, 29714082, 29776354, 29846016		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mouth Diseases	Mouth disease	Pubtator	2209547	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myelofibrosis	Myelofibrosis	BEFREE	14513050		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia	Myeloid Leukemia	BEFREE	1625484		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia, Chronic	Myeloid Leukemia	BEFREE	31018977, 31493871, 7579412, 8350633		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	11243382, 11781220, 16166587, 1625484, 20855495, 23857984, 25301704, 26686090, 28652130, 30914738, 7604814, 8605871, 9116269		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nephroblastoma	Nephroblastoma	BEFREE	28736882		★★★★★ ★☆☆☆☆ Found in Text Mining only
NEUROTICISM	Neuroticism	BEFREE	24374998, 28648138		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nonorganic psychosis	Nonorganic Psychosis	BEFREE	30472336, 31665694		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	28506319, 9118359		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obsessive compulsive behavior	Obsessive-Compulsive Disorder	BEFREE	17481592		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obsessive-Compulsive Disorder	Obsessive-Compulsive Disorder	BEFREE	28885070, 30689871		★★★★★ ★☆☆☆☆ Found in Text Mining only
Oppositional Defiant Disorder	Oppositional Defiant Disorder	BEFREE	31681713		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	33791375	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteolysis	Osteolysis	Pubtator	33791375	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	29234590		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	21455317, 33324055	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Panic Attacks	Panic Disorder	BEFREE	28345374, 28551488		★★★★★ ★☆☆☆☆ Found in Text Mining only
Panic Disorder	Panic Disorder	BEFREE	28167838, 28551488		★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	29100973, 30017779		★★★★★ ★☆☆☆☆ Found in Text Mining only
PARKINSON DISEASE, LATE-ONSET	Parkinson disease	BEFREE	30017779		★★★★★ ★☆☆☆☆ Found in Text Mining only
Phobic anxiety disorder	Phobic Anxiety Disorder	BEFREE	10994648, 24374998, 28551488, 29922611, 30017779, 30472336		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pituitary Neoplasms	Pituitary Neoplasms	BEFREE	24377512		★★★★★ ★☆☆☆☆ Found in Text Mining only
Polycythemia	Polycythemia	Pubtator	22982397	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Polycythemia Vera	Polycythemia Vera	BEFREE	23720412		★★★★★ ★☆☆☆☆ Found in Text Mining only
Polycythemia Vera	Polycythemia vera	Pubtator	23720412	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Post-Traumatic Stress Disorder	Stress Disorder	BEFREE	28834884, 28871848, 30220982, 30791342		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	BEFREE	10049045, 11243385, 22393458, 22563559, 9171354		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	LHGDN	18439091		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	CTD_human_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor T-cell acute lymphoblastic leukemia	Lymphoblastic Leukemia	Orphanet			★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Lymphoblastic Leukemia	BEFREE	10233841, 10688671, 10953971, 11243382, 11781368, 11960364, 12091340, 12199779, 12531481, 12681356, 1311214, 1382561, 1402666, 1402676, 1450410 View all (92 more)		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Lymphoblastic Leukemia	CTD_human_DG	19246562, 24394663		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Lymphoblastic Leukemia	ORPHANET_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	22895549		★★★★★ ★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	BEFREE	30713334		★★★★★ ★☆☆☆☆ Found in Text Mining only
Psychotic Disorders	Psychosis	BEFREE	30472336, 31665694		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	14693349		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	14693349		★★★★★ ★☆☆☆☆ Found in Text Mining only
Scleroderma	Scleroderma	BEFREE	10607488		★★★★★ ★☆☆☆☆ Found in Text Mining only
Shwachman syndrome	Shwachman Syndrome	BEFREE	17539775		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of skin	Skin carcinoma	BEFREE	18624760, 24377512, 26902922, 27907906, 30738056		★★★★★ ★☆☆☆☆ Found in Text Mining only
Systemic Scleroderma	Scleroderma	BEFREE	10607488, 9543562		★★★★★ ★☆☆☆☆ Found in Text Mining only
T-Cell Lymphoma	T-Cell Lymphoma	BEFREE	10091407, 22393458, 8912842		★★★★★ ★☆☆☆☆ Found in Text Mining only
Temporomandibular Joint Disorders	Temporomandibular Joint Disorders	BEFREE	29019477		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thymus Neoplasms	Thymus Neoplasms	BEFREE	17429429		★★★★★ ★☆☆☆☆ Found in Text Mining only
Tumor Lysis Syndrome	Tumor Lysis Syndrome	BEFREE	24040098		★★★★★ ★☆☆☆☆ Found in Text Mining only
Unipolar Depression	Mental Depression	BEFREE	26717541		★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	22529986	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Vascular Diseases	Vascular Diseases	BEFREE	30017593		★★★★★ ★☆☆☆☆ Found in Text Mining only

TAL1 (TAL bHLH transcription factor 1, erythroid differentiation factor)