Gene Gene information from NCBI Gene database.
Entrez ID 6867
Gene name Transforming acidic coiled-coil containing protein 1
Gene symbol TACC1
Synonyms (NCBI Gene)
Ga55
Chromosome 8
Chromosome location 8p11.22
Summary This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by
miRNA miRNA information provided by mirtarbase database.
779
miRTarBase ID miRNA Experiments Reference
MIRT016082 hsa-miR-374b-5p Sequencing 20371350
MIRT016576 hsa-miR-193b-3p Microarray 20304954
MIRT043739 hsa-miR-342-3p CLASH 23622248
MIRT043593 hsa-miR-148b-3p CLASH 23622248
MIRT652856 hsa-miR-500a-5p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23
GO ID Ontology Definition Evidence Reference
GO:0000226 Process Microtubule cytoskeleton organization IBA
GO:0003713 Function Transcription coactivator activity IMP 20078863
GO:0005515 Function Protein binding IPI 11903063, 12165861, 14603251, 15064709, 17500595, 20078863, 21516116, 23275563, 25416956, 26496610, 26871637, 31515488, 32296183, 32814053, 33961781
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605301 11522 ENSG00000147526
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O75410
Protein name Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1)
Protein function Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05010 TACC_C 598 798 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Coiled-coil
Tissue specificity TISSUE SPECIFICITY: Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expressi
Sequence
MAFSPWQILSPVQWAKWTWSAVRGGAAGEDEAGGPEGDPEEEDSQAETKSLSFSSDSEGN
FETPEAETPIRSPFKESCDPSLGLAGPGAKSQESQEADEQLVAEVVEKCSSKTCSKPSEN
EVPQQAIDSHSVKNFREEPEHDFSKISIVRPFSIETKDSTDISAVLGTKAAHGCVTAVSG
KALPSSPPDALQDEAMTEGSMGVTLEASAEADLKAGNSCPELVPSRRSKLRKPKPVPLRK
KAIGGEFSDTNAAVEGTPLPKASYHFSPEELDENTSPLLGDARFQKSPPDLKETPGTLSS
DTNDSGVELGEESRSSPLKLEFDFTEDTGNIEARKALPRKLGRKLGSTLTPKIQKDGISK
SAGLEQPTDPVARDGPLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPLSSEGSYHFDPD
NFDESMDPFKPTTTLTSSDFCSPTGNHVNEILESPKKAKSRLITSGCKVKKHETQSLALD
ACSRDEGAVISQISDISNRDGHATDEEKLASTSCGQKSAGAEVKGEPEEDLEYFECSNVP
VSTINHAFSSSEAGIEKETCQKMEEDGSTVLGLLESSAEKAPVSVSCGGESPLDGICLSE
SDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTS
MTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYL
ARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERAL
QQKNQEIEELTKICDELI
AKLGKTD
Sequence length 805
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
8
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CHRONIC MOUNTAIN SICKNESS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DEMENTIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GIANT CELL GLIOBLASTOMA Orphanet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLIOSARCOMA Orphanet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Breast Carcinoma Breast Carcinoma BEFREE 10366448, 10435627, 12165861, 12389629, 18984771, 23354013
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 21821115 Associate
★☆☆☆☆
Found in Text Mining only
Gastrointestinal Stromal Tumors Gastrointestinal stromal tumor Pubtator 27974047 Associate
★☆☆☆☆
Found in Text Mining only
Giant Cell Glioblastoma Giant Cell Glioblastoma ORPHANET_DG 22837387
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Giant cell glioblastoma Giant Cell Glioblastoma Orphanet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Glioblastoma Glioblastoma BEFREE 23696246
★☆☆☆☆
Found in Text Mining only
Glioblastoma Multiforme Glioblastoma BEFREE 22837387, 23696246
★☆☆☆☆
Found in Text Mining only
gliosarcoma Gliosarcoma ORPHANET_DG 22837387
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Gliosarcoma Gliosarcoma Orphanet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Malignant neoplasm of breast Breast Cancer BEFREE 10366448, 10435627, 12165861, 12389629, 18984771, 23354013
★☆☆☆☆
Found in Text Mining only