Gene Gene information from NCBI Gene database.
Entrez ID 6850
Gene name Spleen associated tyrosine kinase
Gene symbol SYK
Synonyms (NCBI Gene)
IMD82p72-Syk
Chromosome 9
Chromosome location 9q22.2
Summary This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular r
miRNA miRNA information provided by mirtarbase database.
357
miRTarBase ID miRNA Experiments Reference
MIRT043443 hsa-miR-331-3p CLASH 23622248
MIRT040474 hsa-miR-615-3p CLASH 23622248
MIRT038521 hsa-miR-99b-3p CLASH 23622248
MIRT709777 hsa-miR-4766-5p HITS-CLIP 19536157
MIRT709775 hsa-miR-3182 HITS-CLIP 19536157
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
JUN Unknown 22354960
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
186
GO ID Ontology Definition Evidence Reference
GO:0000045 Process Autophagosome assembly IDA 28890335
GO:0000166 Function Nucleotide binding IEA
GO:0001525 Process Angiogenesis IEA
GO:0001775 Process Cell activation IEA
GO:0001775 Process Cell activation ISS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600085 11491 ENSG00000165025
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P43405
Protein name Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
Protein function Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and ad
PDB 1A81 , 1CSY , 1CSZ , 1XBA , 1XBB , 1XBC , 3BUW , 3EMG , 3FQE , 3FQH , 3FQS , 3SRV , 3TUB , 3TUC , 3TUD , 3VF8 , 3VF9 , 4DFL , 4DFN , 4F4P , 4FL1 , 4FL2 , 4FL3 , 4FYN , 4FYO , 4FZ6 , 4FZ7 , 4GFG , 4I0R , 4I0S , 4I0T , 4PUZ , 4PV0 , 4PX6 , 4RSS , 4RX7 , 4RX8 , 4RX9 , 4WNM , 4XG2 , 4XG3 , 4XG4 , 4XG6 , 4XG7 , 4XG8 , 4XG9 , 4YJO , 4YJP , 4YJQ , 4YJR , 4YJS
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00017 SH2 15 92 SH2 domain Domain
PF00017 SH2 168 244 SH2 domain Domain
PF07714 PK_Tyr_Ser-Thr 371 626 Protein tyrosine and serine/threonine kinase Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed in hematopoietic cells (at protein level) (PubMed:8163536). Expressed in neutrophils (at protein level) (PubMed:15123770). Within the B-cell compartment, expressed from pro- and pre-B cells to plasma cells (PubMed:8163
Sequence
Sequence length 635
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  NF-kappa B signaling pathway
Phospholipase D signaling pathway
PI3K-Akt signaling pathway
Osteoclast differentiation
Platelet activation
Neutrophil extracellular trap formation
C-type lectin receptor signaling pathway
Natural killer cell mediated cytotoxicity
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Tuberculosis
Kaposi sarcoma-associated herpesvirus infection
Herpes simplex virus 1 infection
Epstein-Barr virus infection
Coronavirus disease - COVID-19
Viral carcinogenesis
  GPVI-mediated activation cascade
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
DAP12 signaling
Fc epsilon receptor (FCERI) signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
Integrin signaling
Dectin-2 family
Interleukin-2 signaling
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
24
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession Evidence Score
Arthritis Likely pathogenic; Pathogenic rs1304839707, rs1827861920, rs1828636794 RCV001270703
RCV001270909
RCV001270911
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Colitis Likely pathogenic; Pathogenic rs1304839707, rs1827861920, rs1828636794 RCV001270703
RCV001270909
RCV001270911
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Decreased circulating immunoglobulin concentration Likely pathogenic; Pathogenic rs1304839707, rs1827861920, rs1828636794 RCV001270703
RCV001270909
RCV001270911
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Immunodeficiency Likely pathogenic; Pathogenic rs1304839707, rs1827861920, rs1828636794 RCV001270703
RCV001270909
RCV001270911
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Acute myeloid leukemia Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Cervical cancer Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DERMATITIS CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 12717427, 25799995, 31817853
★☆☆☆☆
Found in Text Mining only
Acute monocytic leukemia Monocytic Leukemia BEFREE 23535559
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 27461624, 30251328
★☆☆☆☆
Found in Text Mining only
Adult Acute Lymphocytic Leukemia Lymphocytic Leukemia BEFREE 12717427, 31817853
★☆☆☆☆
Found in Text Mining only
Adult Diffuse Large B-Cell Lymphoma B-cell Lymphoma BEFREE 18006696, 22025527, 30872780
★☆☆☆☆
Found in Text Mining only
Adult T-Cell Lymphoma/Leukemia T-Cell Lymphoma/Leukemia BEFREE 15132768, 30066853
★☆☆☆☆
Found in Text Mining only
Anemia Sickle Cell Sickle cell anemia Pubtator 11698299 Associate
★☆☆☆☆
Found in Text Mining only
Angioimmunoblastic Lymphadenopathy Angioimmunoblastic T-cell lymphoma BEFREE 16341044, 25337257
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 22321643, 24376657, 31545231
★☆☆☆☆
Found in Text Mining only
Arthritis Arthritis BEFREE 22914861
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)