SULT1A1 (sulfotransferase family 1A member 1)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 6817
Gene name Sulfotransferase family 1A member 1
Gene symbol SULT1A1
Synonyms (NCBI Gene)
HAST1/HAST2P-PSTP-PST 1PSTST1A1ST1A3STPSTP1TSPST1ts-PST
Chromosome 16
Chromosome location 16p11.2
Summary Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and
miRNA miRNA information provided by mirtarbase database.
13
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (13)
miRTarBase ID miRNA Experiments Reference
MIRT004760 hsa-miR-631 Luciferase reporter assayqRT-PCRWestern blot 20881232
MIRT004760 hsa-miR-631 Luciferase reporter assayqRT-PCRWestern blot 20881232
MIRT1402802 hsa-miR-1343 CLIP-seq
MIRT1402803 hsa-miR-216a CLIP-seq
MIRT1402804 hsa-miR-378g CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
29
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (29)
GO ID Ontology Definition Evidence Reference
GO:0004062 Function Aryl sulfotransferase activity IBA
GO:0004062 Function Aryl sulfotransferase activity IDA 8093002, 12471039, 23207770
GO:0004062 Function Aryl sulfotransferase activity IEA
GO:0005515 Function Protein binding IPI 25416956, 25910212, 31515488, 32152050, 33961781
GO:0005737 Component Cytoplasm IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
171150 11453 ENSG00000196502
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P50225
Protein name Sulfotransferase 1A1 (ST1A1) (EC 2.8.2.1) (Aryl sulfotransferase 1) (HAST1/HAST2) (Phenol sulfotransferase 1) (Phenol-sulfating phenol sulfotransferase 1) (P-PST 1) (ST1A3) (Thermostable phenol sulfotransferase) (Ts-PST)
Protein function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine group. Sulfonation increases the water solubility
PDB 1LS6 , 1Z28 , 2D06 , 3QVU , 3QVV , 3U3J , 3U3K , 3U3M , 3U3O , 3U3R , 4GRA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00685 Sulfotransfer_1 38 → 288 Sulfotransferase domain Domain
Tissue specificity TISSUE SPECIFICITY: Liver, lung, adrenal, brain, platelets and skin.
Sequence
Sequence length 295
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Chemical carcinogenesis - DNA adducts   Cytosolic sulfonation of small molecules
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
15
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (15)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST NEOPLASMS — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLONIC NEOPLASMS — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (112)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acne Acne BEFREE 30577530
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute leukemia Leukemia BEFREE 25992585
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 14618622, 18483336
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma LHGDN 14618622
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenoma of large intestine Colorectal adenoma BEFREE 14618622, 22740027
★★★★★
★☆☆☆☆
Found in Text Mining only
Allergic rhinitis (disorder) Allergic rhinitis GWASCAT_DG 30013184
★★★★★
★☆☆☆☆
Found in Text Mining only
Arthritis Juvenile Juvenile arthritis Pubtator 34963488 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Bile duct carcinoma Bile duct carcinoma BEFREE 20172949
★★★★★
★☆☆☆☆
Found in Text Mining only
Bladder Neoplasm Bladder Neoplasm BEFREE 14643027, 24763827, 25194687, 26854433, 28403014, 28589969
★★★★★
★☆☆☆☆
Found in Text Mining only
Bladder Neoplasm Bladder Neoplasm LHGDN 14643027, 18365755
★★★★★
★☆☆☆☆
Found in Text Mining only