Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	6787
Gene name	NIMA related kinase 4
Gene symbol	NEK4
Synonyms (NCBI Gene)	NRK2STK2pp12301
Chromosome	3
Chromosome location	3p21.1
Summary	The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a

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SNP ID	Visualize variation	Clinical significance	Consequence
rs770418305	->T	Likely-pathogenic	Coding sequence variant, genic downstream transcript variant, frameshift variant

109

Show/Hide all (109)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004215	hsa-miR-197-3p	Microarray	16822819
MIRT686017	hsa-miR-3714	HITS-CLIP	23313552
MIRT686016	hsa-miR-1910-3p	HITS-CLIP	23313552
MIRT686015	hsa-miR-6511a-5p	HITS-CLIP	23313552
MIRT686014	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT686013	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT686012	hsa-miR-940	HITS-CLIP	23313552
MIRT686011	hsa-miR-6760-5p	HITS-CLIP	23313552
MIRT686010	hsa-miR-1321	HITS-CLIP	23313552
MIRT686009	hsa-miR-4739	HITS-CLIP	23313552
MIRT686008	hsa-miR-4756-5p	HITS-CLIP	23313552
MIRT686007	hsa-miR-3622a-3p	HITS-CLIP	23313552
MIRT686006	hsa-miR-3622b-3p	HITS-CLIP	23313552
MIRT686005	hsa-miR-6765-3p	HITS-CLIP	23313552
MIRT686004	hsa-miR-1288-5p	HITS-CLIP	23313552
MIRT686003	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT686002	hsa-miR-4459	HITS-CLIP	23313552
MIRT686001	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT686000	hsa-miR-4514	HITS-CLIP	23313552
MIRT685999	hsa-miR-4692	HITS-CLIP	23313552
MIRT685998	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT685997	hsa-miR-544b	HITS-CLIP	23313552
MIRT685996	hsa-miR-7162-3p	HITS-CLIP	23313552
MIRT685995	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT685994	hsa-miR-4738-3p	HITS-CLIP	23313552
MIRT685993	hsa-miR-3926	HITS-CLIP	23313552
MIRT685992	hsa-miR-3162-5p	HITS-CLIP	23313552
MIRT685991	hsa-miR-548s	HITS-CLIP	23313552
MIRT685990	hsa-miR-2909	HITS-CLIP	23313552
MIRT650613	hsa-miR-6847-5p	HITS-CLIP	23824327
MIRT650612	hsa-miR-4257	HITS-CLIP	23824327
MIRT650611	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT650610	hsa-miR-3942-3p	HITS-CLIP	23824327
MIRT686017	hsa-miR-3714	HITS-CLIP	23313552
MIRT686016	hsa-miR-1910-3p	HITS-CLIP	23313552
MIRT686015	hsa-miR-6511a-5p	HITS-CLIP	23313552
MIRT686014	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT686013	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT686012	hsa-miR-940	HITS-CLIP	23313552
MIRT686011	hsa-miR-6760-5p	HITS-CLIP	23313552
MIRT686010	hsa-miR-1321	HITS-CLIP	23313552
MIRT686009	hsa-miR-4739	HITS-CLIP	23313552
MIRT686008	hsa-miR-4756-5p	HITS-CLIP	23313552
MIRT686007	hsa-miR-3622a-3p	HITS-CLIP	23313552
MIRT686006	hsa-miR-3622b-3p	HITS-CLIP	23313552
MIRT686005	hsa-miR-6765-3p	HITS-CLIP	23313552
MIRT686004	hsa-miR-1288-5p	HITS-CLIP	23313552
MIRT686003	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT686002	hsa-miR-4459	HITS-CLIP	23313552
MIRT686001	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT686000	hsa-miR-4514	HITS-CLIP	23313552
MIRT685999	hsa-miR-4692	HITS-CLIP	23313552
MIRT685998	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT685997	hsa-miR-544b	HITS-CLIP	23313552
MIRT685996	hsa-miR-7162-3p	HITS-CLIP	23313552
MIRT685995	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT685994	hsa-miR-4738-3p	HITS-CLIP	23313552
MIRT685993	hsa-miR-3926	HITS-CLIP	23313552
MIRT685992	hsa-miR-3162-5p	HITS-CLIP	23313552
MIRT685991	hsa-miR-548s	HITS-CLIP	23313552
MIRT685990	hsa-miR-2909	HITS-CLIP	23313552
MIRT650613	hsa-miR-6847-5p	HITS-CLIP	23824327
MIRT650612	hsa-miR-4257	HITS-CLIP	23824327
MIRT650611	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT650610	hsa-miR-3942-3p	HITS-CLIP	23824327
MIRT1180148	hsa-miR-1297	CLIP-seq
MIRT1180149	hsa-miR-154	CLIP-seq
MIRT1180150	hsa-miR-2355-3p	CLIP-seq
MIRT1180151	hsa-miR-24	CLIP-seq
MIRT1180152	hsa-miR-26a	CLIP-seq
MIRT1180153	hsa-miR-26b	CLIP-seq
MIRT1180154	hsa-miR-28-3p	CLIP-seq
MIRT1180155	hsa-miR-30a	CLIP-seq
MIRT1180156	hsa-miR-30b	CLIP-seq
MIRT1180157	hsa-miR-30c	CLIP-seq
MIRT1180158	hsa-miR-30d	CLIP-seq
MIRT1180159	hsa-miR-30e	CLIP-seq
MIRT1180160	hsa-miR-3123	CLIP-seq
MIRT1180161	hsa-miR-3137	CLIP-seq
MIRT1180162	hsa-miR-3149	CLIP-seq
MIRT1180163	hsa-miR-3163	CLIP-seq
MIRT1180164	hsa-miR-3686	CLIP-seq
MIRT1180165	hsa-miR-374a	CLIP-seq
MIRT1180166	hsa-miR-374b	CLIP-seq
MIRT1180167	hsa-miR-3909	CLIP-seq
MIRT740167	hsa-miR-4279	CLIP-seq
MIRT1180168	hsa-miR-4311	CLIP-seq
MIRT1180169	hsa-miR-4465	CLIP-seq
MIRT1180170	hsa-miR-4477a	CLIP-seq
MIRT1180171	hsa-miR-4517	CLIP-seq
MIRT1180172	hsa-miR-4646-3p	CLIP-seq
MIRT1180173	hsa-miR-4652-3p	CLIP-seq
MIRT1180174	hsa-miR-4690-5p	CLIP-seq
MIRT1180175	hsa-miR-4719	CLIP-seq
MIRT1180176	hsa-miR-4757-3p	CLIP-seq
MIRT1180177	hsa-miR-4775	CLIP-seq
MIRT1180178	hsa-miR-4778-5p	CLIP-seq
MIRT1180179	hsa-miR-4797-3p	CLIP-seq
MIRT1180180	hsa-miR-495	CLIP-seq
MIRT1180181	hsa-miR-568	CLIP-seq
MIRT740168	hsa-miR-579	CLIP-seq
MIRT1180182	hsa-miR-606	CLIP-seq
MIRT740169	hsa-miR-616	CLIP-seq
MIRT1180183	hsa-miR-676	CLIP-seq
MIRT1180184	hsa-miR-767-3p	CLIP-seq
MIRT2052132	hsa-miR-3140-3p	CLIP-seq
MIRT1180163	hsa-miR-3163	CLIP-seq
MIRT1180176	hsa-miR-4757-3p	CLIP-seq
MIRT2052133	hsa-miR-656	CLIP-seq

Show/Hide all (30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000278	Process	Mitotic cell cycle	IMP	22851694
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	ISS
GO:0004674	Function	Protein serine/threonine kinase activity	TAS	8208544
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005829	Component	Cytosol	IDA
GO:0005929	Component	Cilium	IEA
GO:0006468	Process	Protein phosphorylation	ISS
GO:0006468	Process	Protein phosphorylation	TAS	8208544
GO:0006974	Process	DNA damage response	IBA
GO:0006974	Process	DNA damage response	IMP	22851694
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030145	Function	Manganese ion binding	ISS
GO:0035253	Component	Ciliary rootlet	IEA
GO:0035869	Component	Ciliary transition zone	IEA
GO:0036064	Component	Ciliary basal body	IEA
GO:0042995	Component	Cell projection	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IMP	22851694
GO:0046872	Function	Metal ion binding	IEA
GO:0051301	Process	Cell division	IEA
GO:0097014	Component	Ciliary plasm	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:2000772	Process	Regulation of cellular senescence	IMP	22851694

MIM	HGNC	e!Ensembl
601959	11399	ENSG00000114904

P51957

Protein name

Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2)

Protein function

Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycl

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	6 → 261	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highest expression in adult heart, followed by pancreas, skeletal muscle, brain, testis, retina, liver, kidney, lung and placenta. Present in most primary carcinomas. {ECO:0000269|PubMed:21685204, ECO:0000269|PubMed:8208544}.

Sequence

MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL
KHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQ
YLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN
KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRT
MLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAE
SNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELA
TISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQ
PENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQSLALSPKLECSGTILAHSNLRLLG
SSDSPASASRVAGITGVCHHAQDQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQKR
REQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSS
RSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVAGPGKPQEEDQPLPARRL
SSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLDS
KESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVE
VLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYSVKARQLKFFEENMN
F

Sequence length

841

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Ciliopathy	Likely pathogenic	rs770418305	RCV000256411	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (10)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC KIDNEY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CILIOPATHIES	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KIDNEY FAILURE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, HIP	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, KNEE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (18)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of large intestine	Colorectal Cancer	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Attention Deficit Disorder with Hyperactivity	Attention deficit hyperactivity disorder	Pubtator	32238911	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar Disorder	PSYGENET_DG	21926972, 25136889		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar disorder	Pubtator	21926972, 33772305, 37418754	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar Disorder	GWASDB_DG	22182935		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Carcinoma of lung	Lung carcinoma	BEFREE	20103636, 30247800		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ciliopathies	Ciliopathy	Pubtator	27894351	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ciliopathies	Ciliopathies	CLINVAR_DG			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon Carcinoma	Colon Carcinoma	BEFREE	28370249		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	29182684		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	29182684	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	GWASDB_DG	22472876		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	20103636, 30247800		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	28370249		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mood Disorders	Mood disorder	Pubtator	25136889	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	20103636		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	21926972, 28240266, 31723243		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	Pubtator	21926972, 25136889, 37418754	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

NEK4 (NIMA related kinase 4)