Gene Gene information from NCBI Gene database.
Entrez ID 6782
Gene name Heat shock protein family A (Hsp70) member 13
Gene symbol HSPA13
Synonyms (NCBI Gene)
STCH
Chromosome 21
Chromosome location 21q11.2
Summary The protein encoded by this gene is a member of the heat shock protein 70 family and is found associated with microsomes. Members of this protein family play a role in the processing of cytosolic and secretory proteins, as well as in the removal of denatu
miRNA miRNA information provided by mirtarbase database.
428
miRTarBase ID miRNA Experiments Reference
MIRT016077 hsa-miR-374b-5p Sequencing 20371350
MIRT016208 hsa-miR-590-3p Sequencing 20371350
MIRT021026 hsa-miR-155-5p Other 18668040
MIRT025187 hsa-miR-181a-5p Sequencing 20371350
MIRT547878 hsa-miR-33a-3p PAR-CLIP 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0005515 Function Protein binding IPI 16189514, 16713569, 21988832, 25416956, 28514442, 32296183, 33961781, 35914814
GO:0005524 Function ATP binding IEA
GO:0005634 Component Nucleus IBA
GO:0005737 Component Cytoplasm IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601100 11375 ENSG00000155304
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P48723
Protein name Heat shock 70 kDa protein 13 (Heat shock protein family A member 13) (Microsomal stress-70 protein ATPase core) (Stress-70 protein chaperone microsome-associated 60 kDa protein)
Protein function Has peptide-independent ATPase activity.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00012 HSP70 33 345 Hsp70 protein Family
PF00012 HSP70 323 460 Hsp70 protein Family
Tissue specificity TISSUE SPECIFICITY: Constitutively expressed in all tissues.
Sequence
Sequence length 471
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Regulation of HSF1-mediated heat shock response
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
POST-TRAUMATIC STRESS DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 25798051 Associate
★☆☆☆☆
Found in Text Mining only
Down Syndrome Down Syndrome BEFREE 22869728
★☆☆☆☆
Found in Text Mining only
Down Syndrome Down syndrome Pubtator 9548974 Associate
★☆☆☆☆
Found in Text Mining only
Leukemia Leukemia Pubtator 9548974 Associate
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of stomach Stomach Neoplasms BEFREE 16087163, 18793616
★☆☆☆☆
Found in Text Mining only
Myeloproliferative Syndrome Transient Transient myeloproliferative disorder Pubtator 9548974 Associate
★☆☆☆☆
Found in Text Mining only
Partial Trisomy Trisomy BEFREE 25803843
★☆☆☆☆
Found in Text Mining only
Stomach Carcinoma Stomach Carcinoma BEFREE 16087163, 18793616
★☆☆☆☆
Found in Text Mining only
Stomach Neoplasms Stomach Neoplasms LHGDN 16087163
★☆☆☆☆
Found in Text Mining only