STAC (SH3 and cysteine rich domain)

Gene

• Entrez ID: 6769
• Gene name: SH3 and cysteine rich domain
• Gene symbol: STAC
• Synonyms (NCBI Gene): STAC1
• Chromosome: 3
• Chromosome location: 3p22.3-p22.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT719332	hsa-miR-4502	HITS-CLIP	19536157
MIRT719331	hsa-miR-204-3p	HITS-CLIP	19536157
MIRT719330	hsa-miR-4646-5p	HITS-CLIP	19536157
MIRT719329	hsa-miR-6828-5p	HITS-CLIP	19536157
MIRT719328	hsa-miR-4505	HITS-CLIP	19536157
MIRT719327	hsa-miR-5787	HITS-CLIP	19536157
MIRT719326	hsa-miR-4747-5p	HITS-CLIP	19536157
MIRT719325	hsa-miR-5196-5p	HITS-CLIP	19536157
MIRT719324	hsa-miR-4492	HITS-CLIP	19536157
MIRT719323	hsa-miR-4498	HITS-CLIP	19536157
MIRT719322	hsa-miR-5001-5p	HITS-CLIP	19536157
MIRT719321	hsa-miR-762	HITS-CLIP	19536157
MIRT719320	hsa-miR-185-3p	HITS-CLIP	19536157
MIRT719319	hsa-miR-6830-3p	HITS-CLIP	19536157
MIRT719318	hsa-miR-3192-3p	HITS-CLIP	19536157
MIRT719317	hsa-miR-4762-3p	HITS-CLIP	19536157
MIRT719332	hsa-miR-4502	HITS-CLIP	19536157
MIRT719331	hsa-miR-204-3p	HITS-CLIP	19536157
MIRT719330	hsa-miR-4646-5p	HITS-CLIP	19536157
MIRT719329	hsa-miR-6828-5p	HITS-CLIP	19536157
MIRT719328	hsa-miR-4505	HITS-CLIP	19536157
MIRT719327	hsa-miR-5787	HITS-CLIP	19536157
MIRT719326	hsa-miR-4747-5p	HITS-CLIP	19536157
MIRT719325	hsa-miR-5196-5p	HITS-CLIP	19536157
MIRT719324	hsa-miR-4492	HITS-CLIP	19536157
MIRT719323	hsa-miR-4498	HITS-CLIP	19536157
MIRT719322	hsa-miR-5001-5p	HITS-CLIP	19536157
MIRT719321	hsa-miR-762	HITS-CLIP	19536157
MIRT719320	hsa-miR-185-3p	HITS-CLIP	19536157
MIRT719319	hsa-miR-6830-3p	HITS-CLIP	19536157
MIRT719318	hsa-miR-3192-3p	HITS-CLIP	19536157
MIRT719317	hsa-miR-4762-3p	HITS-CLIP	19536157
MIRT1394303	hsa-miR-106a	CLIP-seq
MIRT1394304	hsa-miR-106b	CLIP-seq
MIRT1394305	hsa-miR-10a	CLIP-seq
MIRT1394306	hsa-miR-10b	CLIP-seq
MIRT1394307	hsa-miR-1197	CLIP-seq
MIRT1394308	hsa-miR-1299	CLIP-seq
MIRT1394309	hsa-miR-149	CLIP-seq
MIRT1394310	hsa-miR-17	CLIP-seq
MIRT1394311	hsa-miR-200b	CLIP-seq
MIRT1394312	hsa-miR-200c	CLIP-seq
MIRT1394313	hsa-miR-20a	CLIP-seq
MIRT1394314	hsa-miR-20b	CLIP-seq
MIRT1394315	hsa-miR-221	CLIP-seq
MIRT1394316	hsa-miR-222	CLIP-seq
MIRT1394317	hsa-miR-302a	CLIP-seq
MIRT1394318	hsa-miR-302b	CLIP-seq
MIRT1394319	hsa-miR-302c	CLIP-seq
MIRT1394320	hsa-miR-302d	CLIP-seq
MIRT1394321	hsa-miR-302e	CLIP-seq
MIRT1394322	hsa-miR-3064-5p	CLIP-seq
MIRT1394323	hsa-miR-3126-3p	CLIP-seq
MIRT1394324	hsa-miR-3126-5p	CLIP-seq
MIRT1394325	hsa-miR-3194-3p	CLIP-seq
MIRT1394326	hsa-miR-369-3p	CLIP-seq
MIRT1394327	hsa-miR-370	CLIP-seq
MIRT1394328	hsa-miR-372	CLIP-seq
MIRT1394329	hsa-miR-373	CLIP-seq
MIRT1394330	hsa-miR-378g	CLIP-seq
MIRT1394331	hsa-miR-4263	CLIP-seq
MIRT1394332	hsa-miR-429	CLIP-seq
MIRT1394333	hsa-miR-4419a	CLIP-seq
MIRT1394334	hsa-miR-4426	CLIP-seq
MIRT1394335	hsa-miR-4510	CLIP-seq
MIRT1394336	hsa-miR-4642	CLIP-seq
MIRT1394337	hsa-miR-4647	CLIP-seq
MIRT1394338	hsa-miR-4659a-3p	CLIP-seq
MIRT1394339	hsa-miR-4659b-3p	CLIP-seq
MIRT1394340	hsa-miR-4662b	CLIP-seq
MIRT1394341	hsa-miR-4668-5p	CLIP-seq
MIRT1394342	hsa-miR-4763-5p	CLIP-seq
MIRT1394343	hsa-miR-4794	CLIP-seq
MIRT1394344	hsa-miR-519d	CLIP-seq
MIRT1394345	hsa-miR-520a-3p	CLIP-seq
MIRT1394346	hsa-miR-520b	CLIP-seq
MIRT1394347	hsa-miR-520c-3p	CLIP-seq
MIRT1394348	hsa-miR-520d-3p	CLIP-seq
MIRT1394349	hsa-miR-520e	CLIP-seq
MIRT1394350	hsa-miR-548t	CLIP-seq
MIRT1394351	hsa-miR-628-5p	CLIP-seq
MIRT1394352	hsa-miR-671-5p	CLIP-seq
MIRT1394353	hsa-miR-760	CLIP-seq
MIRT1394354	hsa-miR-875-3p	CLIP-seq
MIRT1394355	hsa-miR-93	CLIP-seq
MIRT2118356	hsa-miR-25	CLIP-seq
MIRT2118357	hsa-miR-30a	CLIP-seq
MIRT2118358	hsa-miR-30b	CLIP-seq
MIRT2118359	hsa-miR-30c	CLIP-seq
MIRT2118360	hsa-miR-30d	CLIP-seq
MIRT2118361	hsa-miR-30e	CLIP-seq
MIRT2118362	hsa-miR-32	CLIP-seq
MIRT2118363	hsa-miR-363	CLIP-seq
MIRT2118364	hsa-miR-367	CLIP-seq
MIRT2118365	hsa-miR-3910	CLIP-seq
MIRT2118366	hsa-miR-4286	CLIP-seq
MIRT2118367	hsa-miR-4659a-5p	CLIP-seq
MIRT2118368	hsa-miR-4659b-5p	CLIP-seq
MIRT2118369	hsa-miR-92a	CLIP-seq
MIRT2118370	hsa-miR-92b	CLIP-seq
MIRT2340470	hsa-miR-1324	CLIP-seq
MIRT2340471	hsa-miR-578	CLIP-seq
MIRT2395278	hsa-miR-1263	CLIP-seq
MIRT1394308	hsa-miR-1299	CLIP-seq
MIRT1394311	hsa-miR-200b	CLIP-seq
MIRT1394312	hsa-miR-200c	CLIP-seq
MIRT1394315	hsa-miR-221	CLIP-seq
MIRT1394316	hsa-miR-222	CLIP-seq
MIRT2395279	hsa-miR-3117-5p	CLIP-seq
MIRT2395280	hsa-miR-3136-5p	CLIP-seq
MIRT2395281	hsa-miR-3200-3p	CLIP-seq
MIRT1394326	hsa-miR-369-3p	CLIP-seq
MIRT1394330	hsa-miR-378g	CLIP-seq
MIRT1394332	hsa-miR-429	CLIP-seq
MIRT2395282	hsa-miR-4299	CLIP-seq
MIRT2395283	hsa-miR-4325	CLIP-seq
MIRT2395284	hsa-miR-4439	CLIP-seq
MIRT2395285	hsa-miR-4513	CLIP-seq
MIRT2395286	hsa-miR-4539	CLIP-seq
MIRT2395287	hsa-miR-4802-3p	CLIP-seq
MIRT2395288	hsa-miR-490-5p	CLIP-seq
MIRT2395289	hsa-miR-509-3p	CLIP-seq
MIRT1394352	hsa-miR-671-5p	CLIP-seq
MIRT1394354	hsa-miR-875-3p	CLIP-seq
MIRT2634226	hsa-miR-1224-3p	CLIP-seq
MIRT2634227	hsa-miR-1254	CLIP-seq
MIRT2634228	hsa-miR-1257	CLIP-seq
MIRT2634229	hsa-miR-1265	CLIP-seq
MIRT2634230	hsa-miR-1972	CLIP-seq
MIRT2634231	hsa-miR-2053	CLIP-seq
MIRT2634232	hsa-miR-214	CLIP-seq
MIRT2634233	hsa-miR-219-2-3p	CLIP-seq
MIRT2634234	hsa-miR-219-5p	CLIP-seq
MIRT2634235	hsa-miR-2392	CLIP-seq
MIRT2634236	hsa-miR-2682	CLIP-seq
MIRT2634237	hsa-miR-2964a-3p	CLIP-seq
MIRT2634238	hsa-miR-296-5p	CLIP-seq
MIRT2634239	hsa-miR-3116	CLIP-seq
MIRT2634240	hsa-miR-3146	CLIP-seq
MIRT2634241	hsa-miR-3188	CLIP-seq
MIRT2634242	hsa-miR-3201	CLIP-seq
MIRT2634243	hsa-miR-3611	CLIP-seq
MIRT2634244	hsa-miR-3616-5p	CLIP-seq
MIRT2634245	hsa-miR-3619-5p	CLIP-seq
MIRT2634246	hsa-miR-3647-5p	CLIP-seq
MIRT2634247	hsa-miR-3688-5p	CLIP-seq
MIRT2118365	hsa-miR-3910	CLIP-seq
MIRT2634248	hsa-miR-3944-5p	CLIP-seq
MIRT2634249	hsa-miR-4266	CLIP-seq
MIRT2118366	hsa-miR-4286	CLIP-seq
MIRT2634250	hsa-miR-4423-3p	CLIP-seq
MIRT2634251	hsa-miR-4445	CLIP-seq
MIRT2634252	hsa-miR-4476	CLIP-seq
MIRT2634253	hsa-miR-449c	CLIP-seq
MIRT2634254	hsa-miR-4522	CLIP-seq
MIRT2634255	hsa-miR-4533	CLIP-seq
MIRT2634256	hsa-miR-4670-3p	CLIP-seq
MIRT2634257	hsa-miR-4695-5p	CLIP-seq
MIRT2634258	hsa-miR-4712-5p	CLIP-seq
MIRT2634259	hsa-miR-4716-5p	CLIP-seq
MIRT2634260	hsa-miR-4728-3p	CLIP-seq
MIRT2634261	hsa-miR-4736	CLIP-seq
MIRT2634262	hsa-miR-4761-5p	CLIP-seq
MIRT2634263	hsa-miR-4773	CLIP-seq
MIRT2634264	hsa-miR-4779	CLIP-seq
MIRT2634265	hsa-miR-4782-3p	CLIP-seq
MIRT2634266	hsa-miR-4791	CLIP-seq
MIRT2634267	hsa-miR-508-3p	CLIP-seq
MIRT2634268	hsa-miR-569	CLIP-seq
MIRT2634269	hsa-miR-573	CLIP-seq
MIRT2634270	hsa-miR-622	CLIP-seq
MIRT2634271	hsa-miR-761	CLIP-seq
MIRT2634272	hsa-miR-770-5p	CLIP-seq
MIRT2634273	hsa-miR-885-3p	CLIP-seq
MIRT2634274	hsa-miR-9	CLIP-seq
MIRT2634275	hsa-miR-940	CLIP-seq
MIRT2395278	hsa-miR-1263	CLIP-seq
MIRT2692158	hsa-miR-1275	CLIP-seq
MIRT1394308	hsa-miR-1299	CLIP-seq
MIRT2340470	hsa-miR-1324	CLIP-seq
MIRT2692159	hsa-miR-1343	CLIP-seq
MIRT2634230	hsa-miR-1972	CLIP-seq
MIRT2634232	hsa-miR-214	CLIP-seq
MIRT2634235	hsa-miR-2392	CLIP-seq
MIRT2634236	hsa-miR-2682	CLIP-seq
MIRT2395279	hsa-miR-3117-5p	CLIP-seq
MIRT2395280	hsa-miR-3136-5p	CLIP-seq
MIRT2634245	hsa-miR-3619-5p	CLIP-seq
MIRT2692160	hsa-miR-3689d	CLIP-seq
MIRT2395282	hsa-miR-4299	CLIP-seq
MIRT2634250	hsa-miR-4423-3p	CLIP-seq
MIRT2395284	hsa-miR-4439	CLIP-seq
MIRT2692161	hsa-miR-4443	CLIP-seq
MIRT2634252	hsa-miR-4476	CLIP-seq
MIRT2692162	hsa-miR-4481	CLIP-seq
MIRT2634253	hsa-miR-449c	CLIP-seq
MIRT2692163	hsa-miR-450b-3p	CLIP-seq
MIRT2395285	hsa-miR-4513	CLIP-seq
MIRT2692164	hsa-miR-4525	CLIP-seq
MIRT2634255	hsa-miR-4533	CLIP-seq
MIRT2692165	hsa-miR-4654	CLIP-seq
MIRT2692166	hsa-miR-4665-5p	CLIP-seq
MIRT2634258	hsa-miR-4712-5p	CLIP-seq
MIRT2692167	hsa-miR-4713-3p	CLIP-seq
MIRT2692168	hsa-miR-4723-5p	CLIP-seq
MIRT2634261	hsa-miR-4736	CLIP-seq
MIRT2692169	hsa-miR-4745-5p	CLIP-seq
MIRT2692170	hsa-miR-4769-5p	CLIP-seq
MIRT2634263	hsa-miR-4773	CLIP-seq
MIRT2395289	hsa-miR-509-3p	CLIP-seq
MIRT2634270	hsa-miR-622	CLIP-seq
MIRT2692171	hsa-miR-625	CLIP-seq
MIRT2692172	hsa-miR-637	CLIP-seq
MIRT2692173	hsa-miR-638	CLIP-seq
MIRT2634271	hsa-miR-761	CLIP-seq
MIRT2692174	hsa-miR-769-3p	CLIP-seq
MIRT2634272	hsa-miR-770-5p	CLIP-seq
MIRT1394354	hsa-miR-875-3p	CLIP-seq
MIRT2634274	hsa-miR-9	CLIP-seq
MIRT2634275	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003009	Process	Skeletal muscle contraction	IBA
GO:0005515	Function	Protein binding	IPI	16260042, 21812934, 28514442, 32296183, 32814053, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	NAS	8954993
GO:0005886	Component	Plasma membrane	IEA
GO:0006936	Process	Muscle contraction	IEA
GO:0007165	Process	Signal transduction	NAS	8954993
GO:0008270	Function	Zinc ion binding	IEA
GO:0009898	Component	Cytoplasmic side of plasma membrane	IEA
GO:0009898	Component	Cytoplasmic side of plasma membrane	ISS
GO:0016020	Component	Membrane	IEA
GO:0030315	Component	T-tubule	IEA
GO:0034605	Process	Cellular response to heat	IEA
GO:0042383	Component	Sarcolemma	IEA
GO:0044325	Function	Transmembrane transporter binding	IBA
GO:0044325	Function	Transmembrane transporter binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:1901387	Process	Positive regulation of voltage-gated calcium channel activity	ISS
GO:1903078	Process	Positive regulation of protein localization to plasma membrane	IBA
GO:1903078	Process	Positive regulation of protein localization to plasma membrane	IEA
GO:1903078	Process	Positive regulation of protein localization to plasma membrane	ISS
GO:2001259	Process	Positive regulation of cation channel activity	ISS

Other IDs

• MIM: 602317
• HGNC: 11353
• e!Ensembl: ENSG00000144681

Protein

• UniProt ID: Q99469
• Protein name: SH3 and cysteine-rich domain-containing protein (Src homology 3 and cysteine-rich domain-containing protein)
• Protein function: Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity. Plays a minor and redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and
• PDB: 2DL4, 6B25
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00130	C1_1	108 → 162	Phorbol esters/diacylglycerol binding domain (C1 domain)	Domain
  PF16664	STAC2_u1	165 → 287		Disordered
  PF14604	SH3_9	292 → 340	Variant SH3 domain	Domain

• Sequence:

  MIPPSSPREDGVDGLPKEAVGAEQPPSPASTSSQESKLQKLKRSLSFKTKSLRSKSADNF
  FQRTNSEDMKLQAHMVAEISPSSSPLPAPGSLTSTPARAGLHPGGKAHAFQEYIFKKPTF
  CDVCNHMIVGTNAKHGLRCKACKMSIHHKCTDGLAPQRCMGKLPKGFRRYYSSPLLIHEQ
  FGCIKEVMPIACGNKVDPVYETLRFGTSLAQRTKKGSSGSGSDSPHRTSTSDLVEVPEEA
  NGPGGGYDLRKRSNSVFTYPENGTDDFRDPAKNINHQGSLSKDPLQMNTYVALYKFVPQE
  NEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIFRCVRTFIGCKE
  QGQITLKENQICVSSEEEQDGFIRVLSGKKKGLIPLDVLENI

• Sequence length: 402

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ASTHMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BRAIN ANEURYSM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CELIAC DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC KIDNEY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DERMATITIS, ALLERGIC CONTACT	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC NEPHROPATHY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GENERALISED EPILEPSY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IMMUNE SYSTEM DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Dermatitis, Allergic Contact	Dermatitis	CTD_human_DG	16033404		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Dyssomnias	Dyssomnia	BEFREE	29108526		★☆☆☆☆ Found in Text Mining only
Sleep Disorders	Sleep Disorders	BEFREE	29108526		★☆☆☆☆ Found in Text Mining only