Gene Gene information from NCBI Gene database.
Entrez ID 6755
Gene name Somatostatin receptor 5
Gene symbol SSTR5
Synonyms (NCBI Gene)
SS-5-RSST5
Chromosome 16
Chromosome location 16p13.3
Summary Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membran
miRNA miRNA information provided by mirtarbase database.
60
miRTarBase ID miRNA Experiments Reference
MIRT1392875 hsa-let-7a CLIP-seq
MIRT1392876 hsa-let-7b CLIP-seq
MIRT1392877 hsa-let-7c CLIP-seq
MIRT1392878 hsa-let-7d CLIP-seq
MIRT1392879 hsa-let-7e CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
26
GO ID Ontology Definition Evidence Reference
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0004994 Function Somatostatin receptor activity IBA
GO:0004994 Function Somatostatin receptor activity IEA
GO:0004994 Function Somatostatin receptor activity TAS 9892014
GO:0005515 Function Protein binding IPI 15247250, 18653781, 19426801
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
182455 11334 ENSG00000162009
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P35346
Protein name Somatostatin receptor type 5 (SS-5-R) (SS5-R) (SS5R) (SST5)
Protein function Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization. {EC
PDB 8X8L , 8X8N , 8ZBE , 8ZCJ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 57 304 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Adult pituitary gland, heart, small intestine, adrenal gland, cerebellum and fetal hypothalamus. No expression in fetal or adult kidney, liver, pancreas, uterus, spleen, lung, thyroid or ovary. {ECO:0000269|PubMed:12072395, ECO:0000269
Sequence
Sequence length 364
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  cAMP signaling pathway
Neuroactive ligand-receptor interaction
Hormone signaling
Growth hormone synthesis, secretion and action
  Peptide ligand-binding receptors
G alpha (i) signalling events
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
11
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BIPOLAR DISORDER Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR I DISORDER, MOST RECENT EPISODE MANIC Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DEPRESSION, BIPOLAR Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acromegaly Acromegaly BEFREE 15914528, 21744088, 21810856, 28396686, 30346538, 7521350
★☆☆☆☆
Found in Text Mining only
Acromegaly Acromegaly Pubtator 21744088, 21810856, 28434012, 39201352 Associate
★☆☆☆☆
Found in Text Mining only
ACTH-Secreting Pituitary Adenoma Pituitary adenoma BEFREE 15817922, 16625843, 28434012
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 20717067
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 10690891, 11231991, 11264647, 15914528, 15994755, 17420609, 28434012, 31518993, 7521350, 8866248
★☆☆☆☆
Found in Text Mining only
Adrenal Gland Pheochromocytoma Adrenal Gland Pheochromocytoma BEFREE 7775631
★☆☆☆☆
Found in Text Mining only
Anaplastic thyroid carcinoma Anaplastic thyroid cancer BEFREE 30415874
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis Pubtator 29685964 Associate
★☆☆☆☆
Found in Text Mining only
Autistic Disorder Autism BEFREE 12898583
★☆☆☆☆
Found in Text Mining only
Bipolar Disorder Bipolar Disorder BEFREE 12192619
★★☆☆☆
Found in Text Mining + Unknown/Other Associations