Gene Gene information from NCBI Gene database.
Entrez ID 6753
Gene name Somatostatin receptor 3
Gene symbol SSTR3
Synonyms (NCBI Gene)
SS-3-RSS3-RSS3RSSR-28SST3
Chromosome 22
Chromosome location 22q13.1
Summary This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of
miRNA miRNA information provided by mirtarbase database.
169
miRTarBase ID miRNA Experiments Reference
MIRT714170 hsa-miR-3918 HITS-CLIP 19536157
MIRT714169 hsa-miR-6849-3p HITS-CLIP 19536157
MIRT647419 hsa-miR-4685-5p HITS-CLIP 19536157
MIRT647417 hsa-miR-6837-5p HITS-CLIP 19536157
MIRT714168 hsa-miR-6840-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
29
GO ID Ontology Definition Evidence Reference
GO:0004930 Function G protein-coupled receptor activity IBA
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0004994 Function Somatostatin receptor activity IEA
GO:0004994 Function Somatostatin receptor activity TAS 8405411
GO:0005102 Function Signaling receptor binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
182453 11332 ENSG00000278195
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P32745
Protein name Somatostatin receptor type 3 (SS-3-R) (SS3-R) (SS3R) (SST3) (SSR-28)
Protein function Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.
PDB 8XIQ , 8XIR
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 61 313 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Brain, pituitary and pancreas. {ECO:0000269|PubMed:1337145}.
Sequence
Sequence length 418
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Neuroactive ligand-receptor interaction
Hormone signaling
Growth hormone synthesis, secretion and action
  Peptide ligand-binding receptors
G alpha (i) signalling events
BBSome-mediated cargo-targeting to cilium
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
MOOD DISORDERS Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PANCREATIC NEOPLASMS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
STATUS EPILEPTICUS CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
ACTH-Secreting Pituitary Adenoma Pituitary adenoma BEFREE 30627156
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 15326367
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma LHGDN 17679363
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 11434667, 17420609, 20797424, 25515731
★☆☆☆☆
Found in Text Mining only
Bladder Neoplasm Bladder Neoplasm BEFREE 24922657
★☆☆☆☆
Found in Text Mining only
Carcinoid Tumor Carcinoid tumor Pubtator 11772967 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 15456543, 29282035 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Merkel Cell Merkel cell carcinoma Pubtator 37540574 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma of bladder Bladder carcinoma BEFREE 24922657
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 21503779
★☆☆☆☆
Found in Text Mining only