Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6746
Gene name	Signal sequence receptor subunit 2
Gene symbol	SSR2
Synonyms (NCBI Gene)	HSD25TLAPTRAP-BETATRAPB
Chromosome	1
Chromosome location	1q22
Summary	The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprote

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miRTarBase ID	miRNA	Experiments	Reference
MIRT045638	hsa-miR-149-5p	CLASH	23622248
MIRT045273	hsa-miR-186-5p	CLASH	23622248
MIRT042799	hsa-miR-339-5p	CLASH	23622248
MIRT042734	hsa-miR-345-5p	CLASH	23622248
MIRT042734	hsa-miR-345-5p	CLASH	23622248
MIRT040270	hsa-miR-615-3p	CLASH	23622248
MIRT698849	hsa-miR-876-5p	HITS-CLIP	23313552
MIRT698848	hsa-miR-3167	HITS-CLIP	23313552
MIRT698847	hsa-miR-6835-3p	HITS-CLIP	23313552
MIRT698846	hsa-miR-4662a-3p	HITS-CLIP	23313552
MIRT698845	hsa-miR-619-3p	HITS-CLIP	23313552
MIRT698844	hsa-miR-6765-3p	HITS-CLIP	23313552
MIRT698843	hsa-miR-875-3p	HITS-CLIP	23313552
MIRT698842	hsa-miR-6128	HITS-CLIP	23313552
MIRT698841	hsa-miR-378j	HITS-CLIP	23313552
MIRT698840	hsa-miR-6839-5p	HITS-CLIP	23313552
MIRT698839	hsa-miR-5186	HITS-CLIP	23313552
MIRT698838	hsa-miR-6804-3p	HITS-CLIP	23313552
MIRT698837	hsa-miR-1289	HITS-CLIP	23313552
MIRT698836	hsa-miR-4294	HITS-CLIP	23313552
MIRT698835	hsa-miR-1290	HITS-CLIP	23313552
MIRT698834	hsa-miR-1299	HITS-CLIP	23313552
MIRT698833	hsa-miR-33a-5p	HITS-CLIP	23313552
MIRT698832	hsa-miR-33b-5p	HITS-CLIP	23313552
MIRT698831	hsa-miR-3978	HITS-CLIP	23313552
MIRT698830	hsa-miR-3198	HITS-CLIP	23313552
MIRT698829	hsa-miR-4309	HITS-CLIP	23313552
MIRT698828	hsa-miR-3658	HITS-CLIP	23313552
MIRT698827	hsa-miR-1185-5p	HITS-CLIP	23313552
MIRT698849	hsa-miR-876-5p	HITS-CLIP	23313552
MIRT698848	hsa-miR-3167	HITS-CLIP	23313552
MIRT698847	hsa-miR-6835-3p	HITS-CLIP	23313552
MIRT698846	hsa-miR-4662a-3p	HITS-CLIP	23313552
MIRT698845	hsa-miR-619-3p	HITS-CLIP	23313552
MIRT698844	hsa-miR-6765-3p	HITS-CLIP	23313552
MIRT698843	hsa-miR-875-3p	HITS-CLIP	23313552
MIRT698842	hsa-miR-6128	HITS-CLIP	23313552
MIRT698841	hsa-miR-378j	HITS-CLIP	23313552
MIRT698840	hsa-miR-6839-5p	HITS-CLIP	23313552
MIRT698839	hsa-miR-5186	HITS-CLIP	23313552
MIRT698838	hsa-miR-6804-3p	HITS-CLIP	23313552
MIRT698837	hsa-miR-1289	HITS-CLIP	23313552
MIRT698836	hsa-miR-4294	HITS-CLIP	23313552
MIRT698835	hsa-miR-1290	HITS-CLIP	23313552
MIRT698834	hsa-miR-1299	HITS-CLIP	23313552
MIRT698833	hsa-miR-33a-5p	HITS-CLIP	23313552
MIRT698832	hsa-miR-33b-5p	HITS-CLIP	23313552
MIRT698831	hsa-miR-3978	HITS-CLIP	23313552
MIRT698830	hsa-miR-3198	HITS-CLIP	23313552
MIRT698829	hsa-miR-4309	HITS-CLIP	23313552
MIRT698828	hsa-miR-3658	HITS-CLIP	23313552
MIRT698827	hsa-miR-1185-5p	HITS-CLIP	23313552
MIRT1392589	hsa-miR-1202	CLIP-seq
MIRT1392590	hsa-miR-1253	CLIP-seq
MIRT1392591	hsa-miR-135a	CLIP-seq
MIRT1392592	hsa-miR-135b	CLIP-seq
MIRT1392593	hsa-miR-2278	CLIP-seq
MIRT1392594	hsa-miR-3065-3p	CLIP-seq
MIRT1392595	hsa-miR-3151	CLIP-seq
MIRT1392596	hsa-miR-3194-5p	CLIP-seq
MIRT1392597	hsa-miR-33a	CLIP-seq
MIRT1392598	hsa-miR-33b	CLIP-seq
MIRT1392599	hsa-miR-3677-5p	CLIP-seq
MIRT1392600	hsa-miR-3926	CLIP-seq
MIRT1392601	hsa-miR-3942-5p	CLIP-seq
MIRT1392602	hsa-miR-3972	CLIP-seq
MIRT1392603	hsa-miR-4257	CLIP-seq
MIRT1392604	hsa-miR-4436b-3p	CLIP-seq
MIRT1392605	hsa-miR-4661-3p	CLIP-seq
MIRT1392606	hsa-miR-4691-5p	CLIP-seq
MIRT1392607	hsa-miR-4703-5p	CLIP-seq
MIRT1392608	hsa-miR-4711-5p	CLIP-seq
MIRT1392609	hsa-miR-4768-3p	CLIP-seq
MIRT1392610	hsa-miR-4796-3p	CLIP-seq
MIRT1392611	hsa-miR-486-3p	CLIP-seq
MIRT1392612	hsa-miR-548s	CLIP-seq
MIRT1392613	hsa-miR-579	CLIP-seq
MIRT1392614	hsa-miR-645	CLIP-seq
MIRT1392615	hsa-miR-665	CLIP-seq
MIRT2117777	hsa-miR-1254	CLIP-seq
MIRT1392591	hsa-miR-135a	CLIP-seq
MIRT1392592	hsa-miR-135b	CLIP-seq
MIRT2117778	hsa-miR-205	CLIP-seq
MIRT1392593	hsa-miR-2278	CLIP-seq
MIRT2117779	hsa-miR-3116	CLIP-seq
MIRT1392595	hsa-miR-3151	CLIP-seq
MIRT2117780	hsa-miR-3158-3p	CLIP-seq
MIRT2117781	hsa-miR-3689a-3p	CLIP-seq
MIRT2117782	hsa-miR-3689c	CLIP-seq
MIRT2117783	hsa-miR-3910	CLIP-seq
MIRT2117784	hsa-miR-3922-5p	CLIP-seq
MIRT1392603	hsa-miR-4257	CLIP-seq
MIRT1392604	hsa-miR-4436b-3p	CLIP-seq
MIRT2117785	hsa-miR-4446-3p	CLIP-seq
MIRT2117786	hsa-miR-4492	CLIP-seq
MIRT2117787	hsa-miR-4498	CLIP-seq
MIRT1392605	hsa-miR-4661-3p	CLIP-seq
MIRT1392608	hsa-miR-4711-5p	CLIP-seq
MIRT1392609	hsa-miR-4768-3p	CLIP-seq
MIRT1392610	hsa-miR-4796-3p	CLIP-seq
MIRT1392611	hsa-miR-486-3p	CLIP-seq
MIRT2117788	hsa-miR-548an	CLIP-seq
MIRT2117789	hsa-miR-578	CLIP-seq
MIRT1392613	hsa-miR-579	CLIP-seq
MIRT2117790	hsa-miR-619	CLIP-seq
MIRT2117791	hsa-miR-635	CLIP-seq
MIRT1392614	hsa-miR-645	CLIP-seq
MIRT1392615	hsa-miR-665	CLIP-seq
MIRT2117792	hsa-miR-762	CLIP-seq
MIRT2117777	hsa-miR-1254	CLIP-seq
MIRT2339745	hsa-miR-125a-5p	CLIP-seq
MIRT2339746	hsa-miR-125b	CLIP-seq
MIRT2339747	hsa-miR-1273d	CLIP-seq
MIRT2339748	hsa-miR-1912	CLIP-seq
MIRT2117779	hsa-miR-3116	CLIP-seq
MIRT2339749	hsa-miR-3123	CLIP-seq
MIRT2339750	hsa-miR-365	CLIP-seq
MIRT2117781	hsa-miR-3689a-3p	CLIP-seq
MIRT2117782	hsa-miR-3689c	CLIP-seq
MIRT2339751	hsa-miR-4319	CLIP-seq
MIRT2339752	hsa-miR-4324	CLIP-seq
MIRT2339753	hsa-miR-4684-5p	CLIP-seq
MIRT2117789	hsa-miR-578	CLIP-seq
MIRT2117791	hsa-miR-635	CLIP-seq
MIRT2339754	hsa-miR-942	CLIP-seq
MIRT1392589	hsa-miR-1202	CLIP-seq
MIRT2339745	hsa-miR-125a-5p	CLIP-seq
MIRT2339746	hsa-miR-125b	CLIP-seq
MIRT1392591	hsa-miR-135a	CLIP-seq
MIRT1392592	hsa-miR-135b	CLIP-seq
MIRT1392594	hsa-miR-3065-3p	CLIP-seq
MIRT2339749	hsa-miR-3123	CLIP-seq
MIRT1392595	hsa-miR-3151	CLIP-seq
MIRT1392596	hsa-miR-3194-5p	CLIP-seq
MIRT2117783	hsa-miR-3910	CLIP-seq
MIRT2117784	hsa-miR-3922-5p	CLIP-seq
MIRT1392601	hsa-miR-3942-5p	CLIP-seq
MIRT1392602	hsa-miR-3972	CLIP-seq
MIRT1392603	hsa-miR-4257	CLIP-seq
MIRT2339751	hsa-miR-4319	CLIP-seq
MIRT2339752	hsa-miR-4324	CLIP-seq
MIRT1392607	hsa-miR-4703-5p	CLIP-seq
MIRT1392608	hsa-miR-4711-5p	CLIP-seq
MIRT1392611	hsa-miR-486-3p	CLIP-seq
MIRT2117788	hsa-miR-548an	CLIP-seq
MIRT1392614	hsa-miR-645	CLIP-seq
MIRT1392590	hsa-miR-1253	CLIP-seq
MIRT1392591	hsa-miR-135a	CLIP-seq
MIRT1392592	hsa-miR-135b	CLIP-seq
MIRT2117778	hsa-miR-205	CLIP-seq
MIRT1392593	hsa-miR-2278	CLIP-seq
MIRT2692047	hsa-miR-2467-5p	CLIP-seq
MIRT1392594	hsa-miR-3065-3p	CLIP-seq
MIRT1392595	hsa-miR-3151	CLIP-seq
MIRT2117780	hsa-miR-3158-3p	CLIP-seq
MIRT2692048	hsa-miR-3173-3p	CLIP-seq
MIRT1392597	hsa-miR-33a	CLIP-seq
MIRT1392598	hsa-miR-33b	CLIP-seq
MIRT1392599	hsa-miR-3677-5p	CLIP-seq
MIRT2117783	hsa-miR-3910	CLIP-seq
MIRT2117784	hsa-miR-3922-5p	CLIP-seq
MIRT1392600	hsa-miR-3926	CLIP-seq
MIRT1392603	hsa-miR-4257	CLIP-seq
MIRT1392604	hsa-miR-4436b-3p	CLIP-seq
MIRT2117785	hsa-miR-4446-3p	CLIP-seq
MIRT2117786	hsa-miR-4492	CLIP-seq
MIRT2117787	hsa-miR-4498	CLIP-seq
MIRT1392605	hsa-miR-4661-3p	CLIP-seq
MIRT2692049	hsa-miR-4695-5p	CLIP-seq
MIRT1392608	hsa-miR-4711-5p	CLIP-seq
MIRT1392609	hsa-miR-4768-3p	CLIP-seq
MIRT2692050	hsa-miR-4771	CLIP-seq
MIRT1392610	hsa-miR-4796-3p	CLIP-seq
MIRT1392611	hsa-miR-486-3p	CLIP-seq
MIRT2117788	hsa-miR-548an	CLIP-seq
MIRT1392612	hsa-miR-548s	CLIP-seq
MIRT1392614	hsa-miR-645	CLIP-seq
MIRT1392615	hsa-miR-665	CLIP-seq
MIRT2117792	hsa-miR-762	CLIP-seq

Show/Hide all (8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001701	Process	In utero embryonic development	IEA
GO:0005515	Function	Protein binding	IPI	18724357
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005783	Component	Endoplasmic reticulum	TAS	7789174
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0006613	Process	Cotranslational protein targeting to membrane	TAS	7789174
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	7789174

MIM	HGNC	e!Ensembl
600867	11324	ENSG00000163479

P43308

Protein name

Translocon-associated protein subunit beta (TRAP-beta) (Signal sequence receptor subunit beta) (SSR-beta)

Protein function

TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

PDB

8B6L

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05753	TRAP_beta	3 → 181		Family

Sequence

MRLLSFVVLALFAVTQAEEGARLLASKSLLNRYAVEGRDLTLQYNIYNVGSSAALDVELS
DDSFPPEDFGIVSGMLNVKWDRIAPASNVSHTVVLRPLKAGYFNFTSATITYLAQEDGPV
VIGSTSAPGQGGILAQREFDRRFSPHFLDWAAFGVMTLPSIGIPLLLWYSSKRKYDTPKT
KKN

Sequence length

183

Interactions

View interactions

	KEGG
	Protein processing in endoplasmic reticulum

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
PROSTATIC NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (11)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	36003068	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	12069503		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	CTD_human_DG	17013881		★★★★★ ★☆☆☆☆ Found in Text Mining only
Medulloblastoma	Medulloblastoma	BEFREE	23455179		★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	27180333		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	12069503, 15138564, 8751588		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	12675130		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroectodermal Tumor, Primitive	Neuroectodermal Tumors	BEFREE	23455179		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroendocrine Tumors	Neuroendocrine Tumors	BEFREE	12675130		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	12069503		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	CTD_human_DG	17013881		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

SSR2 (signal sequence receptor subunit 2)