Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6715
Gene name	Steroid 5 alpha-reductase 1
Gene symbol	SRD5A1
Synonyms (NCBI Gene)	S5AR 1
Chromosome	5
Chromosome location	5p15.31
Summary	Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM, Mar 2008]

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024451	hsa-miR-215-5p	Microarray	19074876
MIRT026876	hsa-miR-192-5p	Microarray	19074876
MIRT711475	hsa-miR-148a-5p	HITS-CLIP	19536157
MIRT711474	hsa-miR-28-5p	HITS-CLIP	19536157
MIRT711473	hsa-miR-3139	HITS-CLIP	19536157
MIRT711472	hsa-miR-708-5p	HITS-CLIP	19536157
MIRT711471	hsa-miR-6793-3p	HITS-CLIP	19536157
MIRT711470	hsa-miR-5193	HITS-CLIP	19536157
MIRT711469	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT711468	hsa-miR-516a-3p	HITS-CLIP	19536157
MIRT711467	hsa-miR-516b-3p	HITS-CLIP	19536157
MIRT711466	hsa-miR-7162-5p	HITS-CLIP	19536157
MIRT711465	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT711464	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT711463	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT695818	hsa-miR-3929	HITS-CLIP	23313552
MIRT695817	hsa-miR-4419b	HITS-CLIP	23313552
MIRT695816	hsa-miR-4478	HITS-CLIP	23313552
MIRT695815	hsa-miR-5690	HITS-CLIP	23313552
MIRT695814	hsa-miR-665	HITS-CLIP	23313552
MIRT695813	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT695812	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT695811	hsa-miR-219a-2-3p	HITS-CLIP	23313552
MIRT695810	hsa-miR-1827	HITS-CLIP	23313552
MIRT695809	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT695808	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT695807	hsa-miR-298	HITS-CLIP	23313552
MIRT695806	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT695805	hsa-miR-7977	HITS-CLIP	23313552
MIRT695804	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT649129	hsa-miR-3664-5p	HITS-CLIP	23824327
MIRT649127	hsa-miR-6729-3p	HITS-CLIP	23824327
MIRT649128	hsa-miR-1470	HITS-CLIP	23824327
MIRT649126	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT649125	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT649124	hsa-miR-1266-3p	HITS-CLIP	23824327
MIRT649123	hsa-miR-205-5p	HITS-CLIP	23824327
MIRT649122	hsa-miR-4287	HITS-CLIP	23824327
MIRT649121	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT649120	hsa-miR-26b-3p	HITS-CLIP	23824327
MIRT649119	hsa-miR-1206	HITS-CLIP	23824327
MIRT649118	hsa-miR-6853-3p	HITS-CLIP	23824327
MIRT649117	hsa-miR-2116-5p	HITS-CLIP	23824327
MIRT649116	hsa-miR-22-5p	HITS-CLIP	23824327
MIRT649115	hsa-miR-4677-5p	HITS-CLIP	23824327
MIRT531560	hsa-miR-4797-5p	PAR-CLIP	22012620
MIRT531559	hsa-miR-759	PAR-CLIP	22012620
MIRT531558	hsa-miR-412-3p	PAR-CLIP	22012620
MIRT531557	hsa-miR-6754-3p	PAR-CLIP	22012620
MIRT531556	hsa-miR-6837-3p	PAR-CLIP	22012620
MIRT531554	hsa-miR-4481	PAR-CLIP	22012620
MIRT531555	hsa-miR-4745-5p	PAR-CLIP	22012620
MIRT531553	hsa-miR-6878-5p	PAR-CLIP	22012620
MIRT531552	hsa-miR-6731-5p	PAR-CLIP	22012620
MIRT531551	hsa-miR-8085	PAR-CLIP	22012620
MIRT531550	hsa-miR-1233-5p	PAR-CLIP	22012620
MIRT531549	hsa-miR-6778-5p	PAR-CLIP	22012620
MIRT531548	hsa-miR-30c-1-3p	PAR-CLIP	22012620
MIRT531547	hsa-miR-30c-2-3p	PAR-CLIP	22012620
MIRT531546	hsa-miR-6788-5p	PAR-CLIP	22012620
MIRT711475	hsa-miR-148a-5p	HITS-CLIP	19536157
MIRT711474	hsa-miR-28-5p	HITS-CLIP	19536157
MIRT711473	hsa-miR-3139	HITS-CLIP	19536157
MIRT711472	hsa-miR-708-5p	HITS-CLIP	19536157
MIRT711471	hsa-miR-6793-3p	HITS-CLIP	19536157
MIRT711470	hsa-miR-5193	HITS-CLIP	19536157
MIRT711469	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT711468	hsa-miR-516a-3p	HITS-CLIP	19536157
MIRT711467	hsa-miR-516b-3p	HITS-CLIP	19536157
MIRT711466	hsa-miR-7162-5p	HITS-CLIP	19536157
MIRT711465	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT711464	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT711463	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT695818	hsa-miR-3929	HITS-CLIP	23313552
MIRT695817	hsa-miR-4419b	HITS-CLIP	23313552
MIRT695816	hsa-miR-4478	HITS-CLIP	23313552
MIRT695815	hsa-miR-5690	HITS-CLIP	23313552
MIRT695814	hsa-miR-665	HITS-CLIP	23313552
MIRT695813	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT695812	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT695811	hsa-miR-219a-2-3p	HITS-CLIP	23313552
MIRT695810	hsa-miR-1827	HITS-CLIP	23313552
MIRT695809	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT695808	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT695807	hsa-miR-298	HITS-CLIP	23313552
MIRT695806	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT695805	hsa-miR-7977	HITS-CLIP	23313552
MIRT695804	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT649129	hsa-miR-3664-5p	HITS-CLIP	23824327
MIRT649127	hsa-miR-6729-3p	HITS-CLIP	23824327
MIRT649128	hsa-miR-1470	HITS-CLIP	23824327
MIRT649126	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT649125	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT649124	hsa-miR-1266-3p	HITS-CLIP	23824327
MIRT649123	hsa-miR-205-5p	HITS-CLIP	23824327
MIRT649122	hsa-miR-4287	HITS-CLIP	23824327
MIRT649121	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT649120	hsa-miR-26b-3p	HITS-CLIP	23824327
MIRT649119	hsa-miR-1206	HITS-CLIP	23824327
MIRT649118	hsa-miR-6853-3p	HITS-CLIP	23824327
MIRT649117	hsa-miR-2116-5p	HITS-CLIP	23824327
MIRT649116	hsa-miR-22-5p	HITS-CLIP	23824327
MIRT649115	hsa-miR-4677-5p	HITS-CLIP	23824327
MIRT531560	hsa-miR-4797-5p	PAR-CLIP	22012620
MIRT531559	hsa-miR-759	PAR-CLIP	22012620
MIRT531558	hsa-miR-412-3p	PAR-CLIP	22012620
MIRT531557	hsa-miR-6754-3p	PAR-CLIP	22012620
MIRT531556	hsa-miR-6837-3p	PAR-CLIP	22012620
MIRT531554	hsa-miR-4481	PAR-CLIP	22012620
MIRT531555	hsa-miR-4745-5p	PAR-CLIP	22012620
MIRT531553	hsa-miR-6878-5p	PAR-CLIP	22012620
MIRT531552	hsa-miR-6731-5p	PAR-CLIP	22012620
MIRT531551	hsa-miR-8085	PAR-CLIP	22012620
MIRT531550	hsa-miR-1233-5p	PAR-CLIP	22012620
MIRT531549	hsa-miR-6778-5p	PAR-CLIP	22012620
MIRT531548	hsa-miR-30c-1-3p	PAR-CLIP	22012620
MIRT531547	hsa-miR-30c-2-3p	PAR-CLIP	22012620
MIRT531546	hsa-miR-6788-5p	PAR-CLIP	22012620
MIRT1387825	hsa-miR-103b	CLIP-seq
MIRT1387826	hsa-miR-1245	CLIP-seq
MIRT1387827	hsa-miR-136	CLIP-seq
MIRT1387828	hsa-miR-182	CLIP-seq
MIRT1387829	hsa-miR-196a	CLIP-seq
MIRT1387830	hsa-miR-196b	CLIP-seq
MIRT1387831	hsa-miR-203	CLIP-seq
MIRT1387832	hsa-miR-2110	CLIP-seq
MIRT1387833	hsa-miR-216b	CLIP-seq
MIRT1387834	hsa-miR-27a	CLIP-seq
MIRT1387835	hsa-miR-27b	CLIP-seq
MIRT1387836	hsa-miR-3065-5p	CLIP-seq
MIRT1387837	hsa-miR-31	CLIP-seq
MIRT1387838	hsa-miR-3120-3p	CLIP-seq
MIRT1387839	hsa-miR-3133	CLIP-seq
MIRT1387840	hsa-miR-3153	CLIP-seq
MIRT1387841	hsa-miR-3184	CLIP-seq
MIRT1387842	hsa-miR-329	CLIP-seq
MIRT1387843	hsa-miR-330-3p	CLIP-seq
MIRT1387844	hsa-miR-331-5p	CLIP-seq
MIRT1387845	hsa-miR-342-3p	CLIP-seq
MIRT1387846	hsa-miR-3545-5p	CLIP-seq
MIRT1387847	hsa-miR-3609	CLIP-seq
MIRT1387848	hsa-miR-3613-3p	CLIP-seq
MIRT1387849	hsa-miR-3614-5p	CLIP-seq
MIRT1387850	hsa-miR-3617	CLIP-seq
MIRT1387851	hsa-miR-362-3p	CLIP-seq
MIRT1387852	hsa-miR-3675-3p	CLIP-seq
MIRT1387853	hsa-miR-377	CLIP-seq
MIRT1387854	hsa-miR-3927	CLIP-seq
MIRT1387855	hsa-miR-3941	CLIP-seq
MIRT1387856	hsa-miR-423-5p	CLIP-seq
MIRT1387857	hsa-miR-4271	CLIP-seq
MIRT1387858	hsa-miR-4305	CLIP-seq
MIRT1387859	hsa-miR-4307	CLIP-seq
MIRT1387860	hsa-miR-4311	CLIP-seq
MIRT1387861	hsa-miR-4438	CLIP-seq
MIRT1387862	hsa-miR-4474-5p	CLIP-seq
MIRT1387863	hsa-miR-450b-5p	CLIP-seq
MIRT1387864	hsa-miR-4514	CLIP-seq
MIRT1387865	hsa-miR-4662a-5p	CLIP-seq
MIRT1387866	hsa-miR-4684-5p	CLIP-seq
MIRT1387867	hsa-miR-4692	CLIP-seq
MIRT1387868	hsa-miR-4696	CLIP-seq
MIRT1387869	hsa-miR-4705	CLIP-seq
MIRT1387870	hsa-miR-4725-3p	CLIP-seq
MIRT1387871	hsa-miR-4796-3p	CLIP-seq
MIRT1387872	hsa-miR-485-3p	CLIP-seq
MIRT1387873	hsa-miR-491-5p	CLIP-seq
MIRT1387874	hsa-miR-495	CLIP-seq
MIRT1387875	hsa-miR-5095	CLIP-seq
MIRT1387876	hsa-miR-513a-3p	CLIP-seq
MIRT1387877	hsa-miR-513a-5p	CLIP-seq
MIRT1387878	hsa-miR-518a-5p	CLIP-seq
MIRT1387879	hsa-miR-527	CLIP-seq
MIRT1387880	hsa-miR-539	CLIP-seq
MIRT1387881	hsa-miR-545	CLIP-seq
MIRT1387882	hsa-miR-548ae	CLIP-seq
MIRT1387883	hsa-miR-548ah	CLIP-seq
MIRT1387884	hsa-miR-548aj	CLIP-seq
MIRT1387885	hsa-miR-548am	CLIP-seq
MIRT1387886	hsa-miR-548p	CLIP-seq
MIRT1387887	hsa-miR-548t	CLIP-seq
MIRT1387888	hsa-miR-548x	CLIP-seq
MIRT1387889	hsa-miR-554	CLIP-seq
MIRT1387890	hsa-miR-583	CLIP-seq
MIRT1387891	hsa-miR-601	CLIP-seq
MIRT1387892	hsa-miR-603	CLIP-seq
MIRT1387893	hsa-miR-641	CLIP-seq
MIRT2116180	hsa-miR-1183	CLIP-seq
MIRT2116181	hsa-miR-1208	CLIP-seq
MIRT1387827	hsa-miR-136	CLIP-seq
MIRT1387828	hsa-miR-182	CLIP-seq
MIRT1387829	hsa-miR-196a	CLIP-seq
MIRT1387830	hsa-miR-196b	CLIP-seq
MIRT1387833	hsa-miR-216b	CLIP-seq
MIRT1387834	hsa-miR-27a	CLIP-seq
MIRT1387835	hsa-miR-27b	CLIP-seq
MIRT1387837	hsa-miR-31	CLIP-seq
MIRT2116182	hsa-miR-3154	CLIP-seq
MIRT2116183	hsa-miR-3161	CLIP-seq
MIRT2116184	hsa-miR-3202	CLIP-seq
MIRT1387842	hsa-miR-329	CLIP-seq
MIRT1387844	hsa-miR-331-5p	CLIP-seq
MIRT2116185	hsa-miR-361-3p	CLIP-seq
MIRT1387851	hsa-miR-362-3p	CLIP-seq
MIRT1387852	hsa-miR-3675-3p	CLIP-seq
MIRT2116186	hsa-miR-3679-3p	CLIP-seq
MIRT1387854	hsa-miR-3927	CLIP-seq
MIRT1387855	hsa-miR-3941	CLIP-seq
MIRT2116187	hsa-miR-4272	CLIP-seq
MIRT2116188	hsa-miR-4278	CLIP-seq
MIRT1387858	hsa-miR-4305	CLIP-seq
MIRT2116189	hsa-miR-4462	CLIP-seq
MIRT2116190	hsa-miR-4489	CLIP-seq
MIRT2116191	hsa-miR-4533	CLIP-seq
MIRT2116192	hsa-miR-4640-3p	CLIP-seq
MIRT2116193	hsa-miR-466	CLIP-seq
MIRT2116194	hsa-miR-4672	CLIP-seq
MIRT1387866	hsa-miR-4684-5p	CLIP-seq
MIRT2116195	hsa-miR-4714-3p	CLIP-seq
MIRT2116196	hsa-miR-4716-3p	CLIP-seq
MIRT2116197	hsa-miR-4721	CLIP-seq
MIRT2116198	hsa-miR-4757-5p	CLIP-seq
MIRT1387876	hsa-miR-513a-3p	CLIP-seq
MIRT1387877	hsa-miR-513a-5p	CLIP-seq
MIRT1387878	hsa-miR-518a-5p	CLIP-seq
MIRT1387879	hsa-miR-527	CLIP-seq
MIRT1387880	hsa-miR-539	CLIP-seq
MIRT1387892	hsa-miR-603	CLIP-seq
MIRT2116199	hsa-miR-663b	CLIP-seq
MIRT2338712	hsa-miR-1179	CLIP-seq
MIRT2338713	hsa-miR-1245b-3p	CLIP-seq
MIRT2338714	hsa-miR-1273f	CLIP-seq
MIRT2338715	hsa-miR-1297	CLIP-seq
MIRT1387827	hsa-miR-136	CLIP-seq
MIRT2338716	hsa-miR-143	CLIP-seq
MIRT1387831	hsa-miR-203	CLIP-seq
MIRT2338717	hsa-miR-26a	CLIP-seq
MIRT2338718	hsa-miR-26b	CLIP-seq
MIRT1387840	hsa-miR-3153	CLIP-seq
MIRT2116183	hsa-miR-3161	CLIP-seq
MIRT1387841	hsa-miR-3184	CLIP-seq
MIRT1387843	hsa-miR-330-3p	CLIP-seq
MIRT1387844	hsa-miR-331-5p	CLIP-seq
MIRT2338719	hsa-miR-3682-3p	CLIP-seq
MIRT1387856	hsa-miR-423-5p	CLIP-seq
MIRT2116187	hsa-miR-4272	CLIP-seq
MIRT1387861	hsa-miR-4438	CLIP-seq
MIRT2338720	hsa-miR-4465	CLIP-seq
MIRT1387863	hsa-miR-450b-5p	CLIP-seq
MIRT2338721	hsa-miR-4699-5p	CLIP-seq
MIRT2338722	hsa-miR-4708-5p	CLIP-seq
MIRT2116195	hsa-miR-4714-3p	CLIP-seq
MIRT2338723	hsa-miR-4770	CLIP-seq
MIRT2338724	hsa-miR-508-5p	CLIP-seq
MIRT1387875	hsa-miR-5095	CLIP-seq
MIRT1387876	hsa-miR-513a-3p	CLIP-seq
MIRT1387878	hsa-miR-518a-5p	CLIP-seq
MIRT1387879	hsa-miR-527	CLIP-seq
MIRT2338725	hsa-miR-548ac	CLIP-seq
MIRT1387882	hsa-miR-548ae	CLIP-seq
MIRT1387884	hsa-miR-548aj	CLIP-seq
MIRT1387885	hsa-miR-548am	CLIP-seq
MIRT2338726	hsa-miR-548d-3p	CLIP-seq
MIRT1387888	hsa-miR-548x	CLIP-seq
MIRT2338727	hsa-miR-548z	CLIP-seq
MIRT2632141	hsa-miR-1226	CLIP-seq
MIRT2632142	hsa-miR-1296	CLIP-seq
MIRT2632143	hsa-miR-1587	CLIP-seq
MIRT2632144	hsa-miR-18a	CLIP-seq
MIRT2632145	hsa-miR-18b	CLIP-seq
MIRT2632146	hsa-miR-2278	CLIP-seq
MIRT2632147	hsa-miR-2909	CLIP-seq
MIRT2632148	hsa-miR-2964a-5p	CLIP-seq
MIRT2632149	hsa-miR-3065-3p	CLIP-seq
MIRT1387845	hsa-miR-342-3p	CLIP-seq
MIRT1387853	hsa-miR-377	CLIP-seq
MIRT2632150	hsa-miR-4417	CLIP-seq
MIRT2632151	hsa-miR-4492	CLIP-seq
MIRT2632152	hsa-miR-4498	CLIP-seq
MIRT2632153	hsa-miR-4505	CLIP-seq
MIRT2632154	hsa-miR-4509	CLIP-seq
MIRT2632155	hsa-miR-4512	CLIP-seq
MIRT1387864	hsa-miR-4514	CLIP-seq
MIRT2632156	hsa-miR-4656	CLIP-seq
MIRT2632157	hsa-miR-4675	CLIP-seq
MIRT1387867	hsa-miR-4692	CLIP-seq
MIRT2632158	hsa-miR-4735-3p	CLIP-seq
MIRT2632159	hsa-miR-4741	CLIP-seq
MIRT2632160	hsa-miR-4783-3p	CLIP-seq
MIRT2632161	hsa-miR-541	CLIP-seq
MIRT2632162	hsa-miR-548m	CLIP-seq
MIRT2632163	hsa-miR-550a	CLIP-seq
MIRT2632164	hsa-miR-550b	CLIP-seq
MIRT2632165	hsa-miR-634	CLIP-seq
MIRT2632166	hsa-miR-646	CLIP-seq
MIRT2632167	hsa-miR-654-5p	CLIP-seq
MIRT2632168	hsa-miR-762	CLIP-seq
MIRT1387853	hsa-miR-377	CLIP-seq

Show/Hide all (63)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001655	Process	Urogenital system development	IEA
GO:0001889	Process	Liver development	IEA
GO:0003865	Function	3-oxo-5-alpha-steroid 4-dehydrogenase activity	IBA
GO:0003865	Function	3-oxo-5-alpha-steroid 4-dehydrogenase activity	IDA	17986282
GO:0003865	Function	3-oxo-5-alpha-steroid 4-dehydrogenase activity	IEA
GO:0003865	Function	3-oxo-5-alpha-steroid 4-dehydrogenase activity	TAS
GO:0005515	Function	Protein binding	IPI	28514442, 33961781
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006694	Process	Steroid biosynthetic process	IEA
GO:0006702	Process	Androgen biosynthetic process	IBA
GO:0006702	Process	Androgen biosynthetic process	IEA
GO:0006702	Process	Androgen biosynthetic process	TAS
GO:0006710	Process	Androgen catabolic process	IEA
GO:0007530	Process	Sex determination	NAS	1686016
GO:0007548	Process	Sex differentiation	IEA
GO:0008202	Process	Steroid metabolic process	IEA
GO:0008209	Process	Androgen metabolic process	IEA
GO:0008584	Process	Male gonad development	IBA
GO:0008584	Process	Male gonad development	IEA
GO:0009055	Function	Electron transfer activity	TAS	1686016
GO:0009267	Process	Cellular response to starvation	IEA
GO:0009410	Process	Response to xenobiotic stimulus	IEA
GO:0014850	Process	Response to muscle activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0016101	Process	Diterpenoid metabolic process	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016627	Function	Oxidoreductase activity, acting on the CH-CH group of donors	IEA
GO:0021510	Process	Spinal cord development	IEA
GO:0021766	Process	Hippocampus development	IEA
GO:0021794	Process	Thalamus development	IEA
GO:0021854	Process	Hypothalamus development	IEA
GO:0021983	Process	Pituitary gland development	IEA
GO:0021987	Process	Cerebral cortex development	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030539	Process	Male genitalia development	IEA
GO:0030540	Process	Female genitalia development	IEA
GO:0032354	Process	Response to follicle-stimulating hormone	IEA
GO:0032355	Process	Response to estradiol	IEA
GO:0032869	Process	Cellular response to insulin stimulus	IEA
GO:0033218	Function	Amide binding	IEA
GO:0033574	Process	Response to testosterone	IEA
GO:0042428	Process	Serotonin metabolic process	IEA
GO:0042448	Process	Progesterone metabolic process	IEA
GO:0043025	Component	Neuronal cell body	IBA
GO:0043025	Component	Neuronal cell body	IEA
GO:0043627	Process	Response to estrogen	IEA
GO:0047751	Function	3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0060348	Process	Bone development	IEA
GO:0060416	Process	Response to growth hormone	IEA
GO:0060992	Process	Response to fungicide	IEA
GO:0070402	Function	NADPH binding	IEA
GO:0070852	Component	Cell body fiber	IEA
GO:0071320	Process	Cellular response to cAMP	IEA
GO:0071363	Process	Cellular response to growth factor stimulus	IEA
GO:0071392	Process	Cellular response to estradiol stimulus	IEA
GO:0071394	Process	Cellular response to testosterone stimulus	IEA
GO:0071549	Process	Cellular response to dexamethasone stimulus	IEA
GO:0071872	Process	Cellular response to epinephrine stimulus	IEA
GO:1904015	Process	Cellular response to serotonin	IEA

MIM	HGNC	e!Ensembl
184753	11284	ENSG00000145545

P18405

Protein name

3-oxo-5-alpha-steroid 4-dehydrogenase 1 (EC 1.3.1.22) (SR type 1) (Steroid 5-alpha-reductase 1) (S5AR 1)

Protein function

Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02544	Steroid_dh	110 → 259	3-oxo-5-alpha-steroid 4-dehydrogenase	Family

Tissue specificity

TISSUE SPECIFICITY: Liver and prostate (at a low level).

Sequence

MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQE
LPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMA
IMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGD
TGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWY
LRKFEEYPKFRKIIIPFLF

Sequence length

259

Interactions

View interactions

	KEGG		Reactome
	Steroid hormone biosynthesis Metabolic pathways		Androgen biosynthesis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
DEPRESSIVE DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIOSIS	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL DEPRESSION	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
POLYCYSTIC OVARY SYNDROME	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATIC HYPERTROPHY	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATIC NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (49)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alopecia	Alopecia	BEFREE	12670724, 22509838		★★★★★ ★☆☆☆☆ Found in Text Mining only
Alopecia, Male Pattern	Alopecia, Male Pattern	BEFREE	12670724		★★★★★ ★☆☆☆☆ Found in Text Mining only
Androgenetic Alopecia	Androgenetic Alopecia	BEFREE	12670724		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anxiety	Anxiety Disorder	BEFREE	24390875		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anxiety Disorders	Anxiety Disorder	BEFREE	24390875		★★★★★ ★☆☆☆☆ Found in Text Mining only
Aortic Aneurysm, Abdominal	Aortic Aneurysm	BEFREE	21119710		★★★★★ ★☆☆☆☆ Found in Text Mining only
Benign Prostatic Hyperplasia	Benign Prostatic Hyperplasia	BEFREE	15136785, 23499746, 25356777, 29084161, 30708032		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	21947678		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	15212687	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebellar Hypoplasia	Cerebellar Hypoplasia	BEFREE	23500598		★★★★★ ★☆☆☆☆ Found in Text Mining only
Depressive disorder	Mental Depression	PSYGENET_DG	15033426		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	16155734		★★★★★ ★☆☆☆☆ Found in Text Mining only
Disorders of Sex Development	Disorders of sex development	Pubtator	35432193	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrioma	Endometrioma	CTD_human_DG	21232532, 23183084		★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometriosis	Endometriosis	CTD_human_DG	21232532, 23183084		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial lichen amyloidosis	Lichen amyloidosis	BEFREE	20056642		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	LHGDN	14997014		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperandrogenism	Hyperandrogenism	Pubtator	16100771	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypospadias	Hypospadias	BEFREE	14739525, 23500598		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypospadias	Hypospadias	LHGDN	14739525		★★★★★ ★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	BEFREE	28589964		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	21947678		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	CTD_human_DG	18500220, 20564326		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	20519274, 24277450, 25960412, 27164191, 28324044		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	20519274, 23579488		★★★★★ ★☆☆☆☆ Found in Text Mining only
Manic	Manic Disorder	BEFREE	21570127		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental Depression	Mental Depression	PSYGENET_DG	15033426		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Metabolic Syndrome	Metabolic syndrome	Pubtator	29084161	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Metastatic Prostate Carcinoma	Metastatic Prostate Carcinoma	BEFREE	22415461, 26169017		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	23579488, 25356728		★★★★★ ★☆☆☆☆ Found in Text Mining only
Panic Disorder	Panic Disorder	BEFREE	24390875		★★★★★ ★☆☆☆☆ Found in Text Mining only
Penile hypospadias	Penile Hypospadias	BEFREE	14739525, 23500598		★★★★★ ★☆☆☆☆ Found in Text Mining only
Peripheral Arterial Diseases	Vascular Diseases	BEFREE	19246976		★★★★★ ★☆☆☆☆ Found in Text Mining only
Peripheral Vascular Diseases	Vascular Diseases	BEFREE	19246976		★★★★★ ★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic Ovary Syndrome	LHGDN	14671189		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Polycystic Ovary Syndrome	Polycystic Ovary Syndrome	BEFREE	16849416, 23375202		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Polycystic Ovary Syndrome	Polycystic Ovary Syndrome	CTD_human_DG	21411543, 22381227		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Polycystic Ovary Syndrome	Polycystic ovary syndrome	Pubtator	38537477	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate carcinoma	Prostate cancer	BEFREE	20519274, 24277450, 25960412, 27164191, 28324044		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Hyperplasia	Prostatic Hyperplasia	LHGDN	15136785		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Hyperplasia	Prostatic hyperplasia	Pubtator	29084161	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	LHGDN	12738739, 15538746, 15543614, 18483391		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostatic Neoplasms	Prostatic Neoplasms	CTD_human_DG	18500220, 20564326		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	23258647, 25371445, 27164191, 30538099	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sclerocystic Ovaries	Sclerocystic Ovaries	CTD_human_DG	21411543, 22381227		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	27893427	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	25356777		★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	25356777	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	21323680	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

SRD5A1 (steroid 5 alpha-reductase 1)