SPAM1 (sperm adhesion molecule 1)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 6677
Gene name Sperm adhesion molecule 1
Gene symbol SPAM1
Synonyms (NCBI Gene)
HEL-S-96nHYA1HYAL1HYAL3HYAL5PH-20PH20SPAG15
Chromosome 7
Chromosome location 7q31.32
Summary Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene
miRNA miRNA information provided by mirtarbase database.
58
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (58)
miRTarBase ID miRNA Experiments Reference
MIRT488677 hsa-miR-5197-3p PAR-CLIP 23592263
MIRT456970 hsa-miR-2682-5p PAR-CLIP 23592263
MIRT456969 hsa-miR-34b-5p PAR-CLIP 23592263
MIRT456968 hsa-miR-449c-5p PAR-CLIP 23592263
MIRT488676 hsa-miR-1827 PAR-CLIP 23592263
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (16)
GO ID Ontology Definition Evidence Reference
GO:0001669 Component Acrosomal vesicle IBA
GO:0004415 Function Hyalurononglucosaminidase activity IBA
GO:0004415 Function Hyalurononglucosaminidase activity IEA
GO:0005886 Component Plasma membrane IEA
GO:0005886 Component Plasma membrane TAS 8195297
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
600930 11217 ENSG00000106304
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P38567
Protein name Hyaluronidase PH-20 (Hyal-PH20) (EC 3.2.1.35) (Hyaluronoglucosaminidase PH-20) (Sperm adhesion molecule 1) (Sperm surface protein PH-20)
Protein function Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is form
PDB 9JUB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01630 Glyco_hydro_56 42 → 373 Hyaluronidase Domain
Tissue specificity TISSUE SPECIFICITY: Testis. {ECO:0000269|PubMed:8234258}.
Sequence
Sequence length 509
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Glycosaminoglycan degradation
Metabolic pathways
Lysosome 		  Interaction With Cumulus Cells And The Zona Pellucida
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (2)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ATRIAL FIBRILLATION — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATRIAL FLUTTER — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (72)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Allergic sensitization Allergic Sensitization BEFREE 24487587
★★★★★
★☆☆☆☆
Found in Text Mining only
Bladder Neoplasm Bladder Neoplasm BEFREE 15781637, 16140946, 17145867, 17503783, 20006858, 20960509, 26138586, 27419371
★★★★★
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 11802201, 11922735, 20473947, 21829529, 28168629
★★★★★
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 22139571, 27764788 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Cap Myopathy Cap myopathy Pubtator 11278412 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Carcinoma BEFREE 23202930
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Basal Cell Basal cell carcinoma Pubtator 26352698 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Endometrioid Endometrioid carcinoma Pubtator 20875124 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma of bladder Bladder carcinoma BEFREE 15781637, 16140946, 17145867, 17503783, 20006858, 20960509, 26138586, 27419371
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Ovarian Epithelial Epithelial ovarian carcinoma Pubtator 19435493 Inhibit
★★★★★
★☆☆☆☆
Found in Text Mining only