Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6650
Gene name	Calpain 15
Gene symbol	CAPN15
Synonyms (NCBI Gene)	OGINSOLH
Chromosome	16
Chromosome location	16p13.3
Summary	This gene encodes a protein containing zinc-finger-like repeats and a calpain-like protease domain. The encoded protein may function as a transcription factor, RNA-binding protein, or in protein-protein interactions during visual system development. [prov

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miRTarBase ID	miRNA	Experiments	Reference
MIRT115781	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT115779	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT115778	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT115786	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT115784	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT115782	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT115787	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT115788	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT494386	hsa-miR-3609	PAR-CLIP	23592263
MIRT494385	hsa-miR-548ah-5p	PAR-CLIP	23592263
MIRT494384	hsa-miR-4796-3p	PAR-CLIP	23592263
MIRT115783	hsa-miR-142-5p	PAR-CLIP	23592263
MIRT115798	hsa-miR-5590-3p	PAR-CLIP	23592263
MIRT115793	hsa-miR-4469	PAR-CLIP	23592263
MIRT494383	hsa-miR-7113-3p	PAR-CLIP	23592263
MIRT494382	hsa-miR-4287	PAR-CLIP	23592263
MIRT494380	hsa-miR-4685-3p	PAR-CLIP	23592263
MIRT494381	hsa-miR-6835-5p	PAR-CLIP	23592263
MIRT115800	hsa-miR-6752-5p	PAR-CLIP	23592263
MIRT115807	hsa-miR-6842-5p	PAR-CLIP	23592263
MIRT115812	hsa-miR-7110-5p	PAR-CLIP	23592263
MIRT115795	hsa-miR-4651	PAR-CLIP	23592263
MIRT115789	hsa-miR-608	PAR-CLIP	23592263
MIRT115801	hsa-miR-6756-5p	PAR-CLIP	23592263
MIRT115802	hsa-miR-6766-5p	PAR-CLIP	23592263
MIRT115780	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT494379	hsa-miR-491-5p	PAR-CLIP	23592263
MIRT494378	hsa-miR-3151-5p	PAR-CLIP	23592263
MIRT115792	hsa-miR-4447	PAR-CLIP	23592263
MIRT115794	hsa-miR-4472	PAR-CLIP	23592263
MIRT494377	hsa-miR-6742-5p	PAR-CLIP	23592263
MIRT115808	hsa-miR-6867-3p	PAR-CLIP	23592263
MIRT115799	hsa-miR-6751-5p	PAR-CLIP	23592263
MIRT115805	hsa-miR-6803-5p	PAR-CLIP	23592263
MIRT115804	hsa-miR-6796-5p	PAR-CLIP	23592263
MIRT284424	hsa-miR-1321	PAR-CLIP	23592263
MIRT284431	hsa-miR-4739	PAR-CLIP	23592263
MIRT284433	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT494376	hsa-miR-4688	PAR-CLIP	23592263
MIRT494375	hsa-miR-6743-5p	PAR-CLIP	23592263
MIRT284426	hsa-miR-4270	PAR-CLIP	23592263
MIRT284428	hsa-miR-4441	PAR-CLIP	23592263
MIRT284435	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT494374	hsa-miR-140-3p	PAR-CLIP	23592263
MIRT494372	hsa-miR-3176	PAR-CLIP	23592263
MIRT494373	hsa-miR-3922-3p	PAR-CLIP	23592263
MIRT494371	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT494370	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT494369	hsa-miR-4757-5p	PAR-CLIP	23592263
MIRT494368	hsa-miR-6744-3p	PAR-CLIP	23592263
MIRT494367	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT494366	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT494365	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT494363	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT494364	hsa-miR-486-3p	PAR-CLIP	23592263
MIRT494362	hsa-miR-6878-3p	PAR-CLIP	23592263
MIRT115781	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT115779	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT115778	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT115786	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT115784	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT115782	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT115787	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT115788	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT754885	hsa-miR-3609	PAR-CLIP	23592263
MIRT754886	hsa-miR-548ah-5p	PAR-CLIP	23592263
MIRT754887	hsa-miR-4796-3p	PAR-CLIP	23592263
MIRT115783	hsa-miR-142-5p	PAR-CLIP	23592263
MIRT115798	hsa-miR-5590-3p	PAR-CLIP	23592263
MIRT115793	hsa-miR-4469	PAR-CLIP	23592263
MIRT754888	hsa-miR-7113-3p	PAR-CLIP	23592263
MIRT754889	hsa-miR-4287	PAR-CLIP	23592263
MIRT754890	hsa-miR-4685-3p	PAR-CLIP	23592263
MIRT754891	hsa-miR-6835-5p	PAR-CLIP	23592263
MIRT115800	hsa-miR-6752-5p	PAR-CLIP	23592263
MIRT115807	hsa-miR-6842-5p	PAR-CLIP	23592263
MIRT115812	hsa-miR-7110-5p	PAR-CLIP	23592263
MIRT115795	hsa-miR-4651	PAR-CLIP	23592263
MIRT115789	hsa-miR-608	PAR-CLIP	23592263
MIRT115801	hsa-miR-6756-5p	PAR-CLIP	23592263
MIRT115802	hsa-miR-6766-5p	PAR-CLIP	23592263
MIRT115780	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT754892	hsa-miR-491-5p	PAR-CLIP	23592263
MIRT754893	hsa-miR-3151-5p	PAR-CLIP	23592263
MIRT115792	hsa-miR-4447	PAR-CLIP	23592263
MIRT115794	hsa-miR-4472	PAR-CLIP	23592263
MIRT754894	hsa-miR-6742-5p	PAR-CLIP	23592263
MIRT115808	hsa-miR-6867-3p	PAR-CLIP	23592263
MIRT115799	hsa-miR-6751-5p	PAR-CLIP	23592263
MIRT115805	hsa-miR-6803-5p	PAR-CLIP	23592263
MIRT115804	hsa-miR-6796-5p	PAR-CLIP	23592263
MIRT284424	hsa-miR-1321	PAR-CLIP	23592263
MIRT284431	hsa-miR-4739	PAR-CLIP	23592263
MIRT284433	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT754895	hsa-miR-4688	PAR-CLIP	23592263
MIRT754896	hsa-miR-6743-5p	PAR-CLIP	23592263
MIRT284426	hsa-miR-4270	PAR-CLIP	23592263
MIRT284428	hsa-miR-4441	PAR-CLIP	23592263
MIRT284435	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT754897	hsa-miR-140-3p	PAR-CLIP	23592263
MIRT754898	hsa-miR-3176	PAR-CLIP	23592263
MIRT754899	hsa-miR-3922-3p	PAR-CLIP	23592263
MIRT754900	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT754901	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT754902	hsa-miR-4757-5p	PAR-CLIP	23592263
MIRT754903	hsa-miR-6744-3p	PAR-CLIP	23592263
MIRT754904	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT754905	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT754906	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT754907	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT754908	hsa-miR-486-3p	PAR-CLIP	23592263
MIRT754909	hsa-miR-6878-3p	PAR-CLIP	23592263

Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004198	Function	Calcium-dependent cysteine-type endopeptidase activity	IBA
GO:0004198	Function	Calcium-dependent cysteine-type endopeptidase activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005737	Component	Cytoplasm	IBA
GO:0006508	Process	Proteolysis	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
603267	11182	ENSG00000103326

O75808

Protein name

Calpain-15 (EC 3.4.22.-) (Small optic lobes homolog)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00641	zf-RanBP	4 → 32	Zn-finger in Ran binding protein and others	Domain
PF00641	zf-RanBP	143 → 172	Zn-finger in Ran binding protein and others	Domain
PF00641	zf-RanBP	412 → 441	Zn-finger in Ran binding protein and others	Domain
PF00648	Peptidase_C2	488 → 791	Calpain family cysteine protease	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed with higher expression in brain. {ECO:0000269|PubMed:9722942}.

Sequence

MATVGEWSCVRCTFLNPAGQRQCSICEAPRHKPDLNHILRLSVEEQKWPCARCTFRNFLG
KEACEVCGFTPEPAPGAAFLPVLNGVLPKPPAILGEPKGSCQEEAGPVRTAGLVATEPAR
GQCEDKDEEEKEEQEEEEGAAEPRGGWACPRCTLHNTPVASSCSVCGGPRRLSLPRIPPE
ALVVPEVVAPAGFHVVPAAPPPGLPGEGAEANPPATSQGPAAEPEPPRVPPFSPFSSTLQ
NNPVPRSRREVPPQLQPPVPEAAQPSPSAGCRGAPQGSGWAGASRLAELLSGKRLSVLEE
EATEGGTSRVEAGSSTSGSDIIDLAGDTVRYTPASPSSPDFTTWSCAKCTLRNPTVAPRC
SACGCSKLHGFQEHGEPPTHCPDCGADKPSPCGRSCGRVSSAQKAARVLPERPGQWACPA
CTLLNALRAKHCAACHTPQLLVAQRRGAAPLRRRESMHVEQRRQTDEGEAKALWENIVAF
CRENNVSFVDDSFPPGPESVGFPAGDSVQQRVRQWLRPQEINCSVFRDHRATWSVFHTLR
PSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAEGAYQVRLCKDGTWTTVLVDD
MLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCESLA
LQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDSAYESLGLRPRHAYS
ILDVRDVQGTRLLRLRNPWGRFSWNGSWSDEWPHWPGHLRGELMPHGSSEGVFWMEYGDF
VRYFDSVDICKVHSDWQEARVQGCFPSSASAPVGVTALTVLERASLEFALFQEGSRRSDA
VDSHLLDLCILVFRATFGSGGHLSLGRLLAHSKRAVKKFVSCDVMLEPGEYAVVCCAFNH
WGPPLPGTPAPQASSPSAGVPRASPEPPGHVLAVYSSRLVMVEPVEAQPTTLADAIILLT
ESRGERHEGREGMTCYYLTHGWAGLIVVVENRHPKAYLHVQCDCTDSFNVVSTRGSLRTQ
DSVPPLHRQVLVILSQLEGNAGFSITHRLAHRKAAQAFLSDWTASKGTHSPPLTPEVAGL
HGPRPL

Sequence length

1086

Interactions

View interactions

	Reactome
			Degradation of the extracellular matrix

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Oculogastrointestinal-neurodevelopmental syndrome	Pathogenic	rs2142085042, rs2142072159, rs762523863, rs2142086271, rs2142084042	RCV001387527 RCV001387528 RCV001387530 RCV001387531 RCV001387533	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (15)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Adrenocortical carcinoma, hereditary	Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CAPN15-related disorder	Uncertain significance; Likely benign; Benign; Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONGENITAL HEART DISEASE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONGENITAL OCULAR COLOBOMA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of urinary bladder	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Cataract	Cataract	BEFREE	9722942		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dehydrated Hereditary Stomatocytosis Pseudohyperkalemia and Perinatal Edema	Hereditary xerocytosis	Pubtator	29221444	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leiomyosarcoma	Leiomyosarcoma	Pubtator	22419440	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	GWASCAT_DG	31164008		★★★★★ ★☆☆☆☆ Found in Text Mining only

CAPN15 (calpain 15)