Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6643
Gene name	Sorting nexin 2
Gene symbol	SNX2
Synonyms (NCBI Gene)	TRG-9
Chromosome	5
Chromosome location	5q23.2
Summary	This gene belongs to the sorting nexin family whose members contain the phosphoinositide-binding phox (PX) domain. The encoded protein is a component of the retromer complex which plays a role in protein sorting in the endocytic pathway. This protein may

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Show/Hide all (201)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029279	hsa-miR-26b-5p	Microarray	19088304
MIRT052540	hsa-let-7a-5p	CLASH	23622248
MIRT047884	hsa-miR-30c-5p	CLASH	23622248
MIRT686815	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT686814	hsa-miR-548aa	HITS-CLIP	21572407
MIRT686813	hsa-miR-548ap-3p	HITS-CLIP	21572407
MIRT686812	hsa-miR-548t-3p	HITS-CLIP	21572407
MIRT686811	hsa-miR-548as-3p	HITS-CLIP	21572407
MIRT686810	hsa-miR-548at-3p	HITS-CLIP	21572407
MIRT686809	hsa-miR-548ay-3p	HITS-CLIP	21572407
MIRT686808	hsa-miR-497-3p	HITS-CLIP	21572407
MIRT686807	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT686815	hsa-miR-410-3p	HITS-CLIP	23313552
MIRT686814	hsa-miR-548aa	HITS-CLIP	23313552
MIRT686813	hsa-miR-548ap-3p	HITS-CLIP	23313552
MIRT686812	hsa-miR-548t-3p	HITS-CLIP	23313552
MIRT686811	hsa-miR-548as-3p	HITS-CLIP	23313552
MIRT686810	hsa-miR-548at-3p	HITS-CLIP	23313552
MIRT686809	hsa-miR-548ay-3p	HITS-CLIP	23313552
MIRT686808	hsa-miR-497-3p	HITS-CLIP	23313552
MIRT686807	hsa-miR-223-5p	HITS-CLIP	23313552
MIRT608826	hsa-miR-6867-5p	HITS-CLIP	23313552
MIRT608827	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT676770	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT676769	hsa-miR-764	HITS-CLIP	23824327
MIRT676768	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT676767	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT676766	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT679889	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT676765	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT676764	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT676763	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT676762	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT679888	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT676761	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT676760	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT676759	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT676758	hsa-miR-640	HITS-CLIP	23824327
MIRT676772	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT676771	hsa-miR-520h	HITS-CLIP	23824327
MIRT676770	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT676769	hsa-miR-764	HITS-CLIP	23824327
MIRT676768	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT676767	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT676766	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT676765	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT676764	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT676763	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT676762	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT676761	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT676760	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT676759	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT676758	hsa-miR-640	HITS-CLIP	23824327
MIRT608829	hsa-miR-513b-3p	HITS-CLIP	24906430
MIRT608828	hsa-miR-759	HITS-CLIP	24906430
MIRT608827	hsa-miR-574-5p	HITS-CLIP	24906430
MIRT608826	hsa-miR-6867-5p	HITS-CLIP	24906430
MIRT686807	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT686807	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT686807	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT686815	hsa-miR-410-3p	HITS-CLIP	27418678
MIRT686815	hsa-miR-410-3p	HITS-CLIP	27418678
MIRT686815	hsa-miR-410-3p	HITS-CLIP	27418678
MIRT686808	hsa-miR-497-3p	HITS-CLIP	27418678
MIRT608829	hsa-miR-513b-3p	HITS-CLIP	27418678
MIRT608829	hsa-miR-513b-3p	HITS-CLIP	27418678
MIRT686814	hsa-miR-548aa	HITS-CLIP	27418678
MIRT686814	hsa-miR-548aa	HITS-CLIP	27418678
MIRT686813	hsa-miR-548ap-3p	HITS-CLIP	27418678
MIRT686813	hsa-miR-548ap-3p	HITS-CLIP	27418678
MIRT686811	hsa-miR-548as-3p	HITS-CLIP	27418678
MIRT686811	hsa-miR-548as-3p	HITS-CLIP	27418678
MIRT686810	hsa-miR-548at-3p	HITS-CLIP	27418678
MIRT686810	hsa-miR-548at-3p	HITS-CLIP	27418678
MIRT686809	hsa-miR-548ay-3p	HITS-CLIP	27418678
MIRT686809	hsa-miR-548ay-3p	HITS-CLIP	27418678
MIRT686812	hsa-miR-548t-3p	HITS-CLIP	27418678
MIRT686812	hsa-miR-548t-3p	HITS-CLIP	27418678
MIRT608827	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT608827	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT608827	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT608827	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT608826	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608826	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608826	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608826	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608828	hsa-miR-759	HITS-CLIP	27418678
MIRT608828	hsa-miR-759	HITS-CLIP	27418678
MIRT608828	hsa-miR-759	HITS-CLIP	27418678
MIRT686815	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT686814	hsa-miR-548aa	HITS-CLIP	21572407
MIRT686813	hsa-miR-548ap-3p	HITS-CLIP	21572407
MIRT686812	hsa-miR-548t-3p	HITS-CLIP	21572407
MIRT686811	hsa-miR-548as-3p	HITS-CLIP	21572407
MIRT686810	hsa-miR-548at-3p	HITS-CLIP	21572407
MIRT686809	hsa-miR-548ay-3p	HITS-CLIP	21572407
MIRT686808	hsa-miR-497-3p	HITS-CLIP	21572407
MIRT686807	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT686815	hsa-miR-410-3p	HITS-CLIP	23313552
MIRT686814	hsa-miR-548aa	HITS-CLIP	23313552
MIRT686813	hsa-miR-548ap-3p	HITS-CLIP	23313552
MIRT686812	hsa-miR-548t-3p	HITS-CLIP	23313552
MIRT686811	hsa-miR-548as-3p	HITS-CLIP	23313552
MIRT686810	hsa-miR-548at-3p	HITS-CLIP	23313552
MIRT686809	hsa-miR-548ay-3p	HITS-CLIP	23313552
MIRT686808	hsa-miR-497-3p	HITS-CLIP	23313552
MIRT686807	hsa-miR-223-5p	HITS-CLIP	23313552
MIRT608826	hsa-miR-6867-5p	HITS-CLIP	23313552
MIRT608827	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT676770	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT676769	hsa-miR-764	HITS-CLIP	23824327
MIRT676768	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT676767	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT676766	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT679889	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT676765	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT676764	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT676763	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT676762	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT679888	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT676761	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT676760	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT676759	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT676758	hsa-miR-640	HITS-CLIP	23824327
MIRT676772	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT676771	hsa-miR-520h	HITS-CLIP	23824327
MIRT676770	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT676769	hsa-miR-764	HITS-CLIP	23824327
MIRT676768	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT676767	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT676766	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT676765	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT676764	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT676763	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT676762	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT676761	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT676760	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT676759	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT676758	hsa-miR-640	HITS-CLIP	23824327
MIRT1377431	hsa-miR-1276	CLIP-seq
MIRT1377432	hsa-miR-1279	CLIP-seq
MIRT1377433	hsa-miR-30a	CLIP-seq
MIRT1377434	hsa-miR-30b	CLIP-seq
MIRT1377435	hsa-miR-30c	CLIP-seq
MIRT1377436	hsa-miR-30d	CLIP-seq
MIRT1377437	hsa-miR-30e	CLIP-seq
MIRT1377438	hsa-miR-337-5p	CLIP-seq
MIRT1377439	hsa-miR-4311	CLIP-seq
MIRT1377440	hsa-miR-4485	CLIP-seq
MIRT1377441	hsa-miR-4760-3p	CLIP-seq
MIRT1377442	hsa-miR-4778-3p	CLIP-seq
MIRT1377443	hsa-miR-548al	CLIP-seq
MIRT1377444	hsa-miR-583	CLIP-seq
MIRT2112336	hsa-miR-1301	CLIP-seq
MIRT2112337	hsa-miR-2054	CLIP-seq
MIRT2112338	hsa-miR-3190	CLIP-seq
MIRT1377438	hsa-miR-337-5p	CLIP-seq
MIRT2112339	hsa-miR-338-3p	CLIP-seq
MIRT2112340	hsa-miR-4318	CLIP-seq
MIRT2112341	hsa-miR-4436a	CLIP-seq
MIRT1377440	hsa-miR-4485	CLIP-seq
MIRT2112342	hsa-miR-4530	CLIP-seq
MIRT2112343	hsa-miR-4660	CLIP-seq
MIRT1377442	hsa-miR-4778-3p	CLIP-seq
MIRT2112344	hsa-miR-5047	CLIP-seq
MIRT1377443	hsa-miR-548al	CLIP-seq
MIRT2112345	hsa-miR-582-3p	CLIP-seq
MIRT1377431	hsa-miR-1276	CLIP-seq
MIRT1377432	hsa-miR-1279	CLIP-seq
MIRT2112336	hsa-miR-1301	CLIP-seq
MIRT2335555	hsa-miR-130a	CLIP-seq
MIRT2335556	hsa-miR-130b	CLIP-seq
MIRT2112337	hsa-miR-2054	CLIP-seq
MIRT2335557	hsa-miR-301a	CLIP-seq
MIRT2335558	hsa-miR-301b	CLIP-seq
MIRT1377433	hsa-miR-30a	CLIP-seq
MIRT1377434	hsa-miR-30b	CLIP-seq
MIRT1377435	hsa-miR-30c	CLIP-seq
MIRT1377436	hsa-miR-30d	CLIP-seq
MIRT1377437	hsa-miR-30e	CLIP-seq
MIRT2335559	hsa-miR-3662	CLIP-seq
MIRT2335560	hsa-miR-3666	CLIP-seq
MIRT2335561	hsa-miR-410	CLIP-seq
MIRT2335562	hsa-miR-4295	CLIP-seq
MIRT1377439	hsa-miR-4311	CLIP-seq
MIRT2112341	hsa-miR-4436a	CLIP-seq
MIRT2335563	hsa-miR-4436b-5p	CLIP-seq
MIRT2335564	hsa-miR-454	CLIP-seq
MIRT2112343	hsa-miR-4660	CLIP-seq
MIRT1377441	hsa-miR-4760-3p	CLIP-seq
MIRT2112344	hsa-miR-5047	CLIP-seq
MIRT1377444	hsa-miR-583	CLIP-seq
MIRT2335561	hsa-miR-410	CLIP-seq
MIRT1377438	hsa-miR-337-5p	CLIP-seq
MIRT1377440	hsa-miR-4485	CLIP-seq
MIRT1377442	hsa-miR-4778-3p	CLIP-seq
MIRT1377443	hsa-miR-548al	CLIP-seq
MIRT1377438	hsa-miR-337-5p	CLIP-seq
MIRT1377440	hsa-miR-4485	CLIP-seq
MIRT1377442	hsa-miR-4778-3p	CLIP-seq
MIRT1377443	hsa-miR-548al	CLIP-seq

Show/Hide all (43)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005154	Function	Epidermal growth factor receptor binding	IDA	9819414
GO:0005154	Function	Epidermal growth factor receptor binding	IEA
GO:0005158	Function	Insulin receptor binding	IDA	9819414
GO:0005158	Function	Insulin receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	9819414, 11102511, 11278302, 11279102, 11438682, 14596906, 19619496, 19935774, 21988832, 28514442, 32296183, 32814053, 33961781, 35271311
GO:0005737	Component	Cytoplasm	IDA	11279102
GO:0005764	Component	Lysosome	IDA
GO:0005768	Component	Endosome	IBA
GO:0005768	Component	Endosome	IDA
GO:0005768	Component	Endosome	IEA
GO:0005829	Component	Cytosol	IEA
GO:0006886	Process	Intracellular protein transport	IEA
GO:0008289	Function	Lipid binding	IEA
GO:0010008	Component	Endosome membrane	IBA
GO:0010008	Component	Endosome membrane	IDA	15673616
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IDA	9819414
GO:0016020	Component	Membrane	IEA
GO:0030027	Component	Lamellipodium	IEA
GO:0030904	Component	Retromer complex	IDA	11102511, 19619496
GO:0030904	Component	Retromer complex	IEA
GO:0030905	Component	Retromer, tubulation complex	IEA
GO:0030905	Component	Retromer, tubulation complex	IPI	11102511
GO:0030905	Component	Retromer, tubulation complex	NAS	26220253
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031901	Component	Early endosome membrane	IEA
GO:0032991	Component	Protein-containing complex	IDA	9819414
GO:0034498	Process	Early endosome to Golgi transport	IBA
GO:0035091	Function	Phosphatidylinositol binding	IBA
GO:0035091	Function	Phosphatidylinositol binding	IEA
GO:0042147	Process	Retrograde transport, endosome to Golgi	IMP	20138391
GO:0042147	Process	Retrograde transport, endosome to Golgi	NAS	26220253
GO:0042802	Function	Identical protein binding	IPI	9819414
GO:0042803	Function	Protein homodimerization activity	IPI	11102511
GO:0042995	Component	Cell projection	IEA
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0046982	Function	Protein heterodimerization activity	IPI	11102511
GO:0072673	Process	Lamellipodium morphogenesis	IDA	20604901
GO:0072673	Process	Lamellipodium morphogenesis	IEA
GO:1990459	Function	Transferrin receptor binding	IDA	9819414
GO:1990459	Function	Transferrin receptor binding	IEA
GO:1990460	Function	Leptin receptor binding	IDA	9819414
GO:1990460	Function	Leptin receptor binding	IEA

MIM	HGNC	e!Ensembl
605929	11173	ENSG00000205302

O60749

Protein name

Sorting nexin-2 (Transformation-related gene 9 protein) (TRG-9)

Protein function

Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:16179610). Acts in part as component of t

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03700	Sorting_nexin	2 → 75	Sorting nexin, N-terminal domain	Family
PF00787	PX	170 → 265	PX domain	Domain
PF09325	Vps5	281 → 514	Vps5 C terminal like	Domain

Sequence

MAAEREPPPLGDGKPTDFEDLEDGEDLFTSTVSTLESSPSSPEPASLPAEDISANSNGPK
PTEVVLDDDREDLFAEATEEVSLDSPEREPILSSEPSPAVTPVTPTTLIAPRIESKSMSA
PVIFDRSREEIEEEANGDIFDIEIGVSDPEKVGDGMNAYMAYRVTTKTSLSMFSKSEFSV
KRRFSDFLGLHSKLASKYLHVGYIVPPAPEKSIVGMTKVKVGKEDSSSTEFVEKRRAALE
RYLQRTVKHPTLLQDPDLRQFLESSELPRAVNTQALSGAGILRMVNKAADAVNKMTIKMN
ESDAWFEEKQQQFENLDQQLRKLHVSVEALVCHRKELSANTAAFAKSAAMLGNSEDHTAL
SRALSQLAEVEEKIDQLHQEQAFADFYMFSELLSDYIRLIAAVKGVFDHRMKCWQKWEDA
QITLLKKREAEAKMMVANKPDKIQQAKNEIREWEAKVQQGERDFEQISKTIRKEVGRFEK
ERVKDFKTVIIKYLESLVQTQQQLIKYWEAFLPEAKAIA

Sequence length

519

Interactions

View interactions

	KEGG		Reactome
	Endocytosis		Golgi Associated Vesicle Biogenesis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIVERTICULAR DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (10)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	21391972, 24215620		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adult Acute Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	24215620		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	23360489		★★★★★ ★☆☆☆☆ Found in Text Mining only
Childhood Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia	BEFREE	24215620		★★★★★ ★☆☆☆☆ Found in Text Mining only
Graves Disease	Graves Disease	BEFREE	23531855		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	23360489	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	23360489		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor B-cell lymphoblastic leukemia	Lymphoblastic Leukemia	BEFREE	24215620		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	35715463	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Diseases	Thyroid Diseases	BEFREE	23531855		★★★★★ ★☆☆☆☆ Found in Text Mining only

SNX2 (sorting nexin 2)