Gene Gene information from NCBI Gene database.
Entrez ID 6642
Gene name Sorting nexin 1
Gene symbol SNX1
Synonyms (NCBI Gene)
HsT17379VPS5
Chromosome 15
Chromosome location 15q22.31
Summary This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface express
miRNA miRNA information provided by mirtarbase database.
659
miRTarBase ID miRNA Experiments Reference
MIRT004201 hsa-miR-197-3p Microarray 16822819
MIRT006354 hsa-miR-95-3p Luciferase reporter assayWestern blot 21427358
MIRT006354 hsa-miR-95-3p Luciferase reporter assayWestern blot 21427358
MIRT006354 hsa-miR-95-3p Luciferase reporter assayWestern blot 21427358
MIRT006354 hsa-miR-95-3p Luciferase reporter assayWestern blot 21427358
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
52
GO ID Ontology Definition Evidence Reference
GO:0005154 Function Epidermal growth factor receptor binding IDA 9819414
GO:0005154 Function Epidermal growth factor receptor binding IEA
GO:0005158 Function Insulin receptor binding IDA 9819414
GO:0005158 Function Insulin receptor binding IEA
GO:0005515 Function Protein binding IPI 9819414, 11102511, 11279102, 19619496, 19935774, 20923837, 21516116, 21988832, 22719997, 23085988, 23524952, 25416956, 28514442, 32296183, 33961781, 35271311, 37158588
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601272 11172 ENSG00000028528
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q13596
Protein name Sorting nexin-1
Protein function Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of t
PDB 2I4K , 4FZS , 8A1G , 8ABQ , 8AFZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03700 Sorting_nexin 10 90 Sorting nexin, N-terminal domain Family
PF00787 PX 173 268 PX domain Domain
PF09325 Vps5 284 517 Vps5 C terminal like Domain
Sequence
Sequence length 522
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Endocytosis  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Carcinoma Carcinoma BEFREE 17145813
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 22859339
★☆☆☆☆
Found in Text Mining only
Colon Carcinoma Colon Carcinoma BEFREE 17145813
★☆☆☆☆
Found in Text Mining only
Colonic Neoplasms Colonic Neoplasms LHGDN 17145813
★☆☆☆☆
Found in Text Mining only
Colorectal Carcinoma Colorectal Cancer BEFREE 21427358, 26643894
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 26643894 Inhibit
★☆☆☆☆
Found in Text Mining only
Essential Hypertension Hypertension BEFREE 23152498
★☆☆☆☆
Found in Text Mining only
Hypertension Hypertension Pubtator 32227373 Associate
★☆☆☆☆
Found in Text Mining only
Hypertensive disease Hypertension BEFREE 23152498
★☆☆☆☆
Found in Text Mining only
insulinoma Insulinoma BEFREE 29284659
★☆☆☆☆
Found in Text Mining only