Gene Gene information from NCBI Gene database.
Entrez ID 664
Gene name BCL2 interacting protein 3
Gene symbol BNIP3
Synonyms (NCBI Gene)
HABONNIP3
Chromosome 10
Chromosome location 10q26.3
Summary This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methy
miRNA miRNA information provided by mirtarbase database.
138
miRTarBase ID miRNA Experiments Reference
MIRT000305 hsa-miR-145-5p Luciferase reporter assayqRT-PCRWestern blot 20332243
MIRT000305 hsa-miR-145-5p Luciferase reporter assayqRT-PCRWestern blot 20332243
MIRT000305 hsa-miR-145-5p Luciferase reporter assay 20332243
MIRT004753 hsa-miR-221-3p Luciferase reporter assayMicroarrayqRT-PCRWestern blot 20018759
MIRT000305 hsa-miR-145-5p MicroarrayqRT-PCR 22815788
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Transcription factor Regulation Reference
HIF1A Activation 17848618
HIF1A Unknown 17513511
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
87
GO ID Ontology Definition Evidence Reference
GO:0000422 Process Autophagy of mitochondrion NAS 22505714
GO:0000423 Process Mitophagy IMP 22505714
GO:0001666 Process Response to hypoxia IEA
GO:0001666 Process Response to hypoxia ISS
GO:0005515 Function Protein binding IPI 7954800, 10381623, 15868100, 16189514, 17360363, 18371312, 19060904, 20436456, 21516116, 22292033, 24981860, 25416956, 27107012, 27499296, 28514442, 32296183, 33961781
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603293 1084 ENSG00000176171
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q12983
Protein name BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
Protein function Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction w
PDB 2J5D , 2KA1 , 2KA2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06553 BNIP3 68 259 BNIP3 Family
Sequence
Sequence length 259
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  FoxO signaling pathway
Mitophagy - animal
Autophagy - animal
Shigellosis
Legionellosis
 
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
8
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MULTIPLE MYELOMA CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute leukemia Leukemia BEFREE 18092960
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 18092960, 18728663
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of prostate Prostate adenocarcinoma BEFREE 29137361
★☆☆☆☆
Found in Text Mining only
Adenoid Cystic Carcinoma Adenocarcinoma BEFREE 25769455
★☆☆☆☆
Found in Text Mining only
Adrenal Gland Pheochromocytoma Adrenal Gland Pheochromocytoma BEFREE 16954163
★☆☆☆☆
Found in Text Mining only
Agenesis of corpus callosum Agenesis Of Corpus Callosum BEFREE 25769455
★☆☆☆☆
Found in Text Mining only
Anaplastic carcinoma Anaplastic Carcinoma BEFREE 28257096
★☆☆☆☆
Found in Text Mining only
Anemia Anemia Pubtator 16827797 Associate
★☆☆☆☆
Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA Syndromic microphthalmia BEFREE 19657213
★☆☆☆☆
Found in Text Mining only
Anxiety Anxiety Disorder BEFREE 31794795
★☆☆☆☆
Found in Text Mining only