Gene Gene information from NCBI Gene database.
Entrez ID 663
Gene name BCL2 interacting protein 2
Gene symbol BNIP2
Synonyms (NCBI Gene)
BNIP-2NIP2
Chromosome 15
Chromosome location 15q22.2
Summary This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of
miRNA miRNA information provided by mirtarbase database.
481
miRTarBase ID miRNA Experiments Reference
MIRT005481 hsa-miR-20a-5p qRT-PCRWestern blot 21242194
MIRT020114 hsa-miR-130b-3p Sequencing 20371350
MIRT021762 hsa-miR-132-3p Microarray 17612493
MIRT027996 hsa-miR-93-5p Sequencing 20371350
MIRT005481 hsa-miR-20a-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
24
GO ID Ontology Definition Evidence Reference
GO:0001824 Process Blastocyst development IEA
GO:0005096 Function GTPase activator activity TAS 10799524
GO:0005509 Function Calcium ion binding TAS 7954800
GO:0005515 Function Protein binding IPI 7954800, 10381623, 21516116, 25416956, 31515488, 32296183
GO:0005635 Component Nuclear envelope IDA 7954800
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603292 1083 ENSG00000140299
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q12982
Protein name BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
Protein function Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12496 BNIP2 49 163 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 Family
PF13716 CRAL_TRIO_2 164 302 Divergent CRAL/TRIO domain Domain
Sequence
Sequence length 314
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Myogenesis
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
OLIGODENDROGLIOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma of large intestine Colorectal Cancer BEFREE 21242194
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of prostate Prostate cancer BEFREE 24040105
★☆☆☆☆
Found in Text Mining only
Neuroblastoma Neuroblastoma BEFREE 16288218
★☆☆☆☆
Found in Text Mining only
Neuroblastoma Neuroblastoma Pubtator 25611382 Associate
★☆☆☆☆
Found in Text Mining only
Prostate carcinoma Prostate cancer BEFREE 24040105
★★☆☆☆
Found in Text Mining + Unknown/Other Associations