Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6627
Gene name	Small nuclear ribonucleoprotein polypeptide A'
Gene symbol	SNRPA1
Synonyms (NCBI Gene)	Lea1U2A'
Chromosome	15
Chromosome location	15q26.3

Show/Hide all (98)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019817	hsa-miR-375	Microarray	20215506
MIRT027521	hsa-miR-98-5p	Microarray	19088304
MIRT031694	hsa-miR-16-5p	Proteomics	18668040
MIRT047363	hsa-miR-34a-5p	CLASH	23622248
MIRT047183	hsa-miR-182-5p	CLASH	23622248
MIRT545583	hsa-miR-3174	PAR-CLIP	21572407
MIRT545582	hsa-miR-4481	PAR-CLIP	21572407
MIRT545581	hsa-miR-4745-5p	PAR-CLIP	21572407
MIRT545580	hsa-miR-4653-3p	PAR-CLIP	21572407
MIRT545579	hsa-miR-921	PAR-CLIP	21572407
MIRT545578	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT545577	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT545576	hsa-miR-489-3p	PAR-CLIP	21572407
MIRT545575	hsa-miR-1238-5p	PAR-CLIP	21572407
MIRT545574	hsa-miR-4758-5p	PAR-CLIP	21572407
MIRT545573	hsa-miR-3674	PAR-CLIP	21572407
MIRT545583	hsa-miR-3174	PAR-CLIP	21572407
MIRT545582	hsa-miR-4481	PAR-CLIP	21572407
MIRT545581	hsa-miR-4745-5p	PAR-CLIP	21572407
MIRT545580	hsa-miR-4653-3p	PAR-CLIP	21572407
MIRT545579	hsa-miR-921	PAR-CLIP	21572407
MIRT545578	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT545577	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT545576	hsa-miR-489-3p	PAR-CLIP	21572407
MIRT545575	hsa-miR-1238-5p	PAR-CLIP	21572407
MIRT545574	hsa-miR-4758-5p	PAR-CLIP	21572407
MIRT545573	hsa-miR-3674	PAR-CLIP	21572407
MIRT1376071	hsa-miR-3144-3p	CLIP-seq
MIRT1376072	hsa-miR-4512	CLIP-seq
MIRT1376073	hsa-miR-451b	CLIP-seq
MIRT1376074	hsa-miR-4696	CLIP-seq
MIRT1376075	hsa-miR-4716-5p	CLIP-seq
MIRT1376076	hsa-miR-4789-5p	CLIP-seq
MIRT1376077	hsa-miR-4795-3p	CLIP-seq
MIRT1376073	hsa-miR-451b	CLIP-seq
MIRT1376074	hsa-miR-4696	CLIP-seq
MIRT1376075	hsa-miR-4716-5p	CLIP-seq
MIRT2335079	hsa-miR-1305	CLIP-seq
MIRT2335080	hsa-miR-15a	CLIP-seq
MIRT2335081	hsa-miR-15b	CLIP-seq
MIRT2335082	hsa-miR-16	CLIP-seq
MIRT2335083	hsa-miR-195	CLIP-seq
MIRT2335084	hsa-miR-214	CLIP-seq
MIRT2335085	hsa-miR-3065-5p	CLIP-seq
MIRT1376071	hsa-miR-3144-3p	CLIP-seq
MIRT2335086	hsa-miR-361-5p	CLIP-seq
MIRT2335087	hsa-miR-3619-5p	CLIP-seq
MIRT2335088	hsa-miR-421	CLIP-seq
MIRT2335089	hsa-miR-424	CLIP-seq
MIRT2335090	hsa-miR-4274	CLIP-seq
MIRT2335091	hsa-miR-4291	CLIP-seq
MIRT2335092	hsa-miR-4503	CLIP-seq
MIRT1376072	hsa-miR-4512	CLIP-seq
MIRT1376073	hsa-miR-451b	CLIP-seq
MIRT1376074	hsa-miR-4696	CLIP-seq
MIRT1376075	hsa-miR-4716-5p	CLIP-seq
MIRT1376077	hsa-miR-4795-3p	CLIP-seq
MIRT2335093	hsa-miR-497	CLIP-seq
MIRT2335094	hsa-miR-520d-5p	CLIP-seq
MIRT2335095	hsa-miR-524-5p	CLIP-seq
MIRT2335096	hsa-miR-656	CLIP-seq
MIRT2335097	hsa-miR-761	CLIP-seq
MIRT2335098	hsa-miR-922	CLIP-seq
MIRT2629140	hsa-miR-1323	CLIP-seq
MIRT2335080	hsa-miR-15a	CLIP-seq
MIRT2335081	hsa-miR-15b	CLIP-seq
MIRT2335082	hsa-miR-16	CLIP-seq
MIRT2335083	hsa-miR-195	CLIP-seq
MIRT2335084	hsa-miR-214	CLIP-seq
MIRT1376071	hsa-miR-3144-3p	CLIP-seq
MIRT2335086	hsa-miR-361-5p	CLIP-seq
MIRT2335087	hsa-miR-3619-5p	CLIP-seq
MIRT2335089	hsa-miR-424	CLIP-seq
MIRT2335090	hsa-miR-4274	CLIP-seq
MIRT2335091	hsa-miR-4291	CLIP-seq
MIRT2335092	hsa-miR-4503	CLIP-seq
MIRT1376072	hsa-miR-4512	CLIP-seq
MIRT1376073	hsa-miR-451b	CLIP-seq
MIRT1376074	hsa-miR-4696	CLIP-seq
MIRT1376075	hsa-miR-4716-5p	CLIP-seq
MIRT2629141	hsa-miR-4760-5p	CLIP-seq
MIRT1376076	hsa-miR-4789-5p	CLIP-seq
MIRT1376077	hsa-miR-4795-3p	CLIP-seq
MIRT2335093	hsa-miR-497	CLIP-seq
MIRT2335094	hsa-miR-520d-5p	CLIP-seq
MIRT2335095	hsa-miR-524-5p	CLIP-seq
MIRT2629142	hsa-miR-548o	CLIP-seq
MIRT2629143	hsa-miR-607	CLIP-seq
MIRT2335096	hsa-miR-656	CLIP-seq
MIRT2335097	hsa-miR-761	CLIP-seq
MIRT2335098	hsa-miR-922	CLIP-seq
MIRT1376071	hsa-miR-3144-3p	CLIP-seq
MIRT1376072	hsa-miR-4512	CLIP-seq
MIRT1376073	hsa-miR-451b	CLIP-seq
MIRT1376074	hsa-miR-4696	CLIP-seq
MIRT1376075	hsa-miR-4716-5p	CLIP-seq
MIRT1376076	hsa-miR-4789-5p	CLIP-seq
MIRT1376077	hsa-miR-4795-3p	CLIP-seq

Show/Hide all (36)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	IBA
GO:0000398	Process	MRNA splicing, via spliceosome	IC	9731529, 11991638
GO:0000398	Process	MRNA splicing, via spliceosome	IDA	28076346, 28781166, 32494006, 36797247
GO:0000398	Process	MRNA splicing, via spliceosome	IEA
GO:0000398	Process	MRNA splicing, via spliceosome	NAS	31744343
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	9716128, 17332742, 22365833, 25416956, 25599396, 28514442, 31515488, 32296183, 33961781, 34819669, 35271311
GO:0005634	Component	Nucleus	IDA	28076346, 28781166
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	31744343
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IDA	9731529
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005681	Component	Spliceosomal complex	NAS	31744343
GO:0005684	Component	U2-type spliceosomal complex	IDA	32494006, 36797247
GO:0005686	Component	U2 snRNP	IBA
GO:0005686	Component	U2 snRNP	IEA
GO:0005686	Component	U2 snRNP	NAS	31744343
GO:0005686	Component	U2 snRNP	TAS	2928112
GO:0006397	Process	MRNA processing	IEA
GO:0007283	Process	Spermatogenesis	IGI	27035939
GO:0008380	Process	RNA splicing	IEA
GO:0008380	Process	RNA splicing	TAS	2928112
GO:0016604	Component	Nuclear body	IDA
GO:0016607	Component	Nuclear speck	IDA
GO:0030532	Component	Small nuclear ribonucleoprotein complex	IEA
GO:0030532	Component	Small nuclear ribonucleoprotein complex	TAS	2928112
GO:0030620	Function	U2 snRNA binding	IBA
GO:0030620	Function	U2 snRNA binding	IEA
GO:0071005	Component	U2-type precatalytic spliceosome	IDA	28781166
GO:0071007	Component	U2-type catalytic step 2 spliceosome	IDA	28076346
GO:0071013	Component	Catalytic step 2 spliceosome	IDA	11991638
GO:1903241	Process	U2-type prespliceosome assembly	NAS	31744343
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
603521	11152	ENSG00000131876

P09661

Protein name

U2 small nuclear ribonucleoprotein A' (U2 snRNP A')

Protein function

Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:27035939, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV

PDB

1A9N , 5MQF , 5O9Z , 5XJC , 5YZG , 5Z56 , 5Z57 , 5Z58 , 6AH0 , 6AHD , 6FF7 , 6ICZ , 6ID0 , 6ID1 , 6QDV , 6QX9 , 6Y53 , 6Y5Q , 7A5P , 7ABG , 7ABI , 7EVO , 7VPX , 7W59 , 7W5A , 7W5B , 8C6J , 8CH6 , 8H6E , 8H6J , 8H6K , 8H6L , 8HK1 , 8I0P , 8I0R , 8I0S , 8I0T , 8I0U , 8I0V , 8I0W , 8QO9 , 8QXD , 8QZS , 8R08 , 8R09 , 8R0A , 8R0B , 8RM5 , 9FMD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF14580	LRR_9	1 → 175		Repeat

Sequence

MVKLTAELIEQAAQYTNAVRDRELDLRGYKIPVIENLGATLDQFDAIDFSDNEIRKLDGF
PLLRRLKTLLVNNNRICRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSI
LRNPVTNKKHYRLYVIYKVPQVRVLDFQKVKLKERQEAEKMFKGKRGAQLAKDIARRSKT
FNPGAGLPTDKKKGGPSPGDVEAIKNAIANASTLAEVERLKGLLQSGQIPGRERRSGPTD
DGEEEMEEDTVTNGS

Sequence length

255

Interactions

View interactions

	KEGG		Reactome
	Spliceosome		mRNA Splicing - Major Pathway Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CONNECTIVE TISSUE DISEASES	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	35281041	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	31203132		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	34266953	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	35392763	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart Defects Congenital	Congenital heart defect	Pubtator	23705960	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	31203132		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	31203132		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	33460399	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

SNRPA1 (small nuclear ribonucleoprotein polypeptide A')