SNCG (synuclein gamma)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID 6623
Gene name Synuclein gamma
Gene symbol SNCG
Synonyms (NCBI Gene)
BCSG1SR
Chromosome 10
Chromosome location 10q23.2
Summary This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development. [provided by RefSeq, Jan 20
miRNA miRNA information provided by mirtarbase database.
25
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (25)
miRTarBase ID miRNA Experiments Reference
MIRT017445 hsa-miR-335-5p Microarray 18185580
MIRT054595 hsa-miR-4437 Luciferase reporter assayqRT-PCRWestern blot 24040069
MIRT054596 hsa-miR-4674 Luciferase reporter assayqRT-PCRWestern blot 24040069
MIRT054597 hsa-miR-4722-5p Luciferase reporter assayqRT-PCRWestern blot 24040069
MIRT054598 hsa-miR-107 Luciferase reporter assayqRT-PCRWestern blot 24040069
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
26
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (26)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 21044950
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IDA 17222866
GO:0005737 Component Cytoplasm IEA
GO:0005794 Component Golgi apparatus IDA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
602998 11141 ENSG00000173267
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O76070
Protein name Gamma-synuclein (Breast cancer-specific gene 1 protein) (Persyn) (Synoretin) (SR)
Protein function Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01387 Synuclein 1 → 126 Synuclein Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung.
Sequence
Sequence length 127
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (5)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BREAST NEOPLASMS — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HYPERKINESIA — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HYPERKINESIS — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (106)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma of large intestine Colorectal Cancer BEFREE 29527422
★★★★★
★☆☆☆☆
Found in Text Mining only
Amyloidosis Amyloidosis BEFREE 10899435
★★★★★
★☆☆☆☆
Found in Text Mining only
Anaplastic carcinoma Anaplastic Carcinoma CTD_human_DG 16316942
★★★★★
★☆☆☆☆
Found in Text Mining only
Autism Spectrum Disorders Autism Spectrum Disorder BEFREE 29850516
★★★★★
★☆☆☆☆
Found in Text Mining only
Autistic Disorder Autism BEFREE 29850516
★★★★★
★☆☆☆☆
Found in Text Mining only
Autonomic nervous system disorders Autonomic Central Nervous System Diseases BEFREE 28871332
★★★★★
★☆☆☆☆
Found in Text Mining only
Autosomal Dominant Parkinsonism Parkinsonian disease BEFREE 15136696
★★★★★
★☆☆☆☆
Found in Text Mining only
Biliary Tract Neoplasms Biliary tract neoplasms Pubtator 34245137 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Bladder Neoplasm Bladder Neoplasm LHGDN 15596044
★★★★★
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 10813729, 11016747, 11526506, 12072430, 12566312, 12873981, 14504205, 14576821, 15231664, 16140929, 16142440, 16773211, 16786148, 16821081, 17016445
View all (19 more)
★★★★★
★☆☆☆☆
Found in Text Mining only