Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	66005
Gene name	Chitinase domain containing 1
Gene symbol	CHID1
Synonyms (NCBI Gene)	GL008SI-CLPSICLP
Chromosome	11
Chromosome location	11p15.5

156

Show/Hide all (156)

miRTarBase ID	miRNA	Experiments
MIRT890028	hsa-miR-1193	CLIP-seq
MIRT890029	hsa-miR-1207-5p	CLIP-seq
MIRT890030	hsa-miR-1278	CLIP-seq
MIRT890031	hsa-miR-296-5p	CLIP-seq
MIRT890032	hsa-miR-3144-5p	CLIP-seq
MIRT890033	hsa-miR-3151	CLIP-seq
MIRT890034	hsa-miR-3180-5p	CLIP-seq
MIRT890035	hsa-miR-3191	CLIP-seq
MIRT890036	hsa-miR-329	CLIP-seq
MIRT890037	hsa-miR-362-3p	CLIP-seq
MIRT890038	hsa-miR-3660	CLIP-seq
MIRT890039	hsa-miR-3973	CLIP-seq
MIRT890040	hsa-miR-4258	CLIP-seq
MIRT890041	hsa-miR-4265	CLIP-seq
MIRT890042	hsa-miR-4296	CLIP-seq
MIRT890043	hsa-miR-4322	CLIP-seq
MIRT890044	hsa-miR-4417	CLIP-seq
MIRT890045	hsa-miR-4438	CLIP-seq
MIRT890046	hsa-miR-4447	CLIP-seq
MIRT890047	hsa-miR-4449	CLIP-seq
MIRT890048	hsa-miR-4455	CLIP-seq
MIRT890049	hsa-miR-4472	CLIP-seq
MIRT890050	hsa-miR-4497	CLIP-seq
MIRT890051	hsa-miR-4526	CLIP-seq
MIRT890052	hsa-miR-4649-5p	CLIP-seq
MIRT890053	hsa-miR-4652-5p	CLIP-seq
MIRT890054	hsa-miR-4701-5p	CLIP-seq
MIRT890055	hsa-miR-4725-5p	CLIP-seq
MIRT890056	hsa-miR-4736	CLIP-seq
MIRT890057	hsa-miR-4763-3p	CLIP-seq
MIRT890058	hsa-miR-4763-5p	CLIP-seq
MIRT890059	hsa-miR-491-5p	CLIP-seq
MIRT890060	hsa-miR-504	CLIP-seq
MIRT890061	hsa-miR-5095	CLIP-seq
MIRT890062	hsa-miR-520a-5p	CLIP-seq
MIRT890063	hsa-miR-525-5p	CLIP-seq
MIRT890064	hsa-miR-548k	CLIP-seq
MIRT890065	hsa-miR-588	CLIP-seq
MIRT890066	hsa-miR-609	CLIP-seq
MIRT890067	hsa-miR-643	CLIP-seq
MIRT890068	hsa-miR-720	CLIP-seq
MIRT890069	hsa-miR-875-3p	CLIP-seq
MIRT890070	hsa-miR-103a	CLIP-seq
MIRT890071	hsa-miR-107	CLIP-seq
MIRT890072	hsa-miR-1184	CLIP-seq
MIRT890028	hsa-miR-1193	CLIP-seq
MIRT890073	hsa-miR-1224-5p	CLIP-seq
MIRT890074	hsa-miR-1288	CLIP-seq
MIRT890075	hsa-miR-1293	CLIP-seq
MIRT890076	hsa-miR-3169	CLIP-seq
MIRT890034	hsa-miR-3180-5p	CLIP-seq
MIRT890077	hsa-miR-3652	CLIP-seq
MIRT890078	hsa-miR-3688-5p	CLIP-seq
MIRT890079	hsa-miR-4318	CLIP-seq
MIRT890080	hsa-miR-4418	CLIP-seq
MIRT890081	hsa-miR-4430	CLIP-seq
MIRT890082	hsa-miR-4435	CLIP-seq
MIRT890047	hsa-miR-4449	CLIP-seq
MIRT890083	hsa-miR-4474-3p	CLIP-seq
MIRT890084	hsa-miR-4483	CLIP-seq
MIRT890050	hsa-miR-4497	CLIP-seq
MIRT890085	hsa-miR-4505	CLIP-seq
MIRT890052	hsa-miR-4649-5p	CLIP-seq
MIRT890086	hsa-miR-4660	CLIP-seq
MIRT890087	hsa-miR-4751	CLIP-seq
MIRT890088	hsa-miR-4793-3p	CLIP-seq
MIRT890089	hsa-miR-509-3-5p	CLIP-seq
MIRT890090	hsa-miR-509-5p	CLIP-seq
MIRT890062	hsa-miR-520a-5p	CLIP-seq
MIRT890063	hsa-miR-525-5p	CLIP-seq
MIRT890068	hsa-miR-720	CLIP-seq
MIRT890069	hsa-miR-875-3p	CLIP-seq
MIRT890091	hsa-miR-885-3p	CLIP-seq
MIRT890092	hsa-miR-922	CLIP-seq
MIRT890093	hsa-miR-147	CLIP-seq
MIRT890094	hsa-miR-296-3p	CLIP-seq
MIRT890032	hsa-miR-3144-5p	CLIP-seq
MIRT890033	hsa-miR-3151	CLIP-seq
MIRT890035	hsa-miR-3191	CLIP-seq
MIRT890095	hsa-miR-3911	CLIP-seq
MIRT890046	hsa-miR-4447	CLIP-seq
MIRT890047	hsa-miR-4449	CLIP-seq
MIRT890049	hsa-miR-4472	CLIP-seq
MIRT890053	hsa-miR-4652-5p	CLIP-seq
MIRT890096	hsa-miR-4710	CLIP-seq
MIRT890055	hsa-miR-4725-5p	CLIP-seq
MIRT890059	hsa-miR-491-5p	CLIP-seq
MIRT890060	hsa-miR-504	CLIP-seq
MIRT890097	hsa-miR-644	CLIP-seq
MIRT890068	hsa-miR-720	CLIP-seq
MIRT890069	hsa-miR-875-3p	CLIP-seq
MIRT890070	hsa-miR-103a	CLIP-seq
MIRT890071	hsa-miR-107	CLIP-seq
MIRT890072	hsa-miR-1184	CLIP-seq
MIRT890073	hsa-miR-1224-5p	CLIP-seq
MIRT1963711	hsa-miR-1285	CLIP-seq
MIRT890074	hsa-miR-1288	CLIP-seq
MIRT1963712	hsa-miR-1291	CLIP-seq
MIRT1963713	hsa-miR-3150a-3p	CLIP-seq
MIRT890076	hsa-miR-3169	CLIP-seq
MIRT1963714	hsa-miR-3175	CLIP-seq
MIRT1963715	hsa-miR-3187-5p	CLIP-seq
MIRT1963716	hsa-miR-342-5p	CLIP-seq
MIRT1963717	hsa-miR-4292	CLIP-seq
MIRT890080	hsa-miR-4418	CLIP-seq
MIRT1963718	hsa-miR-4651	CLIP-seq
MIRT1963719	hsa-miR-4664-5p	CLIP-seq
MIRT1963720	hsa-miR-4717-3p	CLIP-seq
MIRT1963721	hsa-miR-4731-5p	CLIP-seq
MIRT890087	hsa-miR-4751	CLIP-seq
MIRT1963722	hsa-miR-4755-3p	CLIP-seq
MIRT890089	hsa-miR-509-3-5p	CLIP-seq
MIRT890090	hsa-miR-509-5p	CLIP-seq
MIRT1963723	hsa-miR-608	CLIP-seq
MIRT1963724	hsa-miR-612	CLIP-seq
MIRT890092	hsa-miR-922	CLIP-seq
MIRT1963725	hsa-miR-939	CLIP-seq
MIRT890070	hsa-miR-103a	CLIP-seq
MIRT890071	hsa-miR-107	CLIP-seq
MIRT890072	hsa-miR-1184	CLIP-seq
MIRT890029	hsa-miR-1207-5p	CLIP-seq
MIRT890073	hsa-miR-1224-5p	CLIP-seq
MIRT890074	hsa-miR-1288	CLIP-seq
MIRT2200037	hsa-miR-299-3p	CLIP-seq
MIRT1963713	hsa-miR-3150a-3p	CLIP-seq
MIRT890033	hsa-miR-3151	CLIP-seq
MIRT890076	hsa-miR-3169	CLIP-seq
MIRT1963714	hsa-miR-3175	CLIP-seq
MIRT890080	hsa-miR-4418	CLIP-seq
MIRT890046	hsa-miR-4447	CLIP-seq
MIRT890049	hsa-miR-4472	CLIP-seq
MIRT2200038	hsa-miR-4491	CLIP-seq
MIRT2200039	hsa-miR-4633-3p	CLIP-seq
MIRT1963718	hsa-miR-4651	CLIP-seq
MIRT2200040	hsa-miR-4657	CLIP-seq
MIRT1963720	hsa-miR-4717-3p	CLIP-seq
MIRT890056	hsa-miR-4736	CLIP-seq
MIRT890087	hsa-miR-4751	CLIP-seq
MIRT890057	hsa-miR-4763-3p	CLIP-seq
MIRT890059	hsa-miR-491-5p	CLIP-seq
MIRT890089	hsa-miR-509-3-5p	CLIP-seq
MIRT890090	hsa-miR-509-5p	CLIP-seq
MIRT1963723	hsa-miR-608	CLIP-seq
MIRT890092	hsa-miR-922	CLIP-seq
MIRT1963725	hsa-miR-939	CLIP-seq
MIRT890070	hsa-miR-103a	CLIP-seq
MIRT890071	hsa-miR-107	CLIP-seq
MIRT890072	hsa-miR-1184	CLIP-seq
MIRT890073	hsa-miR-1224-5p	CLIP-seq
MIRT890074	hsa-miR-1288	CLIP-seq
MIRT890076	hsa-miR-3169	CLIP-seq
MIRT890080	hsa-miR-4418	CLIP-seq
MIRT890087	hsa-miR-4751	CLIP-seq
MIRT890089	hsa-miR-509-3-5p	CLIP-seq
MIRT890090	hsa-miR-509-5p	CLIP-seq
MIRT890092	hsa-miR-922	CLIP-seq

Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	16357325
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IDA	16357325
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005764	Component	Lysosome	IDA	16357325
GO:0005764	Component	Lysosome	IEA
GO:0005770	Component	Late endosome	IDA	16357325
GO:0005802	Component	Trans-Golgi network	IDA	16357325
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0008061	Function	Chitin binding	IEA
GO:0012505	Component	Endomembrane system	IBA
GO:0016020	Component	Membrane	HDA	19946888
GO:0043202	Component	Lysosomal lumen	TAS
GO:0045087	Process	Innate immune response	IEA
GO:0070062	Component	Extracellular exosome	HDA	19199708
GO:0070492	Function	Oligosaccharide binding	IBA
GO:0070492	Function	Oligosaccharide binding	IPI	20724479
GO:1900016	Process	Negative regulation of cytokine production involved in inflammatory response	IDA	20724479

MIM	HGNC	e!Ensembl
615692	28474	ENSG00000177830

Q9BWS9

Protein name

Chitinase domain-containing protein 1 (Stabilin-1-interacting chitinase-like protein) (SI-CLP)

Protein function

Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro). {ECO:0000269|PubMed

PDB

3BXW

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00704	Glyco_hydro_18	80 → 385	Glycosyl hydrolases family 18	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in cells of monocytic, T, B and epithelial origin. {ECO:0000269|PubMed:16357325, ECO:0000269|PubMed:20724479}.

Sequence

MRTLFNLLWLALACSPVHTTLSKSDAKKAASKTLLEKSQFSDKPVQDRGLVVTDLKAESV
VLEHRSYCSAKARDRHFAGDVLGYVTPWNSHGYDVTKVFGSKFTQISPVWLQLKRRGREM
FEVTGLHDVDQGWMRAVRKHAKGLHIVPRLLFEDWTYDDFRNVLDSEDEIEELSKTVVQV
AKNQHFDGFVVEVWNQLLSQKRVGLIHMLTHLAEALHQARLLALLVIPPAITPGTDQLGM
FTHKEFEQLAPVLDGFSLMTYDYSTAHQPGPNAPLSWVRACVQVLDPKSKWRSKILLGLN
FYGMDYATSKDAREPVVGARYIQTLKDHRPRMVWDSQASEHFFEYKKSRSGRHVVFYPTL
KSLQVRLELARELGVGVSIWELGQGLDYFYDLL

Sequence length

393

Interactions

View interactions

	Reactome
			Platelet degranulation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PEPTIC ULCER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease	Alzheimer disease	Pubtator	33924468	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bronchitis, Chronic	Gastric Cancer	BEFREE	25241909		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	24470346		★★★★★ ★☆☆☆☆ Found in Text Mining only

CHID1 (chitinase domain containing 1)