Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	65991
Gene name	FUN14 domain containing 2
Gene symbol	FUNDC2
Synonyms (NCBI Gene)	DC44HCBP6HCC3PD03104
Chromosome	X
Chromosome location	Xq28

263

Show/Hide all (263)

miRTarBase ID	miRNA	Experiments	Reference
MIRT003098	hsa-miR-122-5p	Luciferase reporter assayqRT-PCR	19296470
MIRT003098	hsa-miR-122-5p	Luciferase reporter assayqRT-PCR	19296470
MIRT044913	hsa-miR-186-5p	CLASH	23622248
MIRT042745	hsa-miR-339-5p	CLASH	23622248
MIRT041249	hsa-miR-193b-3p	CLASH	23622248
MIRT619228	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT619227	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT619226	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT619225	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT619224	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT619223	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT619222	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT619221	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT619220	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT619219	hsa-miR-2053	HITS-CLIP	23824327
MIRT619228	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT619227	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT619226	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT619225	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT619224	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT619223	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT619222	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT619221	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT619220	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT619219	hsa-miR-2053	HITS-CLIP	23824327
MIRT619228	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT619227	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT619226	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT619225	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT619224	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT619223	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT619222	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT619221	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT619220	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT619219	hsa-miR-2053	HITS-CLIP	23824327
MIRT528666	hsa-miR-548a-3p	PAR-CLIP	22012620
MIRT528665	hsa-miR-548ar-3p	PAR-CLIP	22012620
MIRT528664	hsa-miR-548az-3p	PAR-CLIP	22012620
MIRT528663	hsa-miR-548e-3p	PAR-CLIP	22012620
MIRT528662	hsa-miR-548f-3p	PAR-CLIP	22012620
MIRT528661	hsa-miR-3174	PAR-CLIP	22012620
MIRT528660	hsa-miR-4682	PAR-CLIP	22012620
MIRT528659	hsa-miR-633	PAR-CLIP	22012620
MIRT528658	hsa-miR-921	PAR-CLIP	22012620
MIRT528657	hsa-miR-4303	PAR-CLIP	22012620
MIRT619228	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT619227	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT619226	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT619225	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT619224	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT619223	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT619222	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT619221	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT619220	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT619219	hsa-miR-2053	HITS-CLIP	23824327
MIRT619228	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT619227	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT619226	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT619225	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT619224	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT619223	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT619222	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT619221	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT619220	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT619219	hsa-miR-2053	HITS-CLIP	23824327
MIRT619228	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT619227	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT619226	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT619225	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT619224	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT619223	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT619222	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT619221	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT619220	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT619219	hsa-miR-2053	HITS-CLIP	23824327
MIRT528666	hsa-miR-548a-3p	PAR-CLIP	22012620
MIRT528665	hsa-miR-548ar-3p	PAR-CLIP	22012620
MIRT528664	hsa-miR-548az-3p	PAR-CLIP	22012620
MIRT528663	hsa-miR-548e-3p	PAR-CLIP	22012620
MIRT528662	hsa-miR-548f-3p	PAR-CLIP	22012620
MIRT528661	hsa-miR-3174	PAR-CLIP	22012620
MIRT528660	hsa-miR-4682	PAR-CLIP	22012620
MIRT528659	hsa-miR-633	PAR-CLIP	22012620
MIRT528658	hsa-miR-921	PAR-CLIP	22012620
MIRT528657	hsa-miR-4303	PAR-CLIP	22012620
MIRT1006178	hsa-miR-1227	CLIP-seq
MIRT1006179	hsa-miR-1236	CLIP-seq
MIRT1006180	hsa-miR-1253	CLIP-seq
MIRT1006181	hsa-miR-127-5p	CLIP-seq
MIRT1006182	hsa-miR-1303	CLIP-seq
MIRT1006183	hsa-miR-196a	CLIP-seq
MIRT1006184	hsa-miR-196b	CLIP-seq
MIRT1006185	hsa-miR-3064-3p	CLIP-seq
MIRT1006186	hsa-miR-3123	CLIP-seq
MIRT1006187	hsa-miR-3126-5p	CLIP-seq
MIRT1006188	hsa-miR-3182	CLIP-seq
MIRT1006189	hsa-miR-3622b-5p	CLIP-seq
MIRT1006190	hsa-miR-3925-5p	CLIP-seq
MIRT1006191	hsa-miR-4330	CLIP-seq
MIRT1006192	hsa-miR-4434	CLIP-seq
MIRT1006193	hsa-miR-4516	CLIP-seq
MIRT1006194	hsa-miR-4530	CLIP-seq
MIRT1006195	hsa-miR-4715-3p	CLIP-seq
MIRT1006196	hsa-miR-4727-5p	CLIP-seq
MIRT1006197	hsa-miR-4761-5p	CLIP-seq
MIRT1006198	hsa-miR-4769-3p	CLIP-seq
MIRT1006199	hsa-miR-4779	CLIP-seq
MIRT1006200	hsa-miR-4786-3p	CLIP-seq
MIRT1006201	hsa-miR-593	CLIP-seq
MIRT1006202	hsa-miR-634	CLIP-seq
MIRT1006203	hsa-miR-765	CLIP-seq
MIRT1006204	hsa-miR-888	CLIP-seq
MIRT1006205	hsa-miR-922	CLIP-seq
MIRT1920452	hsa-miR-142-5p	CLIP-seq
MIRT1920453	hsa-miR-340	CLIP-seq
MIRT1920454	hsa-miR-3671	CLIP-seq
MIRT1920455	hsa-miR-4272	CLIP-seq
MIRT1920456	hsa-miR-4528	CLIP-seq
MIRT1920457	hsa-miR-607	CLIP-seq
MIRT1920452	hsa-miR-142-5p	CLIP-seq
MIRT1920453	hsa-miR-340	CLIP-seq
MIRT1920454	hsa-miR-3671	CLIP-seq
MIRT1920455	hsa-miR-4272	CLIP-seq
MIRT1920456	hsa-miR-4528	CLIP-seq
MIRT1920457	hsa-miR-607	CLIP-seq
MIRT1920452	hsa-miR-142-5p	CLIP-seq
MIRT1920453	hsa-miR-340	CLIP-seq
MIRT1920454	hsa-miR-3671	CLIP-seq
MIRT1920455	hsa-miR-4272	CLIP-seq
MIRT1920456	hsa-miR-4528	CLIP-seq
MIRT1920457	hsa-miR-607	CLIP-seq
MIRT1998146	hsa-miR-106a	CLIP-seq
MIRT1998147	hsa-miR-106b	CLIP-seq
MIRT1998148	hsa-miR-1184	CLIP-seq
MIRT1998149	hsa-miR-1302	CLIP-seq
MIRT1006182	hsa-miR-1303	CLIP-seq
MIRT1998150	hsa-miR-17	CLIP-seq
MIRT1998151	hsa-miR-2054	CLIP-seq
MIRT1998152	hsa-miR-20a	CLIP-seq
MIRT1998153	hsa-miR-20b	CLIP-seq
MIRT1998154	hsa-miR-224	CLIP-seq
MIRT1998155	hsa-miR-3122	CLIP-seq
MIRT1006186	hsa-miR-3123	CLIP-seq
MIRT1998156	hsa-miR-3148	CLIP-seq
MIRT1998157	hsa-miR-3157-5p	CLIP-seq
MIRT1998158	hsa-miR-3609	CLIP-seq
MIRT1998159	hsa-miR-377	CLIP-seq
MIRT1998160	hsa-miR-3913-5p	CLIP-seq
MIRT1006190	hsa-miR-3925-5p	CLIP-seq
MIRT1998161	hsa-miR-4298	CLIP-seq
MIRT1006191	hsa-miR-4330	CLIP-seq
MIRT1998162	hsa-miR-4661-3p	CLIP-seq
MIRT1998163	hsa-miR-4691-3p	CLIP-seq
MIRT1998164	hsa-miR-4691-5p	CLIP-seq
MIRT1006200	hsa-miR-4786-3p	CLIP-seq
MIRT1998165	hsa-miR-4793-5p	CLIP-seq
MIRT1998166	hsa-miR-4796-3p	CLIP-seq
MIRT1998167	hsa-miR-519d	CLIP-seq
MIRT1998168	hsa-miR-548ah	CLIP-seq
MIRT1998169	hsa-miR-555	CLIP-seq
MIRT1998170	hsa-miR-604	CLIP-seq
MIRT1998171	hsa-miR-643	CLIP-seq
MIRT1998172	hsa-miR-647	CLIP-seq
MIRT1998173	hsa-miR-93	CLIP-seq
MIRT1006180	hsa-miR-1253	CLIP-seq
MIRT1006187	hsa-miR-3126-5p	CLIP-seq
MIRT2231812	hsa-miR-3185	CLIP-seq
MIRT1006189	hsa-miR-3622b-5p	CLIP-seq
MIRT2231813	hsa-miR-3910	CLIP-seq
MIRT2231814	hsa-miR-4277	CLIP-seq
MIRT1006192	hsa-miR-4434	CLIP-seq
MIRT1006193	hsa-miR-4516	CLIP-seq
MIRT1006199	hsa-miR-4779	CLIP-seq
MIRT2231815	hsa-miR-548aa	CLIP-seq
MIRT2231816	hsa-miR-548ac	CLIP-seq
MIRT2231817	hsa-miR-548d-3p	CLIP-seq
MIRT2231818	hsa-miR-548z	CLIP-seq
MIRT2231819	hsa-miR-587	CLIP-seq
MIRT2231820	hsa-miR-630	CLIP-seq
MIRT1006203	hsa-miR-765	CLIP-seq
MIRT2231821	hsa-miR-873	CLIP-seq
MIRT2388243	hsa-miR-1272	CLIP-seq
MIRT2388244	hsa-miR-1322	CLIP-seq
MIRT2535829	hsa-miR-1207-5p	CLIP-seq
MIRT2535830	hsa-miR-122	CLIP-seq
MIRT1006178	hsa-miR-1227	CLIP-seq
MIRT1006180	hsa-miR-1253	CLIP-seq
MIRT2388243	hsa-miR-1272	CLIP-seq
MIRT1006181	hsa-miR-127-5p	CLIP-seq
MIRT1006182	hsa-miR-1303	CLIP-seq
MIRT2388244	hsa-miR-1322	CLIP-seq
MIRT1006183	hsa-miR-196a	CLIP-seq
MIRT1006184	hsa-miR-196b	CLIP-seq
MIRT2535831	hsa-miR-2964a-5p	CLIP-seq
MIRT1006185	hsa-miR-3064-3p	CLIP-seq
MIRT1006186	hsa-miR-3123	CLIP-seq
MIRT1006187	hsa-miR-3126-5p	CLIP-seq
MIRT2535832	hsa-miR-3134	CLIP-seq
MIRT2231812	hsa-miR-3185	CLIP-seq
MIRT1006189	hsa-miR-3622b-5p	CLIP-seq
MIRT2231813	hsa-miR-3910	CLIP-seq
MIRT1006190	hsa-miR-3925-5p	CLIP-seq
MIRT2535833	hsa-miR-4280	CLIP-seq
MIRT1006191	hsa-miR-4330	CLIP-seq
MIRT1006192	hsa-miR-4434	CLIP-seq
MIRT1006193	hsa-miR-4516	CLIP-seq
MIRT1006194	hsa-miR-4530	CLIP-seq
MIRT2535834	hsa-miR-4534	CLIP-seq
MIRT2535835	hsa-miR-4659a-5p	CLIP-seq
MIRT2535836	hsa-miR-4659b-5p	CLIP-seq
MIRT1006195	hsa-miR-4715-3p	CLIP-seq
MIRT2535837	hsa-miR-4732-5p	CLIP-seq
MIRT2535838	hsa-miR-4736	CLIP-seq
MIRT1006197	hsa-miR-4761-5p	CLIP-seq
MIRT2535839	hsa-miR-4763-3p	CLIP-seq
MIRT2535840	hsa-miR-4776-3p	CLIP-seq
MIRT1006199	hsa-miR-4779	CLIP-seq
MIRT1006200	hsa-miR-4786-3p	CLIP-seq
MIRT2535841	hsa-miR-485-5p	CLIP-seq
MIRT1006202	hsa-miR-634	CLIP-seq
MIRT2535842	hsa-miR-676	CLIP-seq
MIRT1006203	hsa-miR-765	CLIP-seq
MIRT1006205	hsa-miR-922	CLIP-seq
MIRT2535829	hsa-miR-1207-5p	CLIP-seq
MIRT2535830	hsa-miR-122	CLIP-seq
MIRT1006178	hsa-miR-1227	CLIP-seq
MIRT1006180	hsa-miR-1253	CLIP-seq
MIRT2388243	hsa-miR-1272	CLIP-seq
MIRT1006181	hsa-miR-127-5p	CLIP-seq
MIRT1006182	hsa-miR-1303	CLIP-seq
MIRT2388244	hsa-miR-1322	CLIP-seq
MIRT1006183	hsa-miR-196a	CLIP-seq
MIRT1006184	hsa-miR-196b	CLIP-seq
MIRT2535831	hsa-miR-2964a-5p	CLIP-seq
MIRT1006185	hsa-miR-3064-3p	CLIP-seq
MIRT1006186	hsa-miR-3123	CLIP-seq
MIRT1006187	hsa-miR-3126-5p	CLIP-seq
MIRT2535832	hsa-miR-3134	CLIP-seq
MIRT2231812	hsa-miR-3185	CLIP-seq
MIRT1006189	hsa-miR-3622b-5p	CLIP-seq
MIRT2231813	hsa-miR-3910	CLIP-seq
MIRT1006190	hsa-miR-3925-5p	CLIP-seq
MIRT2535833	hsa-miR-4280	CLIP-seq
MIRT1006191	hsa-miR-4330	CLIP-seq
MIRT1006192	hsa-miR-4434	CLIP-seq
MIRT1006193	hsa-miR-4516	CLIP-seq
MIRT1006194	hsa-miR-4530	CLIP-seq
MIRT2535834	hsa-miR-4534	CLIP-seq
MIRT2535835	hsa-miR-4659a-5p	CLIP-seq
MIRT2535836	hsa-miR-4659b-5p	CLIP-seq
MIRT1006195	hsa-miR-4715-3p	CLIP-seq
MIRT2535837	hsa-miR-4732-5p	CLIP-seq
MIRT2535838	hsa-miR-4736	CLIP-seq
MIRT1006197	hsa-miR-4761-5p	CLIP-seq
MIRT2535839	hsa-miR-4763-3p	CLIP-seq
MIRT2535840	hsa-miR-4776-3p	CLIP-seq
MIRT1006199	hsa-miR-4779	CLIP-seq
MIRT1006200	hsa-miR-4786-3p	CLIP-seq
MIRT2535841	hsa-miR-485-5p	CLIP-seq
MIRT1006202	hsa-miR-634	CLIP-seq
MIRT2535842	hsa-miR-676	CLIP-seq
MIRT1006203	hsa-miR-765	CLIP-seq
MIRT1006205	hsa-miR-922	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000422	Process	Autophagy of mitochondrion	IBA
GO:0005515	Function	Protein binding	IPI	32296183, 33961781
GO:0005547	Function	Phosphatidylinositol-3,4,5-trisphosphate binding	IDA	29786068
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IEA
GO:0005739	Component	Mitochondrion	HDA	20833797
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005741	Component	Mitochondrial outer membrane	IBA
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0010543	Process	Regulation of platelet activation	ISS
GO:0016020	Component	Membrane	IEA
GO:0035356	Process	Intracellular triglyceride homeostasis	IMP	25855506

MIM	HGNC	e!Ensembl
301042	24925	ENSG00000165775

Q9BWH2

Protein name

FUN14 domain-containing protein 2 (Cervical cancer proto-oncogene 3 protein) (HCC-3) (Hepatitis C virus core-binding protein 6)

Protein function

Binds directly and specifically 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate) (PIP3) leading to the recruitment of PIP3 to mitochondria and may play a role in the regulation of the platelet activation via AKT/GSK3B/cGMP

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04930	FUN14	87 → 187	FUN14 family	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in platelets (at protein level). {ECO:0000269|PubMed:30576423}.

Sequence

METSAPRAGSQVVATTARHSAAYRADPLRVSSRDKLTEMAASSQGNFEGNFESLDLAEFA
KKQPWWRKLFGQESGPSAEKYSVATQLFIGGVTGWCTGFIFQKVGKLAATAVGGGFFLLQ
LANHTGYIKVDWQRVEKDMKKAKEQLKIRKSNQIPTEVRSKAEEVVSFVKKNVLVTGGFF
GGFLLGMAS

Sequence length

189

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
HEMOPHILIA A	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STROKE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (14)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Cerebrovascular accident	Stroke	GWASCAT_DG	26908601		★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	Pubtator	26908601	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Deep Vein Thrombosis	Thrombosis	GWASCAT_DG	26908601		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fatty Liver	Fatty Liver	BEFREE	29735802		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hemophilia A	Hemophilia	BEFREE	17683067		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hypoxia	Hypoxia	Pubtator	34105393	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ischemic stroke	Ischemic Stroke	GWASCAT_DG	26908601		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	23925649		★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	28736522		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mitochondrial Diseases	Mitochondrial disease	Pubtator	34105393	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	29684685		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	28736522		★★★★★ ★☆☆☆☆ Found in Text Mining only
Steatohepatitis	Fatty Liver	BEFREE	29735802		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thrombosis	Thrombosis	Pubtator	26908601	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

FUNDC2 (FUN14 domain containing 2)