CAPRIN2 (caprin family member 2)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 65981 |
| Gene name | Caprin family member 2 |
| Gene symbol | CAPRIN2 |
| Synonyms (NCBI Gene) |
C1QDC1EEG-1EEG1RNG140
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| Chromosome | 12 |
| Chromosome location | 12p11.21 |
| Summary | The protein encoded by this gene may regulate the transport of mRNA. It may play a role in the differentiation of erythroblasts. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016] |
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miRNA
miRNA information provided by mirtarbase database.
419
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q6IMN6 | ||||||||||||||||||||
| Protein name | Caprin-2 (C1q domain-containing protein 1) (Cytoplasmic activation/proliferation-associated protein 2) (Gastric cancer multidrug resistance-associated protein) (Protein EEG-1) (RNA granule protein 140) | ||||||||||||||||||||
| Protein function | Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway (PubMed:18762581). Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which m | ||||||||||||||||||||
| PDB | 4OUL , 4OUM , 5J97 , 8K9C , 8K9D | ||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Detected in all tissues tested with highest levels of expression in brain and spleen. {ECO:0000269|PubMed:14593112}. | ||||||||||||||||||||
| Sequence |
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| Sequence length | 1127 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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