Gene Gene information from NCBI Gene database.
Entrez ID 65981
Gene name Caprin family member 2
Gene symbol CAPRIN2
Synonyms (NCBI Gene)
C1QDC1EEG-1EEG1RNG140
Chromosome 12
Chromosome location 12p11.21
Summary The protein encoded by this gene may regulate the transport of mRNA. It may play a role in the differentiation of erythroblasts. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
miRNA miRNA information provided by mirtarbase database.
419
miRTarBase ID miRNA Experiments Reference
MIRT019554 hsa-miR-340-5p Sequencing 20371350
MIRT002910 hsa-miR-124-3p Microarray 18668037
MIRT027968 hsa-miR-93-5p Sequencing 20371350
MIRT051382 hsa-let-7f-5p CLASH 23622248
MIRT480027 hsa-miR-181b-5p PAR-CLIP 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
27
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding IEA
GO:0005102 Function Signaling receptor binding IBA
GO:0005102 Function Signaling receptor binding IPI 18762581
GO:0005515 Function Protein binding IPI 18762581, 25416956, 32296183
GO:0005654 Component Nucleoplasm IDA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
610375 21259 ENSG00000110888
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6IMN6
Protein name Caprin-2 (C1q domain-containing protein 1) (Cytoplasmic activation/proliferation-associated protein 2) (Gastric cancer multidrug resistance-associated protein) (Protein EEG-1) (RNA granule protein 140)
Protein function Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway (PubMed:18762581). Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which m
PDB 4OUL , 4OUM , 5J97 , 8K9C , 8K9D
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF18293 Caprin-1_dimer 200 315 Caprin-1 dimerization domain Domain
PF12287 Caprin-1_C 620 935 Cytoplasmic activation/proliferation-associated protein-1 C term Family
PF00386 C1q 999 1124 C1q domain Domain
Tissue specificity TISSUE SPECIFICITY: Detected in all tissues tested with highest levels of expression in brain and spleen. {ECO:0000269|PubMed:14593112}.
Sequence
MEVQVSQASLGFELTSVEKSLREWSRLSREVIAWLCPSSPNFILNFPPPPSASSVSMVQL
FSSPFGYQSPSGHSEEEREGNMKSAKPQVNHSQHGESQRALSPLQSTLSSAASPSQAYET
YIENGLICLKHKIRNIEKKKLKLEDYKDRLKSGEHLNPDQLEAVEKYEEVLHNLEFAKEL
QKTFSGLSLDLLKAQKKAQRREHMLKLEAEKKKLRTILQVQYVLQNLTQEHVQKDFKGGL
NGAVYLPSKELDYLIKFSKLTCPERNESLSVEDQMEQSSLYFWDLLEGSEKAVVGTTYKH
LKDLLSKLLNSGYFE
SIPVPKNAKEKEVPLEEEMLIQSEKKTQLSKTESVKESESLMEFA
QPEIQPQEFLNRRYMTEVDYSNKQGEEQPWEADYARKPNLPKRWDMLTEPDGQEKKQESF
KSWEASGKHQEVSKPAVSLEQRKQDTSKLRSTLPEEQKKQEISKSKPSPSQWKQDTPKSK
AGYVQEEQKKQETPKLWPVQLQKEQDPKKQTPKSWTPSMQSEQNTTKSWTTPMCEEQDSK
QPETPKSWENNVESQKHSLTSQSQISPKSWGVATASLIPNDQLLPRKLNTEPKDVPKPVH
QPVGSSSTLPKDPVLRKEKLQDLMTQIQGTCNFMQESVLDFDKPSSAIPTSQPPSATPGS
PVASKEQNLSSQSDFLQEPLQATSSPVTCSSNACLVTTDQASSGSETEFMTSETPEAAIP
PGKQPSSLASPNPPMAKGSEQGFQSPPASSSSVTINTAPFQAMQTVFNVNAPLPPRKEQE
IKESPYSPGYNQSFTTASTQTPPQCQLPSIHVEQTVHSQETAANYHPDGTIQVSNGSLAF
YPAQTNVFPRPTQPFVNSRGSVRGCTRGGRLITNSYRSPGGYKGFDTYRGLPSISNGNYS
QLQFQAREYSGAPYSQRDNFQQCYKRGGTSGGPRA
NSRAGWSDSSQVSSPERDNETFNSG
DSGQGDSRSMTPVDVPVTNPAATILPVHVYPLPQQMRVAFSAARTSNLAPGTLDQPIVFD
LLLNNLGETFDLQLGRFNCPVNGTYVFIFHMLKLAVNVPLYVNLMKNEEVLVSAYANDGA
PDHETASNHAILQLFQGDQIWLRLHRGAIYGSSWKYSTFSGYLL
YQD
Sequence length 1127
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CATARACT GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
EXOSTOSIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Carcinoma of lung Lung carcinoma BEFREE 30813062
★☆☆☆☆
Found in Text Mining only
Cataract Cataract Pubtator 36710479 Associate
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Hepatoblastoma Hepatoblastoma BEFREE 24912477
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of lung Lung Cancer BEFREE 30813062
★☆☆☆☆
Found in Text Mining only
Myopia Myopia Pubtator 36710479 Associate
★☆☆☆☆
Found in Text Mining only
Neoplasms Neoplasms BEFREE 24912477
★☆☆☆☆
Found in Text Mining only