Gene Gene information from NCBI Gene database.
Entrez ID 6564
Gene name Solute carrier family 15 member 1
Gene symbol SLC15A1
Synonyms (NCBI Gene)
HPECT1HPEPT1PEPT1
Chromosome 13
Chromosome location 13q32.2-q32.3
Summary This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from
miRNA miRNA information provided by mirtarbase database.
226
miRTarBase ID miRNA Experiments Reference
MIRT004048 hsa-miR-92b-3p GFP reporter assayLuciferase reporter assayqRT-PCRWestern blot 21030610
MIRT680968 hsa-miR-6808-5p HITS-CLIP 23313552
MIRT680967 hsa-miR-6893-5p HITS-CLIP 23313552
MIRT680966 hsa-miR-940 HITS-CLIP 23313552
MIRT680965 hsa-miR-3929 HITS-CLIP 23313552
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Transcription factor Regulation Reference
CDX2 Activation 16616718
SP1 Unknown 16616718
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
37
GO ID Ontology Definition Evidence Reference
GO:0005427 Function Proton-dependent oligopeptide secondary active transmembrane transporter activity IEA
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IC 18367661
GO:0005886 Component Plasma membrane IDA 23137377
GO:0005886 Component Plasma membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600544 10920 ENSG00000088386
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P46059
Protein name Solute carrier family 15 member 1 (Intestinal H(+)/peptide cotransporter) (Oligopeptide transporter, small intestine isoform) (Peptide transporter 1)
Protein function Electrogenic proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides. Transports neutral and monovalently charged peptides with a proton to peptide stoichiometry of 1:1 or 2:1 (B
PDB 7PMW , 7PMX , 7PN1
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00854 PTR2 81 477 POT family Family
PF00854 PTR2 546 647 POT family Family
Tissue specificity TISSUE SPECIFICITY: Expressed in small intestine. {ECO:0000269|PubMed:28408210}.
Sequence
Sequence length 708
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Protein digestion and absorption   Proton/oligopeptide cotransporters
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
COLORECTAL CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Anemia Anemia BEFREE 27412707
★☆☆☆☆
Found in Text Mining only
Ataxia Telangiectasia Ataxia Telangiectasia BEFREE 30936244
★☆☆☆☆
Found in Text Mining only
Brooke-Spiegler syndrome Brooke-Spiegler Syndrome BEFREE 11976168
★☆☆☆☆
Found in Text Mining only
Chronic Disease Chronic disease Pubtator 39203856 Associate
★☆☆☆☆
Found in Text Mining only
Colitis Colitis BEFREE 21762661, 22842481, 23817423, 24583477, 24586284, 25931122
★☆☆☆☆
Found in Text Mining only
Congenital contractural arachnodactyly Congenital Contractural Arachnodactyly BEFREE 23429232
★☆☆☆☆
Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma Renal Carcinoma BEFREE 18546293, 26245452
★☆☆☆☆
Found in Text Mining only
Crohn Disease Crohn Disease BEFREE 19462432, 24583477, 28867741
★☆☆☆☆
Found in Text Mining only
Dyslipidemias Dyslipidemias BEFREE 31454435
★☆☆☆☆
Found in Text Mining only
Hypercholesterolemia Hypercholesterolemia BEFREE 31454435
★☆☆☆☆
Found in Text Mining only