Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	653808
Gene name	Zymogen granule protein 16
Gene symbol	ZG16
Synonyms (NCBI Gene)	JCLNJCLN1ZG16A
Chromosome	16
Chromosome location	16p11.2

155

Show/Hide all (155)

miRTarBase ID	miRNA	Experiments	Reference
MIRT713090	hsa-miR-2681-3p	HITS-CLIP	19536157
MIRT713089	hsa-miR-96-3p	HITS-CLIP	19536157
MIRT713088	hsa-miR-3607-5p	HITS-CLIP	19536157
MIRT713087	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT713086	hsa-miR-130b-5p	HITS-CLIP	19536157
MIRT713085	hsa-miR-7111-3p	HITS-CLIP	19536157
MIRT713084	hsa-miR-6780a-3p	HITS-CLIP	19536157
MIRT713083	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT713082	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT713081	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT713080	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT713079	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT713078	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT713077	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT713076	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT713090	hsa-miR-2681-3p	HITS-CLIP	19536157
MIRT713089	hsa-miR-96-3p	HITS-CLIP	19536157
MIRT713088	hsa-miR-3607-5p	HITS-CLIP	19536157
MIRT713087	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT713086	hsa-miR-130b-5p	HITS-CLIP	19536157
MIRT713085	hsa-miR-7111-3p	HITS-CLIP	19536157
MIRT713084	hsa-miR-6780a-3p	HITS-CLIP	19536157
MIRT713083	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT713082	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT713081	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT713080	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT713079	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT713078	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT713077	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT713076	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT1512823	hsa-miR-106a	CLIP-seq
MIRT1512824	hsa-miR-106b	CLIP-seq
MIRT1512825	hsa-miR-1197	CLIP-seq
MIRT1512826	hsa-miR-125a-3p	CLIP-seq
MIRT1512827	hsa-miR-1286	CLIP-seq
MIRT1512828	hsa-miR-150	CLIP-seq
MIRT1512829	hsa-miR-17	CLIP-seq
MIRT1512830	hsa-miR-20a	CLIP-seq
MIRT1512831	hsa-miR-20b	CLIP-seq
MIRT1512832	hsa-miR-302a	CLIP-seq
MIRT1512833	hsa-miR-302b	CLIP-seq
MIRT1512834	hsa-miR-302c	CLIP-seq
MIRT1512835	hsa-miR-302d	CLIP-seq
MIRT1512836	hsa-miR-302e	CLIP-seq
MIRT1512837	hsa-miR-3133	CLIP-seq
MIRT1512838	hsa-miR-3153	CLIP-seq
MIRT1512839	hsa-miR-3158-3p	CLIP-seq
MIRT1512840	hsa-miR-3192	CLIP-seq
MIRT1512841	hsa-miR-3663-3p	CLIP-seq
MIRT1512842	hsa-miR-372	CLIP-seq
MIRT1512843	hsa-miR-373	CLIP-seq
MIRT1512844	hsa-miR-3934	CLIP-seq
MIRT1512845	hsa-miR-4312	CLIP-seq
MIRT1512846	hsa-miR-4314	CLIP-seq
MIRT1512847	hsa-miR-4436a	CLIP-seq
MIRT1512848	hsa-miR-4524	CLIP-seq
MIRT1512849	hsa-miR-4646-5p	CLIP-seq
MIRT1512850	hsa-miR-4655-5p	CLIP-seq
MIRT1512851	hsa-miR-4668-5p	CLIP-seq
MIRT1512852	hsa-miR-4690-5p	CLIP-seq
MIRT1512853	hsa-miR-4721	CLIP-seq
MIRT1512854	hsa-miR-4731-5p	CLIP-seq
MIRT1512855	hsa-miR-4757-5p	CLIP-seq
MIRT1512856	hsa-miR-4763-5p	CLIP-seq
MIRT1512857	hsa-miR-5095	CLIP-seq
MIRT1512858	hsa-miR-512-3p	CLIP-seq
MIRT1512859	hsa-miR-519d	CLIP-seq
MIRT1512860	hsa-miR-520a-3p	CLIP-seq
MIRT1512861	hsa-miR-520b	CLIP-seq
MIRT1512862	hsa-miR-520c-3p	CLIP-seq
MIRT1512863	hsa-miR-520d-3p	CLIP-seq
MIRT1512864	hsa-miR-520e	CLIP-seq
MIRT1512865	hsa-miR-520g	CLIP-seq
MIRT1512866	hsa-miR-520h	CLIP-seq
MIRT1512867	hsa-miR-552	CLIP-seq
MIRT1512868	hsa-miR-764	CLIP-seq
MIRT1512869	hsa-miR-93	CLIP-seq
MIRT2154486	hsa-miR-4716-5p	CLIP-seq
MIRT2154487	hsa-miR-4781-3p	CLIP-seq
MIRT1512823	hsa-miR-106a	CLIP-seq
MIRT1512824	hsa-miR-106b	CLIP-seq
MIRT2374650	hsa-miR-1324	CLIP-seq
MIRT1512828	hsa-miR-150	CLIP-seq
MIRT1512829	hsa-miR-17	CLIP-seq
MIRT1512830	hsa-miR-20a	CLIP-seq
MIRT1512831	hsa-miR-20b	CLIP-seq
MIRT2374651	hsa-miR-2964a-5p	CLIP-seq
MIRT1512832	hsa-miR-302a	CLIP-seq
MIRT1512833	hsa-miR-302b	CLIP-seq
MIRT1512834	hsa-miR-302c	CLIP-seq
MIRT1512835	hsa-miR-302d	CLIP-seq
MIRT1512836	hsa-miR-302e	CLIP-seq
MIRT2374652	hsa-miR-3149	CLIP-seq
MIRT2374653	hsa-miR-3180-5p	CLIP-seq
MIRT2374654	hsa-miR-3612	CLIP-seq
MIRT1512841	hsa-miR-3663-3p	CLIP-seq
MIRT1512842	hsa-miR-372	CLIP-seq
MIRT1512843	hsa-miR-373	CLIP-seq
MIRT2374655	hsa-miR-3928	CLIP-seq
MIRT1512844	hsa-miR-3934	CLIP-seq
MIRT2374656	hsa-miR-411	CLIP-seq
MIRT1512845	hsa-miR-4312	CLIP-seq
MIRT2154486	hsa-miR-4716-5p	CLIP-seq
MIRT1512854	hsa-miR-4731-5p	CLIP-seq
MIRT2374657	hsa-miR-4735-5p	CLIP-seq
MIRT1512855	hsa-miR-4757-5p	CLIP-seq
MIRT1512856	hsa-miR-4763-5p	CLIP-seq
MIRT2374658	hsa-miR-4775	CLIP-seq
MIRT2154487	hsa-miR-4781-3p	CLIP-seq
MIRT2374659	hsa-miR-499a-5p	CLIP-seq
MIRT1512857	hsa-miR-5095	CLIP-seq
MIRT1512858	hsa-miR-512-3p	CLIP-seq
MIRT1512859	hsa-miR-519d	CLIP-seq
MIRT1512860	hsa-miR-520a-3p	CLIP-seq
MIRT2374660	hsa-miR-520a-5p	CLIP-seq
MIRT1512861	hsa-miR-520b	CLIP-seq
MIRT1512862	hsa-miR-520c-3p	CLIP-seq
MIRT1512863	hsa-miR-520d-3p	CLIP-seq
MIRT1512864	hsa-miR-520e	CLIP-seq
MIRT1512865	hsa-miR-520g	CLIP-seq
MIRT1512866	hsa-miR-520h	CLIP-seq
MIRT2374661	hsa-miR-525-5p	CLIP-seq
MIRT1512867	hsa-miR-552	CLIP-seq
MIRT2374662	hsa-miR-590-3p	CLIP-seq
MIRT2374663	hsa-miR-650	CLIP-seq
MIRT1512869	hsa-miR-93	CLIP-seq
MIRT2463981	hsa-miR-1228	CLIP-seq
MIRT2374652	hsa-miR-3149	CLIP-seq
MIRT2374656	hsa-miR-411	CLIP-seq
MIRT2463982	hsa-miR-4715-3p	CLIP-seq
MIRT2374657	hsa-miR-4735-5p	CLIP-seq
MIRT2374658	hsa-miR-4775	CLIP-seq
MIRT2463983	hsa-miR-4794	CLIP-seq
MIRT2374662	hsa-miR-590-3p	CLIP-seq
MIRT2463981	hsa-miR-1228	CLIP-seq
MIRT2374652	hsa-miR-3149	CLIP-seq
MIRT2374656	hsa-miR-411	CLIP-seq
MIRT2463982	hsa-miR-4715-3p	CLIP-seq
MIRT2374657	hsa-miR-4735-5p	CLIP-seq
MIRT2374658	hsa-miR-4775	CLIP-seq
MIRT2463983	hsa-miR-4794	CLIP-seq
MIRT2374662	hsa-miR-590-3p	CLIP-seq
MIRT2463981	hsa-miR-1228	CLIP-seq
MIRT2374650	hsa-miR-1324	CLIP-seq
MIRT2374651	hsa-miR-2964a-5p	CLIP-seq
MIRT2374652	hsa-miR-3149	CLIP-seq
MIRT2374653	hsa-miR-3180-5p	CLIP-seq
MIRT2374656	hsa-miR-411	CLIP-seq
MIRT2463982	hsa-miR-4715-3p	CLIP-seq
MIRT2374657	hsa-miR-4735-5p	CLIP-seq
MIRT2374658	hsa-miR-4775	CLIP-seq
MIRT2463983	hsa-miR-4794	CLIP-seq
MIRT2374660	hsa-miR-520a-5p	CLIP-seq
MIRT2374661	hsa-miR-525-5p	CLIP-seq
MIRT2374662	hsa-miR-590-3p	CLIP-seq

Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 16237761, 16713569, 25416956, 32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IDA	17307141
GO:0005794	Component	Golgi apparatus	IEA
GO:0005796	Component	Golgi lumen	IDA	17307141
GO:0005796	Component	Golgi lumen	IEA
GO:0015031	Process	Protein transport	IEA
GO:0015031	Process	Protein transport	TAS	17307141
GO:0030246	Function	Carbohydrate binding	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0042589	Component	Zymogen granule membrane	IEA
GO:0042834	Function	Peptidoglycan binding	IEA
GO:0050830	Process	Defense response to Gram-positive bacterium	IEA
GO:0052373	Process	Suppression of symbiont entry into host	IEA
GO:0070701	Component	Mucus layer	IEA

MIM	HGNC	e!Ensembl
617311	30961	ENSG00000174992

O60844

Protein name

Zymogen granule membrane protein 16 (Zymogen granule protein 16) (hZG16) (Secretory lectin ZG16)

Protein function

May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN. {ECO:0000269|PubMe

PDB

3APA , 3VY6 , 3VY7 , 3VZE , 3VZF , 3VZG , 7O3I , 7O4P , 7O88

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01419	Jacalin	27 → 159	Jacalin-like lectin domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in liver. Detected at lower levels in colon, ileum and jejunum. {ECO:0000269|PubMed:17307141}.

Sequence

MLTVALLALLCASASGNAIQARSSSYSGEYGGGGGKRFSHSGNQLDGPITALRVRVNTYY
IVGLQVRYGKVWSDYVGGRNGDLEEIFLHPGESVIQVSGKYKWYLKKLLFVTDKGRYLSF
GKDSGTSFNAVPLHPNTVLRFISGRSGSLIDAIGLHWDVYPSSCSRC

Sequence length

167

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (11)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	31698633		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenomatous Polyps	Adenomatous Polyposis	BEFREE	29661177		★★★★★ ★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorder	Autism	Pubtator	26290361	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	34414947	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Ulcerative colitis	Pubtator	29661177	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	27880730, 29661177, 31137244		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	29661177	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	31137244, 32462020, 32961078, 33919332, 34077620, 36991484	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hepatitis B Chronic	Hepatitis b	Pubtator	34414947	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	17307141		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29661177		★★★★★ ★☆☆☆☆ Found in Text Mining only

ZG16 (zymogen granule protein 16)