WNK3 (WNK lysine deficient protein kinase 3)

Gene

• Entrez ID: 65267
• Gene name: WNK lysine deficient protein kinase 3
• Gene symbol: WNK3
• Synonyms (NCBI Gene): MRXS2, PRKWNK3, PRS
• Chromosome: X
• Chromosome location: Xp11.22
• Summary: This gene encodes a protein belonging to the `with no lysine` family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT031069	hsa-miR-21-5p	Microarray	21544242
MIRT047011	hsa-miR-204-5p	CLASH	23622248
MIRT045734	hsa-miR-125a-5p	CLASH	23622248
MIRT552844	hsa-miR-19b-3p	HITS-CLIP	21572407
MIRT552843	hsa-miR-19a-3p	HITS-CLIP	21572407
MIRT552842	hsa-miR-548n	HITS-CLIP	21572407
MIRT552841	hsa-miR-548av-5p	HITS-CLIP	21572407
MIRT552840	hsa-miR-548k	HITS-CLIP	21572407
MIRT552838	hsa-miR-8054	HITS-CLIP	21572407
MIRT552839	hsa-miR-660-5p	HITS-CLIP	21572407
MIRT552834	hsa-miR-3613-3p	HITS-CLIP	21572407
MIRT707778	hsa-miR-548aj-5p	HITS-CLIP	21572407
MIRT707777	hsa-miR-548f-5p	HITS-CLIP	21572407
MIRT707776	hsa-miR-548g-5p	HITS-CLIP	21572407
MIRT707775	hsa-miR-548x-5p	HITS-CLIP	21572407
MIRT707774	hsa-miR-1468-3p	HITS-CLIP	21572407
MIRT707773	hsa-miR-548aw	HITS-CLIP	21572407
MIRT552832	hsa-miR-4668-5p	HITS-CLIP	21572407
MIRT665386	hsa-miR-8485	HITS-CLIP	23824327
MIRT665385	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT665384	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT665383	hsa-miR-603	HITS-CLIP	23824327
MIRT665382	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT665381	hsa-miR-3920	HITS-CLIP	23824327
MIRT665380	hsa-miR-29a-5p	HITS-CLIP	23824327
MIRT665379	hsa-miR-3941	HITS-CLIP	23824327
MIRT665378	hsa-miR-3192-3p	HITS-CLIP	23824327
MIRT665377	hsa-miR-4762-3p	HITS-CLIP	23824327
MIRT564989	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT564988	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT564987	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT564986	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT564985	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT564983	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT564984	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT564982	hsa-miR-503-5p	PAR-CLIP	20371350
MIRT564981	hsa-miR-646	PAR-CLIP	20371350
MIRT564980	hsa-miR-3158-5p	PAR-CLIP	20371350
MIRT564979	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT564978	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT552844	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT552843	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT552842	hsa-miR-548n	PAR-CLIP	21572407
MIRT552841	hsa-miR-548av-5p	PAR-CLIP	21572407
MIRT552840	hsa-miR-548k	PAR-CLIP	21572407
MIRT552838	hsa-miR-8054	PAR-CLIP	21572407
MIRT552839	hsa-miR-660-5p	PAR-CLIP	21572407
MIRT552837	hsa-miR-4499	PAR-CLIP	21572407
MIRT552836	hsa-miR-4463	PAR-CLIP	21572407
MIRT552835	hsa-miR-411-5p	PAR-CLIP	21572407
MIRT552834	hsa-miR-3613-3p	PAR-CLIP	21572407
MIRT552833	hsa-miR-151a-3p	PAR-CLIP	21572407
MIRT552832	hsa-miR-4668-5p	PAR-CLIP	21572407
MIRT497387	hsa-miR-6076	PAR-CLIP	22291592
MIRT497386	hsa-miR-6797-3p	PAR-CLIP	22291592
MIRT448328	hsa-miR-301a-3p	PAR-CLIP	22100165
MIRT448327	hsa-miR-130b-3p	PAR-CLIP	22100165
MIRT448326	hsa-miR-130a-3p	PAR-CLIP	22100165
MIRT448325	hsa-miR-3666	PAR-CLIP	22100165
MIRT448324	hsa-miR-454-3p	PAR-CLIP	22100165
MIRT448323	hsa-miR-301b-3p	PAR-CLIP	22100165
MIRT448322	hsa-miR-4295	PAR-CLIP	22100165
MIRT448321	hsa-miR-526b-3p	PAR-CLIP	22100165
MIRT448320	hsa-miR-93-5p	PAR-CLIP	22100165
MIRT448319	hsa-miR-106a-5p	PAR-CLIP	22100165
MIRT448318	hsa-miR-519d-3p	PAR-CLIP	22100165
MIRT448317	hsa-miR-20b-5p	PAR-CLIP	22100165
MIRT448316	hsa-miR-106b-5p	PAR-CLIP	22100165
MIRT448315	hsa-miR-20a-5p	PAR-CLIP	22100165
MIRT448314	hsa-miR-17-5p	PAR-CLIP	22100165
MIRT448313	hsa-miR-548as-3p	PAR-CLIP	22100165
MIRT448312	hsa-miR-3609	PAR-CLIP	22100165
MIRT448311	hsa-miR-548ah-5p	PAR-CLIP	22100165
MIRT448310	hsa-miR-4796-3p	PAR-CLIP	22100165
MIRT448309	hsa-miR-519a-3p	PAR-CLIP	22100165
MIRT448308	hsa-miR-519b-3p	PAR-CLIP	22100165
MIRT448307	hsa-miR-519c-3p	PAR-CLIP	22100165
MIRT448306	hsa-miR-3130-5p	PAR-CLIP	22100165
MIRT448305	hsa-miR-4482-5p	PAR-CLIP	22100165
MIRT448304	hsa-miR-545-5p	PAR-CLIP	22100165
MIRT448303	hsa-miR-4645-3p	PAR-CLIP	22100165
MIRT448302	hsa-miR-891b	PAR-CLIP	22100165
MIRT552844	hsa-miR-19b-3p	HITS-CLIP	21572407
MIRT552843	hsa-miR-19a-3p	HITS-CLIP	21572407
MIRT552842	hsa-miR-548n	HITS-CLIP	21572407
MIRT552841	hsa-miR-548av-5p	HITS-CLIP	21572407
MIRT552840	hsa-miR-548k	HITS-CLIP	21572407
MIRT552838	hsa-miR-8054	HITS-CLIP	21572407
MIRT552839	hsa-miR-660-5p	HITS-CLIP	21572407
MIRT552834	hsa-miR-3613-3p	HITS-CLIP	21572407
MIRT707778	hsa-miR-548aj-5p	HITS-CLIP	21572407
MIRT707777	hsa-miR-548f-5p	HITS-CLIP	21572407
MIRT707776	hsa-miR-548g-5p	HITS-CLIP	21572407
MIRT707775	hsa-miR-548x-5p	HITS-CLIP	21572407
MIRT707774	hsa-miR-1468-3p	HITS-CLIP	21572407
MIRT707773	hsa-miR-548aw	HITS-CLIP	21572407
MIRT552832	hsa-miR-4668-5p	HITS-CLIP	21572407
MIRT665386	hsa-miR-8485	HITS-CLIP	23824327
MIRT665385	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT665384	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT665383	hsa-miR-603	HITS-CLIP	23824327
MIRT665382	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT665381	hsa-miR-3920	HITS-CLIP	23824327
MIRT665380	hsa-miR-29a-5p	HITS-CLIP	23824327
MIRT665379	hsa-miR-3941	HITS-CLIP	23824327
MIRT665378	hsa-miR-3192-3p	HITS-CLIP	23824327
MIRT665377	hsa-miR-4762-3p	HITS-CLIP	23824327
MIRT564989	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT564988	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT564987	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT564986	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT564985	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT564983	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT564984	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT564982	hsa-miR-503-5p	PAR-CLIP	20371350
MIRT564981	hsa-miR-646	PAR-CLIP	20371350
MIRT564980	hsa-miR-3158-5p	PAR-CLIP	20371350
MIRT564979	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT564978	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT552844	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT552843	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT552842	hsa-miR-548n	PAR-CLIP	21572407
MIRT552841	hsa-miR-548av-5p	PAR-CLIP	21572407
MIRT552840	hsa-miR-548k	PAR-CLIP	21572407
MIRT552838	hsa-miR-8054	PAR-CLIP	21572407
MIRT552839	hsa-miR-660-5p	PAR-CLIP	21572407
MIRT552837	hsa-miR-4499	PAR-CLIP	21572407
MIRT552836	hsa-miR-4463	PAR-CLIP	21572407
MIRT552835	hsa-miR-411-5p	PAR-CLIP	21572407
MIRT552834	hsa-miR-3613-3p	PAR-CLIP	21572407
MIRT552833	hsa-miR-151a-3p	PAR-CLIP	21572407
MIRT552832	hsa-miR-4668-5p	PAR-CLIP	21572407
MIRT497387	hsa-miR-6076	PAR-CLIP	22291592
MIRT497386	hsa-miR-6797-3p	PAR-CLIP	22291592
MIRT448328	hsa-miR-301a-3p	PAR-CLIP	22100165
MIRT448327	hsa-miR-130b-3p	PAR-CLIP	22100165
MIRT448326	hsa-miR-130a-3p	PAR-CLIP	22100165
MIRT448325	hsa-miR-3666	PAR-CLIP	22100165
MIRT448324	hsa-miR-454-3p	PAR-CLIP	22100165
MIRT448323	hsa-miR-301b-3p	PAR-CLIP	22100165
MIRT448322	hsa-miR-4295	PAR-CLIP	22100165
MIRT448321	hsa-miR-526b-3p	PAR-CLIP	22100165
MIRT448320	hsa-miR-93-5p	PAR-CLIP	22100165
MIRT448319	hsa-miR-106a-5p	PAR-CLIP	22100165
MIRT448318	hsa-miR-519d-3p	PAR-CLIP	22100165
MIRT448317	hsa-miR-20b-5p	PAR-CLIP	22100165
MIRT448316	hsa-miR-106b-5p	PAR-CLIP	22100165
MIRT448315	hsa-miR-20a-5p	PAR-CLIP	22100165
MIRT448314	hsa-miR-17-5p	PAR-CLIP	22100165
MIRT448313	hsa-miR-548as-3p	PAR-CLIP	22100165
MIRT448312	hsa-miR-3609	PAR-CLIP	22100165
MIRT448311	hsa-miR-548ah-5p	PAR-CLIP	22100165
MIRT448310	hsa-miR-4796-3p	PAR-CLIP	22100165
MIRT448309	hsa-miR-519a-3p	PAR-CLIP	22100165
MIRT448308	hsa-miR-519b-3p	PAR-CLIP	22100165
MIRT448307	hsa-miR-519c-3p	PAR-CLIP	22100165
MIRT448306	hsa-miR-3130-5p	PAR-CLIP	22100165
MIRT448305	hsa-miR-4482-5p	PAR-CLIP	22100165
MIRT448304	hsa-miR-545-5p	PAR-CLIP	22100165
MIRT448303	hsa-miR-4645-3p	PAR-CLIP	22100165
MIRT448302	hsa-miR-891b	PAR-CLIP	22100165
MIRT1493448	hsa-miR-103a	CLIP-seq
MIRT1493449	hsa-miR-107	CLIP-seq
MIRT1493450	hsa-miR-1184	CLIP-seq
MIRT1493451	hsa-miR-1185	CLIP-seq
MIRT1493452	hsa-miR-1205	CLIP-seq
MIRT1493453	hsa-miR-1276	CLIP-seq
MIRT1493454	hsa-miR-129-5p	CLIP-seq
MIRT1493455	hsa-miR-1297	CLIP-seq
MIRT1493456	hsa-miR-1301	CLIP-seq
MIRT1493457	hsa-miR-147	CLIP-seq
MIRT1493458	hsa-miR-153	CLIP-seq
MIRT1493459	hsa-miR-15a	CLIP-seq
MIRT1493460	hsa-miR-15b	CLIP-seq
MIRT1493461	hsa-miR-16	CLIP-seq
MIRT1493462	hsa-miR-1827	CLIP-seq
MIRT1493463	hsa-miR-195	CLIP-seq
MIRT1493464	hsa-miR-204	CLIP-seq
MIRT1493465	hsa-miR-2054	CLIP-seq
MIRT1493466	hsa-miR-211	CLIP-seq
MIRT1493467	hsa-miR-214	CLIP-seq
MIRT1493468	hsa-miR-26a	CLIP-seq
MIRT1493469	hsa-miR-26b	CLIP-seq
MIRT1493470	hsa-miR-27a	CLIP-seq
MIRT1493471	hsa-miR-27b	CLIP-seq
MIRT1493472	hsa-miR-302f	CLIP-seq
MIRT1493473	hsa-miR-3148	CLIP-seq
MIRT1493474	hsa-miR-3619-5p	CLIP-seq
MIRT1493475	hsa-miR-3664-5p	CLIP-seq
MIRT1493476	hsa-miR-3679-5p	CLIP-seq
MIRT1493477	hsa-miR-3978	CLIP-seq
MIRT1493478	hsa-miR-424	CLIP-seq
MIRT1493479	hsa-miR-4287	CLIP-seq
MIRT1493480	hsa-miR-4459	CLIP-seq
MIRT1493481	hsa-miR-4464	CLIP-seq
MIRT1493482	hsa-miR-4465	CLIP-seq
MIRT1493483	hsa-miR-4477a	CLIP-seq
MIRT1493484	hsa-miR-448	CLIP-seq
MIRT1493485	hsa-miR-4519	CLIP-seq
MIRT1493486	hsa-miR-4524	CLIP-seq
MIRT1493487	hsa-miR-4649-3p	CLIP-seq
MIRT1493488	hsa-miR-4685-3p	CLIP-seq
MIRT1493489	hsa-miR-4711-5p	CLIP-seq
MIRT1493490	hsa-miR-4714-5p	CLIP-seq
MIRT1493491	hsa-miR-4716-3p	CLIP-seq
MIRT1493492	hsa-miR-4722-5p	CLIP-seq
MIRT1493493	hsa-miR-4723-5p	CLIP-seq
MIRT1493494	hsa-miR-4748	CLIP-seq
MIRT1493495	hsa-miR-4766-5p	CLIP-seq
MIRT1493496	hsa-miR-4768-3p	CLIP-seq
MIRT1493497	hsa-miR-4775	CLIP-seq
MIRT1493498	hsa-miR-4779	CLIP-seq
MIRT1493499	hsa-miR-4793-5p	CLIP-seq
MIRT1493500	hsa-miR-497	CLIP-seq
MIRT1493501	hsa-miR-503	CLIP-seq
MIRT1493502	hsa-miR-5047	CLIP-seq
MIRT1493503	hsa-miR-5096	CLIP-seq
MIRT1493504	hsa-miR-513a-5p	CLIP-seq
MIRT1493505	hsa-miR-548c-3p	CLIP-seq
MIRT1493506	hsa-miR-561	CLIP-seq
MIRT1493507	hsa-miR-583	CLIP-seq
MIRT1493508	hsa-miR-590-3p	CLIP-seq
MIRT1493509	hsa-miR-599	CLIP-seq
MIRT1493510	hsa-miR-665	CLIP-seq
MIRT1493511	hsa-miR-761	CLIP-seq
MIRT1493512	hsa-miR-940	CLIP-seq
MIRT1493513	hsa-miR-1273d	CLIP-seq
MIRT1493514	hsa-miR-1305	CLIP-seq
MIRT1493462	hsa-miR-1827	CLIP-seq
MIRT1493515	hsa-miR-2114	CLIP-seq
MIRT1493516	hsa-miR-2276	CLIP-seq
MIRT1493470	hsa-miR-27a	CLIP-seq
MIRT1493471	hsa-miR-27b	CLIP-seq
MIRT1493517	hsa-miR-330-3p	CLIP-seq
MIRT1493518	hsa-miR-3622b-5p	CLIP-seq
MIRT1493519	hsa-miR-3652	CLIP-seq
MIRT1493520	hsa-miR-3664-3p	CLIP-seq
MIRT1493521	hsa-miR-371-5p	CLIP-seq
MIRT1493522	hsa-miR-371b-5p	CLIP-seq
MIRT1493523	hsa-miR-3929	CLIP-seq
MIRT1493524	hsa-miR-4255	CLIP-seq
MIRT1493525	hsa-miR-4419b	CLIP-seq
MIRT1493526	hsa-miR-4422	CLIP-seq
MIRT1493527	hsa-miR-4430	CLIP-seq
MIRT1493528	hsa-miR-4433	CLIP-seq
MIRT1493480	hsa-miR-4459	CLIP-seq
MIRT1493529	hsa-miR-4478	CLIP-seq
MIRT1493530	hsa-miR-4505	CLIP-seq
MIRT1493531	hsa-miR-4645-5p	CLIP-seq
MIRT1493487	hsa-miR-4649-3p	CLIP-seq
MIRT1493532	hsa-miR-4662a-5p	CLIP-seq
MIRT1493533	hsa-miR-4673	CLIP-seq
MIRT1493534	hsa-miR-4676-5p	CLIP-seq
MIRT1493535	hsa-miR-4686	CLIP-seq
MIRT1493536	hsa-miR-4695-5p	CLIP-seq
MIRT1493492	hsa-miR-4722-5p	CLIP-seq
MIRT1493537	hsa-miR-4755-3p	CLIP-seq
MIRT1493496	hsa-miR-4768-3p	CLIP-seq
MIRT1493538	hsa-miR-4772-3p	CLIP-seq
MIRT1493497	hsa-miR-4775	CLIP-seq
MIRT1493539	hsa-miR-485-5p	CLIP-seq
MIRT1493540	hsa-miR-510	CLIP-seq
MIRT1493541	hsa-miR-512-5p	CLIP-seq
MIRT1493504	hsa-miR-513a-5p	CLIP-seq
MIRT1493542	hsa-miR-542-3p	CLIP-seq
MIRT1493543	hsa-miR-566	CLIP-seq
MIRT1493544	hsa-miR-575	CLIP-seq
MIRT1493508	hsa-miR-590-3p	CLIP-seq
MIRT1493545	hsa-miR-626	CLIP-seq
MIRT1493546	hsa-miR-660	CLIP-seq
MIRT1493512	hsa-miR-940	CLIP-seq
MIRT2148767	hsa-miR-4793-3p	CLIP-seq
MIRT2148768	hsa-miR-1275	CLIP-seq
MIRT1493454	hsa-miR-129-5p	CLIP-seq
MIRT1493462	hsa-miR-1827	CLIP-seq
MIRT1493515	hsa-miR-2114	CLIP-seq
MIRT2148769	hsa-miR-3173-3p	CLIP-seq
MIRT1493520	hsa-miR-3664-3p	CLIP-seq
MIRT1493523	hsa-miR-3929	CLIP-seq
MIRT2148770	hsa-miR-4260	CLIP-seq
MIRT2148771	hsa-miR-4310	CLIP-seq
MIRT1493525	hsa-miR-4419b	CLIP-seq
MIRT2148772	hsa-miR-4428	CLIP-seq
MIRT1493528	hsa-miR-4433	CLIP-seq
MIRT1493480	hsa-miR-4459	CLIP-seq
MIRT1493529	hsa-miR-4478	CLIP-seq
MIRT2148773	hsa-miR-4489	CLIP-seq
MIRT2148774	hsa-miR-4521	CLIP-seq
MIRT1493487	hsa-miR-4649-3p	CLIP-seq
MIRT2148775	hsa-miR-4665-5p	CLIP-seq
MIRT1493536	hsa-miR-4695-5p	CLIP-seq
MIRT2148776	hsa-miR-4704-5p	CLIP-seq
MIRT1493492	hsa-miR-4722-5p	CLIP-seq
MIRT1493496	hsa-miR-4768-3p	CLIP-seq
MIRT1493497	hsa-miR-4775	CLIP-seq
MIRT1493498	hsa-miR-4779	CLIP-seq
MIRT1493539	hsa-miR-485-5p	CLIP-seq
MIRT1493540	hsa-miR-510	CLIP-seq
MIRT1493541	hsa-miR-512-5p	CLIP-seq
MIRT1493543	hsa-miR-566	CLIP-seq
MIRT1493508	hsa-miR-590-3p	CLIP-seq
MIRT2148777	hsa-miR-656	CLIP-seq
MIRT1493510	hsa-miR-665	CLIP-seq
MIRT1493512	hsa-miR-940	CLIP-seq
MIRT2369158	hsa-miR-1228	CLIP-seq
MIRT2369159	hsa-miR-1262	CLIP-seq
MIRT2369160	hsa-miR-3145-5p	CLIP-seq
MIRT1493480	hsa-miR-4459	CLIP-seq
MIRT2369161	hsa-miR-4701-3p	CLIP-seq
MIRT1493491	hsa-miR-4716-3p	CLIP-seq
MIRT1493492	hsa-miR-4722-5p	CLIP-seq
MIRT1493493	hsa-miR-4723-5p	CLIP-seq
MIRT1493498	hsa-miR-4779	CLIP-seq
MIRT2148767	hsa-miR-4793-3p	CLIP-seq
MIRT2369162	hsa-miR-490-3p	CLIP-seq
MIRT1493542	hsa-miR-542-3p	CLIP-seq
MIRT1493510	hsa-miR-665	CLIP-seq
MIRT2148768	hsa-miR-1275	CLIP-seq
MIRT1493454	hsa-miR-129-5p	CLIP-seq
MIRT2148769	hsa-miR-3173-3p	CLIP-seq
MIRT2397013	hsa-miR-3176	CLIP-seq
MIRT2397014	hsa-miR-3606	CLIP-seq
MIRT2397015	hsa-miR-3922-3p	CLIP-seq
MIRT2397016	hsa-miR-3926	CLIP-seq
MIRT2148770	hsa-miR-4260	CLIP-seq
MIRT2148772	hsa-miR-4428	CLIP-seq
MIRT2148773	hsa-miR-4489	CLIP-seq
MIRT2148774	hsa-miR-4521	CLIP-seq
MIRT2148775	hsa-miR-4665-5p	CLIP-seq
MIRT1493497	hsa-miR-4775	CLIP-seq
MIRT2397017	hsa-miR-4786-5p	CLIP-seq
MIRT2397018	hsa-miR-548s	CLIP-seq
MIRT1493508	hsa-miR-590-3p	CLIP-seq
MIRT2397019	hsa-miR-622	CLIP-seq
MIRT2434715	hsa-miR-4766-3p	CLIP-seq
MIRT2434716	hsa-miR-548p	CLIP-seq
MIRT2434715	hsa-miR-4766-3p	CLIP-seq
MIRT2434716	hsa-miR-548p	CLIP-seq
MIRT2662753	hsa-miR-101	CLIP-seq
MIRT2662754	hsa-miR-1253	CLIP-seq
MIRT2662755	hsa-miR-1272	CLIP-seq
MIRT2662756	hsa-miR-1279	CLIP-seq
MIRT2662757	hsa-miR-1322	CLIP-seq
MIRT2662758	hsa-miR-144	CLIP-seq
MIRT1493462	hsa-miR-1827	CLIP-seq
MIRT2662759	hsa-miR-200b	CLIP-seq
MIRT2662760	hsa-miR-200c	CLIP-seq
MIRT1493515	hsa-miR-2114	CLIP-seq
MIRT2662761	hsa-miR-30a	CLIP-seq
MIRT2662762	hsa-miR-30b	CLIP-seq
MIRT2662763	hsa-miR-30c	CLIP-seq
MIRT2662764	hsa-miR-30d	CLIP-seq
MIRT2662765	hsa-miR-30e	CLIP-seq
MIRT2662766	hsa-miR-323b-3p	CLIP-seq
MIRT1493519	hsa-miR-3652	CLIP-seq
MIRT1493520	hsa-miR-3664-3p	CLIP-seq
MIRT1493523	hsa-miR-3929	CLIP-seq
MIRT2662767	hsa-miR-429	CLIP-seq
MIRT2662768	hsa-miR-4325	CLIP-seq
MIRT1493525	hsa-miR-4419b	CLIP-seq
MIRT1493527	hsa-miR-4430	CLIP-seq
MIRT1493528	hsa-miR-4433	CLIP-seq
MIRT1493480	hsa-miR-4459	CLIP-seq
MIRT1493529	hsa-miR-4478	CLIP-seq
MIRT1493530	hsa-miR-4505	CLIP-seq
MIRT2662769	hsa-miR-4638-3p	CLIP-seq
MIRT1493487	hsa-miR-4649-3p	CLIP-seq
MIRT1493536	hsa-miR-4695-5p	CLIP-seq
MIRT2662770	hsa-miR-4699-3p	CLIP-seq
MIRT1493492	hsa-miR-4722-5p	CLIP-seq
MIRT1493496	hsa-miR-4768-3p	CLIP-seq
MIRT1493539	hsa-miR-485-5p	CLIP-seq
MIRT1493540	hsa-miR-510	CLIP-seq
MIRT1493541	hsa-miR-512-5p	CLIP-seq
MIRT1493543	hsa-miR-566	CLIP-seq
MIRT2662771	hsa-miR-580	CLIP-seq
MIRT1493510	hsa-miR-665	CLIP-seq
MIRT1493512	hsa-miR-940	CLIP-seq
MIRT1493462	hsa-miR-1827	CLIP-seq
MIRT1493515	hsa-miR-2114	CLIP-seq
MIRT1493519	hsa-miR-3652	CLIP-seq
MIRT1493520	hsa-miR-3664-3p	CLIP-seq
MIRT1493523	hsa-miR-3929	CLIP-seq
MIRT1493525	hsa-miR-4419b	CLIP-seq
MIRT1493527	hsa-miR-4430	CLIP-seq
MIRT1493528	hsa-miR-4433	CLIP-seq
MIRT1493480	hsa-miR-4459	CLIP-seq
MIRT1493529	hsa-miR-4478	CLIP-seq
MIRT1493530	hsa-miR-4505	CLIP-seq
MIRT1493487	hsa-miR-4649-3p	CLIP-seq
MIRT1493536	hsa-miR-4695-5p	CLIP-seq
MIRT1493492	hsa-miR-4722-5p	CLIP-seq
MIRT1493496	hsa-miR-4768-3p	CLIP-seq
MIRT1493539	hsa-miR-485-5p	CLIP-seq
MIRT1493540	hsa-miR-510	CLIP-seq
MIRT1493541	hsa-miR-512-5p	CLIP-seq
MIRT1493543	hsa-miR-566	CLIP-seq
MIRT1493512	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IDA	16275913
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	17975670
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	ISS
GO:0005515	Function	Protein binding	IPI	16501604, 32296183
GO:0005524	Function	ATP binding	IEA
GO:0005524	Function	ATP binding	ISS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	16501604
GO:0005737	Component	Cytoplasm	IEA
GO:0005912	Component	Adherens junction	IEA
GO:0005912	Component	Adherens junction	ISS
GO:0005923	Component	Bicellular tight junction	IEA
GO:0005923	Component	Bicellular tight junction	ISS
GO:0006468	Process	Protein phosphorylation	ISS
GO:0006884	Process	Cell volume homeostasis	IDA	36318922
GO:0006884	Process	Cell volume homeostasis	IEA
GO:0006884	Process	Cell volume homeostasis	IEA
GO:0006884	Process	Cell volume homeostasis	IMP	27782176
GO:0006884	Process	Cell volume homeostasis	ISS	27782176
GO:0006974	Process	DNA damage response	IBA
GO:0007231	Process	Osmosensory signaling pathway	IMP	27782176
GO:0010765	Process	Positive regulation of sodium ion transport	IDA	16275913
GO:0010800	Process	Positive regulation of peptidyl-threonine phosphorylation	IDA	16275913
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0035556	Process	Intracellular signal transduction	ISS
GO:0035633	Process	Maintenance of blood-brain barrier	IEA
GO:0035633	Process	Maintenance of blood-brain barrier	ISS	27782176
GO:0043066	Process	Negative regulation of apoptotic process	IMP	16501604
GO:0044325	Function	Transmembrane transporter binding	IPI	16275913
GO:0050801	Process	Monoatomic ion homeostasis	IMP	21613606
GO:0051928	Process	Positive regulation of calcium ion transport	IMP	18768590
GO:0070294	Process	Renal sodium ion absorption	IDA	16275913
GO:0071474	Process	Cellular hyperosmotic response	IDA	36318922
GO:0072659	Process	Protein localization to plasma membrane	IMP	18768590
GO:0090188	Process	Negative regulation of pancreatic juice secretion	IEA
GO:0090279	Process	Regulation of calcium ion import	IMP	18768590
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0140693	Function	Molecular condensate scaffold activity	IDA	36318922
GO:0140694	Process	Membraneless organelle assembly	IDA	36318922
GO:0141109	Function	Transporter activator activity	IDA	16275913
GO:1903077	Process	Negative regulation of protein localization to plasma membrane	IDA	17673510
GO:1903078	Process	Positive regulation of protein localization to plasma membrane	IDA	16275913
GO:1904062	Process	Regulation of monoatomic cation transmembrane transport	IEA
GO:1904062	Process	Regulation of monoatomic cation transmembrane transport	IEA
GO:1904062	Process	Regulation of monoatomic cation transmembrane transport	IMP	27782176
GO:1904062	Process	Regulation of monoatomic cation transmembrane transport	ISS	27782176
GO:2000651	Process	Positive regulation of sodium ion transmembrane transporter activity	IDA	16275913
GO:2000651	Process	Positive regulation of sodium ion transmembrane transporter activity	IMP	21613606

Other IDs

• MIM: 300358
• HGNC: 14543
• e!Ensembl: ENSG00000196632

Protein

• UniProt ID: Q9BYP7
• Protein name: Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3)
• Protein function: Serine/threonine-protein kinase component of the WNK3-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis and regulatory volume increase in response to hyperosmotic stress (PubMed:16275911, PubMed
• PDB: 5NKP, 5O1V, 5O21, 5O23, 5O26, 5O2B, 5O2C, 8EDH, 9D7Q
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	147 → 405	Protein kinase domain	Domain
  PF12202	OSR1_C	426 → 489	Oxidative-stress-responsive kinase 1 C-terminal domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in brain, lung, kidney, liver and pancreas, and in fetal tissues including placenta, fetal brain, lung and kidney. Very low levels of expression were also detected in fetal heart, thymus, liver and spleen. Isoform 1 is brain-
• Sequence:

  MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR
  KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC
  FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD
  RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK
  RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL
  MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK
  VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD
  CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV
  AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE
  TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV
  SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT
  VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS
  GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD
  APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS
  QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR
  HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL
  YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH
  PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP
  GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS
  IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF
  KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGGGYFGLSFTCPSL
  KNPISKKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEEMRSAIAPDPIPLTRESTADTR
  ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL
  VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE
  ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH
  EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ
  ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVATGKSCLIN
  ELENPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHK
  LETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVC
  QYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK
  

• Sequence length: 1800

Pathways

KEGG:

Parathyroid hormone synthesis, secretion and action

Reactome:

Stimuli-sensing channels

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Neurodevelopmental disorder	Pathogenic	rs2521950956, rs2521949809, rs2521921552, rs2521919750, rs2521900262, rs2521649714	RCV002284970 RCV002284971 RCV002284972 RCV002284973 RCV002284974 RCV002284975	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Nonpapillary renal cell carcinoma	Pathogenic	rs2521950956	RCV005922811	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Prieto syndrome	Pathogenic	rs2521949809, rs2521921552, rs2521919750, rs2521900262	RCV003446928 RCV003446929 RCV003446930 RCV003446931	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISTIC DISORDER	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONGENITAL RETROGNATHISM	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SLEEP APNEA SYNDROMES	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
WNK3-related condition	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Attention deficit hyperactivity disorder	Attention Deficit Hyperactivity Disorder	BEFREE	27806167, 31514201		★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	BEFREE	18498374		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Autistic Disorder	Autism	LHGDN	18498374		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Azoospermia Nonobstructive	Nonobstructive azoospermia	Pubtator	29790874	Associate	★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar Disorder	BEFREE	31628696		★☆☆☆☆ Found in Text Mining only
Brain Diseases	Brain disease	Pubtator	35678782	Associate	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	22697792, 28412963	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	34598322	Associate	★☆☆☆☆ Found in Text Mining only
Charcot-Marie-Tooth Disease	Charcot-Marie-Tooth Disease	BEFREE	29047041		★☆☆☆☆ Found in Text Mining only
Chronic Kidney Diseases	Kidney Disease	BEFREE	30917125		★☆☆☆☆ Found in Text Mining only
Chronic schizophrenia	Schizophrenia	BEFREE	25410542		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	29047041		★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	BEFREE	31272697		★☆☆☆☆ Found in Text Mining only
Dementia	Dementia	Pubtator	37177856	Associate	★☆☆☆☆ Found in Text Mining only
Depressive disorder	Mental Depression	BEFREE	30659167		★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	BEFREE	28502217, 30253317		★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	Pubtator	35678782	Associate	★☆☆☆☆ Found in Text Mining only
Epilepsy, Temporal Lobe	Epilepsy	BEFREE	30253317		★☆☆☆☆ Found in Text Mining only
Glaucoma Open Angle	Open angle glaucoma	Pubtator	34774858	Associate	★☆☆☆☆ Found in Text Mining only
Glaucoma, Primary Open Angle	Glaucoma	BEFREE	31323684		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	21813709	Associate	★☆☆☆☆ Found in Text Mining only
Gout	Gout	Pubtator	10066814	Associate	★☆☆☆☆ Found in Text Mining only
Hypertension	Hypertension	Pubtator	22032326	Associate	★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	21963515		★☆☆☆☆ Found in Text Mining only
Infarction, Middle Cerebral Artery	Cerebral Infraction	BEFREE	26861815		★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Intellectual developmental disorder	Pubtator	35678782	Associate	★☆☆☆☆ Found in Text Mining only
Intestinal Volvulus	Intestinal Volvulus	BEFREE	31046663		★☆☆☆☆ Found in Text Mining only
Ischemic stroke	Ischemic Stroke	BEFREE	26861815		★☆☆☆☆ Found in Text Mining only
Large cell carcinoma of lung	Lung Carcinoma	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
Leiomyoma	Leiomyoma	Pubtator	9806586	Associate	★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	BEFREE	30659167		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28087278, 29748739		★☆☆☆☆ Found in Text Mining only
Mental Depression	Mental Depression	BEFREE	30659167		★☆☆☆☆ Found in Text Mining only
Mental disorders	Mental Disorders	BEFREE	27806167		★☆☆☆☆ Found in Text Mining only
Mental Retardation	Mental retardation	BEFREE	1605216		★☆☆☆☆ Found in Text Mining only
Mental Retardation, X-Linked	Mental retardation	LHGDN	15194194		★☆☆☆☆ Found in Text Mining only
Mild cognitive disorder	Cognitive disorder	BEFREE	31272697		★☆☆☆☆ Found in Text Mining only
Myopia	Myopia	BEFREE	31323684		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	29748739, 31138587		★☆☆☆☆ Found in Text Mining only
Neurodevelopmental Disorders	Neurodevelopmental Disorders	BEFREE	27806167, 30564095		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neuropathy	Neuropathy	BEFREE	29047041		★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	Pubtator	35163434	Associate	★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	20819979, 28719030, 29054485, 30564095, 31447354		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	PSYGENET_DG	20819979		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Scleroderma	Scleroderma	BEFREE	29065190		★☆☆☆☆ Found in Text Mining only
Siderius X-linked mental retardation syndrome	Syndromic Mental Retardation, X-Linked	BEFREE	18498374		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of lung	Lung carcinoma	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
Systemic Scleroderma	Scleroderma	BEFREE	29065190		★☆☆☆☆ Found in Text Mining only
Taurodontism	Taurodontism	BEFREE	30391793		★☆☆☆☆ Found in Text Mining only
Testicular regression syndrome	Testicular regression syndrome	BEFREE	31447354		★☆☆☆☆ Found in Text Mining only
Unipolar Depression	Mental Depression	BEFREE	30659167		★☆☆☆☆ Found in Text Mining only