Gene Gene information from NCBI Gene database.
Entrez ID 6526
Gene name Solute carrier family 5 member 3
Gene symbol SLC5A3
Synonyms (NCBI Gene)
BCW2SMITSMIT1SMIT2
Chromosome 21
Chromosome location 21q22.11
miRNA miRNA information provided by mirtarbase database.
1241
miRTarBase ID miRNA Experiments Reference
MIRT018102 hsa-miR-335-5p Microarray 18185580
MIRT020185 hsa-miR-130b-3p Sequencing 20371350
MIRT022015 hsa-miR-128-3p Sequencing 20371350
MIRT028159 hsa-miR-93-5p Sequencing 20371350
MIRT029655 hsa-miR-26b-5p Sequencing 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
43
GO ID Ontology Definition Evidence Reference
GO:0005365 Function Myo-inositol transmembrane transporter activity ISS
GO:0005367 Function Myo-inositol:sodium symporter activity IDA 24595108
GO:0005367 Function Myo-inositol:sodium symporter activity ISS
GO:0005367 Function Myo-inositol:sodium symporter activity TAS 1372904
GO:0005412 Function D-glucose:sodium symporter activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600444 11038 ENSG00000198743
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P53794
Protein name Sodium/myo-inositol cotransporter (Na(+)/myo-inositol cotransporter) (Sodium/myo-inositol transporter 1) (SMIT1) (Solute carrier family 5 member 3)
Protein function Electrogenic Na(+)-coupled sugar symporter that actively transports myo-inositol and its stereoisomer scyllo-inositol across the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1 (By similarity). Maintains myo-inositol concentration g
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00474 SSF 39 477 Sodium:solute symporter family Family
Sequence
Sequence length 718
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
10
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BIPOLAR DISORDER CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR I DISORDER, MOST RECENT EPISODE MANIC Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA, RENAL CELL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHRONIC ISCHEMIC HEART DISEASE Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Alzheimer Disease Alzheimer disease Pubtator 34668150 Associate
★☆☆☆☆
Found in Text Mining only
Bipolar Disorder Bipolar Disorder CTD_human_DG 16420717
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Bipolar Disorder Bipolar disorder Pubtator 16420717 Stimulate
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Central Apnea Apnea BEFREE 18675571
★☆☆☆☆
Found in Text Mining only
Chromophobe Renal Cell Carcinoma Chromophobe Carcinoma CTD_human_DG 25401301
★☆☆☆☆
Found in Text Mining only
Collecting Duct Carcinoma of the Kidney Renal Carcinoma CTD_human_DG 25401301
★☆☆☆☆
Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma Renal Carcinoma CTD_human_DG 25401301
★☆☆☆☆
Found in Text Mining only
Depression, Bipolar Bipolar Disorder CTD_human_DG 16420717
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Dermatomyositis Dermatomyositis Pubtator 27322952 Associate
★☆☆☆☆
Found in Text Mining only
Diabetes Diabetes BEFREE 31166385
★☆☆☆☆
Found in Text Mining only