Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	65123
Gene name	Integrator complex subunit 3
Gene symbol	INTS3
Synonyms (NCBI Gene)	C1orf193C1orf60INT3SOSS-ASOSSA
Chromosome	1
Chromosome location	1q21.3
Summary	The protein encoded by this gene can form a complex with human single-strand DNA binding proteins 1 or 2 (hSSB1 and hSSB2) and other proteins to mediate genome stability and the DNA damage response. The encoded protein is also part of a multiprotein compl

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miRTarBase ID	miRNA	Experiments	Reference
MIRT050495	hsa-miR-20a-5p	CLASH	23622248
MIRT044546	hsa-miR-320a	CLASH	23622248
MIRT037633	hsa-miR-744-5p	CLASH	23622248
MIRT440445	hsa-miR-539-3p	HITS-CLIP	24374217
MIRT440444	hsa-miR-487a-3p	HITS-CLIP	24374217
MIRT440442	hsa-miR-485-3p	HITS-CLIP	24374217
MIRT440443	hsa-miR-544a	HITS-CLIP	24374217
MIRT440441	hsa-miR-412-3p	HITS-CLIP	24374217
MIRT440445	hsa-miR-539-3p	HITS-CLIP	24374217
MIRT440444	hsa-miR-487a-3p	HITS-CLIP	24374217
MIRT440442	hsa-miR-485-3p	HITS-CLIP	24374217
MIRT440443	hsa-miR-544a	HITS-CLIP	24374217
MIRT440441	hsa-miR-412-3p	HITS-CLIP	24374217
MIRT1068094	hsa-miR-1913	CLIP-seq
MIRT1068095	hsa-miR-3189-5p	CLIP-seq
MIRT1068096	hsa-miR-324-3p	CLIP-seq
MIRT1068097	hsa-miR-3688-5p	CLIP-seq
MIRT1068098	hsa-miR-4427	CLIP-seq
MIRT1068099	hsa-miR-4474-3p	CLIP-seq
MIRT1068100	hsa-miR-4642	CLIP-seq
MIRT1068101	hsa-miR-4680-3p	CLIP-seq
MIRT1068102	hsa-miR-4758-3p	CLIP-seq
MIRT2016551	hsa-miR-1292	CLIP-seq
MIRT2016552	hsa-miR-1294	CLIP-seq
MIRT2016553	hsa-miR-149	CLIP-seq
MIRT2016554	hsa-miR-21	CLIP-seq
MIRT2016555	hsa-miR-2110	CLIP-seq
MIRT2016556	hsa-miR-3064-5p	CLIP-seq
MIRT2016557	hsa-miR-3126-3p	CLIP-seq
MIRT2016558	hsa-miR-3150b-3p	CLIP-seq
MIRT2016559	hsa-miR-3157-5p	CLIP-seq
MIRT2016560	hsa-miR-3176	CLIP-seq
MIRT2016561	hsa-miR-3184	CLIP-seq
MIRT2016562	hsa-miR-3667-3p	CLIP-seq
MIRT2016563	hsa-miR-371-5p	CLIP-seq
MIRT2016564	hsa-miR-371b-5p	CLIP-seq
MIRT2016565	hsa-miR-3922-3p	CLIP-seq
MIRT2016566	hsa-miR-423-5p	CLIP-seq
MIRT2016567	hsa-miR-4268	CLIP-seq
MIRT2016568	hsa-miR-4271	CLIP-seq
MIRT2016569	hsa-miR-4302	CLIP-seq
MIRT2016570	hsa-miR-4316	CLIP-seq
MIRT2016571	hsa-miR-4435	CLIP-seq
MIRT2016572	hsa-miR-4471	CLIP-seq
MIRT2016573	hsa-miR-4519	CLIP-seq
MIRT2016574	hsa-miR-455-3p	CLIP-seq
MIRT2016575	hsa-miR-4646-5p	CLIP-seq
MIRT2016576	hsa-miR-4651	CLIP-seq
MIRT2016577	hsa-miR-4654	CLIP-seq
MIRT2016578	hsa-miR-4688	CLIP-seq
MIRT2016579	hsa-miR-4691-3p	CLIP-seq
MIRT2016580	hsa-miR-4725-3p	CLIP-seq
MIRT2016581	hsa-miR-4769-5p	CLIP-seq
MIRT2016582	hsa-miR-4784	CLIP-seq
MIRT2016583	hsa-miR-4787-5p	CLIP-seq
MIRT2016584	hsa-miR-4793-5p	CLIP-seq
MIRT2016585	hsa-miR-4794	CLIP-seq
MIRT2016586	hsa-miR-512-5p	CLIP-seq
MIRT2016587	hsa-miR-513c	CLIP-seq
MIRT2016588	hsa-miR-514b-5p	CLIP-seq
MIRT2016589	hsa-miR-590-5p	CLIP-seq
MIRT2016590	hsa-miR-603	CLIP-seq
MIRT2016591	hsa-miR-608	CLIP-seq
MIRT2016592	hsa-miR-616	CLIP-seq
MIRT2016551	hsa-miR-1292	CLIP-seq
MIRT1068094	hsa-miR-1913	CLIP-seq
MIRT2248757	hsa-miR-22	CLIP-seq
MIRT2016557	hsa-miR-3126-3p	CLIP-seq
MIRT2016560	hsa-miR-3176	CLIP-seq
MIRT1068096	hsa-miR-324-3p	CLIP-seq
MIRT2248758	hsa-miR-34c-3p	CLIP-seq
MIRT2016565	hsa-miR-3922-3p	CLIP-seq
MIRT2016571	hsa-miR-4435	CLIP-seq
MIRT2016572	hsa-miR-4471	CLIP-seq
MIRT2248759	hsa-miR-4494	CLIP-seq
MIRT2016573	hsa-miR-4519	CLIP-seq
MIRT2016575	hsa-miR-4646-5p	CLIP-seq
MIRT2248760	hsa-miR-4749-3p	CLIP-seq
MIRT2248761	hsa-miR-499a-5p	CLIP-seq
MIRT2016553	hsa-miR-149	CLIP-seq
MIRT2016556	hsa-miR-3064-5p	CLIP-seq
MIRT2248758	hsa-miR-34c-3p	CLIP-seq
MIRT2552370	hsa-miR-3920	CLIP-seq
MIRT2552371	hsa-miR-4436b-5p	CLIP-seq
MIRT2552372	hsa-miR-4527	CLIP-seq
MIRT2016575	hsa-miR-4646-5p	CLIP-seq
MIRT2552373	hsa-miR-4704-3p	CLIP-seq
MIRT2552374	hsa-miR-4733-5p	CLIP-seq
MIRT2016585	hsa-miR-4794	CLIP-seq
MIRT2552375	hsa-miR-4797-5p	CLIP-seq
MIRT2016553	hsa-miR-149	CLIP-seq
MIRT2016556	hsa-miR-3064-5p	CLIP-seq
MIRT2552370	hsa-miR-3920	CLIP-seq
MIRT2552371	hsa-miR-4436b-5p	CLIP-seq
MIRT2552372	hsa-miR-4527	CLIP-seq
MIRT2552373	hsa-miR-4704-3p	CLIP-seq
MIRT2552374	hsa-miR-4733-5p	CLIP-seq
MIRT2016585	hsa-miR-4794	CLIP-seq
MIRT2552375	hsa-miR-4797-5p	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000724	Process	Double-strand break repair via homologous recombination	IDA	19683501
GO:0005515	Function	Protein binding	IPI	16239144, 19683501, 25416956, 28506294, 33961781
GO:0005634	Component	Nucleus	IDA	29471365, 39032490
GO:0005634	Component	Nucleus	IDA	19683501, 23904267
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	32647223
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	23904267
GO:0005737	Component	Cytoplasm	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006281	Process	DNA repair	IMP	19605351, 19683501
GO:0006974	Process	DNA damage response	IEA
GO:0006974	Process	DNA damage response	IMP	19683501
GO:0010212	Process	Response to ionizing radiation	IMP	19605351, 19683501
GO:0016180	Process	SnRNA processing	IDA	16239144
GO:0016180	Process	SnRNA processing	NAS	16239144
GO:0032039	Component	Integrator complex	IDA	16239144, 29471365, 36920904, 39032490
GO:0032039	Component	Integrator complex	NAS	33548203
GO:0034243	Process	Regulation of transcription elongation by RNA polymerase II	NAS	32697989
GO:0035861	Component	Site of double-strand break	IDA	19683501
GO:0044818	Process	Mitotic G2/M transition checkpoint	IDA	19683501
GO:0044818	Process	Mitotic G2/M transition checkpoint	IMP	19683501
GO:0070876	Component	SOSS complex	IDA	18449195, 19683501
GO:0070876	Component	SOSS complex	IPI	19683501, 24630995
GO:0160232	Component	INTAC complex	IDA	34004147, 38570683
GO:0160240	Process	RNA polymerase II transcription initiation surveillance	IDA	34004147, 38570683

MIM	HGNC	e!Ensembl
611347	26153	ENSG00000143624

Q68E01

Protein name

Integrator complex subunit 3 (Int3) (SOSS complex subunit A) (Sensor of single-strand DNA complex subunit A) (SOSS-A) (Sensor of ssDNA subunit A)

Protein function

Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683). The integrator complex provides a quality checkpoint during transcri

PDB

4OWT , 4OWW , 4OWX , 6WLG , 7BV7 , 8HPP , 8RBZ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10189	Ints3	271 → 495	Integrator complex subunit 3	Family

Sequence

MELQKGKGAAAAAAASGAAGGGGGGAGAGAPGGGRLLLSTSLDAKDELEERLERCMSIVT
SMTAGVSEREANDALNAYVCKGLPQHEEICLGLFTLILTEPAQAQKCYRDLALVSRDGMN
IVLNKINQILMEKYLKLQDTCRTQLVWLVRELVKSGVLGADGVCMTFMKQIAGGGDVTAK
NIWLAESVLDILTEQREWVLKSSILIAMAVYTYLRLIVDHHGTAQLQALRQKEVDFCISL
LRERFMECLMIGRDLVRLLQNVARIPEFELLWKDIIHNPQALSPQFTGILQLLQSRTSRK
FLACRLTPDMETKLLFMTSRVRFGQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHP
SNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFYDWLFFSPDKDSIMNIEPAILVM
HHSMKPHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLAHLAPLFDNP
KLDKELRAMLREKFPEFCSSPSPPVEVKIEEPVSMEMDNHMSDKDESCYDNAEAAFSDDE
EDLNSKGKKREFRFHPIKETVVEEPVDITPYLDQLDESLRDKVLQLQKGSDTEAQCEVMQ
EIVDQVLEEDFDSEQLSVLASCLQELFKAHFRGEVLPEEITEESLEESVGKPLYLIFRNL
CQMQEDNSSFSLLLDLLSELYQKQPKIGYHLLYYLRASKAAAGKMNLYESFAQATQLGDL
HTCLMMDMKACQEDDVRLLCHLTPSIYTEFPDETLRSGELLNMIVAVIDSAQLQELVCHV
MMGNLVMFRKDSVLNILIQSLDWETFEQYCAWQLFLAHNIPLETIIPILQHLKYKEHPEA
LSCLLLQLRREKPSEEMVKMVLSRPCHPDDQFTTSILRHWCMKHDELLAEHIKSLLIKNN
SLPRKRQSLRSSSSKLAQLTLEQILEHLDNLRLNLTNTKQNFFSQTPILQALQHVQASCD
EAHKMKFSDLFSLAEEYEDSSTKPPKSRRKAALSSPRSRKNATQPPNAEEESGSSSASEE
EDTKPKPTKRKRKGSSAVGSDSD

Sequence length

1043

Interactions

View interactions

	Reactome
			RNA polymerase II transcribes snRNA genes

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
MULTIPLE MYELOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myoepithelial tumor	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Chromosomal Instability	Chromosomal instability	Pubtator	19605351	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Fibrodysplasia Ossificans Progressiva	Fibrodysplasia Ossificans Progressiva	BEFREE	23733509		★★★★★ ★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	14737070		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	18068530		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	17493263, 29057904, 8561865		★★★★★ ★☆☆☆☆ Found in Text Mining only
Primary Myelofibrosis	Myelofibrosis	BEFREE	23733509		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	BEFREE	25609707		★★★★★ ★☆☆☆☆ Found in Text Mining only

INTS3 (integrator complex subunit 3)