Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	65056
Gene name	GC-rich promoter binding protein 1
Gene symbol	GPBP1
Synonyms (NCBI Gene)	GPBPSSH6VASCULIN
Chromosome	5
Chromosome location	5q11.2
Summary	This gene was originally isolated by subtractive hybridization of cDNAs expressed in atherosclerotic plaques with a thrombus, and was found to be expressed only in vascular smooth muscle cells. However, a shorter splice variant was found to be more ubiqui

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Show/Hide all (242)

miRTarBase ID	miRNA	Experiments	Reference
MIRT050359	hsa-miR-25-3p	CLASH	23622248
MIRT044039	hsa-miR-365a-3p	CLASH	23622248
MIRT041884	hsa-miR-484	CLASH	23622248
MIRT720243	hsa-miR-216a-5p	HITS-CLIP	19536157
MIRT720242	hsa-miR-126-5p	HITS-CLIP	19536157
MIRT216197	hsa-miR-3646	HITS-CLIP	19536157
MIRT720241	hsa-miR-1252-3p	HITS-CLIP	19536157
MIRT720240	hsa-miR-6758-3p	HITS-CLIP	19536157
MIRT096759	hsa-miR-539-5p	HITS-CLIP	19536157
MIRT720239	hsa-miR-4477a	HITS-CLIP	19536157
MIRT720238	hsa-miR-579-3p	HITS-CLIP	19536157
MIRT720237	hsa-miR-664b-3p	HITS-CLIP	19536157
MIRT703192	hsa-miR-646	HITS-CLIP	23313552
MIRT703191	hsa-miR-4761-5p	HITS-CLIP	23313552
MIRT703190	hsa-miR-383-3p	HITS-CLIP	23313552
MIRT703189	hsa-miR-4660	HITS-CLIP	23313552
MIRT703188	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT703187	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT703186	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT703185	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT703184	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT703183	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT703182	hsa-miR-7977	HITS-CLIP	23313552
MIRT703181	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT703180	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT703179	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT703178	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT703177	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT703176	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT703175	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT703174	hsa-miR-3689c	HITS-CLIP	23313552
MIRT703173	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT703172	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT703171	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT703170	hsa-miR-3122	HITS-CLIP	23313552
MIRT703169	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT703168	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT703167	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT537106	hsa-miR-4311	PAR-CLIP	22012620
MIRT537105	hsa-miR-1276	PAR-CLIP	22012620
MIRT537104	hsa-miR-583	PAR-CLIP	22012620
MIRT537103	hsa-miR-4744	PAR-CLIP	22012620
MIRT537102	hsa-miR-1283	PAR-CLIP	22012620
MIRT537101	hsa-miR-584-5p	PAR-CLIP	22012620
MIRT720243	hsa-miR-216a-5p	HITS-CLIP	19536157
MIRT720242	hsa-miR-126-5p	HITS-CLIP	19536157
MIRT216197	hsa-miR-3646	HITS-CLIP	19536157
MIRT720241	hsa-miR-1252-3p	HITS-CLIP	19536157
MIRT720240	hsa-miR-6758-3p	HITS-CLIP	19536157
MIRT096759	hsa-miR-539-5p	HITS-CLIP	19536157
MIRT720239	hsa-miR-4477a	HITS-CLIP	19536157
MIRT720238	hsa-miR-579-3p	HITS-CLIP	19536157
MIRT720237	hsa-miR-664b-3p	HITS-CLIP	19536157
MIRT703192	hsa-miR-646	HITS-CLIP	23313552
MIRT703191	hsa-miR-4761-5p	HITS-CLIP	23313552
MIRT703190	hsa-miR-383-3p	HITS-CLIP	23313552
MIRT703189	hsa-miR-4660	HITS-CLIP	23313552
MIRT703188	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT703187	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT703186	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT703185	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT703184	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT703183	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT703182	hsa-miR-7977	HITS-CLIP	23313552
MIRT703181	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT703180	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT703179	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT703178	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT703177	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT703176	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT703175	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT703174	hsa-miR-3689c	HITS-CLIP	23313552
MIRT703173	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT703172	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT703171	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT703170	hsa-miR-3122	HITS-CLIP	23313552
MIRT703169	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT703168	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT703167	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT537106	hsa-miR-4311	PAR-CLIP	22012620
MIRT537105	hsa-miR-1276	PAR-CLIP	22012620
MIRT537104	hsa-miR-583	PAR-CLIP	22012620
MIRT537103	hsa-miR-4744	PAR-CLIP	22012620
MIRT537102	hsa-miR-1283	PAR-CLIP	22012620
MIRT537101	hsa-miR-584-5p	PAR-CLIP	22012620
MIRT1028451	hsa-miR-145	CLIP-seq
MIRT1028452	hsa-miR-181a	CLIP-seq
MIRT1028453	hsa-miR-181b	CLIP-seq
MIRT1028454	hsa-miR-181c	CLIP-seq
MIRT1028455	hsa-miR-181d	CLIP-seq
MIRT1028456	hsa-miR-2054	CLIP-seq
MIRT1028457	hsa-miR-3173-3p	CLIP-seq
MIRT1028458	hsa-miR-3185	CLIP-seq
MIRT1028459	hsa-miR-3619-3p	CLIP-seq
MIRT1028460	hsa-miR-3685	CLIP-seq
MIRT1028461	hsa-miR-3691-3p	CLIP-seq
MIRT1028462	hsa-miR-383	CLIP-seq
MIRT1028463	hsa-miR-3925-3p	CLIP-seq
MIRT1028464	hsa-miR-409-3p	CLIP-seq
MIRT1028465	hsa-miR-4262	CLIP-seq
MIRT1028466	hsa-miR-4264	CLIP-seq
MIRT1028467	hsa-miR-4302	CLIP-seq
MIRT1028468	hsa-miR-4328	CLIP-seq
MIRT1028469	hsa-miR-4428	CLIP-seq
MIRT1028470	hsa-miR-4520a-5p	CLIP-seq
MIRT1028471	hsa-miR-4520b-5p	CLIP-seq
MIRT1028472	hsa-miR-4535	CLIP-seq
MIRT1028473	hsa-miR-4662a-5p	CLIP-seq
MIRT1028474	hsa-miR-4697-3p	CLIP-seq
MIRT1028475	hsa-miR-4698	CLIP-seq
MIRT1028476	hsa-miR-4729	CLIP-seq
MIRT1028477	hsa-miR-4772-5p	CLIP-seq
MIRT1028478	hsa-miR-4776-5p	CLIP-seq
MIRT1028479	hsa-miR-4781-3p	CLIP-seq
MIRT1028480	hsa-miR-4797-3p	CLIP-seq
MIRT1028481	hsa-miR-543	CLIP-seq
MIRT1028482	hsa-miR-544	CLIP-seq
MIRT1028483	hsa-miR-579	CLIP-seq
MIRT1028484	hsa-miR-587	CLIP-seq
MIRT1028485	hsa-miR-622	CLIP-seq
MIRT1028486	hsa-miR-664	CLIP-seq
MIRT1028487	hsa-miR-138	CLIP-seq
MIRT1028488	hsa-miR-19a	CLIP-seq
MIRT1028489	hsa-miR-19b	CLIP-seq
MIRT1028490	hsa-miR-221	CLIP-seq
MIRT1028491	hsa-miR-222	CLIP-seq
MIRT1028492	hsa-miR-23a	CLIP-seq
MIRT1028493	hsa-miR-23b	CLIP-seq
MIRT1028494	hsa-miR-23c	CLIP-seq
MIRT1028495	hsa-miR-3647-3p	CLIP-seq
MIRT1028466	hsa-miR-4264	CLIP-seq
MIRT1028496	hsa-miR-4424	CLIP-seq
MIRT1028497	hsa-miR-4490	CLIP-seq
MIRT1028498	hsa-miR-4694-3p	CLIP-seq
MIRT1028480	hsa-miR-4797-3p	CLIP-seq
MIRT1028499	hsa-miR-522	CLIP-seq
MIRT1028500	hsa-miR-548v	CLIP-seq
MIRT1028483	hsa-miR-579	CLIP-seq
MIRT1028485	hsa-miR-622	CLIP-seq
MIRT1028501	hsa-miR-659	CLIP-seq
MIRT2005089	hsa-miR-1292	CLIP-seq
MIRT1028451	hsa-miR-145	CLIP-seq
MIRT1028490	hsa-miR-221	CLIP-seq
MIRT1028491	hsa-miR-222	CLIP-seq
MIRT1028492	hsa-miR-23a	CLIP-seq
MIRT1028493	hsa-miR-23b	CLIP-seq
MIRT1028494	hsa-miR-23c	CLIP-seq
MIRT2005090	hsa-miR-3919	CLIP-seq
MIRT1028463	hsa-miR-3925-3p	CLIP-seq
MIRT1028464	hsa-miR-409-3p	CLIP-seq
MIRT2005091	hsa-miR-4256	CLIP-seq
MIRT1028466	hsa-miR-4264	CLIP-seq
MIRT1028468	hsa-miR-4328	CLIP-seq
MIRT2005092	hsa-miR-4422	CLIP-seq
MIRT2005093	hsa-miR-4471	CLIP-seq
MIRT1028473	hsa-miR-4662a-5p	CLIP-seq
MIRT2005094	hsa-miR-4668-3p	CLIP-seq
MIRT2005095	hsa-miR-4756-3p	CLIP-seq
MIRT1028480	hsa-miR-4797-3p	CLIP-seq
MIRT2005096	hsa-miR-520d-5p	CLIP-seq
MIRT2005097	hsa-miR-524-5p	CLIP-seq
MIRT2005098	hsa-miR-539	CLIP-seq
MIRT1028481	hsa-miR-543	CLIP-seq
MIRT1028500	hsa-miR-548v	CLIP-seq
MIRT2005099	hsa-miR-576-5p	CLIP-seq
MIRT1028483	hsa-miR-579	CLIP-seq
MIRT1028485	hsa-miR-622	CLIP-seq
MIRT2005100	hsa-miR-873	CLIP-seq
MIRT2237780	hsa-miR-1279	CLIP-seq
MIRT1028451	hsa-miR-145	CLIP-seq
MIRT1028452	hsa-miR-181a	CLIP-seq
MIRT1028453	hsa-miR-181b	CLIP-seq
MIRT1028454	hsa-miR-181c	CLIP-seq
MIRT1028455	hsa-miR-181d	CLIP-seq
MIRT1028490	hsa-miR-221	CLIP-seq
MIRT1028491	hsa-miR-222	CLIP-seq
MIRT1028492	hsa-miR-23a	CLIP-seq
MIRT1028493	hsa-miR-23b	CLIP-seq
MIRT1028494	hsa-miR-23c	CLIP-seq
MIRT2237781	hsa-miR-3168	CLIP-seq
MIRT1028458	hsa-miR-3185	CLIP-seq
MIRT1028495	hsa-miR-3647-3p	CLIP-seq
MIRT2005090	hsa-miR-3919	CLIP-seq
MIRT1028463	hsa-miR-3925-3p	CLIP-seq
MIRT1028464	hsa-miR-409-3p	CLIP-seq
MIRT1028465	hsa-miR-4262	CLIP-seq
MIRT1028468	hsa-miR-4328	CLIP-seq
MIRT2237782	hsa-miR-4659a-3p	CLIP-seq
MIRT2237783	hsa-miR-4659b-3p	CLIP-seq
MIRT1028473	hsa-miR-4662a-5p	CLIP-seq
MIRT2237784	hsa-miR-4684-3p	CLIP-seq
MIRT1028476	hsa-miR-4729	CLIP-seq
MIRT2005095	hsa-miR-4756-3p	CLIP-seq
MIRT2005098	hsa-miR-539	CLIP-seq
MIRT1028481	hsa-miR-543	CLIP-seq
MIRT1028500	hsa-miR-548v	CLIP-seq
MIRT1028483	hsa-miR-579	CLIP-seq
MIRT1028486	hsa-miR-664	CLIP-seq
MIRT2005100	hsa-miR-873	CLIP-seq
MIRT2388599	hsa-miR-130a	CLIP-seq
MIRT2388600	hsa-miR-130b	CLIP-seq
MIRT2388601	hsa-miR-301a	CLIP-seq
MIRT2388602	hsa-miR-301b	CLIP-seq
MIRT2388603	hsa-miR-3591-5p	CLIP-seq
MIRT2388604	hsa-miR-3666	CLIP-seq
MIRT1028466	hsa-miR-4264	CLIP-seq
MIRT2388605	hsa-miR-4295	CLIP-seq
MIRT2388606	hsa-miR-4473	CLIP-seq
MIRT2388607	hsa-miR-454	CLIP-seq
MIRT2388608	hsa-miR-4671-3p	CLIP-seq
MIRT1028480	hsa-miR-4797-3p	CLIP-seq
MIRT1028485	hsa-miR-622	CLIP-seq
MIRT2005100	hsa-miR-873	CLIP-seq
MIRT1028451	hsa-miR-145	CLIP-seq
MIRT1028490	hsa-miR-221	CLIP-seq
MIRT1028491	hsa-miR-222	CLIP-seq
MIRT1028463	hsa-miR-3925-3p	CLIP-seq
MIRT1028468	hsa-miR-4328	CLIP-seq
MIRT1028473	hsa-miR-4662a-5p	CLIP-seq
MIRT1028500	hsa-miR-548v	CLIP-seq
MIRT1028451	hsa-miR-145	CLIP-seq
MIRT1028490	hsa-miR-221	CLIP-seq
MIRT1028491	hsa-miR-222	CLIP-seq
MIRT2541806	hsa-miR-3140-3p	CLIP-seq
MIRT2541807	hsa-miR-320a	CLIP-seq
MIRT2541808	hsa-miR-320b	CLIP-seq
MIRT2541809	hsa-miR-320c	CLIP-seq
MIRT2541810	hsa-miR-320d	CLIP-seq
MIRT1028495	hsa-miR-3647-3p	CLIP-seq
MIRT1028463	hsa-miR-3925-3p	CLIP-seq
MIRT1028468	hsa-miR-4328	CLIP-seq
MIRT2541811	hsa-miR-4429	CLIP-seq
MIRT1028473	hsa-miR-4662a-5p	CLIP-seq
MIRT1028500	hsa-miR-548v	CLIP-seq
MIRT2541812	hsa-miR-549	CLIP-seq
MIRT1028451	hsa-miR-145	CLIP-seq
MIRT1028490	hsa-miR-221	CLIP-seq
MIRT1028491	hsa-miR-222	CLIP-seq
MIRT1028463	hsa-miR-3925-3p	CLIP-seq
MIRT1028468	hsa-miR-4328	CLIP-seq
MIRT1028473	hsa-miR-4662a-5p	CLIP-seq
MIRT1028500	hsa-miR-548v	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	19060904, 25416956, 29433439, 29892012, 31515488, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0006351	Process	DNA-templated transcription	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IBA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA

MIM	HGNC	e!Ensembl
608412	29520	ENSG00000062194

Q86WP2

Protein name

Vasculin (GC-rich promoter-binding protein 1) (Vascular wall-linked protein)

Protein function

Functions as a GC-rich promoter-specific transactivating transcription factor.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15337	Vasculin	375 → 471	Vascular protein family Vasculin-like 1	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Some isoforms may be specifically expressed in veins and arteries (at protein level). Isoform 4 is widely expressed. Isoform 1, isoform 2 and isoform 3 may be specifically expressed in vascular smooth muscle cells. {E

Sequence

MAQHDFAPAWLNFPTPPSSTKSSLNFEKHSENFAWTENRYDVNRRRHNSSDGFDSAIGRP
NGGNFGRKEKNGWRTHGRNGTENINHRGGYHGGSSRSRSSIFHAGKSQGLHENNIPDNET
GRKEDKRERKQFEAEDFPSLNPEYEREPNHNKSLAAGVWEYPPNPKSRAPRMLVIKKGNT
KDLQLSGFPVVGNLPSQPVKNGTGPSVYKGLVPKPAAPPTKPTQWKSQTKENKVGTSFPH
ESTFGVGNFNAFKSTAKNFSPSTNSVKECNRSNSSSPVDKLNQQPRLTKLTRMRTDKKSE
FLKALKRDRVEEEHEDESRAGSEKDDDSFNLHNSNSTHQERDINRNFDENEIPQENGNAS
VISQQIIRSSTFPQTDVLSSSLEAEHRLLKEMGWQEDSENDETCAPLTEDEMREFQVISE
QLQKNGLRKNGILKNGLICDFKFGPWKNSTFKPTTENDDTETSSSDTSDDDDV

Sequence length

473

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IDIOPATHIC OSTEONECROSIS OF THE FEMORAL HEAD	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
POSTERIOR CORTICAL ATROPHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Diabetes Mellitus	Diabetes mellitus	Pubtator	8363571	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Insulin Resistance	Diabetes mellitus, type 2	Pubtator	8363571	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

GPBP1 (GC-rich promoter binding protein 1)