Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	65005
Gene name	Mitochondrial ribosomal protein L9
Gene symbol	MRPL9
Synonyms (NCBI Gene)	L9mtbL9m
Chromosome	1
Chromosome location	1q21.3
Summary	This is a nuclear gene encoding a protein component of the 39S subunit of the mitochondrial ribosome. Alternative splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8. [provided by RefSeq, Jul 2014]

146

Show/Hide all (146)

miRTarBase ID	miRNA	Experiments	Reference
MIRT049094	hsa-miR-92a-3p	CLASH	23622248
MIRT044662	hsa-miR-320a	CLASH	23622248
MIRT456255	hsa-miR-3654	PAR-CLIP	23592263
MIRT456254	hsa-miR-1243	PAR-CLIP	23592263
MIRT456253	hsa-miR-1278	PAR-CLIP	23592263
MIRT456252	hsa-miR-1272	PAR-CLIP	23592263
MIRT456251	hsa-miR-4328	PAR-CLIP	23592263
MIRT456250	hsa-miR-1827	PAR-CLIP	23592263
MIRT456249	hsa-miR-139-3p	PAR-CLIP	23592263
MIRT456248	hsa-miR-6744-5p	PAR-CLIP	23592263
MIRT456247	hsa-miR-1255a	PAR-CLIP	23592263
MIRT456246	hsa-miR-1255b-5p	PAR-CLIP	23592263
MIRT456245	hsa-miR-580-3p	PAR-CLIP	23592263
MIRT456244	hsa-miR-5004-3p	PAR-CLIP	23592263
MIRT456255	hsa-miR-3654	PAR-CLIP	23592263
MIRT456254	hsa-miR-1243	PAR-CLIP	23592263
MIRT456253	hsa-miR-1278	PAR-CLIP	23592263
MIRT456252	hsa-miR-1272	PAR-CLIP	23592263
MIRT456251	hsa-miR-4328	PAR-CLIP	23592263
MIRT456250	hsa-miR-1827	PAR-CLIP	23592263
MIRT456249	hsa-miR-139-3p	PAR-CLIP	23592263
MIRT456248	hsa-miR-6744-5p	PAR-CLIP	23592263
MIRT456247	hsa-miR-1255a	PAR-CLIP	23592263
MIRT456246	hsa-miR-1255b-5p	PAR-CLIP	23592263
MIRT456245	hsa-miR-580-3p	PAR-CLIP	23592263
MIRT456244	hsa-miR-5004-3p	PAR-CLIP	23592263
MIRT1159608	hsa-miR-1245b-3p	CLIP-seq
MIRT1159609	hsa-miR-1255b	CLIP-seq
MIRT1159610	hsa-miR-1299	CLIP-seq
MIRT1159611	hsa-miR-133a	CLIP-seq
MIRT1159612	hsa-miR-133b	CLIP-seq
MIRT1159613	hsa-miR-139-5p	CLIP-seq
MIRT1159614	hsa-miR-148a	CLIP-seq
MIRT1159615	hsa-miR-148b	CLIP-seq
MIRT1159616	hsa-miR-149	CLIP-seq
MIRT1159617	hsa-miR-152	CLIP-seq
MIRT1159618	hsa-miR-1976	CLIP-seq
MIRT1159619	hsa-miR-21	CLIP-seq
MIRT1159620	hsa-miR-2117	CLIP-seq
MIRT1159621	hsa-miR-217	CLIP-seq
MIRT1159622	hsa-miR-2355-3p	CLIP-seq
MIRT1159623	hsa-miR-2964a-5p	CLIP-seq
MIRT1159624	hsa-miR-3145-5p	CLIP-seq
MIRT1159625	hsa-miR-3185	CLIP-seq
MIRT1159626	hsa-miR-3192	CLIP-seq
MIRT1159627	hsa-miR-3652	CLIP-seq
MIRT1159628	hsa-miR-3682-5p	CLIP-seq
MIRT1159629	hsa-miR-3686	CLIP-seq
MIRT1159630	hsa-miR-3942-3p	CLIP-seq
MIRT1159631	hsa-miR-4273	CLIP-seq
MIRT1159632	hsa-miR-4282	CLIP-seq
MIRT1159633	hsa-miR-4327	CLIP-seq
MIRT1159634	hsa-miR-4418	CLIP-seq
MIRT1159635	hsa-miR-4430	CLIP-seq
MIRT1159636	hsa-miR-4487	CLIP-seq
MIRT1159637	hsa-miR-4502	CLIP-seq
MIRT1159638	hsa-miR-4505	CLIP-seq
MIRT1159639	hsa-miR-450b-3p	CLIP-seq
MIRT1159640	hsa-miR-4646-3p	CLIP-seq
MIRT1159641	hsa-miR-4684-5p	CLIP-seq
MIRT1159642	hsa-miR-4700-3p	CLIP-seq
MIRT1159643	hsa-miR-4742-3p	CLIP-seq
MIRT1159644	hsa-miR-4753-3p	CLIP-seq
MIRT1159645	hsa-miR-4762-5p	CLIP-seq
MIRT1159646	hsa-miR-4772-5p	CLIP-seq
MIRT1159647	hsa-miR-4778-5p	CLIP-seq
MIRT1159648	hsa-miR-4782-5p	CLIP-seq
MIRT1159649	hsa-miR-4802-5p	CLIP-seq
MIRT1159650	hsa-miR-509-3-5p	CLIP-seq
MIRT1159651	hsa-miR-509-5p	CLIP-seq
MIRT1159652	hsa-miR-516b	CLIP-seq
MIRT1159653	hsa-miR-544	CLIP-seq
MIRT1159654	hsa-miR-590-5p	CLIP-seq
MIRT1159655	hsa-miR-622	CLIP-seq
MIRT1159656	hsa-miR-636	CLIP-seq
MIRT1159657	hsa-miR-760	CLIP-seq
MIRT1159658	hsa-miR-765	CLIP-seq
MIRT1159659	hsa-miR-769-3p	CLIP-seq
MIRT1159660	hsa-miR-875-3p	CLIP-seq
MIRT1159661	hsa-miR-934	CLIP-seq
MIRT1159608	hsa-miR-1245b-3p	CLIP-seq
MIRT1159611	hsa-miR-133a	CLIP-seq
MIRT1159612	hsa-miR-133b	CLIP-seq
MIRT1159620	hsa-miR-2117	CLIP-seq
MIRT1159626	hsa-miR-3192	CLIP-seq
MIRT1159629	hsa-miR-3686	CLIP-seq
MIRT1159631	hsa-miR-4273	CLIP-seq
MIRT1159632	hsa-miR-4282	CLIP-seq
MIRT1159633	hsa-miR-4327	CLIP-seq
MIRT1159636	hsa-miR-4487	CLIP-seq
MIRT1159641	hsa-miR-4684-5p	CLIP-seq
MIRT1159643	hsa-miR-4742-3p	CLIP-seq
MIRT1159644	hsa-miR-4753-3p	CLIP-seq
MIRT1159646	hsa-miR-4772-5p	CLIP-seq
MIRT1159647	hsa-miR-4778-5p	CLIP-seq
MIRT1159653	hsa-miR-544	CLIP-seq
MIRT1159656	hsa-miR-636	CLIP-seq
MIRT1159608	hsa-miR-1245b-3p	CLIP-seq
MIRT1159611	hsa-miR-133a	CLIP-seq
MIRT1159612	hsa-miR-133b	CLIP-seq
MIRT1159614	hsa-miR-148a	CLIP-seq
MIRT1159615	hsa-miR-148b	CLIP-seq
MIRT1159617	hsa-miR-152	CLIP-seq
MIRT1159620	hsa-miR-2117	CLIP-seq
MIRT1159623	hsa-miR-2964a-5p	CLIP-seq
MIRT1159625	hsa-miR-3185	CLIP-seq
MIRT2573775	hsa-miR-3646	CLIP-seq
MIRT2573776	hsa-miR-3662	CLIP-seq
MIRT1159629	hsa-miR-3686	CLIP-seq
MIRT1159630	hsa-miR-3942-3p	CLIP-seq
MIRT2573777	hsa-miR-421	CLIP-seq
MIRT2573778	hsa-miR-4272	CLIP-seq
MIRT1159631	hsa-miR-4273	CLIP-seq
MIRT1159632	hsa-miR-4282	CLIP-seq
MIRT2573779	hsa-miR-4426	CLIP-seq
MIRT2573780	hsa-miR-4470	CLIP-seq
MIRT1159636	hsa-miR-4487	CLIP-seq
MIRT1159637	hsa-miR-4502	CLIP-seq
MIRT2573781	hsa-miR-4645-3p	CLIP-seq
MIRT2573782	hsa-miR-4647	CLIP-seq
MIRT2573783	hsa-miR-4662b	CLIP-seq
MIRT1159641	hsa-miR-4684-5p	CLIP-seq
MIRT1159643	hsa-miR-4742-3p	CLIP-seq
MIRT1159647	hsa-miR-4778-5p	CLIP-seq
MIRT1159655	hsa-miR-622	CLIP-seq
MIRT1159608	hsa-miR-1245b-3p	CLIP-seq
MIRT1159614	hsa-miR-148a	CLIP-seq
MIRT1159615	hsa-miR-148b	CLIP-seq
MIRT1159617	hsa-miR-152	CLIP-seq
MIRT1159620	hsa-miR-2117	CLIP-seq
MIRT1159623	hsa-miR-2964a-5p	CLIP-seq
MIRT1159625	hsa-miR-3185	CLIP-seq
MIRT2573775	hsa-miR-3646	CLIP-seq
MIRT2573776	hsa-miR-3662	CLIP-seq
MIRT1159630	hsa-miR-3942-3p	CLIP-seq
MIRT2573777	hsa-miR-421	CLIP-seq
MIRT2573778	hsa-miR-4272	CLIP-seq
MIRT1159631	hsa-miR-4273	CLIP-seq
MIRT2573779	hsa-miR-4426	CLIP-seq
MIRT2573780	hsa-miR-4470	CLIP-seq
MIRT1159637	hsa-miR-4502	CLIP-seq
MIRT2573781	hsa-miR-4645-3p	CLIP-seq
MIRT2573782	hsa-miR-4647	CLIP-seq
MIRT2573783	hsa-miR-4662b	CLIP-seq
MIRT1159641	hsa-miR-4684-5p	CLIP-seq
MIRT1159655	hsa-miR-622	CLIP-seq

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	NAS	11543634
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	28892042
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	NAS	27023846
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0005761	Component	Mitochondrial ribosome	NAS	11543634
GO:0005762	Component	Mitochondrial large ribosomal subunit	IDA	25278503, 28892042
GO:0005762	Component	Mitochondrial large ribosomal subunit	NAS	25278503
GO:0005840	Component	Ribosome	IEA
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	11543634
GO:0032543	Process	Mitochondrial translation	NAS	27023846
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
611824	14277	ENSG00000143436

Q9BYD2

Protein name

Large ribosomal subunit protein bL9m (39S ribosomal protein L9, mitochondrial) (L9mt) (MRP-L9)

PDB

3J7Y , 3J9M , 5OOL , 5OOM , 6I9R , 6NU2 , 6NU3 , 6VLZ , 6VMI , 6ZM5 , 6ZM6 , 6ZS9 , 6ZSA , 6ZSB , 6ZSC , 6ZSD , 6ZSE , 6ZSG , 7A5F , 7A5G , 7A5H , 7A5I , 7A5J , 7A5K , 7L08 , 7L20 , 7O9K , 7O9M , 7ODR , 7ODS , 7ODT , 7OF0 , 7OF2 , 7OF3 , 7OF4 , 7OF5 , 7OF6 , 7OF7 , 7OG4 , 7OI6 , 7OI7 , 7OI8 , 7OI9 , 7OIA , 7OIB , 7OIC , 7OID , 7OIE , 7PD3 , 7PO4 , 7QH6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01281	Ribosomal_L9_N	94 → 140	Ribosomal protein L9, N-terminal domain	Domain

Sequence

MAAPVVTAPGRALLRAGAGRLLRGGVQELLRPRHEGNAPDLACNFSLSQNRGTVIVERWW
KVPLAGEGRKPRLHRRHRVYKLVEDTKHRPKENLELILTQSVENVGVRGDLVSVKKSLGR
NRLLPQGLAVYASPENKKLFEEEKLLRQEGKLEKIQTKAGEATVKFLKSCRLEVGMKNNV
KWELNPEIVARHFFKNLGVVVAPHTLKLPEEPITRWGEYWCEVTVNGLDTVRVPMSVVNF
EKPKTKRYKYWLAQQAAKAMAPTSPQI

Sequence length

267

Interactions

View interactions

	KEGG		Reactome
	Ribosome		Mitochondrial translation elongation Mitochondrial translation termination

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BREAST NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Carcinoma	Breast Carcinoma	CTD_human_DG	21466612		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	31759986	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	34603786	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	CTD_human_DG	21466612		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Carcinoma, Human	Marfan Syndrome	CTD_human_DG	21466612		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	CTD_human_DG	21466612		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms, Human	Mammary Neoplasms	CTD_human_DG	21466612		★★★★★ ★☆☆☆☆ Found in Text Mining only

MRPL9 (mitochondrial ribosomal protein L9)