Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	64979
Gene name	Mitochondrial ribosomal protein L36
Gene symbol	MRPL36
Synonyms (NCBI Gene)	BRIP1L36mtMRP-L36PRPL36RPMJbL36m
Chromosome	5
Chromosome location	5p15.33
Summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% prot

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Show/Hide all (180)

miRTarBase ID	miRNA	Experiments	Reference
MIRT039474	hsa-miR-652-3p	CLASH	23622248
MIRT629977	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT629976	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT629975	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT629974	hsa-miR-4532	HITS-CLIP	23824327
MIRT629973	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT629972	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT629971	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT629970	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT629969	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT629968	hsa-miR-6722-5p	HITS-CLIP	23824327
MIRT629967	hsa-miR-4284	HITS-CLIP	23824327
MIRT629977	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT629976	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT629975	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT629974	hsa-miR-4532	HITS-CLIP	23824327
MIRT629973	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT629972	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT629971	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT629970	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT629969	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT629968	hsa-miR-6722-5p	HITS-CLIP	23824327
MIRT629967	hsa-miR-4284	HITS-CLIP	23824327
MIRT561140	hsa-miR-583	PAR-CLIP	20371350
MIRT561139	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT561138	hsa-miR-32-3p	PAR-CLIP	20371350
MIRT561137	hsa-miR-142-5p	PAR-CLIP	20371350
MIRT561136	hsa-miR-5590-3p	PAR-CLIP	20371350
MIRT564385	hsa-miR-6861-5p	PAR-CLIP	20371350
MIRT564384	hsa-miR-555	PAR-CLIP	20371350
MIRT561135	hsa-miR-340-5p	PAR-CLIP	20371350
MIRT561140	hsa-miR-583	PAR-CLIP	20371350
MIRT561139	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT561138	hsa-miR-32-3p	PAR-CLIP	20371350
MIRT561137	hsa-miR-142-5p	PAR-CLIP	20371350
MIRT561136	hsa-miR-5590-3p	PAR-CLIP	20371350
MIRT561135	hsa-miR-340-5p	PAR-CLIP	20371350
MIRT532060	hsa-miR-4803	PAR-CLIP	22012620
MIRT532059	hsa-miR-4797-5p	PAR-CLIP	22012620
MIRT532058	hsa-miR-3143	PAR-CLIP	22012620
MIRT532057	hsa-miR-302c-5p	PAR-CLIP	22012620
MIRT447783	hsa-miR-3654	PAR-CLIP	22100165
MIRT447782	hsa-miR-1243	PAR-CLIP	22100165
MIRT447781	hsa-miR-875-3p	PAR-CLIP	22100165
MIRT447780	hsa-miR-5093	PAR-CLIP	22100165
MIRT629977	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT629976	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT629975	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT629974	hsa-miR-4532	HITS-CLIP	23824327
MIRT629973	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT629972	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT629971	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT629970	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT629969	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT629968	hsa-miR-6722-5p	HITS-CLIP	23824327
MIRT629967	hsa-miR-4284	HITS-CLIP	23824327
MIRT629977	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT629976	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT629975	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT629974	hsa-miR-4532	HITS-CLIP	23824327
MIRT629973	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT629972	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT629971	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT629970	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT629969	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT629968	hsa-miR-6722-5p	HITS-CLIP	23824327
MIRT629967	hsa-miR-4284	HITS-CLIP	23824327
MIRT561140	hsa-miR-583	PAR-CLIP	20371350
MIRT561139	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT561138	hsa-miR-32-3p	PAR-CLIP	20371350
MIRT561137	hsa-miR-142-5p	PAR-CLIP	20371350
MIRT561136	hsa-miR-5590-3p	PAR-CLIP	20371350
MIRT564385	hsa-miR-6861-5p	PAR-CLIP	20371350
MIRT564384	hsa-miR-555	PAR-CLIP	20371350
MIRT561135	hsa-miR-340-5p	PAR-CLIP	20371350
MIRT561140	hsa-miR-583	PAR-CLIP	20371350
MIRT561139	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT561138	hsa-miR-32-3p	PAR-CLIP	20371350
MIRT561137	hsa-miR-142-5p	PAR-CLIP	20371350
MIRT561136	hsa-miR-5590-3p	PAR-CLIP	20371350
MIRT561135	hsa-miR-340-5p	PAR-CLIP	20371350
MIRT532060	hsa-miR-4803	PAR-CLIP	22012620
MIRT532059	hsa-miR-4797-5p	PAR-CLIP	22012620
MIRT532058	hsa-miR-3143	PAR-CLIP	22012620
MIRT532057	hsa-miR-302c-5p	PAR-CLIP	22012620
MIRT447783	hsa-miR-3654	PAR-CLIP	22100165
MIRT447782	hsa-miR-1243	PAR-CLIP	22100165
MIRT447781	hsa-miR-875-3p	PAR-CLIP	22100165
MIRT447780	hsa-miR-5093	PAR-CLIP	22100165
MIRT1159246	hsa-miR-150	CLIP-seq
MIRT1159247	hsa-miR-210	CLIP-seq
MIRT1159248	hsa-miR-3153	CLIP-seq
MIRT1159249	hsa-miR-331-3p	CLIP-seq
MIRT1159250	hsa-miR-345	CLIP-seq
MIRT1159251	hsa-miR-3679-3p	CLIP-seq
MIRT1159252	hsa-miR-3689a-5p	CLIP-seq
MIRT1159253	hsa-miR-3689b	CLIP-seq
MIRT1159254	hsa-miR-3689e	CLIP-seq
MIRT1159255	hsa-miR-3689f	CLIP-seq
MIRT1159256	hsa-miR-3912	CLIP-seq
MIRT1159257	hsa-miR-3978	CLIP-seq
MIRT1159258	hsa-miR-4259	CLIP-seq
MIRT1159259	hsa-miR-4307	CLIP-seq
MIRT1159260	hsa-miR-4522	CLIP-seq
MIRT1159261	hsa-miR-455-5p	CLIP-seq
MIRT1159262	hsa-miR-4662a-3p	CLIP-seq
MIRT1159263	hsa-miR-4704-3p	CLIP-seq
MIRT1159264	hsa-miR-4713-5p	CLIP-seq
MIRT1159265	hsa-miR-4715-5p	CLIP-seq
MIRT1159266	hsa-miR-4732-3p	CLIP-seq
MIRT1159267	hsa-miR-516b	CLIP-seq
MIRT1159268	hsa-miR-532-3p	CLIP-seq
MIRT1159269	hsa-miR-587	CLIP-seq
MIRT1159246	hsa-miR-150	CLIP-seq
MIRT2045662	hsa-miR-3667-3p	CLIP-seq
MIRT1159252	hsa-miR-3689a-5p	CLIP-seq
MIRT1159253	hsa-miR-3689b	CLIP-seq
MIRT1159254	hsa-miR-3689e	CLIP-seq
MIRT1159255	hsa-miR-3689f	CLIP-seq
MIRT1159261	hsa-miR-455-5p	CLIP-seq
MIRT1159262	hsa-miR-4662a-3p	CLIP-seq
MIRT1159264	hsa-miR-4713-5p	CLIP-seq
MIRT1159268	hsa-miR-532-3p	CLIP-seq
MIRT1159269	hsa-miR-587	CLIP-seq
MIRT1159246	hsa-miR-150	CLIP-seq
MIRT2045662	hsa-miR-3667-3p	CLIP-seq
MIRT1159260	hsa-miR-4522	CLIP-seq
MIRT1159261	hsa-miR-455-5p	CLIP-seq
MIRT1159262	hsa-miR-4662a-3p	CLIP-seq
MIRT1159264	hsa-miR-4713-5p	CLIP-seq
MIRT1159268	hsa-miR-532-3p	CLIP-seq
MIRT1159269	hsa-miR-587	CLIP-seq
MIRT2573542	hsa-miR-1282	CLIP-seq
MIRT2573543	hsa-miR-1296	CLIP-seq
MIRT2573544	hsa-miR-145	CLIP-seq
MIRT1159246	hsa-miR-150	CLIP-seq
MIRT1159247	hsa-miR-210	CLIP-seq
MIRT2573545	hsa-miR-2115	CLIP-seq
MIRT2573546	hsa-miR-2909	CLIP-seq
MIRT2573547	hsa-miR-3141	CLIP-seq
MIRT1159249	hsa-miR-331-3p	CLIP-seq
MIRT1159250	hsa-miR-345	CLIP-seq
MIRT2045662	hsa-miR-3667-3p	CLIP-seq
MIRT1159251	hsa-miR-3679-3p	CLIP-seq
MIRT1159252	hsa-miR-3689a-5p	CLIP-seq
MIRT1159253	hsa-miR-3689b	CLIP-seq
MIRT1159254	hsa-miR-3689e	CLIP-seq
MIRT1159255	hsa-miR-3689f	CLIP-seq
MIRT2573548	hsa-miR-3977	CLIP-seq
MIRT1159261	hsa-miR-455-5p	CLIP-seq
MIRT1159262	hsa-miR-4662a-3p	CLIP-seq
MIRT1159263	hsa-miR-4704-3p	CLIP-seq
MIRT1159264	hsa-miR-4713-5p	CLIP-seq
MIRT1159266	hsa-miR-4732-3p	CLIP-seq
MIRT2573549	hsa-miR-516a-3p	CLIP-seq
MIRT1159268	hsa-miR-532-3p	CLIP-seq
MIRT1159269	hsa-miR-587	CLIP-seq
MIRT2573542	hsa-miR-1282	CLIP-seq
MIRT2573543	hsa-miR-1296	CLIP-seq
MIRT2573544	hsa-miR-145	CLIP-seq
MIRT1159246	hsa-miR-150	CLIP-seq
MIRT2573545	hsa-miR-2115	CLIP-seq
MIRT2573546	hsa-miR-2909	CLIP-seq
MIRT2573547	hsa-miR-3141	CLIP-seq
MIRT1159249	hsa-miR-331-3p	CLIP-seq
MIRT1159250	hsa-miR-345	CLIP-seq
MIRT2045662	hsa-miR-3667-3p	CLIP-seq
MIRT1159251	hsa-miR-3679-3p	CLIP-seq
MIRT1159252	hsa-miR-3689a-5p	CLIP-seq
MIRT1159253	hsa-miR-3689b	CLIP-seq
MIRT1159254	hsa-miR-3689e	CLIP-seq
MIRT1159255	hsa-miR-3689f	CLIP-seq
MIRT2573548	hsa-miR-3977	CLIP-seq
MIRT1159262	hsa-miR-4662a-3p	CLIP-seq
MIRT1159263	hsa-miR-4704-3p	CLIP-seq
MIRT1159264	hsa-miR-4713-5p	CLIP-seq
MIRT1159266	hsa-miR-4732-3p	CLIP-seq
MIRT2573549	hsa-miR-516a-3p	CLIP-seq
MIRT1159268	hsa-miR-532-3p	CLIP-seq
MIRT1159269	hsa-miR-587	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	NAS	27023846
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0005762	Component	Mitochondrial large ribosomal subunit	IBA
GO:0005762	Component	Mitochondrial large ribosomal subunit	IDA	25278503
GO:0005762	Component	Mitochondrial large ribosomal subunit	NAS	11279069, 25278503
GO:0005840	Component	Ribosome	IEA
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	11279069
GO:0016604	Component	Nuclear body	IDA
GO:0032543	Process	Mitochondrial translation	NAS	27023846
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
611842	14490	ENSG00000171421

Q9P0J6

Protein name

Large ribosomal subunit protein bL36m (39S ribosomal protein L36, mitochondrial) (L36mt) (MRP-L36) (BRCA1-interacting protein 1)

PDB

3J7Y , 3J9M , 5OOL , 6I9R , 6NU2 , 6NU3 , 6VLZ , 6VMI , 6ZM5 , 6ZM6 , 6ZS9 , 6ZSA , 6ZSB , 6ZSC , 6ZSD , 6ZSE , 6ZSG , 7A5F , 7A5G , 7A5I , 7A5J , 7A5K , 7L08 , 7L20 , 7O9K , 7O9M , 7ODR , 7ODS , 7ODT , 7OF0 , 7OF2 , 7OF3 , 7OF4 , 7OF5 , 7OF6 , 7OF7 , 7OG4 , 7OIC , 7OID , 7OIE , 7PD3 , 7QH7 , 7QI4 , 7QI5 , 7QI6 , 8ANY , 8K2A , 8K2B , 8OIR , 8OIT , 8QSJ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00444	Ribosomal_L36	66 → 103	Ribosomal protein L36	Domain

Sequence

MANLFIRKMVNPLLYLSRHTVKPRALSTFLFGSIRGAAPVAVEPGAAVRSLLSPGLLPHL
LPALGFKNKTVLKKRCKDCYLVKRRGRWYVYCKTHPRHKQRQM

Sequence length

103

Interactions

View interactions

	KEGG		Reactome
	Ribosome		Mitochondrial translation elongation Mitochondrial translation termination

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
MITOCHONDRIAL COMPLEX I DEFICIENCY	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MITOCHONDRIAL COMPLEX I DEFICIENCY, NUCLEAR TYPE 9	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (16)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Anemia Hemolytic	Hemolytic anemia	Pubtator	17504528	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	16430786, 17504528, 23225146, 30799775		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	16430786, 17504528, 18628483, 30799775, 35707265	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	23473757, 23644138, 28231728		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	23473757, 23644138, 28231728		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	31064327		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cri-du-Chat Syndrome	5p partial monosomy syndrome	BEFREE	30985858		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fanconi Anemia	Fanconi Anemia	BEFREE	17504528		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	16430786, 17504528, 23225146, 30799775		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29466248		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	23473757, 23644138, 28231728		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	31064327		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nijmegen Breakage Syndrome	Nijmegen Breakage Syndrome	BEFREE	30799775		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	33934540	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	35675963	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	28231728	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

MRPL36 (mitochondrial ribosomal protein L36)