Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	64927
Gene name	Tetratricopeptide repeat domain 23
Gene symbol	TTC23
Synonyms (NCBI Gene)	HCC-8
Chromosome	15
Chromosome location	15q26.3

123

Show/Hide all (123)

miRTarBase ID	miRNA	Experiments
MIRT1461068	hsa-miR-1343	CLIP-seq
MIRT1461069	hsa-miR-3074-5p	CLIP-seq
MIRT1461070	hsa-miR-3616-3p	CLIP-seq
MIRT1461071	hsa-miR-4299	CLIP-seq
MIRT1461072	hsa-miR-4710	CLIP-seq
MIRT1461073	hsa-miR-4721	CLIP-seq
MIRT1461074	hsa-miR-4792	CLIP-seq
MIRT1461075	hsa-miR-579	CLIP-seq
MIRT1461076	hsa-miR-1267	CLIP-seq
MIRT1461077	hsa-miR-1299	CLIP-seq
MIRT1461078	hsa-miR-3065-3p	CLIP-seq
MIRT1461079	hsa-miR-3120-3p	CLIP-seq
MIRT1461080	hsa-miR-3646	CLIP-seq
MIRT1461081	hsa-miR-3689d	CLIP-seq
MIRT1461082	hsa-miR-3713	CLIP-seq
MIRT1461083	hsa-miR-4277	CLIP-seq
MIRT1461084	hsa-miR-4452	CLIP-seq
MIRT1461085	hsa-miR-4729	CLIP-seq
MIRT1461086	hsa-miR-4782-5p	CLIP-seq
MIRT1461087	hsa-miR-516b	CLIP-seq
MIRT1461088	hsa-miR-582-5p	CLIP-seq
MIRT1461089	hsa-miR-600	CLIP-seq
MIRT1461090	hsa-miR-645	CLIP-seq
MIRT1461091	hsa-miR-653	CLIP-seq
MIRT1461092	hsa-miR-658	CLIP-seq
MIRT1461093	hsa-miR-671-5p	CLIP-seq
MIRT1461094	hsa-miR-875-3p	CLIP-seq
MIRT1461095	hsa-miR-943	CLIP-seq
MIRT1461096	hsa-miR-1208	CLIP-seq
MIRT1461097	hsa-miR-1236	CLIP-seq
MIRT1461077	hsa-miR-1299	CLIP-seq
MIRT1461098	hsa-miR-3147	CLIP-seq
MIRT1461099	hsa-miR-3177-5p	CLIP-seq
MIRT1461100	hsa-miR-320e	CLIP-seq
MIRT1461070	hsa-miR-3616-3p	CLIP-seq
MIRT1461083	hsa-miR-4277	CLIP-seq
MIRT1461071	hsa-miR-4299	CLIP-seq
MIRT1461101	hsa-miR-4425	CLIP-seq
MIRT1461102	hsa-miR-4497	CLIP-seq
MIRT1461103	hsa-miR-4646-5p	CLIP-seq
MIRT1461104	hsa-miR-4656	CLIP-seq
MIRT1461105	hsa-miR-4684-3p	CLIP-seq
MIRT1461072	hsa-miR-4710	CLIP-seq
MIRT1461073	hsa-miR-4721	CLIP-seq
MIRT1461106	hsa-miR-4747-5p	CLIP-seq
MIRT1461107	hsa-miR-4781-3p	CLIP-seq
MIRT1461086	hsa-miR-4782-5p	CLIP-seq
MIRT1461074	hsa-miR-4792	CLIP-seq
MIRT1461087	hsa-miR-516b	CLIP-seq
MIRT1461088	hsa-miR-582-5p	CLIP-seq
MIRT1461108	hsa-miR-584	CLIP-seq
MIRT1461089	hsa-miR-600	CLIP-seq
MIRT1461093	hsa-miR-671-5p	CLIP-seq
MIRT1461094	hsa-miR-875-3p	CLIP-seq
MIRT1461096	hsa-miR-1208	CLIP-seq
MIRT2138470	hsa-miR-1229	CLIP-seq
MIRT2138471	hsa-miR-3657	CLIP-seq
MIRT2138472	hsa-miR-3909	CLIP-seq
MIRT2138473	hsa-miR-4669	CLIP-seq
MIRT2138474	hsa-miR-4717-3p	CLIP-seq
MIRT2138475	hsa-miR-626	CLIP-seq
MIRT2138476	hsa-miR-892a	CLIP-seq
MIRT2138477	hsa-miR-942	CLIP-seq
MIRT2652626	hsa-miR-3620	CLIP-seq
MIRT2694370	hsa-miR-10a	CLIP-seq
MIRT2694371	hsa-miR-10b	CLIP-seq
MIRT2694372	hsa-miR-1200	CLIP-seq
MIRT2694373	hsa-miR-1204	CLIP-seq
MIRT2694374	hsa-miR-1227	CLIP-seq
MIRT1461076	hsa-miR-1267	CLIP-seq
MIRT2694375	hsa-miR-182	CLIP-seq
MIRT2694376	hsa-miR-1976	CLIP-seq
MIRT2694377	hsa-miR-200b	CLIP-seq
MIRT2694378	hsa-miR-200c	CLIP-seq
MIRT2694379	hsa-miR-2355-3p	CLIP-seq
MIRT2694380	hsa-miR-2355-5p	CLIP-seq
MIRT2694381	hsa-miR-31	CLIP-seq
MIRT2694382	hsa-miR-3157-5p	CLIP-seq
MIRT1461099	hsa-miR-3177-5p	CLIP-seq
MIRT2694383	hsa-miR-339-5p	CLIP-seq
MIRT2694384	hsa-miR-3545-3p	CLIP-seq
MIRT2652626	hsa-miR-3620	CLIP-seq
MIRT2694385	hsa-miR-3664-3p	CLIP-seq
MIRT2694386	hsa-miR-3667-3p	CLIP-seq
MIRT2694387	hsa-miR-3679-3p	CLIP-seq
MIRT2694388	hsa-miR-3915	CLIP-seq
MIRT2694389	hsa-miR-3928	CLIP-seq
MIRT2694390	hsa-miR-4281	CLIP-seq
MIRT2694391	hsa-miR-429	CLIP-seq
MIRT2694392	hsa-miR-4324	CLIP-seq
MIRT2694393	hsa-miR-4440	CLIP-seq
MIRT2694394	hsa-miR-4446-5p	CLIP-seq
MIRT2694395	hsa-miR-4464	CLIP-seq
MIRT2694396	hsa-miR-4539	CLIP-seq
MIRT2694397	hsa-miR-4642	CLIP-seq
MIRT2694398	hsa-miR-4646-3p	CLIP-seq
MIRT1461104	hsa-miR-4656	CLIP-seq
MIRT2694399	hsa-miR-4660	CLIP-seq
MIRT2694400	hsa-miR-4682	CLIP-seq
MIRT2694401	hsa-miR-4685-5p	CLIP-seq
MIRT2694402	hsa-miR-4691-3p	CLIP-seq
MIRT2694403	hsa-miR-4709-3p	CLIP-seq
MIRT2694404	hsa-miR-4722-3p	CLIP-seq
MIRT2694405	hsa-miR-4724-5p	CLIP-seq
MIRT2694406	hsa-miR-4748	CLIP-seq
MIRT2694407	hsa-miR-4757-5p	CLIP-seq
MIRT2694408	hsa-miR-4763-5p	CLIP-seq
MIRT2694409	hsa-miR-4768-5p	CLIP-seq
MIRT2694410	hsa-miR-510	CLIP-seq
MIRT2694411	hsa-miR-544b	CLIP-seq
MIRT2694412	hsa-miR-548aa	CLIP-seq
MIRT2694413	hsa-miR-548ac	CLIP-seq
MIRT2694414	hsa-miR-548d-3p	CLIP-seq
MIRT2694415	hsa-miR-548z	CLIP-seq
MIRT2694416	hsa-miR-578	CLIP-seq
MIRT2694417	hsa-miR-646	CLIP-seq
MIRT2694418	hsa-miR-648	CLIP-seq
MIRT1461091	hsa-miR-653	CLIP-seq
MIRT2694419	hsa-miR-676	CLIP-seq
MIRT2694420	hsa-miR-7	CLIP-seq
MIRT2694421	hsa-miR-760	CLIP-seq
MIRT2694422	hsa-miR-873	CLIP-seq
MIRT2138477	hsa-miR-942	CLIP-seq

Show/Hide all (5)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 30886144, 31515488, 32296183, 32814053
GO:0005929	Component	Cilium	IEA
GO:0005929	Component	Cilium	ISS
GO:0042995	Component	Cell projection	IEA
GO:0045880	Process	Positive regulation of smoothened signaling pathway	ISS

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q5W5X9

Protein name

Tetratricopeptide repeat protein 23 (TPR repeat protein 23) (Cervical cancer proto-oncogene 8 protein) (HCC-8)

Protein function

Participates positively in the ciliary Hedgehog (Hh) signaling.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13424	TPR_12	314 → 387		Repeat

Sequence

MQESQETHISNHLDEVVAAVSITHRKKFQNKLLQTALFQPPREKLHLCEEKAKSYSNSHE
YKQAVHELVRCVALTRICYGDSHWKLAEAHVNLAQGYLQLKGLSLQAKQHAEKARQILAN
SIVPPYSENTDVFKFSIELFHTMGRALLSLQKFKEAAENLTKAERLSKELLQCGRIIKEE
WIEIEARIRLSFAQVYQGQKKSKEALSHYQAALEYVEISKGETSRECVPILRELAGVEQA
LGLHDVSINHFLQAHLIILSRSPSQVEAADSAHIVAHAAVASGRHEHHDVAEQYFQESMA
HLKDSEGMGRTKFLSIQDEFCHFLQMTGQKERATSILRESLEAKVEAFGDFSPEVAETYR
LLGGADLAQGNHSGARKKLKKCLQIQTLLYGPQDKRTLATQQAMGMLSTAPKVASKPRQA
SKAKVAFCTSIPQDTLLGKARPGTTAD

Sequence length

447

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BELL'S PALSY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESSENTIAL TREMOR	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Orofaciodigital syndrome	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Ciliopathies	Ciliopathy	Pubtator	32055034	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	28981677		★★★★★ ★☆☆☆☆ Found in Text Mining only

TTC23 (tetratricopeptide repeat domain 23)