RFX7 (regulatory factor X7)

Gene

• Entrez ID: 64864
• Gene name: Regulatory factor X7
• Gene symbol: RFX7
• Synonyms (NCBI Gene): MRD71, RFXDC2
• Chromosome: 15
• Chromosome location: 15q21.3
• Summary: RFX7 is a member of the regulatory factor X (RFX) family of transcription factors (see RFX1, MIM 600006) (Aftab et al., 2008 [PubMed 18673564]).[supplied by OMIM, Mar 2009]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023454	hsa-miR-30b-5p	Sequencing	20371350
MIRT029828	hsa-miR-26b-5p	Microarray	19088304
MIRT044661	hsa-miR-320a	CLASH	23622248
MIRT534723	hsa-miR-130a-3p	PAR-CLIP	22012620
MIRT534722	hsa-miR-130b-3p	PAR-CLIP	22012620
MIRT534721	hsa-miR-301b-3p	PAR-CLIP	22012620
MIRT534720	hsa-miR-4295	PAR-CLIP	22012620
MIRT534719	hsa-miR-301a-3p	PAR-CLIP	22012620
MIRT534718	hsa-miR-454-3p	PAR-CLIP	22012620
MIRT534717	hsa-miR-3666	PAR-CLIP	22012620
MIRT534716	hsa-miR-561-3p	PAR-CLIP	22012620
MIRT534715	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT534714	hsa-miR-32-3p	PAR-CLIP	22012620
MIRT534713	hsa-miR-3135b	PAR-CLIP	22012620
MIRT534712	hsa-miR-1287-5p	PAR-CLIP	22012620
MIRT439778	hsa-miR-205-5p	HITS-CLIP	22473208
MIRT439778	hsa-miR-205-5p	HITS-CLIP	22473208
MIRT534723	hsa-miR-130a-3p	PAR-CLIP	22012620
MIRT534722	hsa-miR-130b-3p	PAR-CLIP	22012620
MIRT534721	hsa-miR-301b-3p	PAR-CLIP	22012620
MIRT534720	hsa-miR-4295	PAR-CLIP	22012620
MIRT534719	hsa-miR-301a-3p	PAR-CLIP	22012620
MIRT534718	hsa-miR-454-3p	PAR-CLIP	22012620
MIRT534717	hsa-miR-3666	PAR-CLIP	22012620
MIRT534716	hsa-miR-561-3p	PAR-CLIP	22012620
MIRT534715	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT534714	hsa-miR-32-3p	PAR-CLIP	22012620
MIRT534713	hsa-miR-3135b	PAR-CLIP	22012620
MIRT534712	hsa-miR-1287-5p	PAR-CLIP	22012620
MIRT1302495	hsa-miR-105	CLIP-seq
MIRT1302496	hsa-miR-1183	CLIP-seq
MIRT1302497	hsa-miR-1237	CLIP-seq
MIRT1302498	hsa-miR-1245	CLIP-seq
MIRT1302499	hsa-miR-1248	CLIP-seq
MIRT1302500	hsa-miR-1251	CLIP-seq
MIRT1302501	hsa-miR-1273g	CLIP-seq
MIRT1302502	hsa-miR-1278	CLIP-seq
MIRT1302503	hsa-miR-1299	CLIP-seq
MIRT1302504	hsa-miR-137	CLIP-seq
MIRT1302505	hsa-miR-139-5p	CLIP-seq
MIRT1302506	hsa-miR-141	CLIP-seq
MIRT1302507	hsa-miR-142-5p	CLIP-seq
MIRT1302508	hsa-miR-148a	CLIP-seq
MIRT1302509	hsa-miR-148b	CLIP-seq
MIRT1302510	hsa-miR-152	CLIP-seq
MIRT1302511	hsa-miR-186	CLIP-seq
MIRT1302512	hsa-miR-200a	CLIP-seq
MIRT1302513	hsa-miR-204	CLIP-seq
MIRT1302514	hsa-miR-208a	CLIP-seq
MIRT1302515	hsa-miR-208b	CLIP-seq
MIRT1302516	hsa-miR-211	CLIP-seq
MIRT1302517	hsa-miR-2110	CLIP-seq
MIRT1302518	hsa-miR-224	CLIP-seq
MIRT1302519	hsa-miR-25	CLIP-seq
MIRT1302520	hsa-miR-29a	CLIP-seq
MIRT1302521	hsa-miR-29b	CLIP-seq
MIRT1302522	hsa-miR-29c	CLIP-seq
MIRT1302523	hsa-miR-3065-5p	CLIP-seq
MIRT1302524	hsa-miR-30a	CLIP-seq
MIRT1302525	hsa-miR-30b	CLIP-seq
MIRT1302526	hsa-miR-30c	CLIP-seq
MIRT1302527	hsa-miR-30d	CLIP-seq
MIRT1302528	hsa-miR-30e	CLIP-seq
MIRT1302529	hsa-miR-3120-3p	CLIP-seq
MIRT1302530	hsa-miR-3127-3p	CLIP-seq
MIRT1302531	hsa-miR-3129-3p	CLIP-seq
MIRT1302532	hsa-miR-3133	CLIP-seq
MIRT1302533	hsa-miR-32	CLIP-seq
MIRT1302534	hsa-miR-338-5p	CLIP-seq
MIRT1302535	hsa-miR-340	CLIP-seq
MIRT1302536	hsa-miR-3609	CLIP-seq
MIRT1302537	hsa-miR-3612	CLIP-seq
MIRT1302538	hsa-miR-3617	CLIP-seq
MIRT1302539	hsa-miR-3618	CLIP-seq
MIRT1302540	hsa-miR-3620	CLIP-seq
MIRT1302541	hsa-miR-363	CLIP-seq
MIRT1302542	hsa-miR-365	CLIP-seq
MIRT1302543	hsa-miR-3655	CLIP-seq
MIRT1302544	hsa-miR-3662	CLIP-seq
MIRT1302545	hsa-miR-367	CLIP-seq
MIRT1302546	hsa-miR-371b-5p	CLIP-seq
MIRT1302547	hsa-miR-3919	CLIP-seq
MIRT1302548	hsa-miR-3942-3p	CLIP-seq
MIRT1302549	hsa-miR-409-5p	CLIP-seq
MIRT1302550	hsa-miR-421	CLIP-seq
MIRT1302551	hsa-miR-4271	CLIP-seq
MIRT1302552	hsa-miR-4272	CLIP-seq
MIRT1302553	hsa-miR-4277	CLIP-seq
MIRT1302554	hsa-miR-4302	CLIP-seq
MIRT1302555	hsa-miR-4323	CLIP-seq
MIRT1302556	hsa-miR-4446-5p	CLIP-seq
MIRT1302557	hsa-miR-4474-3p	CLIP-seq
MIRT1302558	hsa-miR-4476	CLIP-seq
MIRT1302559	hsa-miR-4495	CLIP-seq
MIRT1302560	hsa-miR-4503	CLIP-seq
MIRT1302561	hsa-miR-450b-5p	CLIP-seq
MIRT1302562	hsa-miR-4635	CLIP-seq
MIRT1302563	hsa-miR-4659a-3p	CLIP-seq
MIRT1302564	hsa-miR-4659b-3p	CLIP-seq
MIRT1302565	hsa-miR-4666-3p	CLIP-seq
MIRT1302566	hsa-miR-4667-5p	CLIP-seq
MIRT1302567	hsa-miR-4697-3p	CLIP-seq
MIRT1302568	hsa-miR-4698	CLIP-seq
MIRT1302569	hsa-miR-4700-3p	CLIP-seq
MIRT1302570	hsa-miR-4700-5p	CLIP-seq
MIRT1302571	hsa-miR-4703-3p	CLIP-seq
MIRT1302572	hsa-miR-4719	CLIP-seq
MIRT1302573	hsa-miR-4725-3p	CLIP-seq
MIRT1302574	hsa-miR-4729	CLIP-seq
MIRT1302575	hsa-miR-4734	CLIP-seq
MIRT1302576	hsa-miR-4738-3p	CLIP-seq
MIRT1302577	hsa-miR-4753-3p	CLIP-seq
MIRT1302578	hsa-miR-4755-5p	CLIP-seq
MIRT1302579	hsa-miR-4756-3p	CLIP-seq
MIRT1302580	hsa-miR-4760-5p	CLIP-seq
MIRT1302581	hsa-miR-4778-3p	CLIP-seq
MIRT1302582	hsa-miR-4786-3p	CLIP-seq
MIRT1302583	hsa-miR-4797-5p	CLIP-seq
MIRT1302584	hsa-miR-4803	CLIP-seq
MIRT1302585	hsa-miR-488	CLIP-seq
MIRT1302586	hsa-miR-494	CLIP-seq
MIRT1302587	hsa-miR-499-5p	CLIP-seq
MIRT1302588	hsa-miR-507	CLIP-seq
MIRT1302589	hsa-miR-5095	CLIP-seq
MIRT1302590	hsa-miR-5096	CLIP-seq
MIRT1302591	hsa-miR-511	CLIP-seq
MIRT1302592	hsa-miR-520f	CLIP-seq
MIRT1302593	hsa-miR-545	CLIP-seq
MIRT1302594	hsa-miR-548a-5p	CLIP-seq
MIRT1302595	hsa-miR-548ab	CLIP-seq
MIRT1302596	hsa-miR-548ah	CLIP-seq
MIRT1302597	hsa-miR-548ak	CLIP-seq
MIRT1302598	hsa-miR-548b-5p	CLIP-seq
MIRT1302599	hsa-miR-548c-5p	CLIP-seq
MIRT1302600	hsa-miR-548d-5p	CLIP-seq
MIRT1302601	hsa-miR-548h	CLIP-seq
MIRT1302602	hsa-miR-548i	CLIP-seq
MIRT1302603	hsa-miR-548j	CLIP-seq
MIRT1302604	hsa-miR-548k	CLIP-seq
MIRT1302605	hsa-miR-548l	CLIP-seq
MIRT1302606	hsa-miR-548w	CLIP-seq
MIRT1302607	hsa-miR-548y	CLIP-seq
MIRT1302608	hsa-miR-557	CLIP-seq
MIRT1302609	hsa-miR-559	CLIP-seq
MIRT1302610	hsa-miR-578	CLIP-seq
MIRT1302611	hsa-miR-579	CLIP-seq
MIRT1302612	hsa-miR-582-5p	CLIP-seq
MIRT1302613	hsa-miR-606	CLIP-seq
MIRT1302614	hsa-miR-618	CLIP-seq
MIRT1302615	hsa-miR-623	CLIP-seq
MIRT1302616	hsa-miR-633	CLIP-seq
MIRT1302617	hsa-miR-641	CLIP-seq
MIRT1302618	hsa-miR-648	CLIP-seq
MIRT1302619	hsa-miR-650	CLIP-seq
MIRT1302620	hsa-miR-654-3p	CLIP-seq
MIRT1302621	hsa-miR-759	CLIP-seq
MIRT1302622	hsa-miR-767-5p	CLIP-seq
MIRT1302623	hsa-miR-875-3p	CLIP-seq
MIRT1302624	hsa-miR-885-5p	CLIP-seq
MIRT1302625	hsa-miR-92a	CLIP-seq
MIRT1302626	hsa-miR-92b	CLIP-seq
MIRT1302627	hsa-miR-934	CLIP-seq
MIRT1302628	hsa-miR-944	CLIP-seq
MIRT1553081	hsa-miR-4282	CLIP-seq
MIRT1302496	hsa-miR-1183	CLIP-seq
MIRT2089813	hsa-miR-1225-5p	CLIP-seq
MIRT1302499	hsa-miR-1248	CLIP-seq
MIRT2089814	hsa-miR-1273e	CLIP-seq
MIRT2089815	hsa-miR-130a	CLIP-seq
MIRT2089816	hsa-miR-130b	CLIP-seq
MIRT1302504	hsa-miR-137	CLIP-seq
MIRT1302505	hsa-miR-139-5p	CLIP-seq
MIRT2089817	hsa-miR-144	CLIP-seq
MIRT2089818	hsa-miR-147	CLIP-seq
MIRT2089819	hsa-miR-153	CLIP-seq
MIRT2089820	hsa-miR-1539	CLIP-seq
MIRT2089821	hsa-miR-1827	CLIP-seq
MIRT2089822	hsa-miR-199a-3p	CLIP-seq
MIRT2089823	hsa-miR-199b-3p	CLIP-seq
MIRT2089824	hsa-miR-2052	CLIP-seq
MIRT2089825	hsa-miR-2053	CLIP-seq
MIRT2089826	hsa-miR-2054	CLIP-seq
MIRT2089827	hsa-miR-210	CLIP-seq
MIRT2089828	hsa-miR-2113	CLIP-seq
MIRT1302519	hsa-miR-25	CLIP-seq
MIRT2089829	hsa-miR-301a	CLIP-seq
MIRT2089830	hsa-miR-301b	CLIP-seq
MIRT1302523	hsa-miR-3065-5p	CLIP-seq
MIRT2089831	hsa-miR-3074-5p	CLIP-seq
MIRT1302529	hsa-miR-3120-3p	CLIP-seq
MIRT2089832	hsa-miR-3121-5p	CLIP-seq
MIRT2089833	hsa-miR-3129-5p	CLIP-seq
MIRT2089834	hsa-miR-3182	CLIP-seq
MIRT2089835	hsa-miR-3185	CLIP-seq
MIRT1302533	hsa-miR-32	CLIP-seq
MIRT2089836	hsa-miR-323-3p	CLIP-seq
MIRT1302538	hsa-miR-3617	CLIP-seq
MIRT1302539	hsa-miR-3618	CLIP-seq
MIRT1302540	hsa-miR-3620	CLIP-seq
MIRT1302541	hsa-miR-363	CLIP-seq
MIRT2089837	hsa-miR-3650	CLIP-seq
MIRT2089838	hsa-miR-3653	CLIP-seq
MIRT1302543	hsa-miR-3655	CLIP-seq
MIRT2089839	hsa-miR-3658	CLIP-seq
MIRT1302545	hsa-miR-367	CLIP-seq
MIRT2089840	hsa-miR-3685	CLIP-seq
MIRT2089841	hsa-miR-370	CLIP-seq
MIRT2089842	hsa-miR-374a	CLIP-seq
MIRT2089843	hsa-miR-374b	CLIP-seq
MIRT2089844	hsa-miR-377	CLIP-seq
MIRT2089845	hsa-miR-384	CLIP-seq
MIRT2089846	hsa-miR-3920	CLIP-seq
MIRT1302548	hsa-miR-3942-3p	CLIP-seq
MIRT2089847	hsa-miR-3944-5p	CLIP-seq
MIRT2089848	hsa-miR-3977	CLIP-seq
MIRT1302552	hsa-miR-4272	CLIP-seq
MIRT2089849	hsa-miR-4291	CLIP-seq
MIRT2089850	hsa-miR-4433	CLIP-seq
MIRT2089851	hsa-miR-4459	CLIP-seq
MIRT2089852	hsa-miR-4473	CLIP-seq
MIRT2089853	hsa-miR-448	CLIP-seq
MIRT2089854	hsa-miR-4511	CLIP-seq
MIRT2089855	hsa-miR-454	CLIP-seq
MIRT2089856	hsa-miR-4649-3p	CLIP-seq
MIRT2089857	hsa-miR-4670-3p	CLIP-seq
MIRT2089858	hsa-miR-4699-3p	CLIP-seq
MIRT1302571	hsa-miR-4703-3p	CLIP-seq
MIRT2089859	hsa-miR-4718	CLIP-seq
MIRT1302572	hsa-miR-4719	CLIP-seq
MIRT2089860	hsa-miR-4724-5p	CLIP-seq
MIRT1302579	hsa-miR-4756-3p	CLIP-seq
MIRT2089861	hsa-miR-4762-3p	CLIP-seq
MIRT2089862	hsa-miR-4763-5p	CLIP-seq
MIRT2089863	hsa-miR-4768-3p	CLIP-seq
MIRT1302583	hsa-miR-4797-5p	CLIP-seq
MIRT1302586	hsa-miR-494	CLIP-seq
MIRT2089864	hsa-miR-498	CLIP-seq
MIRT2089865	hsa-miR-509-3p	CLIP-seq
MIRT1302590	hsa-miR-5096	CLIP-seq
MIRT2089866	hsa-miR-512-3p	CLIP-seq
MIRT1302592	hsa-miR-520f	CLIP-seq
MIRT2089867	hsa-miR-539	CLIP-seq
MIRT1302593	hsa-miR-545	CLIP-seq
MIRT2089868	hsa-miR-548b-3p	CLIP-seq
MIRT2089869	hsa-miR-550a	CLIP-seq
MIRT1302610	hsa-miR-578	CLIP-seq
MIRT1302611	hsa-miR-579	CLIP-seq
MIRT1302612	hsa-miR-582-5p	CLIP-seq
MIRT2089870	hsa-miR-587	CLIP-seq
MIRT2089871	hsa-miR-599	CLIP-seq
MIRT1302613	hsa-miR-606	CLIP-seq
MIRT1302617	hsa-miR-641	CLIP-seq
MIRT2089872	hsa-miR-656	CLIP-seq
MIRT1302621	hsa-miR-759	CLIP-seq
MIRT1302624	hsa-miR-885-5p	CLIP-seq
MIRT2089873	hsa-miR-889	CLIP-seq
MIRT2089874	hsa-miR-9	CLIP-seq
MIRT1302625	hsa-miR-92a	CLIP-seq
MIRT1302626	hsa-miR-92b	CLIP-seq
MIRT1302627	hsa-miR-934	CLIP-seq
MIRT1302628	hsa-miR-944	CLIP-seq
MIRT1302496	hsa-miR-1183	CLIP-seq
MIRT1302504	hsa-miR-137	CLIP-seq
MIRT1302506	hsa-miR-141	CLIP-seq
MIRT1302508	hsa-miR-148a	CLIP-seq
MIRT1302509	hsa-miR-148b	CLIP-seq
MIRT1302510	hsa-miR-152	CLIP-seq
MIRT1302512	hsa-miR-200a	CLIP-seq
MIRT2089826	hsa-miR-2054	CLIP-seq
MIRT1302514	hsa-miR-208a	CLIP-seq
MIRT1302515	hsa-miR-208b	CLIP-seq
MIRT2314688	hsa-miR-221	CLIP-seq
MIRT2314689	hsa-miR-222	CLIP-seq
MIRT1302519	hsa-miR-25	CLIP-seq
MIRT1302523	hsa-miR-3065-5p	CLIP-seq
MIRT2089831	hsa-miR-3074-5p	CLIP-seq
MIRT2314690	hsa-miR-3163	CLIP-seq
MIRT1302533	hsa-miR-32	CLIP-seq
MIRT1302534	hsa-miR-338-5p	CLIP-seq
MIRT1302537	hsa-miR-3612	CLIP-seq
MIRT1302538	hsa-miR-3617	CLIP-seq
MIRT1302541	hsa-miR-363	CLIP-seq
MIRT1302542	hsa-miR-365	CLIP-seq
MIRT1302544	hsa-miR-3662	CLIP-seq
MIRT1302545	hsa-miR-367	CLIP-seq
MIRT2089841	hsa-miR-370	CLIP-seq
MIRT1302548	hsa-miR-3942-3p	CLIP-seq
MIRT1302553	hsa-miR-4277	CLIP-seq
MIRT2314691	hsa-miR-4289	CLIP-seq
MIRT1302554	hsa-miR-4302	CLIP-seq
MIRT1302565	hsa-miR-4666-3p	CLIP-seq
MIRT1302567	hsa-miR-4697-3p	CLIP-seq
MIRT1302568	hsa-miR-4698	CLIP-seq
MIRT2089858	hsa-miR-4699-3p	CLIP-seq
MIRT2089859	hsa-miR-4718	CLIP-seq
MIRT1302574	hsa-miR-4729	CLIP-seq
MIRT1302580	hsa-miR-4760-5p	CLIP-seq
MIRT1302587	hsa-miR-499-5p	CLIP-seq
MIRT1302591	hsa-miR-511	CLIP-seq
MIRT1302592	hsa-miR-520f	CLIP-seq
MIRT2314692	hsa-miR-548v	CLIP-seq
MIRT1302617	hsa-miR-641	CLIP-seq
MIRT1302618	hsa-miR-648	CLIP-seq
MIRT1302619	hsa-miR-650	CLIP-seq
MIRT1302620	hsa-miR-654-3p	CLIP-seq
MIRT2314693	hsa-miR-668	CLIP-seq
MIRT1302624	hsa-miR-885-5p	CLIP-seq
MIRT1302625	hsa-miR-92a	CLIP-seq
MIRT1302626	hsa-miR-92b	CLIP-seq
MIRT1302628	hsa-miR-944	CLIP-seq
MIRT1302506	hsa-miR-141	CLIP-seq
MIRT1302512	hsa-miR-200a	CLIP-seq
MIRT1302517	hsa-miR-2110	CLIP-seq
MIRT1302523	hsa-miR-3065-5p	CLIP-seq
MIRT1302551	hsa-miR-4271	CLIP-seq
MIRT1302566	hsa-miR-4667-5p	CLIP-seq
MIRT2393661	hsa-miR-4694-3p	CLIP-seq
MIRT1302570	hsa-miR-4700-5p	CLIP-seq
MIRT1302573	hsa-miR-4725-3p	CLIP-seq
MIRT2393662	hsa-miR-4761-5p	CLIP-seq
MIRT2393663	hsa-miR-522	CLIP-seq
MIRT2393664	hsa-miR-548p	CLIP-seq
MIRT1302546	hsa-miR-371b-5p	CLIP-seq
MIRT1302548	hsa-miR-3942-3p	CLIP-seq
MIRT1302568	hsa-miR-4698	CLIP-seq
MIRT2439894	hsa-miR-4757-5p	CLIP-seq
MIRT1302621	hsa-miR-759	CLIP-seq
MIRT2611003	hsa-miR-1207-3p	CLIP-seq
MIRT2611004	hsa-miR-1257	CLIP-seq
MIRT2611005	hsa-miR-1287	CLIP-seq
MIRT2611006	hsa-miR-140-5p	CLIP-seq
MIRT1302506	hsa-miR-141	CLIP-seq
MIRT2611007	hsa-miR-194	CLIP-seq
MIRT1302512	hsa-miR-200a	CLIP-seq
MIRT2089826	hsa-miR-2054	CLIP-seq
MIRT2089828	hsa-miR-2113	CLIP-seq
MIRT2089831	hsa-miR-3074-5p	CLIP-seq
MIRT2611008	hsa-miR-3123	CLIP-seq
MIRT2611009	hsa-miR-3143	CLIP-seq
MIRT2611010	hsa-miR-369-5p	CLIP-seq
MIRT2089841	hsa-miR-370	CLIP-seq
MIRT2611011	hsa-miR-3941	CLIP-seq
MIRT2611012	hsa-miR-466	CLIP-seq
MIRT2611013	hsa-miR-4672	CLIP-seq
MIRT2611014	hsa-miR-4705	CLIP-seq
MIRT2089859	hsa-miR-4718	CLIP-seq
MIRT2611015	hsa-miR-4731-3p	CLIP-seq
MIRT2611016	hsa-miR-4801	CLIP-seq
MIRT2611017	hsa-miR-570	CLIP-seq
MIRT2611018	hsa-miR-643	CLIP-seq
MIRT2611019	hsa-miR-758	CLIP-seq
MIRT1302506	hsa-miR-141	CLIP-seq
MIRT1302512	hsa-miR-200a	CLIP-seq
MIRT2089826	hsa-miR-2054	CLIP-seq
MIRT2089828	hsa-miR-2113	CLIP-seq
MIRT2089831	hsa-miR-3074-5p	CLIP-seq
MIRT2611009	hsa-miR-3143	CLIP-seq
MIRT2089841	hsa-miR-370	CLIP-seq
MIRT2089859	hsa-miR-4718	CLIP-seq
MIRT2611017	hsa-miR-570	CLIP-seq
MIRT2611019	hsa-miR-758	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000979	Function	RNA polymerase II core promoter sequence-specific DNA binding	IDA	29967452
GO:0000979	Function	RNA polymerase II core promoter sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005515	Function	Protein binding	IPI	25752541, 31864703, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	29967452
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

Other IDs

• MIM: 612660
• HGNC: 25777
• e!Ensembl: ENSG00000181827

Protein

• UniProt ID: Q2KHR2
• Protein name: DNA-binding protein RFX7 (Regulatory factor X 7) (Regulatory factor X domain-containing protein 2)
• Protein function: Transcription factor (PubMed:29967452). Acts as a transcriptional activator by binding to promoter regions of target genes, such as PDCD4, PIK3IP1, MXD4, PNRC1, and RFX5 (PubMed:29967452, PubMed:34197623). Plays a role in natural killer (NK) cel
• PDB: 4QQI, 6MEW
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02257	RFX_DNA_binding	8 → 86	RFX DNA-binding domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed in many different tissue types including thymus and placenta, with high expression in brain (PubMed:18673564). Expressed in both inhibitory and excitatory neurons in cortex (PubMed:33658631). {ECO:0000269|PubMed:186735
• Sequence:

  MSSSRAQQMHAFSWIRNTLEEHPETSLPKQEVYDEYKSYCDNLGYHPLSAADFGKIMKNV
  FPNMKARRLGTRGKSKYCYSGLRKKAFVHMPTLPNLDFHKTGDGLEGAEPSGQLQNIDEE
  VISSACRLVCEWAQKVLSQPFDTVLELARFLVKSHYIGTKSMAALTVMAAAPAGMKGITQ
  PSAFIPTAESNSFQPQVKTLPSPIDAKQQLQRKIQKKQQEQKLQSPLPGESAAKKSESAT
  SNGVTNLPNGNPSILSPQPIGIVVAAVPSPIPVQRTRQLVTSPSPMSSSDGKVLPLNVQV
  VTQHMQSVKQAPKTPQNVPASPGGDRSARHRYPQILPKPANTSALTIRSPTTVLFTSSPI
  KTAVVPASHMSSLNVVKMTTISLTPSNSNTPLKHSASVSSATGTTEESRSVPQIKNGSVV
  SLQSPGSRSSSAGGTSAVEVKVEPETSSDEHPVQCQENSDEAKAPQTPSALLGQKSNTDG
  ALQKPSNEGVIEIKATKVCDQRTKCKSRCNEMLPGTSTGNNQSTITLSVASQNLTFTSSS
  SPPNGDSINKDPKLCTKSPRKRLSSTLQETQVPPVKKPIVEQLSAATIEGQKQGSVKKDQ
  KVPHSGKTEGSTAGAQIPSKVSVNVSSHIGANQPLNSSALVISDSALEQQTTPSSSPDIK
  VKLEGSVFLLDSDSKSVGSFNPNGWQQITKDSEFISASCEQQQDISVMTIPEHSDINDLE
  KSVWELEGMPQDTYSQQLHSQIQESSLNQIQAHSSDQLPLQSELKEFEPSVSQTNESYFP
  FDDELTQDSIVEELVLMEQQMSMNNSHSYGNCLGMTLQSQSVTPGAPMSSHTSSTHFYHP
  IHSNGTPIHTPTPTPTPTPTPTPTPTPTSEMIAGSQSLSRESPCSRLAQTTPVDSALGSS
  RHTPIGTPHSNCSSSVPPSPVECRNPFAFTPISSSMAYHDASIVSSSPVKPMQRPMATHP
  DKTKLEWMNNGYSGVGNSSVSGHGILPSYQELVEDRFRKPHAFAVPGQSYQSQSRHHDTH
  FGRLTPVSPVQHQGATVNNTNKQEGFAVPAPLDNKGTNSSASSNFRCRSVSPAVHRQRNL
  SGSTLYPVSNIPRSNVTPFGSPVTPEVHVFTNVHTDACANNIAQRSQSVPLTVMMQTAFP
  NALQKQANSKKITNVLLSKLDSDNDDAVRGLGMNNLPSNYTARMNLTQILEPSTVFPSAN
  PQNMIDSSTSVYEFQTPSYLTKSNSTGQINFSPGDNQAQSEIGEQQLDFNSTVKDLLSGD
  SLQTNQQLVGQGASDLTNTASDFSSDIRLSSELSGSINDLNTLDPNLLFDPGRQQGQDDE
  ATLEELKNDPLFQQICSESMNSMTSSGFEWIESKDHPTVEMLG

• Sequence length: 1363

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Intellectual developmental disorder, autosomal dominant 71, with behavioral abnormalities	Likely pathogenic; Pathogenic	rs2504987146, rs2504987137, rs2504987254, rs750801787, rs749745135	RCV003223346 RCV003223354 RCV003223379 RCV003223380 RCV004820946	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
RFX7-related disorder	Likely pathogenic	rs2504989200	RCV003412317	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CHRONIC LYMPHOCYTIC LEUKEMIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COMPLEX NEURODEVELOPMENTAL DISORDER	—	ClinGen, GenCC	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Microcephaly	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neurodevelopmental disorder	Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-SPECIFIC SYNDROMIC INTELLECTUAL DISABILITY	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER, FAMILIAL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	28539126	Associate	★☆☆☆☆ Found in Text Mining only
Attention Deficit Disorder with Hyperactivity	Attention deficit hyperactivity disorder	Pubtator	33658631	Associate	★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorder	Autism	Pubtator	33658631	Associate	★☆☆☆☆ Found in Text Mining only
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	30926791		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	20946665	Associate	★☆☆☆☆ Found in Text Mining only
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	GWASCAT_DG	24292274		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	GWASDB_DG	24292274		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	29717269		★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Intellectual developmental disorder	Pubtator	33658631	Associate	★☆☆☆☆ Found in Text Mining only
Miller-McKusick-Malvaux-Syndrome (3M Syndrome)	3M Syndrome	BEFREE	25752541		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	29717269		★☆☆☆☆ Found in Text Mining only
Prostate cancer, familial	Prostate cancer	CTD_human_DG	29892016		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER, HEREDITARY, 1	Prostate Cancer, Hereditary	CTD_human_DG	29892016		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	GWASCAT_DG	29892016		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Small Lymphocytic Lymphoma	Lymphocytic Leukemia	GWASCAT_DG	24292274		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	36045400	Associate	★☆☆☆☆ Found in Text Mining only