Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	64793
Gene name	Centrosomal protein 85
Gene symbol	CEP85
Synonyms (NCBI Gene)	CCDC21
Chromosome	1
Chromosome location	1p36.11
Summary	This gene encodes a protein that belongs to the centrosome-associated family of proteins. The centrosome is a subcellular organelle in the animal cell that functions as a microtubule organizing center and is involved in cell-cycle progression. Alternate s

142

Show/Hide all (142)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029869	hsa-miR-26b-5p	Microarray	19088304
MIRT050307	hsa-miR-25-3p	CLASH	23622248
MIRT049072	hsa-miR-92a-3p	CLASH	23622248
MIRT039259	hsa-miR-671-5p	CLASH	23622248
MIRT440992	ebv-miR-BART10-3p	HITS-CLIP	22473208
MIRT440992	ebv-miR-BART10-3p	HITS-CLIP	22473208
MIRT886484	hsa-miR-1193	CLIP-seq
MIRT886485	hsa-miR-1225-5p	CLIP-seq
MIRT886486	hsa-miR-1244	CLIP-seq
MIRT886487	hsa-miR-1253	CLIP-seq
MIRT886488	hsa-miR-1296	CLIP-seq
MIRT886489	hsa-miR-146a	CLIP-seq
MIRT886490	hsa-miR-146b-5p	CLIP-seq
MIRT886491	hsa-miR-15a	CLIP-seq
MIRT886492	hsa-miR-15b	CLIP-seq
MIRT886493	hsa-miR-16	CLIP-seq
MIRT886494	hsa-miR-195	CLIP-seq
MIRT886495	hsa-miR-199a-5p	CLIP-seq
MIRT886496	hsa-miR-199b-5p	CLIP-seq
MIRT886497	hsa-miR-214	CLIP-seq
MIRT886498	hsa-miR-2682	CLIP-seq
MIRT886499	hsa-miR-296-5p	CLIP-seq
MIRT886500	hsa-miR-3194-3p	CLIP-seq
MIRT886501	hsa-miR-3202	CLIP-seq
MIRT886502	hsa-miR-320a	CLIP-seq
MIRT886503	hsa-miR-320b	CLIP-seq
MIRT886504	hsa-miR-320c	CLIP-seq
MIRT886505	hsa-miR-320d	CLIP-seq
MIRT886506	hsa-miR-325	CLIP-seq
MIRT886507	hsa-miR-340	CLIP-seq
MIRT886508	hsa-miR-3616-5p	CLIP-seq
MIRT886509	hsa-miR-3619-5p	CLIP-seq
MIRT886510	hsa-miR-3622b-5p	CLIP-seq
MIRT886511	hsa-miR-3647-5p	CLIP-seq
MIRT886512	hsa-miR-3667-5p	CLIP-seq
MIRT886513	hsa-miR-3915	CLIP-seq
MIRT886514	hsa-miR-3919	CLIP-seq
MIRT886515	hsa-miR-3928	CLIP-seq
MIRT886516	hsa-miR-3937	CLIP-seq
MIRT886517	hsa-miR-424	CLIP-seq
MIRT886518	hsa-miR-4251	CLIP-seq
MIRT886519	hsa-miR-4302	CLIP-seq
MIRT886520	hsa-miR-4323	CLIP-seq
MIRT886521	hsa-miR-4324	CLIP-seq
MIRT886522	hsa-miR-4428	CLIP-seq
MIRT886523	hsa-miR-4429	CLIP-seq
MIRT886524	hsa-miR-4434	CLIP-seq
MIRT886525	hsa-miR-4493	CLIP-seq
MIRT886526	hsa-miR-449c	CLIP-seq
MIRT886527	hsa-miR-4503	CLIP-seq
MIRT886528	hsa-miR-4512	CLIP-seq
MIRT886529	hsa-miR-4516	CLIP-seq
MIRT886530	hsa-miR-4531	CLIP-seq
MIRT886531	hsa-miR-4533	CLIP-seq
MIRT886532	hsa-miR-4534	CLIP-seq
MIRT886533	hsa-miR-4645-5p	CLIP-seq
MIRT886534	hsa-miR-4673	CLIP-seq
MIRT886535	hsa-miR-4718	CLIP-seq
MIRT886536	hsa-miR-4722-5p	CLIP-seq
MIRT886537	hsa-miR-4786-5p	CLIP-seq
MIRT886538	hsa-miR-4794	CLIP-seq
MIRT886539	hsa-miR-4795-5p	CLIP-seq
MIRT886540	hsa-miR-4802-3p	CLIP-seq
MIRT886541	hsa-miR-490-5p	CLIP-seq
MIRT886542	hsa-miR-497	CLIP-seq
MIRT886543	hsa-miR-539	CLIP-seq
MIRT886544	hsa-miR-561	CLIP-seq
MIRT886545	hsa-miR-573	CLIP-seq
MIRT886546	hsa-miR-582-3p	CLIP-seq
MIRT886547	hsa-miR-589	CLIP-seq
MIRT886548	hsa-miR-760	CLIP-seq
MIRT886549	hsa-miR-761	CLIP-seq
MIRT886550	hsa-miR-940	CLIP-seq
MIRT1962905	hsa-miR-1286	CLIP-seq
MIRT886497	hsa-miR-214	CLIP-seq
MIRT886500	hsa-miR-3194-3p	CLIP-seq
MIRT1962906	hsa-miR-3611	CLIP-seq
MIRT886508	hsa-miR-3616-5p	CLIP-seq
MIRT886509	hsa-miR-3619-5p	CLIP-seq
MIRT886511	hsa-miR-3647-5p	CLIP-seq
MIRT1962907	hsa-miR-3670	CLIP-seq
MIRT886516	hsa-miR-3937	CLIP-seq
MIRT1962908	hsa-miR-4291	CLIP-seq
MIRT1962909	hsa-miR-4446-3p	CLIP-seq
MIRT1962910	hsa-miR-4492	CLIP-seq
MIRT1962911	hsa-miR-4498	CLIP-seq
MIRT886527	hsa-miR-4503	CLIP-seq
MIRT1962912	hsa-miR-4505	CLIP-seq
MIRT1962913	hsa-miR-4761-5p	CLIP-seq
MIRT886539	hsa-miR-4795-5p	CLIP-seq
MIRT1962914	hsa-miR-556-5p	CLIP-seq
MIRT886545	hsa-miR-573	CLIP-seq
MIRT886548	hsa-miR-760	CLIP-seq
MIRT886549	hsa-miR-761	CLIP-seq
MIRT1962915	hsa-miR-762	CLIP-seq
MIRT1962916	hsa-miR-922	CLIP-seq
MIRT2199242	hsa-miR-1178	CLIP-seq
MIRT2199243	hsa-miR-1204	CLIP-seq
MIRT2199244	hsa-miR-1254	CLIP-seq
MIRT2199245	hsa-miR-1293	CLIP-seq
MIRT2199246	hsa-miR-149	CLIP-seq
MIRT2199247	hsa-miR-3116	CLIP-seq
MIRT2199248	hsa-miR-3151	CLIP-seq
MIRT2199249	hsa-miR-3176	CLIP-seq
MIRT2199250	hsa-miR-3180-5p	CLIP-seq
MIRT2199251	hsa-miR-3192	CLIP-seq
MIRT886500	hsa-miR-3194-3p	CLIP-seq
MIRT2199252	hsa-miR-3922-3p	CLIP-seq
MIRT2199253	hsa-miR-4283	CLIP-seq
MIRT2199254	hsa-miR-4314	CLIP-seq
MIRT1962909	hsa-miR-4446-3p	CLIP-seq
MIRT2199255	hsa-miR-4483	CLIP-seq
MIRT2199256	hsa-miR-4489	CLIP-seq
MIRT1962910	hsa-miR-4492	CLIP-seq
MIRT1962911	hsa-miR-4498	CLIP-seq
MIRT2199257	hsa-miR-4502	CLIP-seq
MIRT1962912	hsa-miR-4505	CLIP-seq
MIRT2199258	hsa-miR-4645-3p	CLIP-seq
MIRT886533	hsa-miR-4645-5p	CLIP-seq
MIRT2199259	hsa-miR-4646-5p	CLIP-seq
MIRT886534	hsa-miR-4673	CLIP-seq
MIRT2199260	hsa-miR-4695-5p	CLIP-seq
MIRT2199261	hsa-miR-4749-3p	CLIP-seq
MIRT2199262	hsa-miR-485-5p	CLIP-seq
MIRT2199263	hsa-miR-661	CLIP-seq
MIRT2199264	hsa-miR-663b	CLIP-seq
MIRT1962915	hsa-miR-762	CLIP-seq
MIRT886500	hsa-miR-3194-3p	CLIP-seq
MIRT2385969	hsa-miR-4277	CLIP-seq
MIRT1962909	hsa-miR-4446-3p	CLIP-seq
MIRT1962910	hsa-miR-4492	CLIP-seq
MIRT1962911	hsa-miR-4498	CLIP-seq
MIRT1962912	hsa-miR-4505	CLIP-seq
MIRT1962915	hsa-miR-762	CLIP-seq
MIRT886487	hsa-miR-1253	CLIP-seq
MIRT2199251	hsa-miR-3192	CLIP-seq
MIRT886500	hsa-miR-3194-3p	CLIP-seq
MIRT2502041	hsa-miR-326	CLIP-seq
MIRT2502042	hsa-miR-330-5p	CLIP-seq
MIRT2199254	hsa-miR-4314	CLIP-seq
MIRT2199259	hsa-miR-4646-5p	CLIP-seq
MIRT2502043	hsa-miR-593	CLIP-seq

Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000242	Component	Pericentriolar material	IDA	26220856
GO:0000922	Component	Spindle pole	IDA	21399614
GO:0000922	Component	Spindle pole	IEA
GO:0005515	Function	Protein binding	IPI	18985028, 21044950, 26220856, 29712910, 32107292, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005730	Component	Nucleolus	IDA	21399614
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005813	Component	Centrosome	IBA
GO:0005813	Component	Centrosome	IDA	21399614, 26220856
GO:0005813	Component	Centrosome	IEA
GO:0005814	Component	Centriole	IDA	29712910, 32107292
GO:0005814	Component	Centriole	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005938	Component	Cell cortex	IDA	32107292
GO:0005938	Component	Cell cortex	IEA
GO:0006469	Process	Negative regulation of protein kinase activity	IMP	26220856
GO:0007059	Process	Chromosome segregation	IEA
GO:0007099	Process	Centriole replication	IMP	29712910
GO:0016477	Process	Cell migration	IMP	32107292
GO:0042802	Function	Identical protein binding	IDA	29712910
GO:0046602	Process	Regulation of mitotic centrosome separation	IMP	26220856
GO:0098534	Process	Centriole assembly	IMP	29712910

MIM	HGNC	e!Ensembl
618898	25309	ENSG00000130695

Q6P2H3

Protein name

Centrosomal protein of 85 kDa (Cep85) (Coiled-coil domain-containing protein 21)

Protein function

Acts as a regulator of centriole duplication through a direct interaction with STIL, a key factor involved in the early steps of centriole formation. The CEP85-STIL protein complex acts as a modulator of PLK4-driven cytoskeletal rearrangements a

PDB

5OI7 , 5OID

Family and domains

Sequence

MAMQEKYPTEGISHVTSPSSDVIQKGSSLGTEWQTPVISEPFRSRFSRCSSVADSGDTAI
GTSCSDIAEDFCSSSGSPPFQPIKSHVTIPTAHVMPSTLGTSPAKPNSTPVGPSSSKLPL
SGLAESVGMTRNGDLGAMKHSPGLSRDLMYFSGATGENGIEQSWFPAVGHERQEEARKFD
IPSMESTLNQSAMMETLYSDPHHRVRFHNPRTSTSKELYRVLPEAKKAPGSGAVFERNGP
HSNSSGVLPLGLQPAPGLSKPLPSQVWQPSPDTWHPREQSCELSTCRQQLELIRLQMEQM
QLQNGAICHHPAAFGPSLPILEPAQWISILNSNEHLLKEKELLIDKQRKHISQLEQKVRE
SELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASE
VEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLE
RYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQR
EAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSL
EQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGS
PPSPDTAQLALELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDL
QKPDVIKRKLEEVQQLRRDIEDLRTTMSDRYAQDMGENCVTQ

Sequence length

762

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

CEP85 (centrosomal protein 85)