Gene Gene information from NCBI Gene database.
Entrez ID 64786
Gene name TBC1 domain family member 15
Gene symbol TBC1D15
Synonyms (NCBI Gene)
RAB7-GAP
Chromosome 12
Chromosome location 12q21.1
Summary This gene encodes a member of the Ras-like proteins in brain-GTPase activating protein superfamily that share a conserved Tre-2/Bub2/Cdc16 domain. The encoded protein interacts with Ras-like protein in brain 5A and may function as a regulator of intracell
miRNA miRNA information provided by mirtarbase database.
623
miRTarBase ID miRNA Experiments Reference
MIRT032446 hsa-let-7b-5p Proteomics 18668040
MIRT050825 hsa-miR-17-5p CLASH 23622248
MIRT050522 hsa-miR-20a-5p CLASH 23622248
MIRT041974 hsa-miR-484 CLASH 23622248
MIRT698708 hsa-miR-6771-3p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
9
GO ID Ontology Definition Evidence Reference
GO:0005096 Function GTPase activator activity IBA
GO:0005096 Function GTPase activator activity IEA
GO:0005096 Function GTPase activator activity ISS
GO:0005515 Function Protein binding IPI 20562859, 21516116, 25416956, 26638075, 32296183, 32814053, 33536340
GO:0005576 Component Extracellular region IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
612662 25694 ENSG00000121749
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8TC07
Protein name TBC1 domain family member 15 (GTPase-activating protein RAB7) (GAP for RAB7) (Rab7-GAP)
Protein function Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12068 PH_RBD 10 211 Rab-binding domain (RBD) Domain
PF00566 RabGAP-TBC 349 578 Rab-GTPase-TBC domain Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:33536340}.
Sequence
Sequence length 691
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Mitophagy - animal   TBC/RABGAPs
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Parkinson Disease Parkinson disease Pubtator 33753743 Associate
★☆☆☆☆
Found in Text Mining only