Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	64784
Gene name	CREB regulated transcription coactivator 3
Gene symbol	CRTC3
Synonyms (NCBI Gene)	TORC-3TORC3
Chromosome	15
Chromosome location	15q26.1
Summary	This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this

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miRTarBase ID	miRNA	Experiments	Reference
MIRT023199	hsa-miR-124-3p	Microarray	18668037
MIRT025919	hsa-miR-7-5p	Microarray	19073608
MIRT049715	hsa-miR-92a-3p	CLASH	23622248
MIRT039296	hsa-miR-671-5p	CLASH	23622248
MIRT691025	hsa-miR-6768-5p	HITS-CLIP	23313552
MIRT691024	hsa-miR-383-5p	HITS-CLIP	23313552
MIRT691023	hsa-miR-129-1-3p	HITS-CLIP	23313552
MIRT691022	hsa-miR-129-2-3p	HITS-CLIP	23313552
MIRT691021	hsa-miR-28-5p	HITS-CLIP	23313552
MIRT691020	hsa-miR-3139	HITS-CLIP	23313552
MIRT691019	hsa-miR-708-5p	HITS-CLIP	23313552
MIRT691018	hsa-miR-4464	HITS-CLIP	23313552
MIRT691017	hsa-miR-4748	HITS-CLIP	23313552
MIRT691016	hsa-miR-29b-1-5p	HITS-CLIP	23313552
MIRT691015	hsa-miR-642a-3p	HITS-CLIP	23313552
MIRT691014	hsa-miR-642b-3p	HITS-CLIP	23313552
MIRT691013	hsa-miR-4487	HITS-CLIP	23313552
MIRT691012	hsa-miR-4772-5p	HITS-CLIP	23313552
MIRT691011	hsa-miR-6828-5p	HITS-CLIP	23313552
MIRT039296	hsa-miR-671-5p	HITS-CLIP	23313552
MIRT691010	hsa-miR-6079	HITS-CLIP	23313552
MIRT691009	hsa-miR-29b-2-5p	HITS-CLIP	23313552
MIRT691008	hsa-miR-514a-3p	HITS-CLIP	23313552
MIRT691007	hsa-miR-514b-3p	HITS-CLIP	23313552
MIRT440874	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT440873	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT440874	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT727928	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT727927	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT727925	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT727926	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT440873	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT691025	hsa-miR-6768-5p	HITS-CLIP	23313552
MIRT691024	hsa-miR-383-5p	HITS-CLIP	23313552
MIRT691023	hsa-miR-129-1-3p	HITS-CLIP	23313552
MIRT691022	hsa-miR-129-2-3p	HITS-CLIP	23313552
MIRT691021	hsa-miR-28-5p	HITS-CLIP	23313552
MIRT691020	hsa-miR-3139	HITS-CLIP	23313552
MIRT691019	hsa-miR-708-5p	HITS-CLIP	23313552
MIRT691018	hsa-miR-4464	HITS-CLIP	23313552
MIRT691017	hsa-miR-4748	HITS-CLIP	23313552
MIRT691016	hsa-miR-29b-1-5p	HITS-CLIP	23313552
MIRT691015	hsa-miR-642a-3p	HITS-CLIP	23313552
MIRT691014	hsa-miR-642b-3p	HITS-CLIP	23313552
MIRT691013	hsa-miR-4487	HITS-CLIP	23313552
MIRT691012	hsa-miR-4772-5p	HITS-CLIP	23313552
MIRT691011	hsa-miR-6828-5p	HITS-CLIP	23313552
MIRT039296	hsa-miR-671-5p	HITS-CLIP	23313552
MIRT691010	hsa-miR-6079	HITS-CLIP	23313552
MIRT691009	hsa-miR-29b-2-5p	HITS-CLIP	23313552
MIRT691008	hsa-miR-514a-3p	HITS-CLIP	23313552
MIRT691007	hsa-miR-514b-3p	HITS-CLIP	23313552
MIRT910865	hsa-miR-134	CLIP-seq
MIRT910866	hsa-miR-298	CLIP-seq
MIRT910867	hsa-miR-3118	CLIP-seq
MIRT910868	hsa-miR-3136-5p	CLIP-seq
MIRT910869	hsa-miR-3163	CLIP-seq
MIRT910870	hsa-miR-3182	CLIP-seq
MIRT910871	hsa-miR-3662	CLIP-seq
MIRT910872	hsa-miR-3678-3p	CLIP-seq
MIRT910873	hsa-miR-4276	CLIP-seq
MIRT910874	hsa-miR-4439	CLIP-seq
MIRT910875	hsa-miR-4513	CLIP-seq
MIRT910876	hsa-miR-4652-3p	CLIP-seq
MIRT910877	hsa-miR-4659a-3p	CLIP-seq
MIRT910878	hsa-miR-4659b-3p	CLIP-seq
MIRT910879	hsa-miR-4684-3p	CLIP-seq
MIRT910880	hsa-miR-4718	CLIP-seq
MIRT910881	hsa-miR-4728-3p	CLIP-seq
MIRT910882	hsa-miR-522	CLIP-seq
MIRT910883	hsa-miR-543	CLIP-seq
MIRT910884	hsa-miR-1236	CLIP-seq
MIRT910885	hsa-miR-1249	CLIP-seq
MIRT910886	hsa-miR-1273f	CLIP-seq
MIRT910887	hsa-miR-128	CLIP-seq
MIRT910888	hsa-miR-1292	CLIP-seq
MIRT910889	hsa-miR-143	CLIP-seq
MIRT910890	hsa-miR-144	CLIP-seq
MIRT910891	hsa-miR-1825	CLIP-seq
MIRT910892	hsa-miR-1827	CLIP-seq
MIRT910893	hsa-miR-1972	CLIP-seq
MIRT910894	hsa-miR-199a-5p	CLIP-seq
MIRT910895	hsa-miR-199b-5p	CLIP-seq
MIRT910896	hsa-miR-214	CLIP-seq
MIRT910897	hsa-miR-2682	CLIP-seq
MIRT910898	hsa-miR-3125	CLIP-seq
MIRT910899	hsa-miR-3127-3p	CLIP-seq
MIRT910900	hsa-miR-3135b	CLIP-seq
MIRT910869	hsa-miR-3163	CLIP-seq
MIRT910901	hsa-miR-3174	CLIP-seq
MIRT910902	hsa-miR-3180-5p	CLIP-seq
MIRT910903	hsa-miR-3184	CLIP-seq
MIRT910904	hsa-miR-3187-3p	CLIP-seq
MIRT910905	hsa-miR-3201	CLIP-seq
MIRT910906	hsa-miR-320a	CLIP-seq
MIRT910907	hsa-miR-320b	CLIP-seq
MIRT910908	hsa-miR-320c	CLIP-seq
MIRT910909	hsa-miR-320d	CLIP-seq
MIRT910910	hsa-miR-326	CLIP-seq
MIRT910911	hsa-miR-330-5p	CLIP-seq
MIRT910912	hsa-miR-3619-5p	CLIP-seq
MIRT910913	hsa-miR-3649	CLIP-seq
MIRT910871	hsa-miR-3662	CLIP-seq
MIRT910914	hsa-miR-3663-3p	CLIP-seq
MIRT910915	hsa-miR-3663-5p	CLIP-seq
MIRT910916	hsa-miR-3685	CLIP-seq
MIRT910917	hsa-miR-370	CLIP-seq
MIRT910918	hsa-miR-384	CLIP-seq
MIRT910919	hsa-miR-3916	CLIP-seq
MIRT910920	hsa-miR-3921	CLIP-seq
MIRT910921	hsa-miR-3925-3p	CLIP-seq
MIRT910922	hsa-miR-3937	CLIP-seq
MIRT910923	hsa-miR-423-5p	CLIP-seq
MIRT910924	hsa-miR-4251	CLIP-seq
MIRT910925	hsa-miR-4279	CLIP-seq
MIRT910926	hsa-miR-4320	CLIP-seq
MIRT910927	hsa-miR-4329	CLIP-seq
MIRT910928	hsa-miR-4429	CLIP-seq
MIRT910929	hsa-miR-4435	CLIP-seq
MIRT910930	hsa-miR-4436b-3p	CLIP-seq
MIRT910931	hsa-miR-4471	CLIP-seq
MIRT910932	hsa-miR-4476	CLIP-seq
MIRT910933	hsa-miR-449c	CLIP-seq
MIRT910934	hsa-miR-450b-3p	CLIP-seq
MIRT910935	hsa-miR-4512	CLIP-seq
MIRT910936	hsa-miR-4530	CLIP-seq
MIRT910937	hsa-miR-4646-5p	CLIP-seq
MIRT910938	hsa-miR-4653-5p	CLIP-seq
MIRT910939	hsa-miR-4688	CLIP-seq
MIRT910940	hsa-miR-4695-3p	CLIP-seq
MIRT910941	hsa-miR-4701-5p	CLIP-seq
MIRT910942	hsa-miR-4708-5p	CLIP-seq
MIRT910943	hsa-miR-4713-3p	CLIP-seq
MIRT910880	hsa-miR-4718	CLIP-seq
MIRT910881	hsa-miR-4728-3p	CLIP-seq
MIRT910944	hsa-miR-4757-3p	CLIP-seq
MIRT910945	hsa-miR-4763-5p	CLIP-seq
MIRT910946	hsa-miR-4766-5p	CLIP-seq
MIRT910947	hsa-miR-4770	CLIP-seq
MIRT910948	hsa-miR-4772-3p	CLIP-seq
MIRT910949	hsa-miR-4786-3p	CLIP-seq
MIRT910950	hsa-miR-4791	CLIP-seq
MIRT910951	hsa-miR-516b	CLIP-seq
MIRT910952	hsa-miR-520a-5p	CLIP-seq
MIRT910953	hsa-miR-520d-5p	CLIP-seq
MIRT910954	hsa-miR-521	CLIP-seq
MIRT910882	hsa-miR-522	CLIP-seq
MIRT910955	hsa-miR-524-5p	CLIP-seq
MIRT910956	hsa-miR-525-5p	CLIP-seq
MIRT910957	hsa-miR-526b	CLIP-seq
MIRT910958	hsa-miR-548s	CLIP-seq
MIRT910959	hsa-miR-582-3p	CLIP-seq
MIRT910960	hsa-miR-588	CLIP-seq
MIRT910961	hsa-miR-596	CLIP-seq
MIRT910962	hsa-miR-638	CLIP-seq
MIRT910963	hsa-miR-642b	CLIP-seq
MIRT910964	hsa-miR-660	CLIP-seq
MIRT910965	hsa-miR-761	CLIP-seq
MIRT910966	hsa-miR-765	CLIP-seq
MIRT910967	hsa-miR-769-3p	CLIP-seq
MIRT910880	hsa-miR-4718	CLIP-seq
MIRT910881	hsa-miR-4728-3p	CLIP-seq
MIRT1920373	hsa-miR-197	CLIP-seq
MIRT1920374	hsa-miR-3622a-5p	CLIP-seq
MIRT1920375	hsa-miR-3977	CLIP-seq
MIRT1920376	hsa-miR-412	CLIP-seq
MIRT1920377	hsa-miR-4423-3p	CLIP-seq
MIRT1920373	hsa-miR-197	CLIP-seq
MIRT1920374	hsa-miR-3622a-5p	CLIP-seq
MIRT1920375	hsa-miR-3977	CLIP-seq
MIRT1920376	hsa-miR-412	CLIP-seq
MIRT1920377	hsa-miR-4423-3p	CLIP-seq
MIRT1970048	hsa-miR-148a	CLIP-seq
MIRT1970049	hsa-miR-148b	CLIP-seq
MIRT1970050	hsa-miR-152	CLIP-seq
MIRT1970051	hsa-miR-3155	CLIP-seq
MIRT1970052	hsa-miR-3155b	CLIP-seq
MIRT910869	hsa-miR-3163	CLIP-seq
MIRT910871	hsa-miR-3662	CLIP-seq
MIRT1970053	hsa-miR-3941	CLIP-seq
MIRT910873	hsa-miR-4276	CLIP-seq
MIRT1970054	hsa-miR-4277	CLIP-seq
MIRT1970055	hsa-miR-4457	CLIP-seq
MIRT1970056	hsa-miR-466	CLIP-seq
MIRT1970057	hsa-miR-4672	CLIP-seq
MIRT1970058	hsa-miR-4789-3p	CLIP-seq
MIRT1970059	hsa-miR-484	CLIP-seq
MIRT1970060	hsa-miR-513b	CLIP-seq
MIRT910882	hsa-miR-522	CLIP-seq
MIRT1970061	hsa-miR-1179	CLIP-seq
MIRT1970062	hsa-miR-1271	CLIP-seq
MIRT1970063	hsa-miR-182	CLIP-seq
MIRT1970064	hsa-miR-3132	CLIP-seq
MIRT1970065	hsa-miR-342-5p	CLIP-seq
MIRT910924	hsa-miR-4251	CLIP-seq
MIRT1970066	hsa-miR-4255	CLIP-seq
MIRT910927	hsa-miR-4329	CLIP-seq
MIRT1970067	hsa-miR-4422	CLIP-seq
MIRT1970068	hsa-miR-4493	CLIP-seq
MIRT1970069	hsa-miR-4651	CLIP-seq
MIRT1970070	hsa-miR-4664-5p	CLIP-seq
MIRT1970071	hsa-miR-4717-3p	CLIP-seq
MIRT910880	hsa-miR-4718	CLIP-seq
MIRT910881	hsa-miR-4728-3p	CLIP-seq
MIRT1970072	hsa-miR-4731-5p	CLIP-seq
MIRT1970073	hsa-miR-608	CLIP-seq
MIRT910963	hsa-miR-642b	CLIP-seq
MIRT1970074	hsa-miR-708	CLIP-seq
MIRT1970075	hsa-miR-96	CLIP-seq
MIRT2206019	hsa-miR-1224-3p	CLIP-seq
MIRT2206020	hsa-miR-1260	CLIP-seq
MIRT2206021	hsa-miR-1260b	CLIP-seq
MIRT1970062	hsa-miR-1271	CLIP-seq
MIRT2206022	hsa-miR-1280	CLIP-seq
MIRT2206023	hsa-miR-15a	CLIP-seq
MIRT2206024	hsa-miR-15b	CLIP-seq
MIRT2206025	hsa-miR-16	CLIP-seq
MIRT1970063	hsa-miR-182	CLIP-seq
MIRT910892	hsa-miR-1827	CLIP-seq
MIRT2206026	hsa-miR-195	CLIP-seq
MIRT1920373	hsa-miR-197	CLIP-seq
MIRT910896	hsa-miR-214	CLIP-seq
MIRT910897	hsa-miR-2682	CLIP-seq
MIRT1970051	hsa-miR-3155	CLIP-seq
MIRT1970052	hsa-miR-3155b	CLIP-seq
MIRT910869	hsa-miR-3163	CLIP-seq
MIRT910904	hsa-miR-3187-3p	CLIP-seq
MIRT910906	hsa-miR-320a	CLIP-seq
MIRT910907	hsa-miR-320b	CLIP-seq
MIRT910908	hsa-miR-320c	CLIP-seq
MIRT910909	hsa-miR-320d	CLIP-seq
MIRT2206027	hsa-miR-340	CLIP-seq
MIRT910912	hsa-miR-3619-5p	CLIP-seq
MIRT1920374	hsa-miR-3622a-5p	CLIP-seq
MIRT2206028	hsa-miR-3646	CLIP-seq
MIRT910922	hsa-miR-3937	CLIP-seq
MIRT1920375	hsa-miR-3977	CLIP-seq
MIRT1920376	hsa-miR-412	CLIP-seq
MIRT2206029	hsa-miR-424	CLIP-seq
MIRT2206030	hsa-miR-4252	CLIP-seq
MIRT1920377	hsa-miR-4423-3p	CLIP-seq
MIRT910928	hsa-miR-4429	CLIP-seq
MIRT910929	hsa-miR-4435	CLIP-seq
MIRT1970055	hsa-miR-4457	CLIP-seq
MIRT910933	hsa-miR-449c	CLIP-seq
MIRT2206031	hsa-miR-4528	CLIP-seq
MIRT2206032	hsa-miR-4690-5p	CLIP-seq
MIRT910941	hsa-miR-4701-5p	CLIP-seq
MIRT1970071	hsa-miR-4717-3p	CLIP-seq
MIRT2206033	hsa-miR-4717-5p	CLIP-seq
MIRT2206034	hsa-miR-4762-3p	CLIP-seq
MIRT910948	hsa-miR-4772-3p	CLIP-seq
MIRT1970059	hsa-miR-484	CLIP-seq
MIRT2206035	hsa-miR-494	CLIP-seq
MIRT2206036	hsa-miR-497	CLIP-seq
MIRT1970060	hsa-miR-513b	CLIP-seq
MIRT910951	hsa-miR-516b	CLIP-seq
MIRT910953	hsa-miR-520d-5p	CLIP-seq
MIRT910955	hsa-miR-524-5p	CLIP-seq
MIRT2206037	hsa-miR-532-3p	CLIP-seq
MIRT2206038	hsa-miR-548a-3p	CLIP-seq
MIRT2206039	hsa-miR-548e	CLIP-seq
MIRT2206040	hsa-miR-548f	CLIP-seq
MIRT910958	hsa-miR-548s	CLIP-seq
MIRT910960	hsa-miR-588	CLIP-seq
MIRT910963	hsa-miR-642b	CLIP-seq
MIRT1970074	hsa-miR-708	CLIP-seq
MIRT910965	hsa-miR-761	CLIP-seq
MIRT910966	hsa-miR-765	CLIP-seq
MIRT2206041	hsa-miR-890	CLIP-seq
MIRT2206042	hsa-miR-922	CLIP-seq
MIRT1970075	hsa-miR-96	CLIP-seq
MIRT910917	hsa-miR-370	CLIP-seq
MIRT1970066	hsa-miR-4255	CLIP-seq
MIRT1970067	hsa-miR-4422	CLIP-seq
MIRT2386484	hsa-miR-4690-3p	CLIP-seq
MIRT910945	hsa-miR-4763-5p	CLIP-seq
MIRT910961	hsa-miR-596	CLIP-seq
MIRT910890	hsa-miR-144	CLIP-seq
MIRT910916	hsa-miR-3685	CLIP-seq
MIRT910918	hsa-miR-384	CLIP-seq
MIRT1970053	hsa-miR-3941	CLIP-seq
MIRT2436478	hsa-miR-4643	CLIP-seq
MIRT1970056	hsa-miR-466	CLIP-seq
MIRT1970057	hsa-miR-4672	CLIP-seq
MIRT1970058	hsa-miR-4789-3p	CLIP-seq
MIRT2436479	hsa-miR-600	CLIP-seq
MIRT2509201	hsa-miR-1279	CLIP-seq
MIRT1970048	hsa-miR-148a	CLIP-seq
MIRT1970049	hsa-miR-148b	CLIP-seq
MIRT1970050	hsa-miR-152	CLIP-seq
MIRT2509202	hsa-miR-361-3p	CLIP-seq
MIRT2509203	hsa-miR-3684	CLIP-seq
MIRT2509204	hsa-miR-376a	CLIP-seq
MIRT2509205	hsa-miR-376b	CLIP-seq
MIRT910873	hsa-miR-4276	CLIP-seq
MIRT2509206	hsa-miR-4313	CLIP-seq
MIRT2509207	hsa-miR-4452	CLIP-seq
MIRT2509208	hsa-miR-4521	CLIP-seq
MIRT1970061	hsa-miR-1179	CLIP-seq
MIRT1970062	hsa-miR-1271	CLIP-seq
MIRT2509201	hsa-miR-1279	CLIP-seq
MIRT1970048	hsa-miR-148a	CLIP-seq
MIRT1970049	hsa-miR-148b	CLIP-seq
MIRT1970050	hsa-miR-152	CLIP-seq
MIRT1970063	hsa-miR-182	CLIP-seq
MIRT910894	hsa-miR-199a-5p	CLIP-seq
MIRT910895	hsa-miR-199b-5p	CLIP-seq
MIRT910899	hsa-miR-3127-3p	CLIP-seq
MIRT1970064	hsa-miR-3132	CLIP-seq
MIRT1970065	hsa-miR-342-5p	CLIP-seq
MIRT2509202	hsa-miR-361-3p	CLIP-seq
MIRT2509203	hsa-miR-3684	CLIP-seq
MIRT2509204	hsa-miR-376a	CLIP-seq
MIRT2509205	hsa-miR-376b	CLIP-seq
MIRT910873	hsa-miR-4276	CLIP-seq
MIRT910925	hsa-miR-4279	CLIP-seq
MIRT2509206	hsa-miR-4313	CLIP-seq
MIRT2509207	hsa-miR-4452	CLIP-seq
MIRT1970068	hsa-miR-4493	CLIP-seq
MIRT2509208	hsa-miR-4521	CLIP-seq
MIRT2678678	hsa-miR-4640-3p	CLIP-seq
MIRT1970069	hsa-miR-4651	CLIP-seq
MIRT1970070	hsa-miR-4664-5p	CLIP-seq
MIRT1970071	hsa-miR-4717-3p	CLIP-seq
MIRT1970072	hsa-miR-4731-5p	CLIP-seq
MIRT2678679	hsa-miR-548aa	CLIP-seq
MIRT1970073	hsa-miR-608	CLIP-seq
MIRT910963	hsa-miR-642b	CLIP-seq
MIRT2678680	hsa-miR-676	CLIP-seq
MIRT1970074	hsa-miR-708	CLIP-seq
MIRT1970075	hsa-miR-96	CLIP-seq

Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003713	Function	Transcription coactivator activity	IBA
GO:0005515	Function	Protein binding	IPI	20936779, 28514442, 30611118, 32296183, 33961781, 35271311, 36931259, 39251607
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0008140	Function	CAMP response element binding protein binding	IBA
GO:0008140	Function	CAMP response element binding protein binding	IEA
GO:0016042	Process	Lipid catabolic process	IEA
GO:0042116	Process	Macrophage activation	IMP	23033494
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0050995	Process	Negative regulation of lipid catabolic process	IEA
GO:0051289	Process	Protein homotetramerization	IEA
GO:0071320	Process	Cellular response to cAMP	IBA
GO:0071878	Process	Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway	IBA
GO:0071878	Process	Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway	IEA
GO:0097009	Process	Energy homeostasis	IEA

MIM	HGNC	e!Ensembl
608986	26148	ENSG00000140577

Q6UUV7

Protein name

CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3)

Protein function

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts indep

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12884	TORC_N	11 → 81	Transducer of regulated CREB activity, N terminus	Family
PF12885	TORC_M	159 → 321	Transducer of regulated CREB activity middle domain	Family
PF12886	TORC_C	545 → 619	Transducer of regulated CREB activity, C terminus	Family

Tissue specificity

TISSUE SPECIFICITY: Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach. {ECO:0000269|P

Sequence

MAASPGSGSANPRKFSEKIALHTQRQAEETRAFEQLMTDLTLSRVQFQKLQQLRLTQYHG
GSLPNVSQLRSSASEFQPSFHQADNVRGTRHHGLVERPSRNRFHPLHRRSGDKPGRQFDG
SAFGANYSSQPLDESWPRQQPPWKDEKHPGFRLTSALNRTNSDSALHTSALSTKPQDPYG
GGGQSAWPAPYMGFCDGENNGHGEVASFPGPLKEENLLNVPKPLPKQLWETKEIQSLSGR
PRSCDVGGGNAFPHNGQNLGLSPFLGTLNTGGSLPDLTNLHYSTPLPASLDTTDHHFGSM
SVGNSVNNIPAAMTHLGIRSSSGLQSSRSNPSIQATLNKTVLSSSLNNHPQTSVPNASAL
HPSLRLFSLSNPSLSTTNLSGPSRRRQPPVSPLTLSPGPEAHQGFSRQLSSTSPLAPYPT
SQMVSSDRSQLSFLPTEAQAQVSPPPPYPAPQELTQPLLQQPRAPEAPAQQPQAASSLPQ
SDFQLLPAQGSSLTNFFPDVGFDQQSMRPGPAFPQQVPLVQQGSRELQDSFHLRPSPYSN
CGSLPNTILPEDSSTSLFKDLNSALAGLPEVSLNVDTPFPLEEELQIEPLSLDGLNMLSD
SSMGLLDPSVEETFRADRL

Sequence length

619

Interactions

View interactions

	KEGG		Reactome
	Human T-cell leukemia virus 1 infection		Transcriptional activation of mitochondrial biogenesis Circadian Clock

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ULCERATIVE COLITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (25)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute Coronary Syndrome	Coronary Syndrome	BEFREE	29979427		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of large intestine	Colorectal Cancer	GWASCAT_DG	29228715, 31089142		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	29559730	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Mucoepidermoid	Mucoepidermoid carcinoma	Pubtator	19749740, 23035786, 28438292, 33878706, 36366450	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	BEFREE	29979427		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	GWASCAT_DG	29228715, 31089142		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	GWASCAT_DG	29228715, 31089142		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	33411955	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	GWASCAT_DG	26192919		★★★★★ ★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn disease	Pubtator	26937622	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	GWASCAT_DG	23128233, 26192919, 28067908		★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	GWASDB_DG	23128233		★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	BEFREE	26937622		★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory bowel disease	Pubtator	26937622	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	32648197	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of large intestine	Colorectal Neoplasms	GWASCAT_DG	29228715, 31089142		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	GWASCAT_DG	29228715, 31089142		★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	33741716	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Metabolic Diseases	Metabolic Diseases	BEFREE	24264430		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mucoepidermoid Carcinoma	Mucoepidermoid Carcinoma	BEFREE	18050304, 19749740, 21668476, 23035786, 24121173, 28412212, 28438292, 28930752		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mucoepidermoid Carcinoma	Mucoepidermoid Carcinoma	LHGDN	18050304		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	19749740		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neutrophilia (disorder)	Neutrophilia	BEFREE	29078378		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	21164481, 24264430, 28322447, 29220752		★★★★★ ★☆☆☆☆ Found in Text Mining only
Salivary Gland Neoplasms	Salivary gland neoplasms	Pubtator	33878706	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

CRTC3 (CREB regulated transcription coactivator 3)