Gene Gene information from NCBI Gene database.
Entrez ID 64778
Gene name Fibronectin type III domain containing 3B
Gene symbol FNDC3B
Synonyms (NCBI Gene)
FAD104PRO4979YVTM2421
Chromosome 3
Chromosome location 3q26.31
miRNA miRNA information provided by mirtarbase database.
1018
miRTarBase ID miRNA Experiments Reference
MIRT003060 hsa-miR-143-3p Luciferase reporter assayqRT-PCRWestern blot 19472311
MIRT003060 hsa-miR-143-3p Review 19935707
MIRT003060 hsa-miR-143-3p Luciferase reporter assay 19472311
MIRT003060 hsa-miR-143-3p Review 20026422
MIRT001467 hsa-miR-16-5p pSILAC 18668040
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
5
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674
GO:0005515 Function Protein binding IPI 25416956, 32296183
GO:0005737 Component Cytoplasm IEA
GO:0012505 Component Endomembrane system IEA
GO:0016020 Component Membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
611909 24670 ENSG00000075420
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q53EP0
Protein name Fibronectin type III domain-containing protein 3B (Factor for adipocyte differentiation 104) (HCV NS5A-binding protein 37)
Protein function May be a positive regulator of adipogenesis.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00041 fn3 277 367 Fibronectin type III domain Domain
PF00041 fn3 381 463 Fibronectin type III domain Domain
PF00041 fn3 476 560 Fibronectin type III domain Domain
PF00041 fn3 573 659 Fibronectin type III domain Domain
PF00041 fn3 674 755 Fibronectin type III domain Domain
PF00041 fn3 777 849 Fibronectin type III domain Domain
PF00041 fn3 881 947 Fibronectin type III domain Domain
PF00041 fn3 959 1042 Fibronectin type III domain Domain
PF00041 fn3 1055 1135 Fibronectin type III domain Domain
Tissue specificity TISSUE SPECIFICITY: Predominantly expressed in white adipose tissue (WAT) especially in the stromal vascular cells. Expressed in adipocyte differentiable 3T3-L1 cells but not in the non-adipogenic cell line NIH-3T3. Expression increased in the early stage
Sequence
MYVTMMMTDQIPLELPPLLNGEVAMMPHLVNGDAAQQVILVQVNPGETFTIRAEDGTLQC
IQGPAEVPMMSPNGSIPPIHVPPGYISQVIEDSTGVRRVVVTPQSPECYPPSYPSAMSPT
HHLPPYLTHHPHFIHNSHTAYYPPVTGPGDMPPQFFPQHHLPHTIYGEQEIIPFYGMSTY
ITREDQYSKPPHKKLKDRQIDRQNRLNSPPSSIYKSSCTTVYNGYGKGHSGGSGGGGSGS
GPGIKKTERRARSSPKSNDSDLQEYELEVKRVQDILSGIEKPQVSNIQARAVVLSWAPPV
GLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYN
SVKGSCS
EPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGK
RNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYS
QEVVCYTLGNIPQMPSA
PRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKR
STQYKFRLTASNTEGKSCPS
EVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNG
GSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCS
E
SLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEV
YHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYS
DVSEITTAAGPPGQCKAPCISCTPD
GCVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAF
NQAGAGPYS
ELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEI
LAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFS
QFIKAKTRPLPPL
PPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRL
TEFTCYSFRIQAASEAGEGPFS
ETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSM
KGDPVNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCACRRCLDTS
QELSG
AFSPSAAFVLQRSEVMLTGDMGSLDDPKMKSMMPTDEQFAAIIVLGFATLSILFAFILQY
FLMK
Sequence length 1204
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
15
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ATRIAL FIBRILLATION GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BELL'S PALSY GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute Promyelocytic Leukemia Promyelocytic Leukemia CTD_human_DG 28314734
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 30988707
★☆☆☆☆
Found in Text Mining only
Barrett Esophagus Barrett esophagus BEFREE 29417867
★☆☆☆☆
Found in Text Mining only
Barrett Esophagus Barrett esophagus Pubtator 29417867 Associate
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 29180690 Inhibit
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 22510613, 30945699 Associate
★☆☆☆☆
Found in Text Mining only
Coronary Artery Disease Coronary artery disease GWASCAT_DG 29212778
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Craniosynostosis Craniosynostosis BEFREE 27541078
★☆☆☆☆
Found in Text Mining only
Dysmorphic features Dysmorphic Features BEFREE 27541078
★☆☆☆☆
Found in Text Mining only
Esophageal Squamous Cell Carcinoma Esophageal squamous cell carcinoma Pubtator 35703190, 37667251 Stimulate
★☆☆☆☆
Found in Text Mining only