Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	64761
Gene name	Poly(ADP-ribose) polymerase family member 12
Gene symbol	PARP12
Synonyms (NCBI Gene)	ARTD12MST109MSTP109ZC3H1ZC3HDC1
Chromosome	7
Chromosome location	7q34

235

Show/Hide all (235)

miRTarBase ID	miRNA	Experiments	Reference
MIRT027561	hsa-miR-98-5p	Microarray	19088304
MIRT1214444	hsa-miR-1323	CLIP-seq
MIRT1214445	hsa-miR-3654	CLIP-seq
MIRT1214446	hsa-miR-4477a	CLIP-seq
MIRT1214447	hsa-miR-548a-3p	CLIP-seq
MIRT1214448	hsa-miR-548e	CLIP-seq
MIRT1214449	hsa-miR-548f	CLIP-seq
MIRT1214450	hsa-miR-548o	CLIP-seq
MIRT1214451	hsa-miR-548p	CLIP-seq
MIRT2061690	hsa-miR-134	CLIP-seq
MIRT2061691	hsa-miR-147	CLIP-seq
MIRT2061692	hsa-miR-2113	CLIP-seq
MIRT2061693	hsa-miR-298	CLIP-seq
MIRT2061694	hsa-miR-3118	CLIP-seq
MIRT2061695	hsa-miR-34b	CLIP-seq
MIRT2061696	hsa-miR-3688-5p	CLIP-seq
MIRT2061697	hsa-miR-3911	CLIP-seq
MIRT2061698	hsa-miR-4504	CLIP-seq
MIRT2061699	hsa-miR-4514	CLIP-seq
MIRT2061700	hsa-miR-4632	CLIP-seq
MIRT2061701	hsa-miR-4692	CLIP-seq
MIRT2061702	hsa-miR-542-3p	CLIP-seq
MIRT2061703	hsa-miR-644	CLIP-seq
MIRT2061704	hsa-miR-758	CLIP-seq
MIRT2061705	hsa-miR-943	CLIP-seq
MIRT2290058	hsa-miR-15a	CLIP-seq
MIRT2290059	hsa-miR-15b	CLIP-seq
MIRT2290060	hsa-miR-16	CLIP-seq
MIRT2290061	hsa-miR-1825	CLIP-seq
MIRT2290062	hsa-miR-183	CLIP-seq
MIRT2290063	hsa-miR-195	CLIP-seq
MIRT2290064	hsa-miR-198	CLIP-seq
MIRT2290065	hsa-miR-199a-5p	CLIP-seq
MIRT2290066	hsa-miR-199b-5p	CLIP-seq
MIRT2290067	hsa-miR-218	CLIP-seq
MIRT2290068	hsa-miR-299-3p	CLIP-seq
MIRT2290069	hsa-miR-3065-5p	CLIP-seq
MIRT2290070	hsa-miR-3664-5p	CLIP-seq
MIRT2290071	hsa-miR-3925-5p	CLIP-seq
MIRT2290072	hsa-miR-424	CLIP-seq
MIRT2290073	hsa-miR-4292	CLIP-seq
MIRT2290074	hsa-miR-4302	CLIP-seq
MIRT2290075	hsa-miR-4308	CLIP-seq
MIRT2290076	hsa-miR-4496	CLIP-seq
MIRT2061698	hsa-miR-4504	CLIP-seq
MIRT2290077	hsa-miR-4705	CLIP-seq
MIRT2290078	hsa-miR-4773	CLIP-seq
MIRT2290079	hsa-miR-497	CLIP-seq
MIRT2290080	hsa-miR-505	CLIP-seq
MIRT2290081	hsa-miR-513a-5p	CLIP-seq
MIRT2061702	hsa-miR-542-3p	CLIP-seq
MIRT2290082	hsa-miR-542-5p	CLIP-seq
MIRT2290083	hsa-miR-545	CLIP-seq
MIRT2290084	hsa-miR-548q	CLIP-seq
MIRT2290085	hsa-miR-615-5p	CLIP-seq
MIRT2290086	hsa-miR-629	CLIP-seq
MIRT2290087	hsa-miR-634	CLIP-seq
MIRT2290088	hsa-miR-636	CLIP-seq
MIRT2290089	hsa-miR-637	CLIP-seq
MIRT2290090	hsa-miR-648	CLIP-seq
MIRT2290091	hsa-miR-661	CLIP-seq
MIRT2061698	hsa-miR-4504	CLIP-seq
MIRT2061702	hsa-miR-542-3p	CLIP-seq
MIRT2588072	hsa-miR-1254	CLIP-seq
MIRT2588073	hsa-miR-1272	CLIP-seq
MIRT2588074	hsa-miR-1299	CLIP-seq
MIRT2588075	hsa-miR-1322	CLIP-seq
MIRT2588076	hsa-miR-1587	CLIP-seq
MIRT2588077	hsa-miR-22	CLIP-seq
MIRT2588078	hsa-miR-2467-3p	CLIP-seq
MIRT2588079	hsa-miR-3116	CLIP-seq
MIRT2588080	hsa-miR-3129-3p	CLIP-seq
MIRT2588081	hsa-miR-3148	CLIP-seq
MIRT2588082	hsa-miR-3158-5p	CLIP-seq
MIRT2061695	hsa-miR-34b	CLIP-seq
MIRT2588083	hsa-miR-365	CLIP-seq
MIRT2588084	hsa-miR-3653	CLIP-seq
MIRT2588085	hsa-miR-3658	CLIP-seq
MIRT2588086	hsa-miR-3672	CLIP-seq
MIRT2588087	hsa-miR-3678-3p	CLIP-seq
MIRT2588088	hsa-miR-3921	CLIP-seq
MIRT2290071	hsa-miR-3925-5p	CLIP-seq
MIRT2588089	hsa-miR-3940-5p	CLIP-seq
MIRT2588090	hsa-miR-4251	CLIP-seq
MIRT2588091	hsa-miR-4318	CLIP-seq
MIRT2588092	hsa-miR-4329	CLIP-seq
MIRT2588093	hsa-miR-4417	CLIP-seq
MIRT2588094	hsa-miR-4418	CLIP-seq
MIRT2588095	hsa-miR-4434	CLIP-seq
MIRT2588096	hsa-miR-4461	CLIP-seq
MIRT2588097	hsa-miR-4492	CLIP-seq
MIRT2588098	hsa-miR-4498	CLIP-seq
MIRT2588099	hsa-miR-4507	CLIP-seq
MIRT2588100	hsa-miR-4511	CLIP-seq
MIRT2588101	hsa-miR-4516	CLIP-seq
MIRT2588102	hsa-miR-451b	CLIP-seq
MIRT2588103	hsa-miR-4522	CLIP-seq
MIRT2588104	hsa-miR-4528	CLIP-seq
MIRT2061700	hsa-miR-4632	CLIP-seq
MIRT2588105	hsa-miR-4652-3p	CLIP-seq
MIRT2588106	hsa-miR-4653-5p	CLIP-seq
MIRT2588107	hsa-miR-4656	CLIP-seq
MIRT2588108	hsa-miR-4659a-5p	CLIP-seq
MIRT2588109	hsa-miR-4659b-5p	CLIP-seq
MIRT2588110	hsa-miR-4675	CLIP-seq
MIRT2588111	hsa-miR-4693-5p	CLIP-seq
MIRT2588112	hsa-miR-4714-5p	CLIP-seq
MIRT2588113	hsa-miR-4741	CLIP-seq
MIRT2588114	hsa-miR-4766-3p	CLIP-seq
MIRT2588115	hsa-miR-4768-3p	CLIP-seq
MIRT2290078	hsa-miR-4773	CLIP-seq
MIRT2588116	hsa-miR-4782-5p	CLIP-seq
MIRT2588117	hsa-miR-4786-3p	CLIP-seq
MIRT2588118	hsa-miR-4803	CLIP-seq
MIRT2588119	hsa-miR-509-3-5p	CLIP-seq
MIRT2588120	hsa-miR-509-5p	CLIP-seq
MIRT2588121	hsa-miR-516b	CLIP-seq
MIRT2588122	hsa-miR-539	CLIP-seq
MIRT2588123	hsa-miR-548a-5p	CLIP-seq
MIRT2588124	hsa-miR-548ab	CLIP-seq
MIRT2588125	hsa-miR-548ae	CLIP-seq
MIRT2588126	hsa-miR-548aj	CLIP-seq
MIRT2588127	hsa-miR-548ak	CLIP-seq
MIRT2588128	hsa-miR-548am	CLIP-seq
MIRT2588129	hsa-miR-548b-3p	CLIP-seq
MIRT2588130	hsa-miR-548b-5p	CLIP-seq
MIRT2588131	hsa-miR-548c-3p	CLIP-seq
MIRT2588132	hsa-miR-548c-5p	CLIP-seq
MIRT2588133	hsa-miR-548d-5p	CLIP-seq
MIRT2588134	hsa-miR-548h	CLIP-seq
MIRT2588135	hsa-miR-548i	CLIP-seq
MIRT2588136	hsa-miR-548j	CLIP-seq
MIRT2588137	hsa-miR-548n	CLIP-seq
MIRT2588138	hsa-miR-548t	CLIP-seq
MIRT2588139	hsa-miR-548w	CLIP-seq
MIRT2588140	hsa-miR-548x	CLIP-seq
MIRT2588141	hsa-miR-548y	CLIP-seq
MIRT2588142	hsa-miR-558	CLIP-seq
MIRT2588143	hsa-miR-559	CLIP-seq
MIRT2588144	hsa-miR-561	CLIP-seq
MIRT2588145	hsa-miR-592	CLIP-seq
MIRT2588146	hsa-miR-597	CLIP-seq
MIRT2588147	hsa-miR-616	CLIP-seq
MIRT2588148	hsa-miR-642b	CLIP-seq
MIRT2290091	hsa-miR-661	CLIP-seq
MIRT2588149	hsa-miR-665	CLIP-seq
MIRT2588150	hsa-miR-762	CLIP-seq
MIRT2588151	hsa-miR-875-3p	CLIP-seq
MIRT2588152	hsa-miR-892a	CLIP-seq
MIRT2588153	hsa-miR-922	CLIP-seq
MIRT2588072	hsa-miR-1254	CLIP-seq
MIRT2588073	hsa-miR-1272	CLIP-seq
MIRT2588074	hsa-miR-1299	CLIP-seq
MIRT2588075	hsa-miR-1322	CLIP-seq
MIRT2588076	hsa-miR-1587	CLIP-seq
MIRT2588077	hsa-miR-22	CLIP-seq
MIRT2588078	hsa-miR-2467-3p	CLIP-seq
MIRT2588079	hsa-miR-3116	CLIP-seq
MIRT2588080	hsa-miR-3129-3p	CLIP-seq
MIRT2588081	hsa-miR-3148	CLIP-seq
MIRT2588082	hsa-miR-3158-5p	CLIP-seq
MIRT2061695	hsa-miR-34b	CLIP-seq
MIRT2588083	hsa-miR-365	CLIP-seq
MIRT2588084	hsa-miR-3653	CLIP-seq
MIRT2588085	hsa-miR-3658	CLIP-seq
MIRT2588086	hsa-miR-3672	CLIP-seq
MIRT2588087	hsa-miR-3678-3p	CLIP-seq
MIRT2588088	hsa-miR-3921	CLIP-seq
MIRT2290071	hsa-miR-3925-5p	CLIP-seq
MIRT2588089	hsa-miR-3940-5p	CLIP-seq
MIRT2588090	hsa-miR-4251	CLIP-seq
MIRT2588091	hsa-miR-4318	CLIP-seq
MIRT2588092	hsa-miR-4329	CLIP-seq
MIRT2588093	hsa-miR-4417	CLIP-seq
MIRT2588094	hsa-miR-4418	CLIP-seq
MIRT2588095	hsa-miR-4434	CLIP-seq
MIRT2588096	hsa-miR-4461	CLIP-seq
MIRT2588097	hsa-miR-4492	CLIP-seq
MIRT2588098	hsa-miR-4498	CLIP-seq
MIRT2588099	hsa-miR-4507	CLIP-seq
MIRT2588100	hsa-miR-4511	CLIP-seq
MIRT2588101	hsa-miR-4516	CLIP-seq
MIRT2588102	hsa-miR-451b	CLIP-seq
MIRT2588103	hsa-miR-4522	CLIP-seq
MIRT2588104	hsa-miR-4528	CLIP-seq
MIRT2061700	hsa-miR-4632	CLIP-seq
MIRT2588106	hsa-miR-4653-5p	CLIP-seq
MIRT2588107	hsa-miR-4656	CLIP-seq
MIRT2588108	hsa-miR-4659a-5p	CLIP-seq
MIRT2588109	hsa-miR-4659b-5p	CLIP-seq
MIRT2588110	hsa-miR-4675	CLIP-seq
MIRT2588111	hsa-miR-4693-5p	CLIP-seq
MIRT2588112	hsa-miR-4714-5p	CLIP-seq
MIRT2588113	hsa-miR-4741	CLIP-seq
MIRT2588114	hsa-miR-4766-3p	CLIP-seq
MIRT2588115	hsa-miR-4768-3p	CLIP-seq
MIRT2290078	hsa-miR-4773	CLIP-seq
MIRT2588116	hsa-miR-4782-5p	CLIP-seq
MIRT2588117	hsa-miR-4786-3p	CLIP-seq
MIRT2588118	hsa-miR-4803	CLIP-seq
MIRT2588119	hsa-miR-509-3-5p	CLIP-seq
MIRT2588120	hsa-miR-509-5p	CLIP-seq
MIRT2588121	hsa-miR-516b	CLIP-seq
MIRT2588122	hsa-miR-539	CLIP-seq
MIRT2588123	hsa-miR-548a-5p	CLIP-seq
MIRT2588124	hsa-miR-548ab	CLIP-seq
MIRT2588125	hsa-miR-548ae	CLIP-seq
MIRT2588126	hsa-miR-548aj	CLIP-seq
MIRT2588127	hsa-miR-548ak	CLIP-seq
MIRT2588128	hsa-miR-548am	CLIP-seq
MIRT2588129	hsa-miR-548b-3p	CLIP-seq
MIRT2588130	hsa-miR-548b-5p	CLIP-seq
MIRT2588131	hsa-miR-548c-3p	CLIP-seq
MIRT2588132	hsa-miR-548c-5p	CLIP-seq
MIRT2588133	hsa-miR-548d-5p	CLIP-seq
MIRT2588134	hsa-miR-548h	CLIP-seq
MIRT2588135	hsa-miR-548i	CLIP-seq
MIRT2588136	hsa-miR-548j	CLIP-seq
MIRT2588137	hsa-miR-548n	CLIP-seq
MIRT2588138	hsa-miR-548t	CLIP-seq
MIRT2588139	hsa-miR-548w	CLIP-seq
MIRT2588140	hsa-miR-548x	CLIP-seq
MIRT2588141	hsa-miR-548y	CLIP-seq
MIRT2588142	hsa-miR-558	CLIP-seq
MIRT2588143	hsa-miR-559	CLIP-seq
MIRT2588145	hsa-miR-592	CLIP-seq
MIRT2588146	hsa-miR-597	CLIP-seq
MIRT2588147	hsa-miR-616	CLIP-seq
MIRT2588148	hsa-miR-642b	CLIP-seq
MIRT2290091	hsa-miR-661	CLIP-seq
MIRT2588149	hsa-miR-665	CLIP-seq
MIRT2588150	hsa-miR-762	CLIP-seq
MIRT2588151	hsa-miR-875-3p	CLIP-seq
MIRT2588152	hsa-miR-892a	CLIP-seq
MIRT2588153	hsa-miR-922	CLIP-seq

Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003950	Function	NAD+ poly-ADP-ribosyltransferase activity	IBA
GO:0003950	Function	NAD+ poly-ADP-ribosyltransferase activity	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005802	Component	Trans-Golgi network	IDA	29070863
GO:0008270	Function	Zinc ion binding	IEA
GO:0010494	Component	Cytoplasmic stress granule	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA
GO:0016779	Function	Nucleotidyltransferase activity	IEA
GO:0044331	Process	Cell-cell adhesion mediated by cadherin	IDA	18593713
GO:0046872	Function	Metal ion binding	IEA
GO:0070213	Process	Protein auto-ADP-ribosylation	IDA	25043379
GO:0070633	Process	Transepithelial transport	IDA	34969853
GO:0070633	Process	Transepithelial transport	IDA	34969853
GO:0140803	Function	NAD+-protein-cysteine ADP-ribosyltransferase activity	IEA
GO:0140806	Function	NAD+-protein-aspartate ADP-ribosyltransferase activity	IEA
GO:1990404	Function	NAD+-protein mono-ADP-ribosyltransferase activity	IDA	25043379
GO:1990404	Function	NAD+-protein mono-ADP-ribosyltransferase activity	IEA

MIM	HGNC	e!Ensembl
612481	21919	ENSG00000059378

Q9H0J9

Protein name

Protein mono-ADP-ribosyltransferase PARP12 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Poly [ADP-ribose] polymerase 12) (PARP-12) (Zinc finger CCCH domain-containing protein 1)

Protein function

Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:25043379, PubMed:34969853). Acts as an antiviral factor by cooperating with PARP11 to suppress Zika virus replication (PubMed:34187568). Displays anti-alp

PDB

2PQF , 6V3W , 8XPX

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00642	zf-CCCH	177 → 201	Zinc finger C-x8-C-x5-C-x3-H type (and similar)	Family
PF02825	WWE	377 → 458	WWE domain	Family
PF00644	PARP	507 → 679	Poly(ADP-ribose) polymerase catalytic domain	Family

Sequence

MAQAGVVGEVTQVLCAAGGALELPELRRRLRMGLSADALERLLRQRGRFVVAVRAGGAAA
APERVVLAASPLRLCRAHQGSKPGCVGLCAQLHLCRFMVYGACKFLRAGKNCRNSHSLTT
EHNLSVLRTHGVDHLSYNELCQLLFQNDPWLLPEICQHYNKGDGPHGSCAFQKQCIKLHI
CQYFLQGECKFGTSCKRSHDFSNSENLEKLEKLGMSSDLVSRLPTIYRNAHDIKNKSSAP
SRVPPLFVPQGTSERKDSSGSVSPNTLSQEEGDQICLYHIRKSCSFQDKCHRVHFHLPYR
WQFLDRGKWEDLDNMELIEEAYCNPKIERILCSESASTFHSHCLNFNAMTYGATQARRLS
TASSVTKPPHFILTTDWIWYWSDEFGSWQEYGRQGTVHPVTTVSSSDVEKAYLAYCTPGS
DGQAATLKFQAGKHNYELDFKAFVQKNLVYGTTKKVCRRPKYVSPQDVTTMQTCNTKFPG
PKSIPDYWDSSALPDPGFQKITLSSSSEEYQKVWNLFNRTLPFYFVQKIERVQNLALWEV
YQWQKGQMQKQNGGKAVDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARD
AAYSHHYSKSDTQTHTMFLARVLVGEFVRGNASFVRPPAKEGWSNAFYDSCVNSVSDPSI
FVIFEKHQVYPEYVIQYTTSSKPSVTPSILLALGSLFSSRQ

Sequence length

701

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Clear cell carcinoma of kidney	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MACULAR DEGENERATION	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VITILIGO	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (10)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Age related macular degeneration	Age-related macular degeneration	CTD_human_DG	30742112		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	38302034	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	22194930, 28615517	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	GWASCAT_DG	29212778		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Liver carcinoma	Liver carcinoma	BEFREE	30154409		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	30154409		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	36063278	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	Pubtator	36929572	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	34880209	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Vitiligo	Vitiligo	GWASCAT_DG	27723757		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

PARP12 (poly(ADP-ribose) polymerase family member 12)