Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	64753
Gene name	Coiled-coil domain containing 136
Gene symbol	CCDC136
Synonyms (NCBI Gene)	NAG6
Chromosome	7
Chromosome location	7q32.1

116

Show/Hide all (116)

miRTarBase ID	miRNA	Experiments	Reference
MIRT041851	hsa-miR-484	CLASH	23622248
MIRT868037	hsa-miR-2116	CLIP-seq
MIRT868038	hsa-miR-3144-5p	CLIP-seq
MIRT868039	hsa-miR-3191	CLIP-seq
MIRT868040	hsa-miR-3675-5p	CLIP-seq
MIRT868041	hsa-miR-3714	CLIP-seq
MIRT868042	hsa-miR-3941	CLIP-seq
MIRT868043	hsa-miR-4457	CLIP-seq
MIRT868044	hsa-miR-4643	CLIP-seq
MIRT868045	hsa-miR-4652-5p	CLIP-seq
MIRT868046	hsa-miR-466	CLIP-seq
MIRT868047	hsa-miR-4662a-5p	CLIP-seq
MIRT868048	hsa-miR-4672	CLIP-seq
MIRT868049	hsa-miR-4717-3p	CLIP-seq
MIRT868050	hsa-miR-4731-3p	CLIP-seq
MIRT868051	hsa-miR-4797-5p	CLIP-seq
MIRT868052	hsa-miR-4801	CLIP-seq
MIRT868053	hsa-miR-4802-3p	CLIP-seq
MIRT868054	hsa-miR-510	CLIP-seq
MIRT868055	hsa-miR-600	CLIP-seq
MIRT868056	hsa-miR-642b	CLIP-seq
MIRT868057	hsa-miR-940	CLIP-seq
MIRT2497927	hsa-miR-1225-5p	CLIP-seq
MIRT2497928	hsa-miR-1273f	CLIP-seq
MIRT2497929	hsa-miR-128	CLIP-seq
MIRT2497930	hsa-miR-1293	CLIP-seq
MIRT2497931	hsa-miR-1913	CLIP-seq
MIRT2497932	hsa-miR-1976	CLIP-seq
MIRT2497933	hsa-miR-2467-5p	CLIP-seq
MIRT2497934	hsa-miR-3128	CLIP-seq
MIRT868038	hsa-miR-3144-5p	CLIP-seq
MIRT2497935	hsa-miR-3147	CLIP-seq
MIRT2497936	hsa-miR-3150a-3p	CLIP-seq
MIRT2497937	hsa-miR-3150b-3p	CLIP-seq
MIRT2497938	hsa-miR-3175	CLIP-seq
MIRT2497939	hsa-miR-3188	CLIP-seq
MIRT868039	hsa-miR-3191	CLIP-seq
MIRT2497940	hsa-miR-320a	CLIP-seq
MIRT2497941	hsa-miR-320b	CLIP-seq
MIRT2497942	hsa-miR-320c	CLIP-seq
MIRT2497943	hsa-miR-320d	CLIP-seq
MIRT2497944	hsa-miR-324-3p	CLIP-seq
MIRT2497945	hsa-miR-346	CLIP-seq
MIRT2497946	hsa-miR-3657	CLIP-seq
MIRT868040	hsa-miR-3675-5p	CLIP-seq
MIRT2497947	hsa-miR-370	CLIP-seq
MIRT2497948	hsa-miR-3926	CLIP-seq
MIRT2497949	hsa-miR-3929	CLIP-seq
MIRT2497950	hsa-miR-3975	CLIP-seq
MIRT2497951	hsa-miR-4252	CLIP-seq
MIRT2497952	hsa-miR-4290	CLIP-seq
MIRT2497953	hsa-miR-4302	CLIP-seq
MIRT2497954	hsa-miR-4419b	CLIP-seq
MIRT2497955	hsa-miR-4425	CLIP-seq
MIRT2497956	hsa-miR-4429	CLIP-seq
MIRT2497957	hsa-miR-4450	CLIP-seq
MIRT2497958	hsa-miR-4478	CLIP-seq
MIRT2497959	hsa-miR-4483	CLIP-seq
MIRT2497960	hsa-miR-4527	CLIP-seq
MIRT868044	hsa-miR-4643	CLIP-seq
MIRT868045	hsa-miR-4652-5p	CLIP-seq
MIRT2497961	hsa-miR-4667-5p	CLIP-seq
MIRT2497962	hsa-miR-4669	CLIP-seq
MIRT2497963	hsa-miR-4689	CLIP-seq
MIRT2497964	hsa-miR-4700-5p	CLIP-seq
MIRT2497965	hsa-miR-4701-5p	CLIP-seq
MIRT868049	hsa-miR-4717-3p	CLIP-seq
MIRT2497966	hsa-miR-4720-5p	CLIP-seq
MIRT2497967	hsa-miR-4722-3p	CLIP-seq
MIRT2497968	hsa-miR-4728-5p	CLIP-seq
MIRT2497969	hsa-miR-4781-3p	CLIP-seq
MIRT2497970	hsa-miR-4784	CLIP-seq
MIRT2497971	hsa-miR-4789-3p	CLIP-seq
MIRT868051	hsa-miR-4797-5p	CLIP-seq
MIRT2497972	hsa-miR-4799-3p	CLIP-seq
MIRT868053	hsa-miR-4802-3p	CLIP-seq
MIRT2497973	hsa-miR-485-5p	CLIP-seq
MIRT2497974	hsa-miR-548s	CLIP-seq
MIRT2497975	hsa-miR-555	CLIP-seq
MIRT2497976	hsa-miR-588	CLIP-seq
MIRT2497977	hsa-miR-626	CLIP-seq
MIRT868056	hsa-miR-642b	CLIP-seq
MIRT2497978	hsa-miR-939	CLIP-seq
MIRT2497927	hsa-miR-1225-5p	CLIP-seq
MIRT2497929	hsa-miR-128	CLIP-seq
MIRT2497930	hsa-miR-1293	CLIP-seq
MIRT2497931	hsa-miR-1913	CLIP-seq
MIRT2497932	hsa-miR-1976	CLIP-seq
MIRT2497935	hsa-miR-3147	CLIP-seq
MIRT2497940	hsa-miR-320a	CLIP-seq
MIRT2497941	hsa-miR-320b	CLIP-seq
MIRT2497942	hsa-miR-320c	CLIP-seq
MIRT2497943	hsa-miR-320d	CLIP-seq
MIRT2497944	hsa-miR-324-3p	CLIP-seq
MIRT2497946	hsa-miR-3657	CLIP-seq
MIRT2497947	hsa-miR-370	CLIP-seq
MIRT2497948	hsa-miR-3926	CLIP-seq
MIRT2497951	hsa-miR-4252	CLIP-seq
MIRT2497952	hsa-miR-4290	CLIP-seq
MIRT2497953	hsa-miR-4302	CLIP-seq
MIRT2497955	hsa-miR-4425	CLIP-seq
MIRT2497956	hsa-miR-4429	CLIP-seq
MIRT2497957	hsa-miR-4450	CLIP-seq
MIRT2497959	hsa-miR-4483	CLIP-seq
MIRT2497961	hsa-miR-4667-5p	CLIP-seq
MIRT2497962	hsa-miR-4669	CLIP-seq
MIRT2497964	hsa-miR-4700-5p	CLIP-seq
MIRT2497965	hsa-miR-4701-5p	CLIP-seq
MIRT2497967	hsa-miR-4722-3p	CLIP-seq
MIRT2497969	hsa-miR-4781-3p	CLIP-seq
MIRT2497971	hsa-miR-4789-3p	CLIP-seq
MIRT868051	hsa-miR-4797-5p	CLIP-seq
MIRT2497974	hsa-miR-548s	CLIP-seq
MIRT2497975	hsa-miR-555	CLIP-seq
MIRT2497976	hsa-miR-588	CLIP-seq
MIRT2497977	hsa-miR-626	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001675	Process	Acrosome assembly	IBA
GO:0001675	Process	Acrosome assembly	ISS
GO:0002080	Component	Acrosomal membrane	IBA
GO:0002080	Component	Acrosomal membrane	IEA
GO:0002080	Component	Acrosomal membrane	ISS
GO:0005515	Function	Protein binding	IPI	25416956, 28514442
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	ISS
GO:0007338	Process	Single fertilization	IBA
GO:0007338	Process	Single fertilization	IEA
GO:0007338	Process	Single fertilization	ISS
GO:0016020	Component	Membrane	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA

MIM	HGNC	e!Ensembl
611902	22225	ENSG00000128596

Q96JN2

Protein name

Coiled-coil domain-containing protein 136 (Nasopharyngeal carcinoma-associated gene 6 protein)

Protein function

May play a role in acrosome formation in spermatogenesis and in fertilization.

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Expressed in gastric tissues. Down-regulated in gastric cancer. {ECO:0000269|PubMed:15112360}.

Sequence

MQAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEE
LRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRS
LREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQN
ELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEY
RALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLR
QQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHS
VTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLC
RLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQ
LQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLL
SRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLK
SQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLEN
PDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADL
QLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQ
TSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEP
AEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACER
EFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCC
QEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVV
LYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEE
NEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLSESKKSSPTPNPPIFSLPLVGLVV
ISALLWCWWAETSS

Sequence length

1154

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (9)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATRIAL FIBRILLATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FLUTTER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOEMBOLIC STROKE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DILATED CARDIOMYOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DYSLEXIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEART FAILURE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTROPHIC CARDIOMYOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SPECIFIC LANGUAGE IMPAIRMENT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma	Carcinoma	BEFREE	15112360		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dyslexia	Dyslexia	GWASCAT_DG	25065397		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	15112360		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	15112360		★★★★★ ★☆☆☆☆ Found in Text Mining only
Specific language impairment	Specific Language Impairment	GWASCAT_DG	25065397		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Stomach Carcinoma	Stomach Carcinoma	BEFREE	15112360		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	15112360	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

CCDC136 (coiled-coil domain containing 136)