SMAP2 (small ArfGAP2)

Gene

• Entrez ID: 64744
• Gene name: Small ArfGAP2
• Gene symbol: SMAP2
• Synonyms (NCBI Gene): SMAP1L
• Chromosome: 1
• Chromosome location: 1p34.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT051572	hsa-let-7e-5p	CLASH	23622248
MIRT050238	hsa-miR-25-3p	CLASH	23622248
MIRT049376	hsa-miR-92a-3p	CLASH	23622248
MIRT040553	hsa-miR-92b-3p	CLASH	23622248
MIRT039542	hsa-miR-652-3p	CLASH	23622248
MIRT037758	hsa-miR-708-5p	CLASH	23622248
MIRT1371360	hsa-miR-1260	CLIP-seq
MIRT1371361	hsa-miR-1260b	CLIP-seq
MIRT1371362	hsa-miR-1273g	CLIP-seq
MIRT1371363	hsa-miR-188-3p	CLIP-seq
MIRT1371364	hsa-miR-3126-5p	CLIP-seq
MIRT1371365	hsa-miR-3156-3p	CLIP-seq
MIRT1371366	hsa-miR-3202	CLIP-seq
MIRT1371367	hsa-miR-329	CLIP-seq
MIRT1371368	hsa-miR-362-3p	CLIP-seq
MIRT1371369	hsa-miR-3714	CLIP-seq
MIRT1371370	hsa-miR-3941	CLIP-seq
MIRT1371371	hsa-miR-4318	CLIP-seq
MIRT1371372	hsa-miR-4419a	CLIP-seq
MIRT1371373	hsa-miR-4475	CLIP-seq
MIRT1371374	hsa-miR-4510	CLIP-seq
MIRT1371375	hsa-miR-4643	CLIP-seq
MIRT1371376	hsa-miR-466	CLIP-seq
MIRT1371377	hsa-miR-4672	CLIP-seq
MIRT1371378	hsa-miR-4691-3p	CLIP-seq
MIRT1371379	hsa-miR-4691-5p	CLIP-seq
MIRT1371380	hsa-miR-4747-5p	CLIP-seq
MIRT1371381	hsa-miR-4768-3p	CLIP-seq
MIRT1371382	hsa-miR-4789-3p	CLIP-seq
MIRT1371383	hsa-miR-4798-3p	CLIP-seq
MIRT1371384	hsa-miR-548an	CLIP-seq
MIRT1371385	hsa-miR-603	CLIP-seq
MIRT1371386	hsa-miR-766	CLIP-seq
MIRT1371387	hsa-miR-873	CLIP-seq
MIRT1371388	hsa-miR-888	CLIP-seq
MIRT1371389	hsa-let-7a	CLIP-seq
MIRT1371390	hsa-let-7b	CLIP-seq
MIRT1371391	hsa-let-7c	CLIP-seq
MIRT1371392	hsa-let-7d	CLIP-seq
MIRT1371393	hsa-let-7e	CLIP-seq
MIRT1371394	hsa-let-7f	CLIP-seq
MIRT1371395	hsa-let-7g	CLIP-seq
MIRT1371396	hsa-let-7i	CLIP-seq
MIRT1371397	hsa-miR-4263	CLIP-seq
MIRT1371398	hsa-miR-4458	CLIP-seq
MIRT1371399	hsa-miR-4461	CLIP-seq
MIRT1371400	hsa-miR-4496	CLIP-seq
MIRT1371401	hsa-miR-4500	CLIP-seq
MIRT1371378	hsa-miR-4691-3p	CLIP-seq
MIRT1371379	hsa-miR-4691-5p	CLIP-seq
MIRT1371402	hsa-miR-4799-5p	CLIP-seq
MIRT1371403	hsa-miR-576-5p	CLIP-seq
MIRT1371386	hsa-miR-766	CLIP-seq
MIRT1371404	hsa-miR-98	CLIP-seq
MIRT1553865	hsa-miR-3612	CLIP-seq
MIRT1553866	hsa-miR-4443	CLIP-seq
MIRT1553867	hsa-miR-4651	CLIP-seq
MIRT1553868	hsa-miR-485-5p	CLIP-seq
MIRT1553869	hsa-miR-608	CLIP-seq
MIRT1553870	hsa-miR-650	CLIP-seq
MIRT2110167	hsa-miR-1207-5p	CLIP-seq
MIRT2110168	hsa-miR-133a	CLIP-seq
MIRT2110169	hsa-miR-133b	CLIP-seq
MIRT2110170	hsa-miR-1909	CLIP-seq
MIRT1371366	hsa-miR-3202	CLIP-seq
MIRT1371378	hsa-miR-4691-3p	CLIP-seq
MIRT1371379	hsa-miR-4691-5p	CLIP-seq
MIRT2110171	hsa-miR-4723-5p	CLIP-seq
MIRT1371380	hsa-miR-4747-5p	CLIP-seq
MIRT2110172	hsa-miR-4763-3p	CLIP-seq
MIRT2110173	hsa-miR-4764-5p	CLIP-seq
MIRT2110174	hsa-miR-485-3p	CLIP-seq
MIRT1371386	hsa-miR-766	CLIP-seq
MIRT2333731	hsa-miR-1237	CLIP-seq
MIRT2110168	hsa-miR-133a	CLIP-seq
MIRT2110169	hsa-miR-133b	CLIP-seq
MIRT2333732	hsa-miR-138	CLIP-seq
MIRT1371363	hsa-miR-188-3p	CLIP-seq
MIRT2333733	hsa-miR-18a	CLIP-seq
MIRT2333734	hsa-miR-18b	CLIP-seq
MIRT2333735	hsa-miR-1915	CLIP-seq
MIRT2333736	hsa-miR-2392	CLIP-seq
MIRT2333737	hsa-miR-302a	CLIP-seq
MIRT2333738	hsa-miR-302b	CLIP-seq
MIRT2333739	hsa-miR-302c	CLIP-seq
MIRT2333740	hsa-miR-302d	CLIP-seq
MIRT2333741	hsa-miR-302e	CLIP-seq
MIRT2333742	hsa-miR-3152-5p	CLIP-seq
MIRT2333743	hsa-miR-3154	CLIP-seq
MIRT1371367	hsa-miR-329	CLIP-seq
MIRT2333744	hsa-miR-331-3p	CLIP-seq
MIRT2333745	hsa-miR-3605-5p	CLIP-seq
MIRT1553865	hsa-miR-3612	CLIP-seq
MIRT1371368	hsa-miR-362-3p	CLIP-seq
MIRT2333746	hsa-miR-3679-3p	CLIP-seq
MIRT2333747	hsa-miR-372	CLIP-seq
MIRT2333748	hsa-miR-373	CLIP-seq
MIRT1371370	hsa-miR-3941	CLIP-seq
MIRT1371397	hsa-miR-4263	CLIP-seq
MIRT2333749	hsa-miR-4297	CLIP-seq
MIRT1553866	hsa-miR-4443	CLIP-seq
MIRT2333750	hsa-miR-4521	CLIP-seq
MIRT1553867	hsa-miR-4651	CLIP-seq
MIRT1371378	hsa-miR-4691-3p	CLIP-seq
MIRT1371379	hsa-miR-4691-5p	CLIP-seq
MIRT2333751	hsa-miR-4727-5p	CLIP-seq
MIRT2333752	hsa-miR-4731-3p	CLIP-seq
MIRT2333753	hsa-miR-4735-3p	CLIP-seq
MIRT2333754	hsa-miR-4755-3p	CLIP-seq
MIRT1371381	hsa-miR-4768-3p	CLIP-seq
MIRT2333755	hsa-miR-4769-3p	CLIP-seq
MIRT1371382	hsa-miR-4789-3p	CLIP-seq
MIRT1371383	hsa-miR-4798-3p	CLIP-seq
MIRT2333756	hsa-miR-4801	CLIP-seq
MIRT2110174	hsa-miR-485-3p	CLIP-seq
MIRT1553868	hsa-miR-485-5p	CLIP-seq
MIRT2333757	hsa-miR-515-3p	CLIP-seq
MIRT2333758	hsa-miR-519a	CLIP-seq
MIRT2333759	hsa-miR-519b-3p	CLIP-seq
MIRT2333760	hsa-miR-519c-3p	CLIP-seq
MIRT2333761	hsa-miR-519e	CLIP-seq
MIRT2333762	hsa-miR-520a-3p	CLIP-seq
MIRT2333763	hsa-miR-520b	CLIP-seq
MIRT2333764	hsa-miR-520c-3p	CLIP-seq
MIRT2333765	hsa-miR-520d-3p	CLIP-seq
MIRT2333766	hsa-miR-520e	CLIP-seq
MIRT2333767	hsa-miR-548q	CLIP-seq
MIRT1371385	hsa-miR-603	CLIP-seq
MIRT1553869	hsa-miR-608	CLIP-seq
MIRT1553870	hsa-miR-650	CLIP-seq
MIRT2333768	hsa-miR-665	CLIP-seq
MIRT1371386	hsa-miR-766	CLIP-seq
MIRT2460005	hsa-miR-1264	CLIP-seq
MIRT2460006	hsa-miR-142-5p	CLIP-seq
MIRT2460007	hsa-miR-3907	CLIP-seq
MIRT2460008	hsa-miR-9	CLIP-seq
MIRT2627954	hsa-miR-1178	CLIP-seq
MIRT2627955	hsa-miR-1245	CLIP-seq
MIRT2627956	hsa-miR-1266	CLIP-seq
MIRT2627957	hsa-miR-1292	CLIP-seq
MIRT2627958	hsa-miR-129-5p	CLIP-seq
MIRT2627959	hsa-miR-1298	CLIP-seq
MIRT2627960	hsa-miR-1305	CLIP-seq
MIRT2627961	hsa-miR-1322	CLIP-seq
MIRT2627962	hsa-miR-146a	CLIP-seq
MIRT2627963	hsa-miR-146b-5p	CLIP-seq
MIRT2627964	hsa-miR-15a	CLIP-seq
MIRT2627965	hsa-miR-15b	CLIP-seq
MIRT2627966	hsa-miR-16	CLIP-seq
MIRT2333735	hsa-miR-1915	CLIP-seq
MIRT2627967	hsa-miR-195	CLIP-seq
MIRT2627968	hsa-miR-2110	CLIP-seq
MIRT2627969	hsa-miR-214	CLIP-seq
MIRT2627970	hsa-miR-3125	CLIP-seq
MIRT2627971	hsa-miR-3127-5p	CLIP-seq
MIRT2627972	hsa-miR-3140-3p	CLIP-seq
MIRT2627973	hsa-miR-3140-5p	CLIP-seq
MIRT2627974	hsa-miR-320a	CLIP-seq
MIRT2627975	hsa-miR-320b	CLIP-seq
MIRT2627976	hsa-miR-320c	CLIP-seq
MIRT2627977	hsa-miR-320d	CLIP-seq
MIRT2627978	hsa-miR-3619-5p	CLIP-seq
MIRT2627979	hsa-miR-3620	CLIP-seq
MIRT2627980	hsa-miR-3663-3p	CLIP-seq
MIRT2627981	hsa-miR-3671	CLIP-seq
MIRT2627982	hsa-miR-383	CLIP-seq
MIRT2627983	hsa-miR-3916	CLIP-seq
MIRT2627984	hsa-miR-3918	CLIP-seq
MIRT2627985	hsa-miR-3977	CLIP-seq
MIRT2627986	hsa-miR-424	CLIP-seq
MIRT2627987	hsa-miR-4261	CLIP-seq
MIRT2627988	hsa-miR-4270	CLIP-seq
MIRT2627989	hsa-miR-4271	CLIP-seq
MIRT2627990	hsa-miR-4291	CLIP-seq
MIRT2627991	hsa-miR-4308	CLIP-seq
MIRT2627992	hsa-miR-4323	CLIP-seq
MIRT2627993	hsa-miR-4429	CLIP-seq
MIRT2627994	hsa-miR-4441	CLIP-seq
MIRT2627995	hsa-miR-4449	CLIP-seq
MIRT2627996	hsa-miR-4471	CLIP-seq
MIRT2627997	hsa-miR-4518	CLIP-seq
MIRT2627998	hsa-miR-4646-5p	CLIP-seq
MIRT1371377	hsa-miR-4672	CLIP-seq
MIRT2627999	hsa-miR-4725-3p	CLIP-seq
MIRT2628000	hsa-miR-4765	CLIP-seq
MIRT2628001	hsa-miR-4772-5p	CLIP-seq
MIRT2628002	hsa-miR-4775	CLIP-seq
MIRT2628003	hsa-miR-4786-3p	CLIP-seq
MIRT2628004	hsa-miR-491-5p	CLIP-seq
MIRT2628005	hsa-miR-496	CLIP-seq
MIRT2628006	hsa-miR-497	CLIP-seq
MIRT2628007	hsa-miR-510	CLIP-seq
MIRT2628008	hsa-miR-589	CLIP-seq
MIRT2628009	hsa-miR-607	CLIP-seq
MIRT2628010	hsa-miR-711	CLIP-seq
MIRT2628011	hsa-miR-761	CLIP-seq
MIRT2628012	hsa-miR-922	CLIP-seq
MIRT2627955	hsa-miR-1245	CLIP-seq
MIRT2627956	hsa-miR-1266	CLIP-seq
MIRT2627957	hsa-miR-1292	CLIP-seq
MIRT2627959	hsa-miR-1298	CLIP-seq
MIRT2627964	hsa-miR-15a	CLIP-seq
MIRT2627965	hsa-miR-15b	CLIP-seq
MIRT2627966	hsa-miR-16	CLIP-seq
MIRT2333735	hsa-miR-1915	CLIP-seq
MIRT2627967	hsa-miR-195	CLIP-seq
MIRT2627968	hsa-miR-2110	CLIP-seq
MIRT2691406	hsa-miR-28-5p	CLIP-seq
MIRT2627970	hsa-miR-3125	CLIP-seq
MIRT1371364	hsa-miR-3126-5p	CLIP-seq
MIRT2627971	hsa-miR-3127-5p	CLIP-seq
MIRT2691407	hsa-miR-3139	CLIP-seq
MIRT2627973	hsa-miR-3140-5p	CLIP-seq
MIRT2627974	hsa-miR-320a	CLIP-seq
MIRT2627975	hsa-miR-320b	CLIP-seq
MIRT2627976	hsa-miR-320c	CLIP-seq
MIRT2627977	hsa-miR-320d	CLIP-seq
MIRT2627979	hsa-miR-3620	CLIP-seq
MIRT2691408	hsa-miR-3660	CLIP-seq
MIRT2627980	hsa-miR-3663-3p	CLIP-seq
MIRT2627983	hsa-miR-3916	CLIP-seq
MIRT2627984	hsa-miR-3918	CLIP-seq
MIRT2627985	hsa-miR-3977	CLIP-seq
MIRT2627986	hsa-miR-424	CLIP-seq
MIRT2627987	hsa-miR-4261	CLIP-seq
MIRT2627988	hsa-miR-4270	CLIP-seq
MIRT2627989	hsa-miR-4271	CLIP-seq
MIRT2627991	hsa-miR-4308	CLIP-seq
MIRT2627992	hsa-miR-4323	CLIP-seq
MIRT1371372	hsa-miR-4419a	CLIP-seq
MIRT2627993	hsa-miR-4429	CLIP-seq
MIRT2627994	hsa-miR-4441	CLIP-seq
MIRT2627995	hsa-miR-4449	CLIP-seq
MIRT2627996	hsa-miR-4471	CLIP-seq
MIRT1371374	hsa-miR-4510	CLIP-seq
MIRT2627997	hsa-miR-4518	CLIP-seq
MIRT2691409	hsa-miR-4526	CLIP-seq
MIRT2627998	hsa-miR-4646-5p	CLIP-seq
MIRT1371377	hsa-miR-4672	CLIP-seq
MIRT2627999	hsa-miR-4725-3p	CLIP-seq
MIRT2628000	hsa-miR-4765	CLIP-seq
MIRT2628002	hsa-miR-4775	CLIP-seq
MIRT2628003	hsa-miR-4786-3p	CLIP-seq
MIRT2628004	hsa-miR-491-5p	CLIP-seq
MIRT2628005	hsa-miR-496	CLIP-seq
MIRT2628006	hsa-miR-497	CLIP-seq
MIRT2628007	hsa-miR-510	CLIP-seq
MIRT2691410	hsa-miR-708	CLIP-seq
MIRT2628010	hsa-miR-711	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 616916
• HGNC: 25082
• e!Ensembl: ENSG00000084070

Protein

• UniProt ID: Q8WU79
• Protein name: Stromal membrane-associated protein 2 (Stromal membrane-associated protein 1-like)
• Protein function: GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity).
• PDB: 2IQJ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01412	ArfGap	13 → 127	Putative GTPase activating protein for Arf	Domain

• Sequence:

  MTGKSVKDVDRYQAVLANLLLEEDNKFCADCQSKGPRWASWNIGVFICIRCAGIHRNLGV
  HISRVKSVNLDQWTQEQIQCMQEMGNGKANRLYEAYLPETFRRPQIDPAVEGFIRDKYEK
  KKYMDRSLDINAFRKEKDDKWKRGSEPVPEKKLEPVVFEKVKMPQKKEDPQLPRKSSPKS
  TAPVMDLLGLDAPVACSIANSKTSNTLEKDLDLLASVPSPSSSGSRKVVGSMPTAGSAGS
  VPENLNLFPEPGSKSEEIGKKQLSKDSILSLYGSQTPQMPTQAMFMAPAQMAYPTAYPSF
  PGVTPPNSIMGSMMPPPVGMVAQPGASGMVAPMAMPAGYMGGMQASMMGVPNGMMTTQQA
  GYMAGMAAMPQTVYGVQPAQQLQWNLTQMTQQMAGMNFYGANGMMNYGQSMSGGNGQAAN
  QTLSPQMWK

• Sequence length: 429

Pathways

KEGG:

Endocytosis

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
PANCREATIC CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Asthma	Asthma	BEFREE	20831471		★☆☆☆☆ Found in Text Mining only
Ataxia Telangiectasia	Ataxia Telangiectasia	BEFREE	20831471		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	39294296	Associate	★☆☆☆☆ Found in Text Mining only