GMNC (geminin coiled-coil domain containing)

Gene

• Entrez ID: 647309
• Gene name: Geminin coiled-coil domain containing
• Gene symbol: GMNC
• Synonyms (NCBI Gene): GEMC1
• Chromosome: 3
• Chromosome location: 3q28

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT449294	hsa-miR-4453	PAR-CLIP	22100165
MIRT449293	hsa-miR-4538	PAR-CLIP	22100165
MIRT449292	hsa-miR-5011-5p	PAR-CLIP	22100165
MIRT449291	hsa-miR-4528	PAR-CLIP	22100165
MIRT449290	hsa-miR-570-3p	PAR-CLIP	22100165
MIRT449289	hsa-miR-190a-3p	PAR-CLIP	22100165
MIRT449287	hsa-miR-3674	PAR-CLIP	22100165
MIRT449294	hsa-miR-4453	PAR-CLIP	22100165
MIRT449293	hsa-miR-4538	PAR-CLIP	22100165
MIRT449292	hsa-miR-5011-5p	PAR-CLIP	22100165
MIRT449291	hsa-miR-4528	PAR-CLIP	22100165
MIRT449290	hsa-miR-570-3p	PAR-CLIP	22100165
MIRT449289	hsa-miR-190a-3p	PAR-CLIP	22100165
MIRT449287	hsa-miR-3674	PAR-CLIP	22100165

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003682	Function	Chromatin binding	ISS
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0006260	Process	DNA replication	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007338	Process	Single fertilization	IEA
GO:0030174	Process	Regulation of DNA-templated DNA replication initiation	IBA
GO:0035264	Process	Multicellular organism growth	IEA
GO:0045786	Process	Negative regulation of cell cycle	IBA
GO:0060271	Process	Cilium assembly	IEA
GO:0072520	Process	Seminiferous tubule development	IEA
GO:0090660	Process	Cerebrospinal fluid circulation	IEA
GO:1903251	Process	Multi-ciliated epithelial cell differentiation	IEA

Other IDs

• MIM: 614448
• HGNC: 40049
• e!Ensembl: ENSG00000205835

Protein

• UniProt ID: A6NCL1
• Protein name: Geminin coiled-coil domain-containing protein 1
• Protein function: Regulator of DNA replication. Promotes initiation of chromosomal DNA replication by mediating TOPBP1- and CDK2-dependent recruitment of CDC45L onto replication origins (By similarity).
• PDB: 5C9N
• Sequence:

  MNTILPCQDQYFVGGQSYNCPYSTTTSESSVDVSTETWVSFWAAGLLDNRELQQAPQAQE
  SFSDSNFPLPDLCSWEEAQLSSQLYRNKQLQDTLVQKEEELARLHEENNHLRQYLNSALV
  KCLEEKAKKLLSSDEFSKAYGKFRKGKRKSKEQRYSPAEIPHPKNAKRNLSSEFANCEEQ
  AGPPVDPWVLQTLGLKDLDTIDDTSSANYSALASHPRRVASTFSQFPDDAVDYKNIPRED
  MPIDYRGDRTTPLHSTATHGEDFHILSQLSNPPVGLKTLPYYTAHVSPNKTEMAFSTSLS
  PHCNVKTHSFHQGQAFVRRDEEGGWKFTWVPKQS

• Sequence length: 334

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ALZHEIMER'S DISEASE NEUROPATHOLOGIC CHANGE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Brain Diseases	Brain disease	Pubtator	39457408	Associate	★☆☆☆☆ Found in Text Mining only
Congenital Hydrocephalus	Congenital Hydrocephalus	BEFREE	31328313		★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	37236919	Associate	★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	Pubtator	37236919	Associate	★☆☆☆☆ Found in Text Mining only
SCLEROSING CHOLANGITIS, NEONATAL	Sclerosing Cholangitis	BEFREE	31328313		★☆☆☆☆ Found in Text Mining only