CTAGE1 (cutaneous T cell lymphoma-associated antigen 1)

Gene

• Entrez ID: 64693
• Gene name: Cutaneous T cell lymphoma-associated antigen 1
• Gene symbol: CTAGE1
• Synonyms (NCBI Gene): CT21.1, CT21.2, CTAGE, CTAGE-1, CTAGE-2
• Chromosome: 18
• Chromosome location: 18q11.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT913636	hsa-miR-1283	CLIP-seq
MIRT913637	hsa-miR-1343	CLIP-seq
MIRT913638	hsa-miR-140-3p	CLIP-seq
MIRT913639	hsa-miR-23a	CLIP-seq
MIRT913640	hsa-miR-23b	CLIP-seq
MIRT913641	hsa-miR-23c	CLIP-seq
MIRT913642	hsa-miR-3618	CLIP-seq
MIRT913643	hsa-miR-3662	CLIP-seq
MIRT913644	hsa-miR-4646-5p	CLIP-seq
MIRT913645	hsa-miR-4729	CLIP-seq
MIRT913646	hsa-miR-520d-5p	CLIP-seq
MIRT913647	hsa-miR-524-5p	CLIP-seq
MIRT913648	hsa-miR-561	CLIP-seq
MIRT913649	hsa-miR-934	CLIP-seq
MIRT1970914	hsa-miR-410	CLIP-seq
MIRT1970915	hsa-miR-548k	CLIP-seq
MIRT2206713	hsa-miR-1299	CLIP-seq
MIRT2206714	hsa-miR-142-5p	CLIP-seq
MIRT2206715	hsa-miR-15a	CLIP-seq
MIRT2206716	hsa-miR-15b	CLIP-seq
MIRT2206717	hsa-miR-16	CLIP-seq
MIRT2206718	hsa-miR-195	CLIP-seq
MIRT2206719	hsa-miR-214	CLIP-seq
MIRT913639	hsa-miR-23a	CLIP-seq
MIRT913640	hsa-miR-23b	CLIP-seq
MIRT913641	hsa-miR-23c	CLIP-seq
MIRT913642	hsa-miR-3618	CLIP-seq
MIRT2206720	hsa-miR-3619-5p	CLIP-seq
MIRT1970914	hsa-miR-410	CLIP-seq
MIRT2206721	hsa-miR-424	CLIP-seq
MIRT2206722	hsa-miR-4291	CLIP-seq
MIRT2206723	hsa-miR-4690-5p	CLIP-seq
MIRT2206724	hsa-miR-4764-5p	CLIP-seq
MIRT2206725	hsa-miR-4782-5p	CLIP-seq
MIRT2206726	hsa-miR-497	CLIP-seq
MIRT2206727	hsa-miR-516b	CLIP-seq
MIRT2206728	hsa-miR-548t	CLIP-seq
MIRT913648	hsa-miR-561	CLIP-seq
MIRT2206729	hsa-miR-761	CLIP-seq
MIRT2206730	hsa-miR-922	CLIP-seq
MIRT913649	hsa-miR-934	CLIP-seq
MIRT2447742	hsa-miR-1279	CLIP-seq
MIRT2447743	hsa-miR-3158-3p	CLIP-seq
MIRT2447744	hsa-miR-4446-3p	CLIP-seq
MIRT913645	hsa-miR-4729	CLIP-seq
MIRT2447745	hsa-miR-4773	CLIP-seq
MIRT2447746	hsa-miR-4793-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IBA
GO:0009306	Process	Protein secretion	IBA
GO:0016020	Component	Membrane	IEA
GO:0035459	Process	Vesicle cargo loading	IBA
GO:0070971	Component	Endoplasmic reticulum exit site	IBA

Other IDs

• MIM: 608856
• HGNC: 24346
• e!Ensembl: ENSG00000212710

Protein

• UniProt ID: Q96RT6
• Protein name: cTAGE family member 2 (Protein cTAGE-2) (Cancer/testis antigen 21.2) (CT21.2)
• Tissue specificity: TISSUE SPECIFICITY: Testis. Not found in tumor.
• Sequence:

  MRPDSHPYGFPWELVIRAAVAGFFAVLFLWRSFRSVTSRLYVRREKKFAVALSGLIEEKC
  KLLEKFSLVQKEYEGYEVESSLKNASFEKEATEAQSLEATCEKLNRFNSELVHEILCLEK
  ELKEEKSKHSEQNELMADISKRIQSLEDESKSLKSQVAEAKMTFKRFQANEERLEIEIQD
  AWKENSELQESQKQLLQEAEVWKEQVSELIKQKRTFEDSKVHAEQVLNDKENHIKTLTER
  LLKMKDGVAMLEEDVTDDDNLELEMNSESEDGAYLDNPPKGALKKLIHAAKLNASLKTLE
  GERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFESENQKLQQKLKVMTELYQ
  ENEMKLYRKLIVEEKCRLEKEEKLSKVDEMISHATEELETYRKRAKDLKEFEKTIHFYQK
  KIILHEKKAHDNWSAAWTAERNLNDLRKENAHNRQKLTEIEFKIKLLEKDPYGLDVPNTA
  FGRQHSPYGPSPLGWPSSETRASLYPPTLLEGPLRLSPLLPRGGGRGSRGPGNPPDHQIT
  KERGESSCDRLTDPHRAPSDAGPLAPPWEQDYRMMFPPPGQSYPDSALPPQRQDRFYSNC
  ARLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDNLGNLKVPDSSLPAENEATGPGF
  VPPPLAPIRGLLFPVDTRGPFIRRGPPFPPPPPGTVFGASPDYFSPRDVPGPPRAPFAMR
  NVYLPRGFLPYRPPRPAFFPPAPTF

• Sequence length: 745
• UniProt ID: Q9HC47
• Protein name: Cutaneous T-cell lymphoma-associated antigen 1 (Protein cTAGE-1) (Cancer/testis antigen 21.1) (CT21.1)
• Tissue specificity: TISSUE SPECIFICITY: Testis. Expressed in several cutaneous T-cell lymphoma (CTCL) cell lines, in head-neck carcinomas and carcinoma of ovarian tissues. {ECO:0000269|PubMed:11149944}.
• Sequence:

  MFVIISLHNCVVISFVLFLFGGNNFIQNFYLPQNYIDQFLLTSFPTFTSVGVLIVLVLCS
  AFLLLWQGEGVNLR

• Sequence length: 74

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BENIGN PROSTATIC HYPERPLASIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIAL CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIAL CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIAL NEOPLASM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Neoplasms	Breast neoplasm	Pubtator	12839582	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	25120790	Associate	★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	12839582		★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	12839582	Associate	★☆☆☆☆ Found in Text Mining only
Fahr's disease	Fahr's disease	Pubtator	17917073	Associate	★☆☆☆☆ Found in Text Mining only
Lymphoma, T-Cell, Cutaneous	Lymphoma	BEFREE	11149944, 12839582, 24850846		★☆☆☆☆ Found in Text Mining only
Lymphoma, T-Cell, Cutaneous	Lymphoma	LHGDN	12839582		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	12839582		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	12839582		★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	12839582	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	11149944		★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	12839582	Associate	★☆☆☆☆ Found in Text Mining only
TARSAL-CARPAL COALITION SYNDROME	Tarsal-Carpal Coalition Syndrome	BEFREE	21396841		★☆☆☆☆ Found in Text Mining only