SH2D7 (SH2 domain containing 7)

Gene

• Entrez ID: 646892
• Gene name: SH2 domain containing 7
• Gene symbol: SH2D7
• Synonyms (NCBI Gene): -
• Chromosome: 15
• Chromosome location: 15q25.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1344388	hsa-miR-2964a-5p	CLIP-seq
MIRT1344389	hsa-miR-3187-3p	CLIP-seq
MIRT1344390	hsa-miR-3614-5p	CLIP-seq
MIRT1344391	hsa-miR-4435	CLIP-seq
MIRT1344392	hsa-miR-4701-5p	CLIP-seq
MIRT1344393	hsa-miR-548s	CLIP-seq
MIRT1344394	hsa-miR-588	CLIP-seq
MIRT1344395	hsa-miR-668	CLIP-seq
MIRT1344388	hsa-miR-2964a-5p	CLIP-seq
MIRT1344390	hsa-miR-3614-5p	CLIP-seq
MIRT2326200	hsa-miR-3908	CLIP-seq
MIRT2326201	hsa-miR-3942-5p	CLIP-seq
MIRT2326202	hsa-miR-4703-5p	CLIP-seq
MIRT2326203	hsa-miR-4766-3p	CLIP-seq
MIRT1344395	hsa-miR-668	CLIP-seq
MIRT2621883	hsa-miR-1587	CLIP-seq
MIRT2621884	hsa-miR-4417	CLIP-seq
MIRT2621885	hsa-miR-4456	CLIP-seq
MIRT2621886	hsa-miR-4492	CLIP-seq
MIRT2621887	hsa-miR-4498	CLIP-seq
MIRT2621888	hsa-miR-4656	CLIP-seq
MIRT2621889	hsa-miR-4675	CLIP-seq
MIRT2621890	hsa-miR-4741	CLIP-seq
MIRT2621891	hsa-miR-4755-3p	CLIP-seq
MIRT2621892	hsa-miR-541	CLIP-seq
MIRT2621893	hsa-miR-654-5p	CLIP-seq
MIRT2621894	hsa-miR-762	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IBA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: A6NKC9
• Protein name: SH2 domain-containing protein 7
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00017	SH2	51 → 126	SH2 domain	Domain

• Sequence:

  MEDSLKQLSLGRDPEGAGDSQALAELQELALKWFMETQAPFILQNGALPPWFHGFITRKQ
  TEQLLRDKALGSFLIRLSDRATGYILSYRGSDRCRHFVINQLRNRRYIISGDTQSHSTLA
  ELVHHYQEAQLEPFKEMLTAACPRPEDNDLYDAITRGLHQTIVDPENPPATAFLTVVPDK
  AASPRSSPKPQVSFLHAQKSLDVSPRNLSQEESMEAPIRVSPLPEKSSSLLEESFGGPSD
  IIYADLRRMNQARLGLGTEGSGRHGPVPAGSQAYSPGREAQRRLSDGEQNRPDGLGPVLS
  GVSPDQGPTESPTSWGCSDAMGSLGATWRQEFPKLSQEAQPCSQGSSADIYEFIGTEGLL
  QEARDTPDQEGSTYEQIPACWGGPARAPHPGASPTYSPWVHGYKRISGTPELSEPGNTYE
  QIPATKSKETGRTHKPDKLRRLFFTYRKHKF

• Sequence length: 451

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL RECESSIVE 48	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations