Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	64582
Gene name	G protein-coupled receptor 135
Gene symbol	GPR135
Synonyms (NCBI Gene)	HUMNPIIY20
Chromosome	14
Chromosome location	14q23.1

Show/Hide all (52)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029231	hsa-miR-26b-5p	Microarray	19088304
MIRT657692	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT657691	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT537095	hsa-miR-101-3p	PAR-CLIP	22012620
MIRT537094	hsa-miR-624-5p	PAR-CLIP	22012620
MIRT537093	hsa-miR-4645-3p	PAR-CLIP	22012620
MIRT537092	hsa-miR-433-3p	PAR-CLIP	22012620
MIRT657692	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT657691	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT537095	hsa-miR-101-3p	PAR-CLIP	22012620
MIRT537094	hsa-miR-624-5p	PAR-CLIP	22012620
MIRT537093	hsa-miR-4645-3p	PAR-CLIP	22012620
MIRT537092	hsa-miR-433-3p	PAR-CLIP	22012620
MIRT1030410	hsa-miR-1271	CLIP-seq
MIRT1030411	hsa-miR-129-5p	CLIP-seq
MIRT1030412	hsa-miR-181a	CLIP-seq
MIRT1030413	hsa-miR-181b	CLIP-seq
MIRT1030414	hsa-miR-181c	CLIP-seq
MIRT1030415	hsa-miR-181d	CLIP-seq
MIRT1030416	hsa-miR-182	CLIP-seq
MIRT1030417	hsa-miR-299-5p	CLIP-seq
MIRT1030418	hsa-miR-3154	CLIP-seq
MIRT1030419	hsa-miR-3185	CLIP-seq
MIRT1030420	hsa-miR-33a	CLIP-seq
MIRT1030421	hsa-miR-33b	CLIP-seq
MIRT1030422	hsa-miR-361-3p	CLIP-seq
MIRT1030423	hsa-miR-3658	CLIP-seq
MIRT1030424	hsa-miR-4262	CLIP-seq
MIRT1030425	hsa-miR-4445	CLIP-seq
MIRT1030426	hsa-miR-4475	CLIP-seq
MIRT1030427	hsa-miR-450b-5p	CLIP-seq
MIRT1030428	hsa-miR-4709-3p	CLIP-seq
MIRT1030429	hsa-miR-4775	CLIP-seq
MIRT1030430	hsa-miR-507	CLIP-seq
MIRT1030431	hsa-miR-557	CLIP-seq
MIRT1030432	hsa-miR-590-3p	CLIP-seq
MIRT1030433	hsa-miR-96	CLIP-seq
MIRT1030418	hsa-miR-3154	CLIP-seq
MIRT1030419	hsa-miR-3185	CLIP-seq
MIRT1030422	hsa-miR-361-3p	CLIP-seq
MIRT1030426	hsa-miR-4475	CLIP-seq
MIRT1030428	hsa-miR-4709-3p	CLIP-seq
MIRT2005739	hsa-miR-4781-3p	CLIP-seq
MIRT2005740	hsa-miR-511	CLIP-seq
MIRT2005740	hsa-miR-511	CLIP-seq
MIRT2437472	hsa-miR-2110	CLIP-seq
MIRT2437473	hsa-miR-3150a-3p	CLIP-seq
MIRT2437474	hsa-miR-3153	CLIP-seq
MIRT2437475	hsa-miR-4260	CLIP-seq
MIRT2437476	hsa-miR-4271	CLIP-seq
MIRT2437477	hsa-miR-4725-3p	CLIP-seq
MIRT2437478	hsa-miR-4796-3p	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	28827538
GO:0005768	Component	Endosome	IDA	28827538
GO:0005768	Component	Endosome	IEA
GO:0005886	Component	Plasma membrane	IDA	28827538
GO:0005886	Component	Plasma membrane	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0010008	Component	Endosome membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:1990763	Function	Arrestin family protein binding	IDA	28827538

MIM	HGNC	e!Ensembl
607970	19991	ENSG00000181619

Q8IZ08

Protein name

G-protein coupled receptor 135

Protein function

Orphan receptor. Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538). {ECO:0000269

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	120 → 387	7 transmembrane receptor (rhodopsin family)	Family

Sequence

MEEPQPPRPPASMALLGSQHSGAPSAAGPPGGTSSAATAAVLSFSTVATAALGNLSDASG
GGTAAAPGGGGLGGSGAAREAGAAVRRPLGPEAAPLLSHGAAVAAQALVLLLIFLLSSLG
NCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTPPGGSAPAAAAGPW
RGFCAASRFFSSCFGIVSTLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGF
SLPWELLGAPRELAAAQSFHGCLYRTSPDPAQLGAAFSVGLVVACYLLPFLLMCFCHYHI
CKTVRLSDVRVRPVNTYARVLRFFSEVRTATTVLIMIVFVICCWGPYCFLVLLAAARQAQ
TMQAPSLLSVVAVWLTWANGAINPVIYAIRNPNISMLLGRNREEGYRTRNVDAFLPSQGP
GLQARSRSRLRNRYANRLGACNRMSSSNPASGVAGDVAMWARKNPVVLFCREGPPEPVTA
VTKQPKSEAGDTSL

Sequence length

494

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, NON-SMALL-CELL LUNG	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBSESSIVE-COMPULSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Azoospermia	Azoospermia	Pubtator	37283758	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	28722770		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	BEFREE	28722770		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	28722770		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial Infarction	GWASDB_DG	21211798		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obsessive-Compulsive Disorder	Obsessive-Compulsive Disorder	GWASCAT_DG	30456828		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

GPR135 (G protein-coupled receptor 135)