BLVRB (biliverdin reductase B)

Gene

• Entrez ID: 645
• Gene name: Biliverdin reductase B
• Gene symbol: BLVRB
• Synonyms (NCBI Gene): BVRB, FLR, HEL-S-10, SDR43U1
• Chromosome: 19
• Chromosome location: 19q13.2
• Summary: The final step in heme metabolism in mammals is catalyzed by the cytosolic biliverdin reductase enzymes A and B (EC 1.3.1.24).[supplied by OMIM, Jul 2009]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029434	hsa-miR-26b-5p	Microarray	19088304
MIRT732044	hsa-miR-127-5p	Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot	26708147
MIRT732044	hsa-miR-127-5p	Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot	26708147
MIRT822194	hsa-miR-137	CLIP-seq
MIRT822195	hsa-miR-24	CLIP-seq
MIRT822196	hsa-miR-3121-5p	CLIP-seq
MIRT822197	hsa-miR-3127-3p	CLIP-seq
MIRT822198	hsa-miR-3667-3p	CLIP-seq
MIRT822199	hsa-miR-4268	CLIP-seq
MIRT822200	hsa-miR-4284	CLIP-seq
MIRT822201	hsa-miR-4313	CLIP-seq
MIRT822202	hsa-miR-4448	CLIP-seq
MIRT822203	hsa-miR-4729	CLIP-seq
MIRT822194	hsa-miR-137	CLIP-seq
MIRT822195	hsa-miR-24	CLIP-seq
MIRT822196	hsa-miR-3121-5p	CLIP-seq
MIRT822197	hsa-miR-3127-3p	CLIP-seq
MIRT822198	hsa-miR-3667-3p	CLIP-seq
MIRT822199	hsa-miR-4268	CLIP-seq
MIRT822200	hsa-miR-4284	CLIP-seq
MIRT822201	hsa-miR-4313	CLIP-seq
MIRT822202	hsa-miR-4448	CLIP-seq
MIRT822203	hsa-miR-4729	CLIP-seq
MIRT822194	hsa-miR-137	CLIP-seq
MIRT822196	hsa-miR-3121-5p	CLIP-seq
MIRT822197	hsa-miR-3127-3p	CLIP-seq
MIRT822198	hsa-miR-3667-3p	CLIP-seq
MIRT822199	hsa-miR-4268	CLIP-seq
MIRT822201	hsa-miR-4313	CLIP-seq
MIRT822202	hsa-miR-4448	CLIP-seq
MIRT2485427	hsa-miR-3144-5p	CLIP-seq
MIRT2485428	hsa-miR-3191	CLIP-seq
MIRT2485429	hsa-miR-4652-5p	CLIP-seq
MIRT2485430	hsa-miR-4715-3p	CLIP-seq
MIRT2485431	hsa-miR-4797-5p	CLIP-seq
MIRT2485432	hsa-miR-759	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004074	Function	Biliverdin reductase [NAD(P)H] activity	IBA
GO:0004074	Function	Biliverdin reductase [NAD(P)H] activity	IDA	7929092, 10858451
GO:0004074	Function	Biliverdin reductase [NAD(P)H] activity	IEA
GO:0004074	Function	Biliverdin reductase [NAD(P)H] activity	TAS	8117274
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	38056462
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	7929092
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0008286	Process	Insulin receptor signaling pathway	IDA	8440175, 38056462
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030219	Process	Megakaryocyte differentiation	IMP	27207795
GO:0035605	Function	Peptidyl-cysteine S-nitrosylase activity	IDA	38056462
GO:0035605	Function	Peptidyl-cysteine S-nitrosylase activity	IEA
GO:0042167	Process	Heme catabolic process	IDA	7929092, 10858451
GO:0042602	Function	Riboflavin reductase (NADPH) activity	IBA
GO:0042602	Function	Riboflavin reductase (NADPH) activity	IDA	11224564
GO:0042602	Function	Riboflavin reductase (NADPH) activity	IEA
GO:0042602	Function	Riboflavin reductase (NADPH) activity	IMP	27207795
GO:0046627	Process	Negative regulation of insulin receptor signaling pathway	IDA	38056462
GO:0046627	Process	Negative regulation of insulin receptor signaling pathway	IEA
GO:0052873	Function	FMN reductase (NADPH) activity	IEA
GO:0052874	Function	FMN reductase (NADH) activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867

Other IDs

• MIM: 600941
• HGNC: 1063
• e!Ensembl: ENSG00000090013

Protein

• UniProt ID: P30043
• Protein name: Flavin reductase (NADPH) (FR) (EC 1.5.1.30) (Biliverdin reductase B) (BVR-B) (EC 1.3.1.-) (Biliverdin-IX beta-reductase) (Green heme-binding protein) (GHBP) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (FLR) (S-nitroso-CoA-assisted nitrosyltransf
• Protein function: Enzyme that can both act as a NAD(P)H-dependent reductase and a S-nitroso-CoA-dependent nitrosyltransferase (PubMed:10620517, PubMed:18241201, PubMed:27207795, PubMed:38056462, PubMed:7929092). Promotes fetal heme degradation during development
• PDB: 1HDO, 1HE2, 1HE3, 1HE4, 1HE5, 5OOG, 5OOH, 6OPL, 7ER6, 7ER7, 7ER8, 7ER9, 7ERA, 7ERB, 7ERC, 7ERD, 7ERE, 8ELL, 8ELM, 8K4K
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13460	NAD_binding_10	10 → 192	NAD(P)H-binding	Domain

• Tissue specificity: TISSUE SPECIFICITY: Predominantly expressed in liver and erythrocytes (PubMed:7929092). At lower levels in heart, lung, adrenal gland and cerebrum (PubMed:7929092). Expressed in adult red blood cells (PubMed:29932944). {ECO:0000269|PubMed:29932944, ECO:00
• Sequence:

  MAVKKIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPRPAHVVVGDVLQAAD
  VDKTVAGQDAVIVLLGTRNDLSPTTVMSEGARNIVAAMKAHGVDKVVACTSAFLLWDPTK
  VPPRLQAVTDDHIRMHKVLRESGLKYVAVMPPHIGDQPLTGAYTVTLDGRGPSRVISKHD
  LGHFMLRCLTTDEYDGHSTYPSHQYQ

• Sequence length: 206

Pathways

KEGG:

Riboflavin metabolism
Porphyrin metabolism
Metabolic pathways

Reactome:

Heme degradation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ESOPHAGEAL SQUAMOUS CELL CARCINOMA	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STOMACH NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	22897724		★☆☆☆☆ Found in Text Mining only
Adult Acute Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	22897724		★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	Pubtator	32653974	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	26708147	Associate	★☆☆☆☆ Found in Text Mining only
Cerebral Infarction	Ischemic stroke	Pubtator	32653974	Associate	★☆☆☆☆ Found in Text Mining only
Childhood Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia	BEFREE	22897724		★☆☆☆☆ Found in Text Mining only
Dwarfism	Dwarfism	BEFREE	10810295		★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	21517111	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hereditary Diffuse Gastric Cancer	Gastric Cancer	CTD_human_DG	19424620		★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	8321021		★☆☆☆☆ Found in Text Mining only
Leukemia, Myelomonocytic, Chronic	Myelomonocytic Leukemia	BEFREE	8321021		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	10810295, 11916628, 26708147, 27740521		★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	BEFREE	10810295, 11916628		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	CTD_human_DG	19424620		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29500232		★☆☆☆☆ Found in Text Mining only
Malnutrition	Malnutrition	BEFREE	7509216		★☆☆☆☆ Found in Text Mining only
Microcephaly	Microcephaly	BEFREE	28128342		★☆☆☆☆ Found in Text Mining only
MYELODYSPLASTIC SYNDROME	Myelodysplastic Syndrome	BEFREE	8321021		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	30132102, 7769857		★☆☆☆☆ Found in Text Mining only
Neurofibromatosis 1	Neurofibromatosis	BEFREE	7769857, 8018414, 8321021, 8528106		★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	29042073		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	CTD_human_DG	21517111		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach Neoplasms	CTD_human_DG	19424620		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thrombocytosis	Thrombocytosis	BEFREE	27207795		★☆☆☆☆ Found in Text Mining only
Thrombocytosis	Thrombocytosis	Pubtator	27207795	Associate	★☆☆☆☆ Found in Text Mining only